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Tadamoto IsogaiView profile

Assistant Professor

• Cancer Biology
• Cell Biology
• Biomedical Engineering
• +3 more

Tadamoto Isogai is an Assistant Professor at the Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center since 2023. His research integrates high-resolution 3D single-cell imaging with computational methods to study cytoskeletal architecture's role in cancer cell survival. He applies mathematical models inspired by financial economics to analyze gene pathway dynamics without experimental perturbation, focusing on actin-binding proteins in membrane protrusions. Dr. Isogai earned his PhD from The Netherlands Cancer Institute in Amsterdam. His work bridges cell biology, biophysics, and bioinformatics, emphasizing systems-level approaches to understand mechanotransduction and cell migration. Notable contributions include uncovering CLIC4's role in RhoA signaling and developing algorithms for 3D microscopy analysis. His recent studies explore actin-membrane interactions during cell protrusion initiation, mechanical regulation of glycolysis, and systems biology approaches to lamellipodial actin networks. Research outputs span Nature , Cell Systems , and Philosophical Transactions of the Royal Society , reflecting interdisciplinary impact.

• Chemical Biology
• Medicinal Chemistry
• Cancer Therapy
• +3 more

Lanron Bi is an Associate Professor of Chemistry at Michigan Technological University (MTU), affiliated as an Associate Professor in Biological Sciences and an Associate Research Scientist at Columbia University’s Genome Center. Their research focuses on chemical biology for DNA sequencing innovation, medicinal chemistry targeting cardiovascular and cancer therapies, and prodrug design for enhanced drug delivery. Key collaborations include work at Columbia’s Department of Chemical Engineering and the College of Physicians and Surgeons. Research interests include developing molecular probes for disease gene discovery, imaging agents for cancer and cardiovascular diseases, and peptide prodrugs. Major contributions include patents on four-color DNA sequencing technologies using cleavable fluorescent nucleotides. Publications span mitochondrial imaging probes, exosomal biomarkers in neurodegenerative diseases, and therapeutic strategies for ischemia-reperfusion injury. Recent work emphasizes brain-targeted ROS detection, extracellular vesicle signaling in hypertension, and neuroinflammation mechanisms. The lab innovates fluorescent dyes and spin probes for mitochondrial tracking in stroke and neurodegenerative models. No specific awards are listed, but their interdisciplinary work bridges chemical synthesis, biomedicine, and molecular diagnostics.

Ryuichi ShigemotoView profile

Professor

• Molecular Neuroscience
• Synaptic Transmission
• Receptor Localization
• +6 more

Ryuichi Shigemoto is a Professor at the Institute of Science and Technology Austria (ISTA) since 2013, focusing on Molecular Neuroscience within the School of Life Sciences. He previously held professorships at the National Institute for Physiological Sciences, Kyoto University (1998–2013) and Kyoto University Faculty of Medicine (1990–1998). His research pioneers high-resolution methods like SDS-digested freeze-fracture replica labeling to study synaptic molecule localization. MD (1985) and PhD (1994) from Kyoto University His research interests include: Ultrastructural localization of glutamate receptors , GABAB receptors , and calcium channels Synaptic plasticity mechanisms in cerebellum and hippocampus Left-right brain asymmetry and its impact on memory formation Neurotransmitter release dynamics using Flash & Freeze techniques His recent 15 publications span calcium channel organization , receptor subunit composition , and synaptic dysfunction in Alzheimer’s models . Notably, he received two ERC Advanced Grants (2016, 2015) and was elected to Academia Europaea (2017) and Leopoldina (2022). His lab includes PhD students like Abdylla Parahadov and postdocs such as Cihan Önal , investigating topics from neurotransmitter release to synaptic pathologies .

