Florian Huber is a Research Associate at Paracelsus Medical University's Institute of Pharmacology and Toxicology, investigating molecular mechanisms of genetic hearing disorders. His work focuses on ubiquitin-proteasome regulation of pendrin (SLC26A4) variants associated with Pendred syndrome. Recent studies demonstrate how proteasome inhibitors rescue function of pathogenic pendrin mutants, offering therapeutic pathways for hearing restoration. Huber develops experimental and computational approaches to map degradation pathways of membrane transport proteins. He supervises medical doctoral candidates and teaches pharmacology in graduate programs.
Kristian Helin is Chief Executive and President of The Institute of Cancer Research (ICR), London, and a Professor with affiliations at the University of Copenhagen and Memorial Sloan Kettering Cancer Center. He founded/directed the Biotech Research & Innovation Centre (BRIC), Centre for Epigenetics, and Danish Stem Cell Center. His research focuses on epigenetic regulation, cancer biology, and stem cell differentiation. Education: Ph.D. Molecular Biology, University of Copenhagen (1991) M.Sc. Chemical Engineering, Technical University of Denmark (1988) Research Interests: Helin's work deciphers molecular mechanisms in cancer, emphasizing epigenetic drivers (e.g., H3K4/H3K36 methylation), transcriptional control, and therapeutic targeting. His lab identified E2F transcription factors, linked epigenetic dysregulation to leukemia/lymphoma, and develops drugs targeting kinases/epigenetic enzymes. Research spans acute myeloid leukemia, B-cell lymphoma, and solid tumors using CRISPR screens and preclinical models. Publication Trends: Recent articles (2023-2025) focus on epigenetic therapy, chromatin remodeling, and kinase signaling in cancer. Key themes include targeting NSD1/KDM5C/RIOK2 enzymes, combination therapies (EZH2/DOT1L inhibitors), and metabolic regulation in leukemia. Studies bridge basic mechanisms (enhancer regulation, insulator accessibility) with translational applications. Awards: Anders Jahre Prize (2014), ERC Advanced Grant (2011), Novo Nordisk Prize (2008) Memberships: Academia Europaea, Royal Danish Academy, EMBO Leadership: Helin co-founded EpiTherapeutics (acquired by Gilead) and leads the Epigenetics and Cancer lab at ICR. His team investigates AML pathogenesis and chromatin complexes like HUSH/NURF. Grants include ERC funding and innovation prizes.
Christian Friedrich Wilhelm Becker is a full Professor at the University of Vienna, holding a position within the Faculty of Chemistry and the Department of Biological Chemistry. His research profile shows extensive activity in protein chemistry and biochemistry, with particular focus on post-translational modifications and their implications in disease mechanisms. His work bridges chemical biology, biochemistry, and biomedical applications, contributing significantly to the academic and research landscape at one of Europe's oldest and most prestigious universities. Faculty of Chemistry, University of Vienna Department of Biological Chemistry Active research leader with numerous ongoing projects Significant publication record spanning multiple disciplines Professor Becker's research primarily focuses on protein chemistry, particularly post-translational modifications and their role in protein function and dysfunction. His work spans multiple interconnected areas including ubiquitination, protein aggregation, prion protein behavior, and biomimetic approaches to protein analysis. His research has significant implications for understanding neurodegenerative diseases and developing novel therapeutic approaches. The fingerprint analysis of his work shows strong connections to biochemistry, molecular biology, and chemistry, with particular emphasis on cysteine chemistry, glycosylation, and amino acid modifications. Analysis of Professor Becker's recent publications (2021-2025) reveals a consistent research trajectory focused on protein modification techniques and their biological implications. His work shows increasing sophistication in chemical biology approaches to study protein function, with particular emphasis on ubiquitination pathways and protein aggregation mechanisms. The integration of chemical synthesis methods with biological analysis represents a hallmark of his research approach. His publications span high-impact journals in biochemistry, chemical biology, and peptide science, demonstrating the interdisciplinary nature of his contributions. Professor Becker has received notable recognition for his research contributions, most prominently the Cathay Award in 2020. This award acknowledges his significant contributions to the field of protein chemistry and chemical biology. His work appears to have practical applications in therapeutic development, particularly in the areas of targeted protein degradation and immunotherapy, which likely