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Sriram SubramaniamView profile

Professor

• cryo-electron microscopy
• structural biology
• drug-design
• +4 more

Sriram Subramaniam is a Professor in the Department of Biochemistry and Molecular Biology at the University of British Columbia (UBC) and holds the Gobind Khorana Canada Excellence Research Chair in Precision Cancer Drug Design. His research leverages cryo-electron microscopy (cryo-EM) to advance structural biology and drug design, focusing on protein dynamics and therapeutic target identification. Education: PhD in Physical Chemistry (1987) from Stanford University; MSc in Chemistry (1981) from Indian Institute of Technology, Kanpur. Subramaniam's interdisciplinary work combines cryo-EM with computational tools and molecular biology to study protein structures at atomic resolution. His lab has pioneered cryo-EM applications in precision medicine, including mapping small molecule drugs on patient-specific cancer mutants. Recent publications (2024-2022) highlight his contributions to understanding SARS-CoV-2 immune evasion, structural mechanisms of ATPases, and AI integration in structural biology. His research spans viral entry mechanisms, CRISPR systems, and neurodegenerative disease pathways. Scientific Awards: Gobind Khorana Canada Excellence Research Chair NIH Director’s Award for Scientific Excellence Fellow of the Biophysical Society Breakthrough Prize nomination Based at the Djavad Mowafaghian Center for Brain Health, Subramaniam leads the Program in Cryo-EM Guided Drug Design, contributing to over 177 peer-reviewed publications with a career h-index of 58 and citations exceeding 12,340.

• Drug Delivery
• Nanomedicine
• Biopharmaceutics
• +7 more

Dr. Shyh-Dar Li is a Professor and Tong Louie Chair in Pharmaceutical Sciences at the University of British Columbia's Faculty of Pharmaceutical Sciences, where he also serves as Chair of Nanomedicine and Chemical Biology. With a BSc in pharmacy from National Taiwan University (1998) and PhD in pharmaceutical sciences from UNC Chapel Hill (2008), followed by postdoctoral training at UC San Diego's Moores Cancer Center (2009), Dr. Li has established himself as a leading researcher in advanced drug delivery systems. His research focuses on developing innovative nanomedicine platforms for targeted delivery of biological therapeutics including peptides, proteins, antibodies, and nucleic acids. Dr. Li's laboratory has pioneered several novel drug delivery approaches, particularly in lipid-based nanoparticles, phospholipid-free vesicles, and polymer systems for cancer immunotherapy, pain management, and protein delivery. His work bridges fundamental nanotechnology with translational applications for difficult-to-treat diseases. Analysis of his recent publications reveals a strong emphasis on tumor microenvironment modulation, endosomal escape mechanisms for nucleic acid delivery, and non-invasive delivery routes for protein therapeutics. His research demonstrates increasing sophistication in nanocarrier engineering, with recent work incorporating machine learning approaches to optimize nanoparticle design and expanding into immunomodulatory therapies that harness the body's immune system to fight cancer. Scientific Recognition: 2014 AFPC New Investigator Award 2013 AAPS New Investigator Award in Pharmaceutics and Pharmaceutical Technologies 2013 CIHR New Investigator Award 2013 CSPS Early Career Award 2012 Prostate Cancer Foundation Young Investigator Award Dr. Li's research program has been consistently supported by major Canadian funding agencies including CIHR, NSERC, and MITACS. He actively collaborates across disciplines and accepts graduate students into his research program, focusing on cutting-edge approaches to overcome biological barriers in drug delivery. His laboratory, the Laboratory of Targeted Drug Delivery and Nanomedicine, serves as a hub for innovation in pharmaceutical nanotechnology.

Vikramaditya G. YadavView profile

Associate Professor

• Biocatalysis
• Bioremediation
• Bioprocess engineering
• +15 more

Vikramaditya G. Yadav is an Associate Professor at the University of British Columbia (UBC) in the Department of Chemical and Biological Engineering, Faculty of Applied Science. He directs the Master of Engineering Leadership (MEL) Program in Sustainable Process Engineering and leads the BioFoundry research group. Education: B.A.Sc., University of Waterloo (2007) Ph.D., Massachusetts Institute of Technology (2013) Postdoctoral Associate, Harvard University (2014) His research spans sustainable chemical manufacturing, metabolic engineering, and biotechnology. Key areas include: Designing biosynthetic enzymes for biomass valorization Developing bioremediation strategies for industrial water quality Creating innovative drug delivery systems and tissue engineering solutions Advancing synthetic biology for pharmaceutical and bioenergy applications His recent work focuses on ocular drug delivery, cannabinoid biosynthesis in E. coli, lignin-based nanoparticles for cancer therapy, and computational analysis of plant secondary metabolites. Collaborations with start-ups, industry, and medical labs drive innovation in Canada's bioeconomy. Professional Leadership: Chair, Biotechnology Division of the Chemical Institute of Canada Associate Editor, The Canadian Journal of Chemical Engineering He is affiliated with UBC's BioProducts Institute and contributes to project-based learning pedagogy.