• Plant Biochemistry
• Lipid Metabolism
• Enzymology
• +3 more

Dr. Katarzyna Jasieniecka-Gazarkiewicz is a Lecturer at the Intercollegiate Faculty of Biotechnology of the University of Gdańsk and the Medical University of Gdańsk (MUG), affiliated with the Department of Plant Biochemistry at the Institute of Biotechnology. Her research focuses on lipid metabolism in plants and microorganisms, particularly enzymatic pathways involved in lipid biosynthesis, remodeling, and storage. Key areas include acyltransferase enzymes (e.g., LPCAT, LPEAT, PDAT), stress responses in plants, and the biochemical mechanisms underlying seed development and germination. Her work integrates molecular biology, biochemistry, and cell biology to explore topics such as: Lipid dynamics in diatoms (e.g., Phaeodactylum tricornutum) and plants (e.g., Camelina sativa, Momordica charantia), Enzymatic regulation of phospholipid and triacylglycerol composition, Temperature and stress effects on lipid metabolism, Functional roles of acyl-CoA: lysophospholipid acyltransferases (LPLATs) in membrane homeostasis and autophagy. Publications emphasize experimental systems like in vitro cultures, seed germination studies, and genetic manipulation to dissect enzyme functions. Findings contribute to understanding plant adaptation to environmental stresses and optimizing oilseed crop productivity.

• Protein Biochemistry
• Molecular Biology
• Neurodevelopmental Disorders
• +3 more

Dr. hab. Szymon Ziętkiewicz is a Lecturer in the Department of Protein Biochemistry at the Faculty of Biotechnology, University of Gdańsk, in collaboration with the Medical University of Gdańsk. His research focuses on molecular mechanisms of protein folding, chaperone systems, and their implications in neurodevelopmental, genetic, and metabolic diseases. Key research areas include: Neurogenetic disorders (e.g., KCNK4 mutations, CLPB deficiency) Mitochondrial proteostasis and heat shock proteins Immune checkpoint receptors (HVEM/CD160) in melanoma Genotype-phenotype correlations in rare diseases Protein aggregation and disaggregation dynamics His publications span clinical genetics, structural biology, and biochemical characterization of disease-linked proteins, with a focus on neurology, nephrology, and immunotherapy. Recent work highlights epilepsy phenotypes, mitochondrial refoldases, and immune signaling mechanisms.

Miguel ChiurilloView profile

Assistant Professor

• Molecular Parasitology
• Genomic Organization
• Host-Parasite Interactions
• +6 more

Miguel Chiurillo is an Assistant Professor at the Department of Biological Sciences , University of Cincinnati , with prior appointments at institutions including Universidad Centroccidental Lisandro Alvarado (Venezuela) and Universidade Federal de São Paulo (Brazil). His research focuses on molecular mechanisms underlying Trypanosoma cruzi adaptation, utilizing CRISPR/Cas9 to study gene functions in parasite differentiation, host-pathogen interactions, and mitochondrial bioenergetics. MD from Universidad Centroccidental Lisandro Alvarado (1991), PhD in Biological Sciences from Universidad Simon Bolivar (1999) Postdoctoral training at Institute of Advanced Studies (IDEA) (Venezuela), State University of Campinas (Brazil), and University of Georgia (USA) His work explores protein kinases in cell signaling during T. cruzi life cycle stages, linking mitochondrial calcium homeostasis to bioenergetics and life/death decisions. He has developed genomic tools for reverse genetics in trypanosomes , enabling gene knockout , endogenous tagging , and functional studies of cytokinesis regulators and signaling pathways . Publications highlight trends in mitochondrial signaling (2021-2025), CRISPR/Cas9 applications (2016-2023), and protein kinase validation (2021). His American Heart Association Grant (2023-2025) and NIAID grant (2023-2025) fund studies on multigene analysis and barcode screening in T. cruzi .