contributed to this recognition. Cathay Award (2020) Professor Becker leads multiple significant research projects, including 'Targeted protein degradation - from small molecules to complex organelles' (2020-2024), 'Taktira: Development of an improved, low-side-effect and sustainable immunotherapy' (2019-2023), and 'Structure Zoom: Zooming in on protein functional sites with atomic resolution' (2018-2021). These projects demonstrate substantial grant funding and collaborative research efforts across multiple institutions. His active participation in 290 recorded activities through 2025 indicates a highly engaged research program with numerous collaborators and trainees. Targeted protein degradation project (2020-2024) Taktira immunotherapy project (2019-2023) Structure Zoom project (2018-2021) Professor Becker's research environment includes a robust team of collaborators and junior researchers, as evidenced by the numerous co-authored publications and activities. His work intersects with multiple research groups studying protein function, modification, and therapeutic applications. The international collaboration network shown in his profile indicates significant engagement with researchers across multiple countries, creating a dynamic research ecosystem focused on advancing protein science and its biomedical applications.
Janusz Bujnicki is a Professor and head of the Laboratory of Bioinformatics and Protein Engineering at the International Institute of Molecular and Cell Biology in Warsaw (IIMCB), Poland. He holds concurrent roles in science policy advisory bodies, including the European Commission's Group of Chief Scientific Advisors (2015-2020, then expert) and the Polish Academy of Sciences’ advisory panel (2024-). He is also a founding member of the Association of ERC Grantees (AERG) and serves on the Scientific Advisory Board of Life Science Center at Vilnius University. Academia Europaea Member (2018-) EMBO Member (2018-) Leadership Academy for Poland (2018) His research spans structural biology, RNA modification, computational biology, and molecular evolution. He has pioneered computational methods like ModeRNA, SimRNA, and ClaRNA for RNA structure prediction and analysis, and developed databases like MODOMICS for RNA modification pathways. His work has applications in understanding RNA function and drug design targeting RNA-processing enzymes. The 15 most recent publications focus on RNA structural modeling (e.g., ModeRNA, ClaRNA, SupeRNAlign), RNA-ligand interactions (LigandRNA), and RNA modification biology (MODOMICS database). These works bridge computational methods with experimental validation in RNA enzymology and structure-function relationships. Scientific Awards: ERC Starting Grant (2010), EMBO Member (2018), Crystal Brussels Sprout (2016), Prime Minister’s Award (2014), Knight’s Cross of Polonia Restituta (2014) Grants & Leadership: Founded RNA bioinformatics infrastructure at IIMCB, led EU science policy advisory groups, and organized international research competitions (RNA Puzzles)
University of Natural Resources and Life Sciences ViennaAustria
Fabian Pfrengle is a full Professor of Organic Chemistry at the Institute of Organic Chemistry , Department of Natural Sciences and Sustainable Resources , University of Natural Resources and Life Sciences Vienna (BOKU). He previously led research groups at the Max Planck Institute of Colloids and Interfaces (2013-2020) and worked at The Scripps Research Institute (2010-2013). Research Focus: His work bridges carbohydrate chemistry and plant biology , specializing in plant cell wall glycans and glycosyltransferases . He develops synthetic glycan arrays for enzyme characterization and investigates immune response triggering mechanisms in plants through oligosaccharide fragments . His projects include automated polysaccharide synthesis and liposome-based immune tolerance applications. Publication Trends: His 15 most recent articles emphasize chemical synthesis of sugar nucleotides , plant glycan arrays , and enzyme specificity analysis , reflecting his focus on carbohydrate engineering and plant immunity . Key subfields include UDP-sugar derivatization , Xylan structure-function relationships , and Glycosyltransferase profiling . Grants & Projects: Currently leads 5 major projects including Automated Algal Polysaccharide Synthesis (EU-funded, 2023-2028) and Synthetic Glycan Ligands for Plant Immune Receptors (FWF-funded, 2022-2026). His research also explores thrombocyte biology and Rhamnogalacturonan-II fragments with support from FWF and City of Vienna . Community Service: Serves on editorial boards ( Monatshefte für Chemie , 2021-present) and as reviewer for 12 journals including JACS Au , Nature Communications , and Angewandte Chemie . Member of professional societies: Gesellschaft Österreichischer Chemiker (2020), Deutscher Hochschulverband (2019), and Gesellschaft Deutscher Chemiker (2008).
