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Paul KayeView profile

Professor

• Leishmaniasis
• Immunopathology
• Macrophages
• +5 more

Paul Kaye is Professor of Immunology at the University of York and a member of the Experimental Medicine and Biomedicine research group at Hull York Medical School. With over 30 years of experience in leishmaniasis immunology, he is internationally recognized for pioneering research on macrophages, dendritic cells, and granulomatous inflammation during chronic infection. His academic foundation includes a BSc in Zoology from University College London (1981) and a PhD in Immunology from the London School of Hygiene and Tropical Medicine (1984), followed by progressive appointments at Imperial College London culminating in Professor of Cellular Immunology before joining York in 2004. Professor Kaye's research adopts a holistic approach to leishmaniasis, integrating immunology with mathematics, ecology, vector biology, and neuroscience. Current work focuses on host-directed therapies, lymphoid tissue remodeling, sand fly transmission dynamics, and therapeutic vaccine development through Phase II trials in Sudan. His lab employs cutting-edge technologies including 2-photon intravital microscopy, digital pathology, and computational immunology. Recent publications demonstrate deep specialization in leishmaniasis immunopathology while expanding into spatial transcriptomics for COVID-19 research, reflecting his ability to translate fundamental immunological insights across disease contexts using advanced molecular and imaging techniques. Key scientific recognitions include: Wellcome Trust Senior Investigator designation Election as Fellow of the UK Academy of Medical Sciences (FMedSci) FRCPath accreditation awarded by publication in 2004 As Principal Investigator, he has secured major funding including a Wellcome Trust Translation Award for therapeutic vaccine trials and an MRC Global Challenges Research Fund award for molecular pathological stratification. His research group maintains active collaborations across leishmaniasis-endemic regions in Brazil, India, Sri Lanka, and East Africa, with emphasis on clinical translation and capacity building. He leads the LeishPathNet digital pathology platform to enable global data sharing and is developing multidimensional molecular characterization methods for tissue biopsies, while continuing his role as Director of the Centre for Immunology and Infection until 2015 and ongoing research leadership within York's immunology ecosystem.

• Haematopoietic Stem Cell Biology
• Leukemia
• Myeloid Malignancies
• +7 more

Kristian Gurashi is a Postdoctoral Researcher in the Mead Group at the University of Oxford, focusing on Normal and Malignant Haematopoietic Stem Cell Biology . His work integrates multiomic approaches to study myeloid malignancies such as chronic myelomonocytic leukemia (CMML), myelofibrosis, and myelodysplastic syndromes (MDS). Key Research Areas: Haematopoietic Stem Cell Biology Myeloid Malignancies Single-Cell Genomics Organoid Modeling Precision Medicine Immune Suppression Mechanisms His recent publications highlight the application of single-cell sequencing , spatial transcriptomics , and organoid models to dissect clonal evolution, microenvironmental interactions, and therapeutic resistance. Notable trends include studies on TP53 mutations , JAK2 allelic burden , and MDMX expression as prognostic and therapeutic indicators. His work also explores inflammatory signaling and aberrant cell communication in disease progression.

Mudassar IqbalView profile

Senior Lecturer

• Gene Regulatory Networks
• Machine Learning
• Bioinformatics
• +4 more

Mudassar Iqbal holds the position of Senior Lecturer in Health Data Sciences within the Division of Informatics, Imaging & Data Sciences. His research focuses on integrating computational methods with biological data to study gene regulatory networks, circadian rhythms, and cancer biology. He earned a Doctor of Philosophy from the University of Kent in 2009, specializing in machine learning applications for protein-protein interaction prediction. His work contributes to UN Sustainable Development Goals related to health and innovation. Key research interests include spatial transcriptomics, single-cell multiomics analysis, and computational modeling of biological systems. His recent studies explore age-related gene networks in AML, chronotype associations with psoriasis, and algorithm development for integrating imaging and genomic data. He collaborates internationally on projects analyzing gene expression, circadian biology, and cancer genomics. His methods like CellPie and TriTan advance scalable tools for spatial and multi-omics data analysis. Research affiliations include the Digital Futures, Lydia Becker Institute, and Christabel Pankhurst Institute. He has supervised three academic works and published widely in journals like Nucleic Acids Research and eLife , focusing on bioinformatics-driven discoveries in health and disease.

