Protein Complex Formation Professors and Supervisors | ApplySharif

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Gideon James GroganView profile

Professor

University of YorkUnited Kingdom

Professor Gideon James Grogan is a distinguished academic at the University of York, holding a position in the Department of Chemistry within the Faculty of Sciences. With expertise spanning structural and applied enzymology, he leads research at the intersection of chemistry and biology, developing novel biocatalysts for sustainable chemical synthesis and pharmaceutical applications. Professor Grogan's research focuses on the identification, characterization, and application of enzymes with biotechnological potential. His work encompasses: Oxygenases including P450s, flavoprotein monooxygenases, and peroxygenases Reductases such as ketoreductases (KREDs), imine reductases (IREDs), and reductive aminases (RedAms) Lyases catalyzing asymmetric hydration of alkenes Ligases for amide bond formation His multidisciplinary approach integrates synthetic chemistry, microbiology, molecular biology, and X-ray crystallography to engineer enzymes using in vitro evolution techniques. Recent research has yielded significant advances in biocatalytic pathways for chiral pharmaceutical precursors and renewable material processing. Professor Grogan's publication record demonstrates consistent innovation in biocatalysis, with recent work focusing on peroxygenase applications, reductive amination technologies, and enzyme engineering for improved catalytic properties. His research shows strong trends in developing sustainable enzymatic routes for pharmaceutical synthesis, with particular emphasis on stereoselective transformations and cascade reactions. Professor Grogan has received significant research funding through major grants from: BBSRC (Biotechnology and Biological Sciences Research Council) EPSRC (Engineering and Physical Sciences Research Council) He actively supervises PhD students and collaborates extensively both within the University of York and internationally. His work bridges the Departments of Chemistry and the York Structural Biology Laboratory (YSBL), leveraging state-of-the-art facilities for organic synthesis, protein expression, and structural analysis. Professor Grogan maintains strong industry connections, translating fundamental research into practical applications for pharmaceutical and chemical manufacturing. His current projects include sustainable production of menthol enantiomers, development of native amine dehydrogenases for chiral amine synthesis, and discovery of securinine alkaloid biosynthesis pathways.

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Jeffrey GuastoView profile

Associate Professor

Tufts UniversityUnited States

Jeffrey Guasto , Associate Professor at Tufts University, holds joint appointments in the School of Engineering (Mechanical Engineering) and School of Arts and Sciences (Physics & Astronomy). His work bridges engineering, physics, and biology to study transport properties in complex systems. Ph.D., Engineering (2009), Brown University Sc.M., Engineering (2004), Brown University Dual B.S. in Physics and Mechanical Engineering (2003), Lehigh University Research Interests focus on: Biophysics : Flagellar mechanics, chemotaxis, cell-fluid interactions Soft Matter : Active suspensions, colloids, viscoelastic materials Microfluidics : Device design for cell motility studies and gradient generation Environmental Transport : Microbial ecology in porous systems Scientific Trends from his 77+ publications show emphasis on microscale fluid dynamics, bacterial transport mechanisms, and viscoelastic flow instabilities. His 2024 Nature Microbiology work reveals phage-infected bacteria driving marine chemotaxis, while 2023 PNAS research explores stress topology in viscoelastic flows. Scientific Awards : NSF CAREER Award (2016) for cell dispersal mechanisms Collaborative NSF grants (2015-2023) Advising includes mentoring 15+ students and postdocs. His grants portfolio features 9+ awards, notably NSF grants for viral-microbe interactions (2018) and flagellar mechanics (2020). Labs & Teams : Leads the Guasto Laboratory at Tufts, integrating microfluidics and high-speed imaging for studying microbial transport, while collaborating with MIT, Harvard, and international institutions.

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Michael KrisingerView profile

Academic

University of British ColumbiaCanada

Michael Krisinger is an Associate Professor of Teaching in the Department of Biochemistry & Molecular Biology at the University of British Columbia . He began his teaching career in 2010, transitioning to full-time in 2013. He lectures Biochemistry 202 (Introductory Medical Biochemistry) and Biochemistry 303 (Molecular Biochemistry) while serving as a tutor in the Faculty of Medicine's Case Based Learning program. Krisinger co-developed the department's two-course summer program for international students and mentors postdoctoral fellows in teaching. He also manages the department's CANVAS digital learning platform. Krisinger's research focuses on the molecular mechanisms of coagulation and complement system regulation , particularly their evolutionary relationship and functional interplay. His work has explored thrombin's role in complement activation, polyphosphate-mediated complement suppression, and nanoparticle surface interactions with proteolytic cascades. He previously co-supervised graduate students at UBC's Centre for Blood Research before prioritizing education. Publications highlight his expertise in protease-substrate dynamics , lipoprotein-phospholipid interactions , and hemostasis-immunity crosstalk . He remains engaged in public science through community environmental initiatives and local outreach activities.