University of Natural Resources and Life Sciences ViennaAustria
Roland Ludwig is an Associate Professor at the Institute of Food Technology, Department of Food Science and Technology, University of Natural Resources and Life Sciences, Vienna (BOKU). He is also the current Senate Chairman at BOKU, demonstrating strong institutional leadership. His research is centered on enzyme technology, biocatalysis, biosensors, and electrochemistry, with a particular focus on oxidoreductases such as cellobiose dehydrogenase (CDH) and lytic polysaccharide monooxygenases (LPMOs), which are crucial in biomass degradation and bioenergy applications. His research interests span food biotechnology, enzyme technology, biocatalysis, biosensors, process engineering, electrochemistry, and nanobiotechnology. He investigates the molecular mechanisms of electron transfer in redox enzymes, their application in biosensors and biofuel cells, and their role in the depolymerization of lignocellulosic biomass. His work integrates biochemical, electrochemical, and structural approaches to understand and engineer enzyme function. The recent publication trends highlight a strong focus on LPMOs and CDHs, with studies on their kinetics, substrate specificity, domain dynamics, electron transfer mechanisms, and engineering for improved stability and activity. These works frequently appear in high-impact journals such as ACS Catalysis and Bioelectrochemistry, reflecting the significance and innovation of his research in biocatalysis and bioelectrochemistry. International DropSens Award for Applied Electroanalytical Chemistry Medal of Honour, Faculty of Food Technology and Biotechnology, University of Zagreb RIZ Genius Award for Innovative Sensor Technology Austrian APART Fellowship INiTS Award 2007 (Life Science) Förderpreis der Österreichischen Gesellschaft für Biotechnologie Roland Ludwig actively supervises students and leads multiple externally funded research projects from FWF and EU, including grants focused on electron transfer in oxidoreductases and the kinetic analysis of oxidative biomass-degrading enzymes. He collaborates with international research groups and is a frequent speaker at major scientific conferences. His research contributes to sustainable bioprocesses, green chemistry, and the development of novel bio-based technologies. He is involved in research teams and collaborative projects such as the FWF-funded Doktoratskolleg "Biomolecular Technology of Proteins" and participates in interdisciplinary initiatives bridging food technology, biotechnology, and materials science. His lab focuses on enzyme characterization, protein engineering, and the development of bioelectrochemical devices.
Alexander Varshavsky is a Professor of Biology at the California Institute of Technology (Caltech), holding the Thomas Hunt Morgan Professorship since 2017. Previously, he served as the Howard & Gwen Laurie Smits Professor of Cell Biology at Caltech from 1992 to 2016 and held faculty roles at MIT from 1977 to 1987, including Associate Professor and Professor positions. Education: B.S. in Chemistry, Moscow University (1970) Ph.D. in Biochemistry, Institute of Molecular Biology, Moscow (1973) Research Fellow, Institute of Molecular Biology, Moscow (1973-1976) Varshavsky's research focuses on the ubiquitin system and the N-end rule pathway , which are critical for protein degradation and regulation in cells. His work has pioneered novel approaches to cancer therapy by elucidating mechanisms of cellular homeostasis and targeted protein destruction. Scientific Awards highlight his contributions to biomedicine and cancer research, including the Albert Lasker Award (2000), Breakthrough Prize in Life Sciences (2014), and Dr. Paul Janssen Award (2024). Notably, he has received international recognition through the Wolf Prize (2001), King Faisal Prize (2012), and Grande Médaille of the French Academy of Sciences (2016).