Thibault MayorView profile

Professor

• Protein Homeostasis
• Ubiquitin Proteasome System
• Neurodegenerative Diseases
• +7 more

Thibault Mayor is a Professor in the Department of Biochemistry and Molecular Biology and the Michael Smith Laboratories at the University of British Columbia (Vancouver). His research focuses on understanding how cells manage misfolded proteins, with implications for neurodegenerative diseases like Parkinson's and Alzheimer's. He holds academic affiliations with the Centre for High-Throughput Biology (CHiBi) and has been recognized with awards including the UBC Killam Teaching Award (2020). Education: BSc, University of Geneva, Switzerland (1997) PhD, University of Geneva & Max Planck Institute of Biochemistry, Germany (2001) Postdoctoral Fellow, California Institute of Technology (2002) Research Interests: Mayor's lab investigates protein homeostasis, ubiquitin-proteasome system dynamics, and the molecular mechanisms underlying protein aggregation in aging and disease. Projects include proteomic approaches to identify aggregation-prone proteins and develop microbial cell factories for protein production. Grants & Awards: CIHR Project Grant ($730K, 2018) Michael Smith Foundation Career Award (2012) UBC Killam Teaching Award (2020) Labs & Collaborations: The Mayor Lab is part of the Michael Smith Laboratories and collaborates with computational biologists like Jörg Gsponer. They maintain active partnerships in proteomics and systems biology, contributing to initiatives like the BC Proteomics Network.

Christopher M. OverallView profile

Professor

• Protease Proteomics
• Systems Biology
• Degradomics
• +6 more

Christopher M. Overall is a Full Professor at the University of British Columbia in the Faculty of Dentistry, Department of Oral Biological and Medical Sciences . He is also a Principal Scientist at the Centre for Blood Research and holds associate memberships in UBC's Biochemistry & Molecular Biology , Obstetrics and Gynecology , and Bioinformatics Graduate Program departments. As a Canada Research Chair Laureate , he pioneered the field of degradomics to study proteases in vivo. B.D.S., University of Adelaide Ph.D., University of Toronto Postdoctoral Fellowship, UBC (with Nobel Laureate Michael Smith) Dr. Overall’s research focuses on protease proteomics and systems biology , particularly degradomics to analyze protease substrates in diseases like COVID-19 and immunodeficiency . His work on matrix metalloproteinases has revealed new therapeutic strategies for inflammatory diseases and cancer . His 15 most recent articles (2015–2008) demonstrate expertise in TAILS proteomics , protein terminomics , and protease network analysis with applications in arthritis , antiviral immunity , and precision medicine . Scientific Awards 2022 Helmut Holzer Award 2018 Royal Society of Canada Fellow 2014 Tony Pawson Canadian Proteomics Award 2013 IADR Distinguished Scientist Award Dr. Overall has mentored 61 trainees , including 9 full professors with department chairs, and received the UBC John McNeill Mentorship Award (2023). He leads the HUPO Chromosome-centric Human Proteome Project and consults for Genentech and Novartis .

David VocadloView profile

Professor

• Bioorganic Chemistry
• Chemical Biology
• Glycobiology
• +3 more

David Vocadlo is a Distinguished Professor of Chemistry and Molecular Biology & Biochemistry at Simon Fraser University (SFU), holding the Canada Research Chair in Chemical Biology. His research focuses on Chemical Glycobiology, investigating carbohydrate-processing enzymes and developing chemical tools to study glycan roles in health and disease. His lab explores O-GlcNAc signaling, neurodegenerative disorders (e.g., Alzheimer’s, Parkinson’s), and enzyme inhibitors for therapeutic applications. Education: PhD from University of British Columbia (UBC), followed by a CIHR postdoctoral fellowship at UC Berkeley. Key roles include E.W.R. Steacie Memorial Fellow and Royal Society Fellow. Research highlights include O-GlcNAcase inhibitors for neuroprotection, glycan structure-function relationships, and enzyme activity imaging tools. Collaborates globally with experts in glycobiology and employs cutting-edge techniques like chemical synthesis, mass spectrometry, and live-cell imaging. Awards: Distinguished Professor title, Canada Research Chair, Royal Society Fellowship. Active in training researchers through SFU’s graduate programs, emphasizing interdisciplinary approaches. Lab members work on topics ranging from enzyme mechanisms to disease modeling.

