Protein Complex Assembly Professors and Supervisors | ApplySharif

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Hala ZreiqatView profile

Professor

University of SydneyAustralia

Professor Hala Zreiqat AM is a leading biomedical engineer at The University of Sydney , serving as the Director of the ARC Training Centre for Innovative BioEngineering . A Fellow of all major Australian academies (AAS, ATSE, FAHMS, FRSN), she develops 3D printed bioceramics for bone regeneration while championing diversity through initiatives like the IDEAL Society and BIOTech Futures mentorship program. Her work bridges academia, clinical practice, and industry in musculoskeletal research . Research Focus: Her lab creates synthetic bone scaffolds that mimic natural bone architecture, strength, and porosity, enabling non-rejected bone regeneration via patient-matched implants. Key applications include orthopaedic, dental, and maxillofacial repair , with over $18M in competitive funding and multiple patents. Current projects explore AI-driven scaffold performance prediction and anti-senescence strategies for aging-related bone loss. Scientific Trends: Recent publications highlight 3D printed nanovoxelated ceramics , antisenescence biomaterials , and multifunctional theranostic platforms . Her team integrates machine learning for scaffold design, atom probe tomography for interface analysis, and two-photon imaging for cellular monitoring in 3D environments. 2021-2022 Fulbright Senior Scholar 2018 NSW Premier's Woman of the Year 2019 Eureka Prize for Innovative Use of Technology Fellow of Australian Academy of Science (2021) Over $18M in research funding Teaching & Leadership: She designed core courses like Tissue Engineering and Nanomaterials in Medicine , mentoring 158 students in 2020 alone. As Chair of CAAR (2020-2023), she strengthens Australia-Arab collaborations. Her lab trains early-career researchers , with alumni now in academia and industry.

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Masato KatoView profile

Professor

University of Texas Southwestern Medical CenterUnited States

Masato Kato serves as Professor in the Department of Biochemistry at the University of Texas Southwestern Medical Center since 2020 and concurrently as Team Leader at Japan's National Institutes for Quantum and Radiological Science and Technology. His academic trajectory includes progressive appointments from Assistant Professor (2004-2014) to Associate Professor (2014-2020) at UT Southwestern, with prior postdoctoral training at Harvard Medical School and Nara Institute of Science and Technology. 2020-present: Professor, Department of Biochemistry, UT Southwestern 2020-present: Team Leader, National Institutes for Quantum and Radiological Science and Technology, Japan 2014-2020: Associate Professor, Department of Biochemistry, UT Southwestern 2010-2014: Assistant Professor, Department of Biochemistry and Internal Medicine, UT Southwestern 2004-2010: Assistant Professor, Department of Internal Medicine, UT Southwestern 1999-2004: Postdoctoral Fellow, Ellenberger Lab, Harvard Medical School 1998-1999: Postdoctoral Fellow, Hakoshima Lab, Nara Institute of Science and Technology Dr. Kato's research pioneers the biophysical characterization of protein phase separation, particularly focusing on low-complexity domains (LCDs) in neurodegenerative disease contexts. His work establishes fundamental mechanisms of biomolecular condensate formation, including hydrogel polymerization, liquid-solid transitions, and mutation-induced dysregulation in ALS/FTD. Key contributions demonstrate how C9orf72-encoded poly-dipeptides disrupt nucleocytoplasmic transport and how redox states regulate Ataxin-2 phase behavior, bridging structural biochemistry with pathological mechanisms. Analysis of his 22 publications reveals a cohesive research program centered on LCD-driven phase transitions. The most recent 15 articles (2012-2019) systematically investigate pathological aggregation in neurodegeneration, structural basis of condensate formation, and regulatory mechanisms like phosphorylation and oxidation. This body of work establishes LCDs as central players in both physiological RNA granule assembly and disease-associated solidification, with strong emphasis on C9orf72-related ALS/FTD mechanisms. Dr. Kato maintains active leadership within the McKnight Laboratory at UT Southwestern, where his team employs integrated approaches spanning structural biology, cell biology, and biophysics to dissect phase separation mechanisms. His collaborative network includes prominent neuroscience and biochemistry groups, with co-authorship on key studies in Cell, Science, and PNAS.