University of Natural Resources and Life Sciences ViennaAustria
Lea Atanasova is a Senior Researcher and Principal Investigator at the Institute of Food Technology, Department of Biotechnology and Food Science, University of Natural Resources and Life Sciences Vienna (BOKU). She holds a PhD (Dr. rer. nat.) and a Master’s degree (Mag. rer. nat.) and has extensive postdoctoral experience in fungal molecular biology and genomics. Her research is centered on mycoparasitic fungi such as Trichoderma and Clonostachys , with a focus on carbohydrate-active enzymes, signal transduction, gene expression, and ecological genomics. Her research interests span molecular biology, genetics, genomics, microbiology, mycology, and enzyme technology. She investigates the functional roles of genes and proteins in fungal biocontrol, nutrient acquisition, and host interactions. Her work integrates comparative genomics, transcriptomics, and functional proteomics to understand fungal evolution and ecological niches. The most recent publications highlight a strong trend in understanding fungal signaling pathways (e.g., TOR and MAPK), enzyme diversification (e.g., CDHs, pectate lyases), and the molecular mechanisms of mycoparasitism. Her work also extends to fungal secondary metabolites, host-microbe interactions, and advanced imaging techniques for protein localization. Scientific Awards: Carl Trygger scholarship for research at SLU (Uppsala, Sweden) GSA fungal meeting award, Genetics Society of America (Asilomar, CA, United States) FEMS Young Scientist Meeting Grant, Federation of European Microbiological Societies (Sant Feliu de Guíxols, Spain) Price Award for best Master-/Diploma research, Ecological Society of Germany, Austria and Switzerland (GFÖ) (Bayreuth, Germany) Austria National Park Research Award, Austrian Federal Ministry of Agriculture, Forestry, Environment and Water Management (Vienna, Austria) Ad Futura Special Achievements Fellowship for studies abroad, Slovene human resources development and scholarship fund (Ljubljana, Slovenia) Lea Atanasova has supervised several Master’s and Diploma theses on topics related to fungal biotechnology and enzymology. She leads an Austrian Science Fund (FWF)-funded project on GMC oxidoreductases in Clonostachys rosea . She is actively engaged in the scientific community, serving on editorial boards and as a guest editor. She has organized and chaired sessions at major conferences, including ECFG, and frequently presents her research internationally. She is a key member of the research community at BOKU, contributing to knowledge transfer through student supervision, editorial roles, and conference participation. Her work bridges fundamental fungal biology with applications in agriculture and biotechnology.
Prof. Ferenc Nagy is a distinguished academic at the University of Edinburgh, UK, holding the position of Professor of Plant Cell and System Biology. He is also affiliated with the Biological Research Centre (BRC) in Szeged, Hungary, where he serves as Deputy Director, and holds honorary roles at the University of Freiburg, Germany. His expertise spans plant molecular biology, photobiology, chronobiology, and optogenetics, with a focus on light signaling pathways, circadian clocks, and stress responses in plants. Education: Ph.D. in Biochemistry and Genetics (1981), József Attila University, Szeged D.Sc. in Molecular Mechanisms of Gene Expression (1997), Hungarian Academy of Sciences Habilitation (2001), Eötvös Loránd University, Budapest Research Interests: His work explores phytochrome signaling , UV-B light responses , and circadian clock regulation . Key areas include the molecular mechanisms of light-controlled plant development, stress signaling integration, and optogenetic tools for mammalian gene control. His lab has pioneered studies on protein phosphorylation in phytochrome function and the role of UVR8 in UV-B perception. Scientific Impact: With 160+ publications, over 10,000 citations, and an H-index of 59, his research bridges fundamental biology and applied optogenetics. Notable contributions include defining the structure/function of phytochromes and identifying critical cis-regulatory elements in plant stress responses. Leadership and Awards: He has served as Deputy Director of BRC Szeged, General Director of the Agricultural Biotechnology Center, and Monitoring Editor of Plant Physiology . Recognitions include the Commander’s Cross of the Order of Merit (2013), Humboldt Research Award (1997), and membership in the German Academy of Sciences (Leopoldina).