Jane LangdaleView profile

Professor

• Plant Development
• C4 Photosynthesis
• Genetics
• +4 more

Professor Jane Langdale, CBE FRS FAA, is a Professor of Plant Development at the University of Oxford, affiliated with the Department of Biology and The Queen's College. Her research focuses on the genetics and evolution of plant development, particularly the mechanisms underlying C4 photosynthesis in plants. She leads the Langdale Lab, which investigates how developmental pathways evolved to enable the C4 photosynthetic pathway, with a long-term goal of engineering this trait into C3 crops like rice. Her work integrates genetics, genomics, and cell biology to understand leaf anatomy and photosynthetic efficiency. Professor Langdale’s research has explored diverse plant taxa, including mosses, lycophytes, ferns, and grasses. She has pioneered methods for studying leaf development, such as spatial transcriptomics and single-cell analysis. Her contributions include identifying key genes like WIP6 and GOLDEN2-like that regulate leaf anatomy and chloroplast biogenesis. She has also developed genetic tools for rice, enabling precise tissue-specific gene expression. Her scientific achievements are recognized through prestigious awards: Commander of the British Empire (CBE), Fellow of the Royal Society (FRS), and Fellow of the Australian Academy of Science (FAA). These honors reflect her global impact on plant science and agricultural innovation. Professor Langdale collaborates widely, contributing to initiatives like the C4 Rice Project. Her lab’s work bridges fundamental biology with applied challenges, aiming to enhance crop yields through photosynthetic improvements. Despite no listed students or grants in the provided text, her leadership in high-impact research underscores her role in mentoring and funding acquisition. Her research extends to understanding evolutionary transitions in plant development, such as the shift from 2D to 3D growth in mosses and the genetic basis of Kranz anatomy in C4 species. This work provides insights into how plants adapt to environmental challenges, including climate change.

Simon CoxView profile

Professor

• Brain and Cognitive Ageing
• Neuroimaging
• Lifecourse Correlates of Brain Structure
• +3 more

Professor Simon Cox is a leading academic in brain and cognitive ageing at the University of Edinburgh's School of Philosophy, Psychology and Language Sciences. As a Sir Henry Dale Fellow and Director of the Lothian Birth Cohort Studies, he investigates lifecourse determinants of brain structure and cognitive differences using multi-cohort neuroimaging and genomic data. Principal Investigator on Age UK, BBSRC, ESRC, and NIH-funded projects Research focuses on neurodevelopment, epigenetics, and environmental influences on ageing Research Interests span: Brain-cognition relationships across the lifespan Multi-omics approaches to neurodegeneration Environmental and genetic mediators of cognitive decline Neuroimaging methodology development Frailty and multimorbidity in ageing populations Life-course epidemiology of brain health Selected Publications (2023-2025) reveal trends in: Epigenetic biomarkers of brain ageing Genomic structural equation modeling Environmental impacts (air pollution, socioeconomic status) Neuroinflammation and mental health Connectomic analysis of depression Vascular risk and brain structure Scientific Awards : Sir Henry Dale Fellowship National Institute on Aging R01 funding NIH RF1 grant for Alzheimer's research PhD Supervision includes projects on: PRENCOG cohort (preterm birth effects) Wellcome-funded mental health data science Translational neuroscience (15+ students)