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Matthew GauntView profile

Professor

University of CambridgeUnited Kingdom

Matthew Gaunt is the 1702 Yusuf Hamied Professor of Chemistry at the University of Cambridge , specializing in C–H activation , visible-light photocatalysis , and bioconjugation . He leads a research group in Lab 177 , focusing on alkylamine synthesis and chemical biology applications. Gaunt's group has 23 members, including 14 PhD students and 6 postdocs. His research spans catalytic reactivity for organic synthesis, with a focus on metal-catalyzed C–H activation , photoredox strategies , and high-throughput experimentation for rapid reaction development. Key innovations include stereoselective methods for β-lactam synthesis and methionine-targeted protein modification . Scientific Awards & Fellowships: GlaxoWellcome Postdoctoral Fellowship Ramsay Memorial Fellow His group contributes to the SynTech Centre for Doctoral Training , integrating automation and data science into chemical synthesis education. Current students include Joseph Phelps, Marcus Grocott, James Robinson, and Tobias Kraus under his direct supervision.

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Nicolas ThomäView profile

Professor

Swiss Federal Institute of Technology in LausanneSwitzerland

Nicolas Thomä is a Full Professor and head of the Thomä Lab at the École Polytechnique Fédérale de Lausanne (EPFL), where he holds the Paternot Chair in Cancer Research. He is affiliated with the School of Life Sciences (SV) and the Institute of Chemical and Biological Technology (ISREC), leading the UPTHOMAE research unit. His work bridges structural biology, chemical biology, and cancer research, with a focus on transcriptional regulation and targeted protein degradation. His research interests center on chromatin biology and the molecular mechanisms by which transcription factors access gene promoters within chromatin. He investigates how multi-protein complexes regulate gene expression, particularly focusing on the role of E3 ubiquitin ligases and molecular glues in targeted protein degradation. His lab combines structural techniques (including cryo-EM), biochemical assays, and functional genomics to unravel how small molecules can rewire protein interactions and induce degradation of disease-relevant proteins, especially transcription factors involved in cancer. The recent publications of his lab demonstrate a strong trajectory in understanding the structural basis of transcription factor binding to nucleosomes (e.g., OCT4-SOX2, MYC-MAX, CLOCK-BMAL1) and the mechanism of action of molecular glues like thalidomide. These studies highlight a shift toward therapeutic innovation through chemical biology, aiming to develop novel strategies for targeting 'undruggable' proteins in human diseases. Scientific Awards No specific awards listed in the provided text. Advising and Grants Thomä actively supervises a team of PhD students and postdoctoral researchers, including David Domjan, Laurin Tim Kanis, Alessandro Minafra, and Pierre Alexander Miranda Herrera. His lab is supported by institutional funding from EPFL and likely external grants related to cancer research, structural biology, and chemical biology, though specific grants are not mentioned. The lab’s interdisciplinary approach suggests collaboration with pharmaceutical and biotech partners. Labs and Teams The Thomä Lab, based at EPFL’s SV building, includes a multidisciplinary team of scientists, technical specialists, and administrative support. Key members include Fiona Bello (Technical Specialist), Regina Baur, Alexandra Bendel, Manuel Carminati, and others. The lab is structured around two main research pillars: Transcription Factors in Chromatin Biology and Ubiquitin Biology and Molecular Glues, reflecting its dual focus on fundamental mechanisms and therapeutic applications.