Matthias Peter is a Professor of Biochemistry at ETH Zurich, leading research into mechanisms governing cell growth and division. His laboratory focuses on ubiquitin-dependent regulation of DNA replication and mitosis, and autophagy's role in cellular quality control. He chairs the Department of Biology (2011-2015) and holds leadership roles in Switzerland's research infrastructure, including Vice Chair of ScopeM's microscopy platform. His academic career includes roles at ISREC (1996-2002) and postdoctoral training at UCSF (1991-1996). Education: PhD in Biochemistry from ISREC (1991), ETH Zurich diploma in Gene Technology (1987). Research interests span molecular mechanisms of cell division, ubiquitin systems, and autophagy. Awards include ERC Advanced Grant (2011) and UBS Excellence in Research (2002). Leadership: Member of Swiss National Research Council, SNF selection committee, and SWTR council. Over 20 years of committee service in national research programs. His lab's work is published in top journals like Science, Nature, and Molecular Cell.
**Pernilla Wittung Stafshede** is a Full Professor with Tenure and Head of the Chemical Biology division at Chalmers University of Technology (Gothenburg, Sweden). She previously held professorships at Umeå University (Sweden) and Rice University (USA). Her research focuses on protein folding, metalloproteins, biophysical methods, and applications to diseases like cancer and Parkinson’s. She leads the Wittung-Stafshede Lab , part of Chalmers’ Chemical Biology infrastructure. **Research Interests**: Protein folding mechanisms, metal transfer proteins, spectroscopic techniques, amyloid formation, and biophysical studies of macromolecules. Her work bridges fundamental biochemistry with disease mechanisms, leveraging advanced experimental and computational methods. **Awards**: Notable honors include the Arrhenius Medal (2016), membership in the Swedish Royal Academy of Sciences (2016), and sustained Wallenberg Scholar funding (2010–2022). She is recognized for pioneering contributions to chemical biology. **Key Contributions**: Her lab’s work spans protein dynamics, metallomics, and disease-related protein misfolding. Recent publications highlight systems biology approaches to yeast metabolism and drought stress responses in plants.
Aaron Ciechanover is a Distinguished Research Professor in the Faculty of Medicine at the Technion - Israel Institute of Technology, where he has served as a Full Professor of Biochemistry since 1992. He is globally recognized for his groundbreaking work in the field of ubiquitin-mediated protein degradation, which earned him the Nobel Prize in Chemistry. His primary research focuses on: Ubiquitin-mediated protein degradation mechanisms Cellular protein regulation systems Molecular pathways in protein quality control Biochemical processes related to cellular function and disease Ciechanover's discoveries have revolutionized our understanding of how cells regulate protein breakdown, with profound implications for cancer research, neurodegenerative diseases, and numerous other medical conditions. His major scientific honors include: Nobel Prize in Chemistry (2004, shared with Avram Hershko and Irwin Rose) The Israel Prize for Biology (2003) EMET (Truth) Prize (2002) The Albert and Mary Lasker Award for Basic Medical Research (2000) Sir Hans Krebs Medal (2006) Medical Magnus Medal (2007) Professor Ciechanover maintains extensive international collaborations, holding adjunct positions at Nanjing University in China and numerous visiting professorships worldwide. He serves on editorial boards of prominent journals including Cell Death and Differentiation (Nature Group) and has received over twenty honorary doctorates from universities across five continents.