Owen SansomView profile

Professor

• Colorectal Cancer
• Wnt Signalling
• Cancer Biology
• +6 more

Professor Owen Sansom is Director of the Cancer Research UK Scotland Institute in Glasgow, where he leads the Colorectal Cancer and Wnt Signalling research group. His work focuses on understanding the molecular mechanisms underlying colorectal cancer initiation, progression, and metastasis using state-of-the-art preclinical models. His educational background includes a PhD from the University of Edinburgh (2002), MRes in Biology from the University of Manchester (1997), and BSc in Genetics (First Class Honours) from the University of Nottingham (1996). Prior to his current role as Director (since 2017), he served as Deputy Director of the CRUK Beatson Institute (2011-2017) and has been a Group Leader at the institute since 2005. Professor Sansom's research interests center on colorectal cancer biology, particularly Wnt signaling pathways, cancer stem cells, and therapeutic resistance mechanisms. His lab utilizes genetically engineered mouse models to investigate how key driver mutations contribute to cancer development and response to therapy. He is particularly interested in developing stage- and subtype-specific targeted therapies for colorectal cancer patients. His recent publications reveal significant trends in colorectal cancer research, with strong emphasis on cellular plasticity, tumor heterogeneity, metabolic reprogramming, and the tumor microenvironment. His work spans molecular mechanisms, preclinical models, and translational applications, with particular focus on WNT-dependent colorectal cancer, therapeutic vulnerabilities, and metastasis mechanisms. Fellow of the Academy of Medical Sciences (2017) CRUK Future Leaders in Cancer Research Prize (2012) Fellow of the Royal Society of Edinburgh (2012) BACR/AstraZeneca Young Scientist Frank Rose Award (2007) Professor Sansom actively mentors numerous PhD students and postdoctoral researchers in his lab, supervising projects related to colorectal cancer biology, metastasis, and therapeutic resistance. His research is supported by multiple funding sources including Cancer Research UK, industry partnerships with Novartis, and participation in major cancer consortia such as ACRCelerate, CRUK Grand Challenge Rosetta, and CRUK Grand Challenge SpecifiCancer. His lab operates as part of the Cancer Research UK Scotland Institute, where they utilize advanced preclinical models, organoid culture systems, and multi-omics approaches to investigate colorectal cancer biology. The team includes bioinformaticians, postdoctoral scientists, clinical research fellows, and graduate students working collaboratively on various aspects of colorectal cancer research.

Mekayla A StorerView profile

Researcher

• Developmental Biology
• Stem Cell Biology
• Regenerative Medicine
• +4 more

Dr. Mekayla A Storer is a Group Leader at the Wellcome-MRC Cambridge Stem Cell Institute and an affiliate of the University of Cambridge's Physiology, Development and Neuroscience department. Her research focuses on the cellular and molecular mechanisms of blastema formation during mammalian digit tip regeneration, combining single-cell transcriptomics , genetic lineage tracing , and in vitro blastema cultures . Education : PhD from Centre for Genomic Regulation (Barcelona, Spain), supervised by Dr. Bill Keyes Postdoctoral Training : Drs. Freda Miller and David Kaplan at Hospital for Sick Children (Toronto, Canada) Her work explores how stem cells and senescence contribute to regeneration, with implications for therapies targeting broader tissue repair. Key publications include studies on blastema dynamics (2020), digit regeneration (2022), and a human embryonic limb cell atlas (2023). Laboratory Members : PhD Student: Jia Hua Wang Research Associates: Camille Dumas, Kentaro Hirose, Joseph Wong Biomedical Research Technician: Evelina Sliauteryte Postgraduate Student: Lauren Connolly

Rob KramsView profile

Professor

• Cardiovascular Disease
• Atherosclerosis
• Biomaterials
• +7 more

Professor Rob Krams is Chair of the Division of Bioengineering and Scientific Director of the CVDHub at Queen Mary University of London's School of Engineering and Materials Science. His research integrates engineering and molecular biology to study cardiovascular biomechanics, epigenetic regulation, and atherosclerosis. With over 500 publications, he focuses on mechanotransduction, shear stress effects on vascular biology, and advanced imaging techniques. Research Interests: His lab investigates how mechanical forces influence gene expression in endothelial cells using CRISPR, high-throughput screening, and fluid-structure interaction modeling. Key areas include non-coding RNA networks, synthetic biology approaches for vascular repair, and multi-scale computational models bridging cellular responses to hemodynamics. Publication Trends: Recent work emphasizes machine learning applications in hemodynamics, deep learning for plaque classification, and novel imaging techniques for shear stress quantification. His articles consistently explore intersections of computational modeling, molecular biology, and translational cardiology. Awards & Recognition: Established Investigator Award (2003–2008) Associate Editor for 12 scientific journals Research Infrastructure: Leads a multidisciplinary team at the Centre for Bioengineering, developing pipelines for in vivo endothelial cell isolation, RNA analysis, and CRISPR validation. Collaborates globally on projects involving intravascular imaging, animal models of atherosclerosis, and biomechanical diagnostics.

