Job DekkerView profile
Professor
Job Dekker is a Professor holding the Joseph J. Byrne Chair in Biomedical Research at UMass Chan Medical School, where he serves as faculty across multiple departments including Systems Biology, Biochemistry and Molecular Biotechnology, and Bioinformatics and Integrative Biology. His work bridges the T.H. Chan School of Medicine and Morningside Graduate School of Biomedical Sciences, with significant contributions to understanding the three-dimensional organization of genomes. Utrecht University, Utrecht, Netherlands: MS Biology Utrecht University, Utrecht, Netherlands: PhD Physiological Chemistry Dekker's research focuses on the fundamental question of how chromosomes are organized in three-dimensional space and how this organization influences gene regulation. As a pioneer in chromosome conformation capture technologies (particularly Hi-C), his laboratory investigates long-range gene regulation, higher-order chromosome organization, and the mechanisms of chromatin folding. The lab employs a multidisciplinary approach combining cell culture, protein biochemistry, microscopy, genomics, and computational modeling to address these questions. Analysis of Dekker's recent publications reveals a continued focus on the structural principles governing chromosome organization, with particular emphasis on mitotic chromosome formation, loop extrusion mechanisms, and the role of cohesin and condensin complexes. His work spans multiple model systems and has increasingly incorporated multi-omics approaches to understand how 3D genome architecture relates to cellular function in both normal and disease states. Member, National Academy of Sciences (2022) Member, National Academy of Medicine (2021) EMBO Associate Member (2020) International Award of the Biochemical Society (2018) Novitski Prize of the Genetics Society of America (2018) Investigator, Howard Hughes Medical Institute (2015) Fellow, American Association for the Advancement of Science (2014) As Principal Investigator of the Dekker Lab within the Program in Systems Biology, Dekker has secured substantial funding including his HHMI Investigator position, which supports his research into chromosome organization. His laboratory offers multiple rotation projects for graduate students focusing on long-range gene regulation and chromosome organization using high-throughput genomics technologies. Dekker's work has been instrumental in developing and refining chromosome conformation capture techniques that are now widely used across the genomics field. The Dekker Lab is a leader in the 4D Nucleome field, contributing significantly to our understanding of how chromosomes fold in three-dimensional space and how this organization changes over time (the fourth dimension). His research group continues to push the boundaries of chromosome conformation capture technologies, developing new methodologies to investigate genome architecture at increasingly higher resolutions and across diverse biological contexts.
