Evangelos K. OikonomouView profile
Assistant Professor
Dr. Evangelos (Evan) Oikonomou is an Assistant Professor in the Section of Cardiovascular Medicine at Yale School of Medicine. A physician-scientist specializing in AI applications for cardiovascular disease, he leads research at the intersection of computer vision, machine learning, and precision cardiology. His work focuses on developing scalable digital tools that can be integrated into clinical care pathways to improve cardiovascular diagnosis and risk assessment. Dr. Oikonomou's educational background includes: MD from the University of Athens Medical School (graduated as valedictorian) D.Phil. in Medical Sciences from the University of Oxford Internal Medicine Residency and Cardiology Fellowship at Yale School of Medicine His research spans multiple domains of AI in cardiovascular medicine, with particular focus on precision phenotyping and digital biomarkers. Key areas include developing perivascular adipose tissue imaging biomarkers for vascular inflammation assessment, designing deep learning algorithms for point-of-care echocardiography, and leading data-driven evaluations of treatment effect heterogeneity across clinical trials. His work aims to leverage multimodal AI to redefine diagnostic and prognostic frameworks in cardiovascular disease, emphasizing real-world implementation and equity in access to advanced diagnostics. Dr. Oikonomou's recent publications demonstrate a strong trend toward developing and validating AI algorithms that can be deployed in clinical settings for cardiovascular disease detection and risk stratification. His research increasingly focuses on multimodal approaches combining echocardiography, electrocardiography, and other data sources to create comprehensive cardiovascular assessment tools. His work has particular emphasis on making these tools accessible and applicable across diverse patient populations. Dr. Oikonomou has received numerous prestigious awards, including: NIH F32 Ruth L. Kirschstein National Research Service Award Young Investigator Awards from American Heart Association, American College of Cardiology, and European Society of Cardiology Heart Tank For the Cardiovascular Investigator - Imaging (Winner) from American College of Cardiology Trainee Poster Award Winner from CERSI Summit 2024 ASCI emerging generation (e-Gen) award from American Society of Clinical Investigation Elizabeth Barrett-Connor Research Award in Epidemiology and Prevention from American Heart Association Dr. Oikonomou leads the Cardiovascular Data Science Lab (CarDS) at Yale, where his team develops and implements AI-driven solutions for cardiovascular disease diagnosis and risk assessment. The lab focuses on creating practical, scalable tools that can be integrated into existing clinical workflows to enhance precision medicine approaches in cardiology.