• Peroxisome Biology
• Innate Immunity
• Immunometabolism
• +7 more

Francesca DiCara is an Associate Professor in the Departments of Microbiology & Immunology and Pediatrics at Dalhousie University's Faculty of Medicine. Her research focuses on peroxisomes' role in innate immunity using Drosophila models. She holds a PhD from the University of Naples 'Federico II' and completed postdoctoral training at the Universities of Edinburgh, Alberta, and remained as a Research Associate at the latter until 2018. Education: Laurea Magistrale (BSc + MSc), University of Naples 'Federico II' PhD, University of Naples 'Federico II' Her research investigates peroxisome-mediated immune signaling, particularly in macrophages and gut cells, exploring how peroxisome metabolic products influence Toll/IMD pathways (analogous to human Toll/TNF pathways). Key areas include peroxisome roles in inflammation, immunodeficiency, cancer, and diabetes. Current projects address peroxisome-dependent gene networks during infections and gut health maintenance. Her work has been recognized with awards such as the 2016 Open European Peroxisome Meeting Presentation Award and the 2009 British Society of Cell Biology Travelling Award. She leads the Di Cara Lab, supported by grants from CIHR, NSERC, and others, and is recruiting students and technicians. Funding Sources: Canadian Institutes of Health Research (CIHR) Natural Sciences and Engineering Research Council (NSERC) Research Nova Scotia Beatrice Hunter Cancer Research Institute Canada Research Chairs (Tier 2 in Human Immunology) Lab activities include defining peroxisome roles in macrophage function, immune signaling pathways, and enteric immunity. Collaborations explore neurodegenerative diseases and rare disorders like Roifman syndrome through Drosophila models.

John BlenisView profile

Professor

• Cancer Biology
• Cell Signaling
• Metabolic Pathways
• +3 more

John Blenis, PhD, is the Anna-Maria and Stephen Kellen Professor in Cancer Research and Professor of Pharmacology at Weill Cornell Medical College. His research focuses on biochemical mechanisms integrating extracellular signals, intracellular pathways, and metabolic processes to regulate cellular bioenergetics, mRNA metabolism, and protein synthesis. The lab pioneered studies on Ras/ERK/RSK, PI3K/Akt, and mTOR signaling, identifying cancer biomarkers and drug targets. Current work includes investigating mTOR-driven metabolic reprogramming, drug resistance mechanisms, and combination therapies for cancer. Education: PhD (1983, Michigan State University), BS (1977, University of California, Berkeley). Research Interests: mTOR signaling, metabolic regulation, kinase inhibitors, tumor microenvironment, propionate metabolism in cancer, and aging-related metabolic diseases. The lab employs high-throughput screens, CRISPR-based approaches, and metabolomics to uncover therapeutic targets. Publications highlight mTOR's role in mRNA splicing, nutrient sensing, and oncogene addiction. Key findings include FABP5-mTORC1 fatty acid sensing and methylmalonic acid's role in metastasis. Grants: Active NIH/NCI and DoD funding for projects targeting STING in cancer, BRCA1/2-deficient tumors, and folate/vitamin C combinations. Collaborates with industry via Elikia INC. Labs/Teams: Leads a multidisciplinary team at Weill Cornell, collaborating with computational biologists and clinical researchers to translate findings into therapies.

• Human Anatomy
• Bone Biology
• Regenerative Medicine
• +3 more

Carla Palumbo is a Full Professor at the University of Modena and Reggio Emilia, affiliated with the Department of Biomedical, Metabolic and Neuroscience Sciences. Her research focuses on human anatomy, bone biology, and regenerative medicine, with particular emphasis on osteogenesis mechanisms, biomaterials, and cellular signaling pathways. Her work integrates molecular, cellular, and translational research, addressing topics such as bone regeneration using novel biomaterials like scleral ossicles, the role of osteocytes in skeletal health, and the impact of muscle-bone crosstalk. Dr. Palumbo is also involved in medical education, advocating for gender medicine and personalized physical activity prescription in medical curricula. Her studies explore innovative approaches to bone repair, including the use of bioactive glasses and 3D-printed scaffolds. She investigates nuclear envelope dynamics in cancer progression and the effects of nanoparticles on cellular processes. Key projects include evaluating angiogenic potential of biomaterials using the chick chorioallantoic membrane (CAM) model and examining autophagy in colorectal carcinogenesis. Her lab employs advanced techniques such as exosome-mediated therapies and proteomic analyses to advance regenerative strategies and disease understanding. Dr. Palumbo’s research has contributed to clinical insights in orthopedic surgery, such as comparing surgical techniques like Piezosurgery versus traditional osteotomes. She collaborates across disciplines, bridging basic science with clinical applications, and emphasizes eco-sustainable materials in regenerative medicine.