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Lara A. EstroffView profile

Professor

Cornell UniversityUnited States

Lara A. Estroff is a Full Professor and the current Chair of the Department of Materials Science and Engineering at Cornell University's College of Engineering. She has been a faculty member since 2005 and served as Director of Graduate Studies from 2015 to 2019. Her academic leadership and research excellence position her at the forefront of bio-inspired materials and biomineralization research. Her educational background includes a B.A. in Chemistry from Swarthmore College (1997) and a Ph.D. in Chemistry from Yale University (2003), followed by an NIH-funded postdoctoral fellowship at Harvard University in the lab of Prof. George M. Whitesides. Dr. Estroff's research centers on the fundamental mechanisms of crystal growth, biomineralization, and pathological mineralization. She investigates how organisms control mineral formation and applies these principles to engineer synthetic materials with complex structures and functionalities. Her work spans biomaterials, tissue engineering, and energy materials—particularly hybrid organic-inorganic perovskites for photovoltaics. She employs advanced characterization techniques and has pioneered in situ methods to monitor crystallization dynamics. Her recent publications reveal a strong trend toward interdisciplinary research, integrating materials science with cancer biology, immunology, and machine learning. The articles emphasize bio-inspired synthesis, mineral-tissue interactions, and the development of functional crystalline materials for medical and energy applications. Faculty Early CAREER Award, National Science Foundation (2009) Fiona Ip Li '78 and Donald Li '75 Excellence in Teaching Award, Cornell College of Engineering (2007) Marilyn Emmons Williams Award, Cornell Undergraduate Research Board (2009) Keynote Speaker, Gordon Research Seminar on Biomineralization (2012) Lawrence Berkeley National Lab Affiliate (2013) Dr. Estroff leads a major DOE-funded project titled “Formulation Engineering of Energy Materials via Multiscale Learning Spirals,” a $3 million, three-year initiative using machine learning to optimize perovskite synthesis for solar cells. She has advised numerous graduate students and postdoctoral researchers, and her lab is known for fostering collaborative, cross-disciplinary research. She has also contributed to educational initiatives at Cornell, particularly in undergraduate research and materials education. Her research group operates at the intersection of chemistry, engineering, and biology, focusing on high-resolution characterization of biominerals, in situ crystal growth studies, and the design of in vitro models for cell-mineral interactions. The lab actively collaborates with institutions including Lawrence Livermore National Laboratory, National Renewable Energy Laboratory, and Johns Hopkins University.

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Ralph BockView profile

Professor

Max Planck Institute of Molecular Plant PhysiologyGermany

Prof. Dr. Ralph Bock serves as Director of Department 3: Organelle Biology, Biotechnology and Molecular Ecophysiology at the Max Planck Institute of Molecular Plant Physiology in Potsdam, Germany, where he also leads the Organelle Biology and Biotechnology research group. Previously, he held positions as C4 Professor for Plant Biochemistry and Biotechnology at the University of Münster (2001-2004) and Group Leader at the Institute of Biology III, University of Freiburg (1996-2001). His academic credentials include: Habilitation: University of Freiburg, 1999 Doctorate: University of Freiburg, 1996 Diploma: University of Halle, 1993 Prof. Bock's research focuses on plant molecular biology with particular emphasis on chloroplast biology, organelle biotechnology, and molecular ecophysiology. His work spans genetic engineering of plastids, photosynthesis research, plant biotechnology applications, and understanding organelle-nucleus communication. He has made significant contributions to developing chloroplast transformation systems and applying them to molecular farming, metabolic engineering, and understanding fundamental processes in plant cell biology. His research has important implications for sustainable agriculture, bioenergy, and pharmaceutical production, particularly through the development of plant-based systems for producing vaccines and therapeutic proteins. Analysis of Prof. Bock's recent publications (2023-2025) reveals a strong focus on chloroplast biology, genetic engineering, and molecular farming applications. His work spans fundamental research on organelle genetics, photosynthesis, and stress responses, as well as applied research on using plant and algal systems for biopharmaceutical production. A notable trend is the increasing use of advanced genetic engineering techniques, including CRISPR-based approaches, to manipulate organelle genomes. His research also shows growing interest in algal systems as alternative expression platforms for molecular farming, particularly red algae like Porphyridium for producing viral antigens and glycoproteins.

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Timur Alexander YorganView profile

Researcher

University Medical Center Hamburg-EppendorfGermany

Dr. Timur Alexander Yorgan is a prominent researcher at the Department of Osteology and Biomechanics at University Medical Center Hamburg-Eppendorf (UKE). Holding a Dr. rer. nat. degree, he has established himself as a leading figure in bone biology with over 60 publications spanning from 2013 to 2025. His research is deeply integrated with key institutional research areas including the Hamburg Center of Neuroscience and immunology research networks at UKE. Dr. Yorgan's research focuses on skeletal development, bone remodeling, and genetic bone disorders, with particular emphasis on Wnt signaling pathways and their role in bone homeostasis. His work spans multiple approaches from molecular genetics to translational studies, investigating osteoblast and osteocyte biology, genetic mechanisms underlying disorders like osteogenesis imperfecta, and the effects of various mutations on skeletal integrity. Recent research has expanded into the gut-bone axis, mechanobiology of bone cells, and neuro-immune interactions affecting bone metabolism. Analysis of Dr. Yorgan's publication record reveals a consistent trajectory of high-impact research in bone biology. His work increasingly explores interdisciplinary connections between bone metabolism and other physiological systems, with growing emphasis on translational approaches for therapeutic interventions. The research demonstrates sophisticated use of mouse models and molecular techniques to unravel complex bone disorders and identify potential treatment targets. Dr. Yorgan appears to be actively involved in collaborative research across multiple institutions, as evidenced by his extensive publication record with numerous co-authors from various departments and institutions. His work is frequently published in high-impact journals including Journal of Bone and Mineral Research, Nature Communications, and Bone Research. The Department of Osteology and Biomechanics at UKE, where Dr. Yorgan is based, is part of a vibrant research ecosystem that includes the Hamburg Center of Neuroscience and other key research networks focusing on immunology, oncology, and cardiovascular research. This collaborative environment enables interdisciplinary approaches to understanding skeletal disorders and developing novel therapeutic strategies.