Christopher PughView profile

Professor

• Cellular Oxygen Sensing
• Renal Medicine
• Oncology
• +3 more

Christopher Pugh is a Professor of Renal Medicine at the University of Oxford’s Nuffield Department of Clinical Medicine. He has held multiple academic roles, including Fellowships at Kellogg College (since 2004), Green College, and prior positions at Trinity College and Keble College. His research focuses on cellular oxygen sensing, particularly the hypoxia-inducible factor (HIF) pathway, and its implications in cancer, kidney disease, and ischemic conditions. He co-founded ReOx Limited, a spinout company targeting oxygen-sensing system therapies. In clinical practice, he cares for patients with acute/chronic kidney diseases and runs a specialist clinic for renal metabolic issues and kidney stones. He directs the Oxford University Clinical Academic Graduate School, supporting future clinician-scientists. Educationally, he teaches renal medicine on Oxford’s standard and graduate-entry medical courses, chairs committees, and advises on university-wide policies. Key collaborations include work with Sir Peter Ratcliffe (Nobel laureate), Chris Schofield, and Patrick Maxwell. His scientific awards include FRCP (2000) and FMedSci (2003). Current projects include the PEDAL Trial consortium on dialysis patient exercise and data fusion of vital signs during dialysis treatments. He also explores genetic sequencing for renal disease understanding.

Maria VeretennikovaView profile

Research Fellow

• Biomedical Sciences
• Machine Learning
• Statistics
• +6 more

Maria Veretennikova is a Junior Research Fellow and Senior Bioinformatician in the Nuffield Department of Medicine at the University of Oxford. Her work focuses on applying mathematical, machine learning, and statistical methods to biomedical problems. Education: PhD, MSc, and Master’s (Warwick University). Research Interests: Single-cell RNASeq and spatial transcriptomics analysis related to immune system functionality. Active in quantifying circadian rhythm disruption in diseases, numerical computations of Markov processes, stochastic analysis of brain data, and anomalous diffusion modeling. No specific grants or awards explicitly listed in the provided text.

• Microbiology
• Immunology
• Dermatology
• +3 more

Yiwei WANG is a Research Fellow in the Damsky Lab at the Yale School of Medicine's Department of Dermatology. Their research focuses on the role of the microbiome in immune-mediated diseases, including atopic dermatitis, cancer, and post-viral syndromes. WANG holds a PhD in Biomedical Sciences from The Chinese University of Hong Kong (2021) and a BSc in Biotechnology from Jilin University (2017). Key research interests include gut microbiota dynamics, immune checkpoint modulation in cancer therapy, and transcriptomic/proteomic profiling of skin disorders. Collaborations with William Damsky, Erica Hwang, and others have produced studies on spatial transcriptomics in granulomatous disorders and probiotic effects on atopic dermatitis. Recent work highlights the use of advanced genomic techniques to explore dysbiosis in male infertility, PASC syndrome pathophysiology, and regulatory mechanisms in alopecia areata. Their publications span high-impact journals in immunology, microbiology, and dermatology.