Brian OxhornView profile

Associate Professor

• Nursing Education
• Healthcare Administration
• Nursing Simulation
• +3 more

Brian Oxhorn, PhD, MSN, RN is the Dean and Associate Professor at Roseman University's College of Nursing. Prior roles include Director of the Simulation and Skills Laboratory (2012–present) and Assistant Professor (2012–2015). His career spans critical care nursing, emergency nursing, and academic administration. He holds a BS in Nursing (1992, University of Nevada-Reno), PhD in Pharmacology (2002, same institution), and a postdoctoral fellowship at the University of Connecticut (2003). His MSN in Nursing Education was earned at Drexel University (2005). Dr. Oxhorn's research focuses on nursing education innovation, simulation-based training, and healthcare administration. Key areas include: Development of high-fidelity simulation curricula for mental health competencies Pharmacology-driven signaling pathways in endothelial cells Policy analysis in health systems management His publications emphasize simulation efficacy (e.g., 2016 study on mental health skills) and foundational pharmacology work on caspase signaling (2001–2003). Presentations highlight simulation implementation strategies in nursing education. Awards include the 2003 George G. Bierkamper Outstanding Pharmacology Graduate Student Award. Leadership roles span AACN (2012–present), Nevada State Grassroots Liaisons (2022–present), and multiple national nursing organizations. Advising contributions include collaborative work on simulation studies. His Simulation and Skills Laboratory at Roseman supports innovative clinical training methodologies.

Roland BenderView profile

Professor

• Neuroanatomy
• Neuroscience
• Molecular Biology
• +1 more

Roland Bender is Professor at the Institute of Neuroanatomy within the University Medical Center Hamburg-Eppendorf. His research focuses on neuroendocrine interactions, particularly sex hormone influences on brain development, plasticity, and injury responses. Experimental approaches span molecular biology, electrophysiology, and neuroanatomical techniques. Research Focus: Examines estrogen receptor signaling pathways in hippocampal plasticity, sexual dimorphism in neural circuits, and hormonal modulation of traumatic brain injury outcomes. Recent work explores GPER1 receptor functions and aromatase-mediated synaptic regulation. Publication Trends: Research demonstrates consistent focus on hormonal regulation of ion channels and synaptic mechanisms, with recent expansion into medical education innovation.

Xiaoxiao ZhangView profile

Lecturer

• Protein Engineering
• Synthetic Biology
• Plant Innate Immunity
• +4 more

Xiaoxiao Zhang is a Lecturer and Group Leader at the Research School of Chemistry, Australian National University (ANU), leading research in synthetic biology for crop disease resistance. Previously, she completed her PhD at the University of Queensland (2012-2015) and worked as a postdoctoral fellow at CSIRO Agriculture & Food (2015-2018). Education PhD, University of Queensland (2012-2015) Research Focus Her work integrates protein engineering and synthetic biology to enhance immune signaling mechanisms in plant and animal innate immunity. Key investigations include structural analysis of NLR receptors, Toll/interleukin-1 receptor domains, and pathogen effector interactions. She develops chimeric proteins to engineer conserved immune mechanisms across biological contexts, with emphasis on cereal crop protection. Publication Trends Recent publications (2022-2025) demonstrate consistent focus on plant immune receptor mechanics, particularly NLR proteins and TIR domains in pathogen recognition. Her work bridges structural biology insights with practical applications in genome editing for disease-resistant crops, showing increasing emphasis on translational synthetic biology approaches. Scientific Recognition Discovery Early Career Researcher Award (DECRA) from Australian Research Council (2021) JG Russell Award for synthetic biology research Research Leadership As Principal Investigator, she manages three major projects: an ARC DECRA fellowship (2021-2023), a synthetic biology initiative for cereal disease resistance (2021-2024), and an active project extending this work until 2027. She is registered to supervise graduate students and leads a multidisciplinary team combining protein biochemistry, structural analysis, and plant pathology. Research Environment Her group operates within ANU's Research School of Chemistry, leveraging institutional resources for protein engineering and structural analysis. Collaborations span CSIRO, University of Queensland, and international partners in plant immunity research, with active participation in networks focused on cereal pathogen resistance.

