Fatma Kübra TombultürkView profile
Assistant Professor
Dr. Fatma Kübra Tombultürk serves as Assistant Professor at Istinye University's Vocational School of Health Care Services, where she leads research at the intersection of molecular biology and clinical wound management. Her academic foundation includes a BSc in Biology from Dumlupınar University (2010) and an MSc in Medical Biology from Istanbul University's Cerrahpasa Faculty of Medicine (2015). Her research portfolio centers on diabetic wound healing mechanisms , with three primary pillars: 1) Therapeutic modulation of oxidative stress and autophagy through topical metformin, 2) Molecular characterization of Lucilia sericata maggot therapy's secretome, and 3) Genetic investigations of polymorphisms (NFKB1, miRNA variants) in inflammatory conditions. This work spans biochemical, proteomic, and genetic methodologies using streptozotocin-induced diabetic rat models. Analysis of her 13 publications (2015-2025) reveals escalating focus on translational applications: Early work (2015-2018) established genetic correlations in obesity and infertility, while recent studies (2021-2025) demonstrate metformin's dual action on collagen synthesis/apoptosis and Lucilia 's protease-mediated tissue remodeling. Her 2024-2025 papers specifically address keratin heterodimers and hypoxia responses—highlighting evolving sophistication in targeting molecular wound pathways. Dr. Tombultürk actively supervises student research in medical biochemistry and wound science, with recent projects including proteome-level analysis of maggot excretions and topical metformin formulations. Her collaborative network includes co-authors from multiple Turkish institutions (e.g., Kasap Murat, Polat Erdal), indicating strong interdisciplinary partnerships. Future directions focus on clinical translation of metformin-based topical therapies and genetic biomarker validation for personalized wound care.