Gi Fay MokView profile

Lecturer

• Developmental Biology
• Stem Cell Biology
• Hematopoietic Stem Cells
• +12 more

Dr. Gi Fay Mok is a Lecturer in Biomedicine and Group Leader at the BioMedical Research Centre (BMRC), School of Biological Sciences, University of East Anglia. He leads an independent research lab focused on developmental and stem cell biology, with funding from the British Heart Foundation, the Royal Society, and UKRI DTP. He is actively mentoring PhD and MSc students and contributes to academic leadership as the organizer of the 'Cell, Development and Molecular Biology' seminar series and as BIO Research Staff Co-ordinator. PhD, University of Nottingham (2009–2012) Postdoctoral Research Associate, University of East Anglia (2013–2019) Post-doctoral Research Associate, Earlham Institute (2020) Lecturer & Group Leader, University of East Anglia (2022–present) Dr. Mok's research centers on the embryonic origin of hematopoietic and endothelial stem cells, aiming to inform regenerative medicine. His lab uses the chick embryo as a model system and integrates CRISPR-based genome editing , advanced live imaging , single-cell sequencing (scRNA-seq, ATAC-seq), and computational biology to dissect gene regulatory networks and cellular dynamics during early blood development. A key goal is to enable the in vitro generation of clinically relevant stem cells for therapeutic use. The recent publications highlight a strong focus on developmental genomics , spatial transcriptomics , and gene regulation in embryogenesis . His work spans single-cell profiling of avian and mouse embryos, regulatory mapping of somite maturation, and functional studies of genes like Talpid3 in stem cell behavior. The research consistently bridges fundamental developmental mechanisms with translational applications in regenerative medicine. Dr. Mok has secured competitive research funding from major bodies including the British Heart Foundation , the Royal Society , and UKRI . These grants support projects on enhancer validation, hematoendothelial lineage tracing, and chromatin remodeling in development. Royal Society: Rapid in vivo validation of enhancer elements during embryonic hematoendothelial development (2023–2025) British Heart Foundation: Characterizing the embryonic origin of haemangioblasts (2020–2023) BBSRC: Unravelling microRNA-chromatin remodelling in myogenesis (2016–2019) John & Pamela Salter Charitable Trust: microRNA detection in embryonic tissues (2014–2015) Dr. Mok advises multiple students, including UKRI-BBSRC NRP DTP PhD candidates Lydia Pouncey and Andreas Nikolopoulos. His lab, the Mok Lab, is embedded within the BMRC at UEA and collaborates extensively with researchers such as Prof. Andrea Münsterberg and Dr. Iain Macaulay. The team combines wet-lab and computational approaches to address key questions in developmental biology.

• Hematopoietic Stem Cell Biology
• Myeloid Cell Differentiation
• Transcription Factor Regulation
• +3 more

Roy Drissen is a Postdoctoral Researcher at the Weatherall Institute of Molecular Medicine (University of Oxford) working within the Hematopoietic Stem Cell Genetics department under the Nerlov Group. He holds a PhD from Erasmus MC in Rotterdam and has held postdoctoral positions at the WIMM (2005–2009) and the Centre for Regenerative Medicine in Edinburgh (2009–2012), before returning to the WIMM. PhD: Erasmus MC, Rotterdam (1999–2005) Postdoc: WIMM (2005–2009) Postdoc: Centre for Regenerative Medicine, Edinburgh (2009–2012) Current: WIMM (University of Oxford) Drissen investigates hematopoietic stem cell (HSC) lineage commitment and myeloid cell differentiation using single-cell technologies. His work has revealed dual pathways in myeloid development, particularly focusing on eosinophils, basophils, and mast cells, with implications for myeloid malignancies like systemic mastocytosis. He combines mouse and human models to study normal and malignant hematopoiesis, emphasizing transcription factor regulation and epigenetic programming. His recent publications highlight epigenetic mechanisms in HSC fate restriction (2023), enhancer-driven oncogene synergy in CEBPA/CSF3R mutant AML (2019), and identification of distinct myeloid pathways (2016). His research spans from basic erythroid gene regulation to malignant transformation models, reflecting a trajectory from transcriptional control to cancer biology.