Eric BetzigView profile

Professor

• Super-Resolution Microscopy
• Cell Biology
• Biophysics
• +5 more

Eric Betzig is a Howard Hughes Medical Institute (HHMI) Investigator and Professor of Cell Biology, Development, and Physiology. His research focuses on advancing microscopy technologies to study biological systems at high spatiotemporal resolution. He leads a lab pioneering innovations like lattice light-sheet microscopy and super-resolution imaging, enabling real-time observation of dynamic cellular processes in living organisms. His work bridges physics, cell biology, and biophysics to decode complex biological phenomena. Research interests include developing imaging tools to visualize subcellular dynamics, organelle interactions, and cellular mechanisms in multicellular contexts. Betzig’s contributions have revitalized microscopy as a cornerstone of biological discovery, particularly in studying live tissues and embryos. His Nobel Prize in Physics (2015) recognizes breakthroughs in super-resolution microscopy. Key collaborative applications span immunology, neurobiology, and developmental biology, with studies on T-cell dynamics, endocytic pathways, and ER organization. Articles emphasize high-resolution imaging techniques and their application to unravel cellular processes like actin-myosin interactions and Huntingtin aggregate formation. Awards include the Nobel Prize and HHMI Investigator status. Betzig’s lab continues to address challenges in data analysis and large-scale imaging, fostering interdisciplinary approaches to biological discovery.

Sabeeha MerchantView profile

Professor

• Trace Metal Metabolism
• Photosynthesis
• Algal Genomics
• +5 more

Sabeeha Merchant holds the Warren C. Eveland Endowed Chair in Biological Sciences and is a Professor of Biochemistry, Biophysics and Structural Biology at the University of California, Berkeley. Her research focuses on trace metal metabolism and homeostasis in green algae like Chlamydomonas reinhardtii, leveraging genomics, proteomics, and elemental analysis. Key areas include metal economy dynamics, photosynthetic acclimation, and algal-bacterial symbiosis. She leads projects on comparative genomics to understand metabolic adaptations across green algae, with applications in biofuel production and environmental biology. Research Themes: Metal homeostasis, photosynthesis, algal genomics, extremophile adaptation Key Techniques: Transcriptomics, cryo-EM, multi-omics integration Collaborations: DOE-funded projects with Kris Niyogi, Trent Northen, and others Her lab investigates how algae optimize metal use under stress, with recent work on manganese storage mechanisms and diurnal metabolic rhythms. Publications span molecular mechanisms of metal sensing to genome-scale studies of bioenergy-relevant algae like Chromochloris zofingiensis. Ongoing work explores symbiotic interactions between algae and bacteria, aiming to identify metabolite exchange patterns across daily cycles.

• Developmental Biology
• Molecular Biology
• Cell Biology
• +5 more

Mary E. Lane is a Professor at UMass Chan Medical School's T.H. Chan School of Medicine in the Department of Neurobiology. Her research focuses on developmental biology, molecular biology, and cell biology, particularly investigating mechanisms in zebrafish and Drosophila. Colgate University, BA in Molecular Biology Columbia University, PhD in Biological Sciences Lane’s work explores cell cycle regulation , signal transduction , and gene expression dynamics during embryogenesis. Her publications span topics like zebrafish hindbrain development , JNK signaling , and RNA localization in Drosophila oogenesis. Her selected publications (1993–2020) reveal a strong emphasis on cell cycle progression , developmental signaling pathways , and gene regulatory networks in model organisms. Key areas include CDC25a , LMO4 , and Protein Kinase A studies. Lane collaborates with researchers like Andreas Bergmann and others in Developmental Biology and Signal Transduction networks. Her work is cited in 11 patents and followed by 88 readers on Mendeley .