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Paul C. BressloffView profile

Professor

Imperial College LondonUnited Kingdom

Professor Paul C. Bressloff holds the Chair in Applied Mathematics and Stochastic Processes at Imperial College London's Department of Mathematics within the Faculty of Natural Sciences. His research focuses on stochastic and non-equilibrium processes, particularly in molecular and cell biology, utilizing tools from probability theory, statistical physics, and dynamical systems. He authored a seminal textbook Stochastic Processes in Cell Biology (Springer), with a 2nd edition published in 2022. Previously, he led the graduate program in mathematical biology at the University of Utah from 2001 to 2023. Research interests include stochastic multi-particle systems, active particles, phase separation, and diffusion across semi-permeable interfaces. His work spans applications in neural field theory, cytoneme-mediated morphogenesis, and protein trafficking. He is affiliated with the Biomathematics Group and Mathematical Physics Group at Imperial. Recent articles explore stochastic resetting in search processes, narrow-capture problems, and hybrid models of switching diffusions. His advising includes over 20 graduate students, many now faculty in mathematical biology. His contributions bridge applied mathematics and biological systems, emphasizing interdisciplinary approaches to complex stochastic phenomena.

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Nathan YeeView profile

Professor

Rutgers, The State University of New JerseyUnited States

Nathan Yee is a Professor at Rutgers University, where he has held academic appointments since 2004. He earned his B.Sc. from McGill University (1997) and Ph.D. from the University of Notre Dame (2001), followed by postdoctoral research at the University of Leeds (2001-2003). His career progression includes positions as Assistant Professor (2004-2010), Associate Professor (2010-2016), and full Professor since 2016. Research Focus Yee's research integrates geochemistry and geomicrobiology to study: mineral transformation processes, interactions between metal ions and mineral surfaces, microbial influences on inorganic element cycling, and contaminant behavior in environmental systems. His work combines experimental approaches with modeling to investigate biogeochemical processes relevant to early Earth evolution, microbial metabolism, and environmental remediation. Key themes include biologically catalyzed redox reactions, metal isotope fractionation, and geomicrobial controls on contaminant transport. Publication Trends Yee's recent publications (2021-2025) demonstrate strong emphasis on microbial-metal interactions, isotope geochemistry, and planetary science. Dominant themes include: isotopic tracing of metal cycling (Ni, Cu, Hg), microbial redox transformations of contaminants (Se, Te, U), photochemical processes in early Earth systems, and astrobiological investigations of planetary bodies like Mars and Enceladus. Methodologies frequently combine laboratory experiments with geochemical modeling.

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Onur VarolView profile

Assistant Professor

Sabanci UniversityTurkey

Onur Varol is an Assistant Professor at Sabanci University's Computer Science Department and leads the VIRAL Lab, which focuses on computational social science, network science, and machine learning. He has affiliations with the Center of Excellence for Data Analytics. His research spans social bot detection, misinformation analysis, and online behavior modeling.

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Michael J. ShelleyView profile

Professor

New York UniversityUnited States

Michael J. Shelley is the Lilian and George Lyttle Professor of Applied Mathematics and holds joint appointments in Mathematics, Neural Science, and Mechanical Engineering at New York University's Courant Institute of Mathematical Sciences. He also serves as Co-Director of the Applied Mathematics Laboratory and Director of the Center for Computational Biology at the Flatiron Institute. Education: PhD (Applied Mathematics) from the University of Arizona (1985), MS (Applied Mathematics) from the University of Arizona (1984), BA (Mathematics) from the University of Colorado (1981). Research: Focuses on complex phenomena in active matter, biophysics, and complex fluids. Key areas include fluid-structure interactions (e.g., swimming/flying mechanics), cytoskeletal dynamics, and collective behavior in biological systems. Collaborates closely with experimentalists through the Applied Math Lab and Flatiron Institute. Labs & Affiliations: Co-Director, Applied Mathematics Laboratory; Director, Center for Computational Biology (Simons Foundation); affiliated with NYU’s Courant Institute and Department of Mathematics. Notable Work: Models for microtubule-motor assemblies, active suspensions, and fluid-structure interactions. Pioneered computational frameworks for Stokes suspensions and fiber dynamics in viscous fluids.