• Biosensors
• Functional Nucleic Acids
• Sol-Gel Materials
• +3 more

John D Brennan is a Professor in the Department of Chemistry & Chemical Biology at McMaster University. He is affiliated with the Biointerfaces Institute and focuses on developing innovative biosensing technologies and functional nucleic acid-based assays. His research integrates materials science, biochemistry, and analytical chemistry to create practical diagnostic tools for healthcare applications. Key research areas include the design of DNA aptamers and DNAzymes for detecting biomarkers (e.g., eosinophil peroxidase, SARS-CoV-2 spike proteins), development of paper-based diagnostic platforms, and optimization of sol-gel materials for enzyme entrapment. His work emphasizes high-throughput screening, point-of-care testing, and CRISPR-based biosensing systems. Notable contributions include a rapid sputum-based assay for asthma biomarkers and a universal DNA aptamer for SARS-CoV-2 variants. His lab also explores functional nucleic acid circuits and their integration into scalable diagnostic devices. Brennan’s teaching includes advanced courses in analytical chemistry and biochemical assay development. His work has been featured in journals like *Angewandte Chemie*, *Analytical Chemistry*, and *ChemBioChem*, with a focus on translating fundamental research into practical clinical applications.

Sachdev SidhuView profile

Research Professor

• Synthetic Antibodies
• Protein Engineering
• Biotechnology
• +5 more

Sachdev Sidhu is a Research Professor and Entrepreneur in Residence at the University of Waterloo. His research focuses on synthetic antibodies, protein engineering, and biotechnological applications. He leads efforts in developing novel therapeutic antibodies, engineered protein systems, and molecular tools for biomedical research. His work spans cancer therapy, viral infection countermeasures, and regenerative medicine. Sidhu is also involved in translational research, bridging academic discoveries with commercial applications through entrepreneurial ventures. Key research interests include synthetic antibody libraries, CAR T-cell engineering, ubiquitin-based therapeutics, and phage display technologies. He has contributed to advancements in targeted therapies for glioblastoma, leukemia, and ocular diseases. His team develops innovative methods for protein design, such as engineered ubiquitin variants and modular antibody architectures. Publications highlight breakthroughs in antibody-based treatments, including synNotch CAR T cells for glioblastoma and neutralizing antibodies against SARS-CoV-2. His work integrates structural biology, molecular biology, and computational approaches to address complex biomedical challenges. Sidhu collaborates with industry partners to advance technologies into clinical and commercial settings.

Lawrence GoodridgeView profile

Professor

• Food Safety
• Antibiotic Resistance
• Foodborne Pathogens
• +6 more

Lawrence Goodridge is a Professor and Director of the Canadian Research Institute for Food Safety (CRIFS) at the University of Guelph's Ontario Agricultural College. He holds the Leung Family Professorship in Food Safety and leads research at the intersection of food safety, antibiotic resistance, and One Health principles. His work focuses on applying genomic technologies to study foodborne pathogens (E. coli, Salmonella, Listeria, Cronobacter) and leveraging wastewater surveillance for infectious disease outbreak prediction. Academic History: BSc Microbiology (University of Guelph, 1995), MSc Food Microbiology (2003), PhD Food Microbiology (2002), followed by post-doctoral training in Food Safety at the University of Georgia (2002). Joined CRIFS in 2003. Research Interests: Genomic analysis of pathogen emergence, wastewater-based epidemiology, bacteriophage applications, and consumer education strategies for food safety. His lab develops innovative methods for rapid pathogen detection in food systems and environmental samples. Articles Trends: Over 100 peer-reviewed publications emphasize genomic surveillance of foodborne pathogens and SARS-CoV-2, with a focus on wastewater sampling innovations. Recent work explores multi-modal data integration for public health forecasting and ethical data protection frameworks for surveillance programs. Awards: While no specific prizes are listed, his $50M+ research funding from Canadian/international sources underscores recognition of his impactful work. Grants support projects like phage-based sanitization and antimicrobial resistance tracking. Advising & Labs: Leads CRIFS laboratory operations and collaborates globally on food safety initiatives. His research has informed food industry guidelines and policy frameworks for mitigating pathogen risks in agricultural and environmental systems.