• Endometriosis
• Reproductive Medicine
• Gynaecological conditions
• +9 more

Christian M. Becker is Professor of Reproductive Sciences at the University of Oxford and Co-Director of the Oxford Endometriosis CaRe Centre. He serves as Principal Investigator and Consultant Gynaecologist & Subspecialist in Reproductive Medicine at the Nuffield Department of Women's and Reproductive Health. As Clinical Lead for the Oxford BSGE Endometriosis Centre, he oversees Endometriosis, Pelvic Pain, Infertility and Adolescent Gynaecology Services at Oxford University Hospitals NHS Foundation Trust. Dr. Becker completed his MD at Freie Universität Berlin in 1998 after undergraduate training at Semmelweis University in Budapest. He completed his residency in obstetrics and gynaecology at Charité Berlin, receiving full registration in 2003. He spent five years as a postdoctoral fellow at Children's Hospital and Brigham and Women's Hospital Harvard Medical School in Boston, working under Judah Folkman on angiogenesis and antiangiogenic therapy. His research focuses on women's health, particularly endometriosis, a common condition associated with abdominal pain and subfertility. He co-directs the Oxford Endometriosis CaRe Centre, which combines clinical care with research on endometriosis, adenomyosis, PCOS, and uterine fibroids. His work includes identifying biomarkers, improving endometriosis categorization, and discovering novel management approaches. Current clinical studies include the FENOX Study (biorepository), DETECT Study (imaging technique), and FEMaLe Study (machine learning for diagnosis). His recent publications (2024-2025) demonstrate a strong focus on molecular mechanisms of gynecological conditions, particularly endometriosis and uterine fibroids, using advanced techniques like single-cell analysis, spatial transcriptomics, and metabolomics. His work bridges basic science with clinical applications, addressing both diagnostic challenges and therapeutic innovations in reproductive medicine. Chairperson of the ESHRE Guideline Development Group for Management of Women with Endometriosis Member of the NICE Guideline Committee for Endometriosis As Clinical Lead for the Oxford BSGE Endometriosis Centre, one of the UK's largest tertiary referral centers, he works with a dedicated team of nurses, doctors, and administrators. He is part of the Children and Young Adult Tissue Preservation Team, helping cancer patients preserve fertility. His research is supported by EU Horizon funding, NIHR Oxford Biomedical Research Centre, and industry collaborations. The Endometriosis CaRe Centre, which he co-founded in 2013 with Prof Krina Zondervan, relies on biological samples and clinical data donated by patients for translational research. His laboratory work focuses on improving the genetic and molecular understanding of gynecological conditions, with particular emphasis on developing more individualized management approaches for patients. The CaRe Centre serves as both a clinical service provider and research hub, creating a unique integration of patient care and scientific investigation in reproductive medicine.

• Microbial Genomics
• Next Generation Sequencing
• Bioinformatics
• +7 more

Professor Ian Goodhead is a leading academic in Microbial Genomics at the University of Salford's School of Science, Engineering & Environment. With a PhD and Fellow of the Higher Education Academy (FHEA) status, he directs research on microbial symbiosis, pathogenesis, and host-microbe interactions using multi-omic strategies. His work bridges wet-lab and computational biology with significant focus on infectious diseases and capacity building in low-middle income countries. His primary research interests include Genomics, Next Generation Sequencing, Bioinformatics, Microbiomes, Neglected Tropical Diseases, and Genome Evolution. He maintains strong field applications in vector-borne diseases and emerging pathogens, particularly through DNA sequencing technology development. His recent publications demonstrate interdisciplinary work spanning primate genomics, bacterial pathogenesis, and environmental microbiology. Professor Goodhead has secured over £2 million in research funding from major bodies including Wellcome, NERC, BBSRC, the Royal Society, and the Royal Society of Tropical Medicine and Hygiene. He actively supervises PhD students in Microbial Genomics and teaches across Genomics, Microbiology, and Bioinformatics disciplines. His leadership roles include serving as Associate Dean for Research and Innovation (2018-2024) and as an External Examiner for the University of Liverpool's MSc Advanced Biological Sciences program. He contributes to the University's Biomedical Research and Environmental Research centres, aligning with UN Sustainable Development Goals for health, education, sustainable cities, and ecosystem conservation. His innovative projects include brewing sustainability initiatives (SAHIB, DIV-BA), tick-borne disease surveillance, and microbial diagnostics for refugee communities in Uganda.