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Soeren LienkampView profile

Assistant Professor

University of ZurichSwitzerland

Prof. Dr. Soeren Lienkamp is an Assistant Professor at the Institute of Anatomy , Faculty of Medicine , University of Zurich . His work bridges digital education and genetic research , focusing on enhancing medical teaching through innovative formats. Research Interests : Genetics, developmental biology, kidney disease modeling, CRISPR applications, digital medical education, and advanced microscopy. Methodologies : Combines Xenopus tropicalis models, deep learning , and bioengineering to study genetic kidney disorders and improve diagnostic tools. Publication Trends : His recent articles highlight predictable genome editing , 3D imaging technologies , and mechanistic insights into kidney and eye development. Earlier works focus on ciliary function , Wnt signaling , and metabolic stress in renal cells.

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Sarah L. KellerView profile

Professor

University of WashingtonUnited States

Sarah L. Keller is a Professor of Chemistry at the University of Washington, holding the Duane and Barbara LaViolette Endowed Chair. She earned her Ph.D. in Physics from Princeton University and completed postdoctoral research at UC Santa Barbara and Stanford University. Her research focuses on self-assembling soft matter systems, particularly lipid membrane biophysics and prebiotic chemistry. She investigates how lipid mixtures form complex phases and their biological implications. Education: Ph.D. in Physics, Princeton University (1995); postdoctoral training at UC Santa Barbara (Presidential Fellow) and Stanford University (NIH NRSA Fellow). Research Interests: Keller's lab explores phase behavior in lipid membranes, prebiotic vesicle formation, and membrane-driven cellular processes. They employ interdisciplinary approaches combining physics, chemistry, and bioengineering to study systems like yeast vacuoles and protocell models. Awards: Biophysical Society Avanti Award, Cottrell Scholar, NSF CAREER Award, Fellow of the American Physical Society, and recognition for mentoring and teaching excellence. Her students frequently win NSF Graduate Fellowships and international awards. Advising & Grants: Keller has mentored over 50 students/postdocs, many of whom hold academic or industry roles. Her lab emphasizes interdisciplinary collaboration, with funding from NSF, NIH, and private foundations. The Keller Lab also supports career development resources for early-career researchers. Labs/Teams: The lab is part of the UW Chemistry Department and collaborates with the UW Biophysics program. Research is conducted in the Bagley Hall laboratory, with access to advanced microscopy and simulation tools.

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Jens Øllgaard DuusView profile

Professor

Technical University of DenmarkDenmark

Jens Øllgaard Duus is a Professor and Vice Dean at the Technical University of Denmark (DTU), with dual roles in the Office for Study Programmes and Student Affairs and the Center for Teaching and Learning in Engineering Education. His primary academic affiliation is with the Department of Chemistry at DTU, where he conducts advanced research in NMR spectroscopy and structural analysis of complex organic molecules. His research focuses on the development and application of analytical methods for carbohydrates, natural products, and peptides, with applications in food and pharmaceutical sciences. Key areas include glycosylation, enzyme mechanisms, and structural elucidation of bioactive compounds. His work contributes to UN Sustainable Development Goals in life sciences and analytical chemistry. The recent publications highlight a strong trend in glycoscience, particularly in enzyme-catalyzed glycosylation, structural analysis of polysaccharides, and engineering of glycosyltransferases and glycosidases for synthetic applications. His work bridges chemistry, biotechnology, and medicine. Jens Øllgaard Duus actively supervises multiple PhD students across interdisciplinary projects, including work on drug delivery to the CNS, nucleic acid analogues, and AI in education. He is involved in both fundamental and applied research, contributing to sustainable chemistry and biotechnology. Structural elucidation of novel pro-inflammatory polysaccharides from Daphne mezereum L. (2024) Denmark as the Energy Island Pioneer (2023) Promiscuous Yet Specific: A Methionine-Aromatic Interaction in Glycosyltransferase (2023) Engineered Hexosaminidase as a Glycoligase (2023) Family 1 Glycosyltransferase from Zea mays (2022) He has supervised PhD projects on generative AI in education, nucleic acid analogues, CNS drug delivery, and asymmetric catalysis. His leadership in educational innovation and research supervision underscores his dual impact on science and pedagogy. He is affiliated with research groups in chemistry and biotechnology at DTU, contributing to a collaborative network focused on sustainable science and engineering education. His work integrates analytical chemistry with biological applications, forming a unique interdisciplinary fingerprint.

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