Joel WeadgeView profile

Associate Professor

• Bacterial Biofilms
• Bacterial Carbohydrates
• Protein Structure and Function
• +7 more

Joel Weadge is an Associate Professor in the Biology Department at Wilfrid Laurier University , Waterloo, Ontario. His research focuses on bacterial biofilms, glycobiology, and protein structure-function relationships. Contact: jweadge@wlu.ca , Office: BA425 (Bricker Academic). Education: PhD in Microbiology (University of Guelph, 2006) BSc (Hons) in Microbiology (University of Guelph, 2000) Research Interests center on bacterial biofilms as virulence factors in pathogens like E. coli and Salmonella . Key areas include: Structural and functional characterization of biofilm proteins (cellulose, curli fimbriae) Enzymology of carbohydrate modifications (acetylation, phosphoethanolamine transfer) Developing therapeutics targeting biofilm synthesis Biopolymer applications for medical/industrial use Publications highlight studies on Pseudomonas and Salmonella biofilm mechanisms, glycosyltransferases, and carbohydrate-active enzymes, with methodologies spanning X-ray crystallography to high-throughput biofilm profiling. Labs and Teams: The Weadge Lab investigates biofilm roles in food/water security and oral health, utilizing enzymology, mass spectrometry, and structural biology. Current members include graduate students, technicians, and research assistants.

Roberto A. ChicaView profile

Professor

• Protein Engineering
• Computational Protein Design
• Biocatalysis
• +5 more

Roberto A. Chica is a Full Professor in the Department of Chemistry and Biomolecular Sciences at the University of Ottawa, Faculty of Science. His research focuses on computational and experimental protein engineering, particularly in designing novel enzymes and fluorescent proteins for biotechnological applications. He develops advanced algorithms for protein design and investigates enzyme dynamics using molecular modeling and structural biology approaches. Key research interests include biocatalysis, structural biology, and the application of computational methods to engineer proteins with tailored functions. His lab integrates experimental protein chemistry with computational simulations to understand catalytic mechanisms and design proteins for industrial and biomedical uses. Recent work emphasizes ensemble-based computational enzyme design, exploring how conformational landscapes influence catalytic efficiency. His articles highlight advancements in artificial enzyme creation, substrate specificity modulation, and fluorescent protein optimization. Chica’s contributions bridge fundamental biochemistry with applied innovations in protein engineering. Notable achievements include the design of bright red fluorescent proteins via computational approaches and the development of biosensors for protein expression monitoring. His research has implications for drug discovery, biocatalytic synthesis, and personalized medicine.

Simon SharpeView profile

Professor

• Biophysics
• Structural Biology
• Molecular Biophysics
• +9 more

Simon Sharpe is a Professor in the Department of Biochemistry at the University of Toronto and a Senior Scientist at The Hospital for Sick Children. His research focuses on the structural and dynamic properties of self-assembling proteins, particularly those involved in degenerative diseases, elastomeric proteins, and biological phase separation. The Sharpe Lab utilizes advanced biophysical techniques such as NMR spectroscopy, X-ray scattering, and electron microscopy to investigate these phenomena. BSc: Memorial University of Newfoundland (Cell Biology and Biochemistry, 1997) PhD: University of Western Ontario (Biochemistry, 2002) Postdoctoral Training: NIH (Solid-State NMR, 2002-2006) Research interests include: Protein self-assembly mechanisms Amyloid formation in neurodegenerative diseases Elastin and resilin biophysics Lipid-protein interactions Biological phase separation Structure-function relationships Lab members include Research Associate Dr. Sean Reichheld and PhD students James Otis, Asal Nady, and Robert Lu. The lab has dedicated access to 600 and 700 MHz NMR spectrometers and collaborates with SickKids facilities including the SBC Facility and Imaging Facility. Scientific awards: Canada Research Chair (2006-2016) Ontario Early Researcher Award (2010) Dr. Sharpe has taught courses including BCH374Y1 (Research Project in Biochemistry) and BCH425H (Structural Biology: Principles and Practice). His recent publications examine topics ranging from serum amyloid A structure to bacterial phase separation defenses, with methodologies combining solid-state NMR, fluorescence microscopy, and computational approaches.