University of Natural Resources and Life Sciences ViennaAustria
Dr. Alexandra Machado Ferreira Castilho is a leading researcher at the Institute of Plant Biotechnology and Cell Biology within the University of Natural Resources and Life Sciences, Vienna (BOKU) . She has served as Principal Investigator since 2018 and previously as Scientific Coordinator of the Laura Bassi Center PlantBioP (2010-2017). Her work focuses on Plant Molecular Farming and Glycoengineering , aiming to optimize plant-based production of therapeutically relevant glycoproteins. Specializes in tailoring N-glycan profiles for biopharmaceuticals Develops plant cell factories for antibody and decoy receptor production Key projects include SARS-CoV-2 neutralization strategies and cancer immunotherapy agents Her recent publications analyze glycoengineering techniques in Nicotiana benthamiana , covering topics like ACE2-Fc decoys for viral neutralization, PD1/PDL1 blockade for oncology, and protease suppression for protein stability. She has received funding from the Austrian Science Fund (FWF) for projects on immune checkpoint inhibitors and glycosylation pathway modulation.
University of Natural Resources and Life Sciences ViennaAustria
Joseph Strauss is a Full Professor at the University of Natural Resources and Life Sciences Vienna (BOKU), leading the Institute of Microbial Genetics. With a career spanning over three decades, he has focused on fungal genetics, epigenetics, and bioactive metabolite discovery, particularly in filamentous fungi and pathogens. His work bridges fundamental research with applications in agriculture, medicine, and environmental biotechnology. Research Focus: Epigenetic regulation of fungal secondary metabolism, chromatin dynamics, bioactive compounds, nitrate signaling, and microbial interactions. Projects: Leads multiple grants from Austrian Science Fund (FWF), European Commission, and industry partners, including studies on chromatin engineering, fungal biotechnology, and toxin biosynthesis. His recent publications highlight advancements in chromatin proteomics, fungal pathogenicity, and novel bioactive molecules like luteapyrone and rasfonin. Articles emphasize broad disciplines such as Fungal Genetics, Epigenetics, and Natural Product Discovery, with subfields including secondary metabolite clusters, histone modifications, and stress response mechanisms. Scientific Awards: 2021 - Keratinophyton straussii fungal species named after him 1999 - START Preis 1995 - EMBO Stipendium 1994 - OTTO LOEWI Stipendium He has supervised over 69 theses and contributed to 186 publications, reflecting his leadership in fungal genomics and its applications. Projects like 'Bioaktive Mikrobielle Metaboliten' and 'TASSMATA' underscore his commitment to translating research into sustainable solutions.
Giulia De Lorenzo is a Full Professor of Plant Physiology at Sapienza University of Rome since 2000, with prior roles as Associate Professor at Sapienza University of Rome (1994-1999) and University of Bari (1991-1994). Her research focuses on plant immunity, molecular recognition, and cell wall dynamics, particularly in plant-pathogen interactions involving damage-associated molecular patterns (DAMPs) and their role in signal transduction. Education: Laurea in Biology (1980, Sapienza University of Rome, cum laude), PhD in Evolutionary Biology (1987, Sapienza University of Rome) Her work explores the structural and functional basis of plant defense mechanisms, including the inhibition of cell wall-degrading enzymes and engineering plant resistance through chimeric receptors. Articles highlight her contributions to understanding DAMPs, PGIP proteins, and their applications in crop protection and bioconversion. Notable scientific awards include the 2011 Sapienza University of Rome Award for Excellence in Research , 1997 Giovanni Armenise-Harvard Foundation Award , and the 1983 Fondazione V.V. Landi Award from the Accademia dei Lincei. She has served on editorial boards and organized international conferences in plant science.