• Developmental Psychophysiology
• Temperament and Personality Development
• Neuroscience of Shyness and Social Anxiety
• +4 more

Professor Louis Schmidt is a leading academic in the Department of Psychology, Neuroscience & Behaviour at McMaster University , with a research focus on developmental psychophysiology, temperament, and the long-term effects of early adversity. His work bridges neuroscience, psychology, and behavioral science, emphasizing the interplay between brain function and socio-emotional development across the lifespan. Key research themes: Shyness, social anxiety, autism spectrum disorder, schizophrenia, and outcomes of extremely low birth weight. Recognized for mentoring postdoctoral fellow Kristie Poole, who was celebrated as a role model in the Child Emotion Laboratory. Scientific Awards : Royal Society of Canada recognition for contributions to research and scholarship. Research Trends from 15 recent publications include: Neurophysiological mechanisms of shyness (EEG, ERP, RSA) Impact of antenatal corticosteroids on adult brain function Intergenerational effects of maternal mental health interventions Cross-cultural comparisons of temperamental shyness Developmental consequences of preterm birth Behavioral and neural correlates of social anxiety in diverse populations Grants & Collaborations : Led the SNACS randomized controlled trial on antenatal corticosteroids, with applications in obstetrics and developmental neuroscience. Collaborates extensively on topics like autism spectrum disorder, schizophrenia, and emotion regulation. Labs & Teams : Directs the Child Emotion Laboratory at McMaster University, fostering interdisciplinary research on developmental psychopathology and neural mechanisms of temperament.

Jacques ArchambaultView profile

Professor

• Human Papillomavirus (HPV)
• Polyomavirus
• Viral DNA Replication
• +4 more

Dr. Jacques Archambault is a Professor in the Department of Microbiology and Immunology at McGill University , and an associate member of the Division of Experimental Medicine since 2016. His research focuses on the molecular biology and pathogenesis of human papillomaviruses (HPVs) and polyomaviruses (HPyVs), with an emphasis on their replication mechanisms as episomes in host cells. The Archambault laboratory employs functional genomics, proteomics, and chemical biology approaches to identify cellular pathways exploited by these viruses and develop high-throughput assays for screening small molecule inhibitors of viral replication. Analysis of his recent publications reveals a strong focus on HPV and HPyV replication machinery, including studies on the E1 helicase, UAF1-USP1 interactions, and structural characterization of viral proteins involved in DNA replication. His work bridges virology, oncology, and drug discovery, particularly targeting oncogenic HPV types implicated in anogenital and oropharyngeal cancers, as well as HPyVs like BKPyV and JCPyV that cause pathologies in immunosuppressed patients. Current efforts in the lab aim to elucidate the molecular mechanisms by which HPVs and HPyVs replicate their genomes and to develop antiviral therapies targeting these processes. Techniques such as fluorescence anisotropy, NMR spectroscopy, and crystallography are frequently employed to study protein-DNA and protein-protein interactions critical to viral replication.

Cristina RosellView profile

Professor

• Design and development of innovative grain-based foods
• Quality assessment of cereals and other grains
• Starch physical properties in foods
• +7 more

Dr. Cristina Rosell is a Professor and Head of the Department of Food and Human Nutritional Sciences at the Faculty of Agricultural and Food Sciences, University of Manitoba. Her research focuses on grain-based food innovation, starch properties, and sustainable bakery processes. Education: PhD and BSc in Pharmacy from Universidad Complutense de Madrid, Spain Dr. Rosell specializes in cereal science, enzymatic food modification, and gluten-free product development. Her current projects include optimizing bakery processes with computational tools, tracing rice supply chains via blockchain, and integrating bioactives into gluten-free foods. Her work bridges food chemistry, nutritional science, and industrial bakery technology. Her recent research trends emphasize gluten-free bread using legume and root starches, starch-plant compound interactions , and sustainable food processing via microwave-assisted extraction, high-pressure treatments, and fermentation. Key subfields include dough rheology, polyphenol bioactivity, and techno-functional ingredient development. Dr. Rosell’s teaching includes graduate seminars in food science (HNSC 7130). She supervises graduate students in breadmaking, starch hydrolysis, and functional food design. Her lab explores grain quality, enzymatic treatments, and bakery product optimization through interdisciplinary approaches combining chemistry, nutrition, and process engineering.