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Michael LampsonView profile

Professor

University of PennsylvaniaUnited States

Michael Lampson is Professor of Biology at the University of Pennsylvania's School of Arts and Sciences, with secondary appointments in the Department of Cell and Developmental Biology. He serves as faculty in the Cell and Molecular Biology (CAMB) and Biochemistry and Molecular Biophysics (BMB) Graduate Groups, and is affiliated with the American Society for Cell Biology (ASCB). Ph.D., Cornell University, Weill Medical College, 2002 AB, Harvard College, 1994 Dr. Lampson's research program focuses on fundamental mechanisms of chromosome biology, with particular emphasis on cell division, centromere inheritance, and meiotic drive. His lab investigates how selfish genetic elements can violate Mendel's First Law through meiotic drive, the stability of centromere chromatin through the germline, and the role of repetitive satellite DNA in chromosome segregation. Using innovative approaches including mouse model systems, optogenetic tools, and biochemical techniques, his work bridges cell biology, genetics, and evolutionary biology to address questions with implications for reproductive biology, cancer, and genetic inheritance. Analysis of Dr. Lampson's recent publications reveals a strong focus on the intersection of centromere biology, meiotic drive, and chromosome segregation mechanisms. His work increasingly incorporates computational approaches alongside experimental systems to study evolutionary aspects of centromere function. The research demonstrates consistent innovation in methodology, particularly in developing optogenetic tools for precise manipulation of cellular processes. Key themes include the role of satellite DNA variation, mechanisms of non-Mendelian inheritance, and the stability of chromatin structures through cell division and development. Searle Scholar Award American Association for the Advancement of Science (AAAS) fellow Dr. Lampson's research is supported by multiple NIH grants including from NIGMS, NHGRI, NICHD, and NCI, as well as University of Pennsylvania funding sources including the University Research Foundation, Abramson Cancer Center, and several specialized research centers. He collaborates extensively with researchers across disciplines, including Ben Black (Biochemistry), Dennis Discher (Chemical Engineering), Dave Chenoweth (Chemistry), and Roger Greenberg (Cancer Biology), reflecting the interdisciplinary nature of his work. His lab has trained numerous graduate students and postdocs who have gone on to successful careers in academia and industry. The Lampson Lab maintains state-of-the-art facilities for cell biological, genetic, and biochemical research, with specialized equipment for live-cell imaging, optogenetic manipulation, and mouse genetics. The lab fosters a collaborative environment that bridges molecular, cellular, and evolutionary perspectives on chromosome biology.

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Pim de VinkView profile

Researcher

Eindhoven University of TechnologyNetherlands

Pim de Vink is a doctoral researcher at Eindhoven University of Technology , affiliated with the Biomedical Engineering department and Chemical Biology group. Supervised by dr. L.-G. Milroy and prof. L. Brunsveld , his work bridges supramolecular chemistry and chemical biology , focusing on host/guest chemistry for protein complex modulation. Education: B.Sc. in Chemistry (2014) from University of Amsterdam M.Sc. in Biomedical Engineering (2016) from TU/e Internship at Max Planck Institute for Molecular Physiology (2016) on gold-catalyzed synthesis Research Themes: His research develops switchable cucurbituril-based systems for light-controlled enzyme activation and artificial signaling networks. Key areas include protein-protein interaction stabilization , thermodynamic modeling , and allosteric nuclear receptor modulation . Publication Trends: Across JACS , Chemical Science , and RSC Chemical Biology , his work from 2017–2023 emphasizes supramolecular tools for biochemical applications. Notable contributions include 100-fold affinity enhancement of 14-3-3 ligands and UV-responsive cucurbituril release mechanisms . Grants: Funded by Netherlands Organization for Scientific Research (NWO) through Gravity program 024.001.035 and VICI grant 016.150.366.

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Thomas MeierView profile

Visiting Professor

Imperial College LondonUnited Kingdom

Professor Thomas Meier is a Visiting Professor at the Department of Life Sciences, Imperial College London (since 2015), and Director of the Centre for Structural Biology (2017–2021). He leads research on ATP synthase structure, drug targets for tuberculosis, and molecular mechanisms of disease. Previously, he was a Group Leader at the Max-Planck-Institute of Biophysics (2006–2015) and ETH Zurich's Institute of Microbiology. His work combines structural biology (X-ray crystallography, electron microscopy) with biochemical studies. Education: Dr. sc. nat. (2002) and Dipl. sc. nat. (1998) from ETH Zurich. Awards include the Wellcome Trust Investigator (2015–present). Research focuses on ATP synthase's role in energy conversion, drug development, and structural biology. His lab includes postdocs and students like Lisa Uhrig and Anthony Cheuk. Key affiliations: Centre for Structural Biology, Membrane Biology Group, and Bacterial Pathogenesis studies. Languages: German, English, French (fluent), Latin (read/write). Publications span structural biology, planetary science, and drug discovery. His work on ATP synthase inhibitors for TB has clinical implications, while astrophysical studies explore planetary formation via giant impacts.

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Celeste SaguiView profile

Professor

North Carolina State UniversityUnited States

Celeste Sagui is a Professor in the Department of Physics at North Carolina State University (NC State), affiliated with the College of Sciences. She holds additional roles as a faculty affiliate in Genomics Sciences at NC State and is a member of the Center for High Performance Simulation. Her research focuses on computational biophysics, biomolecular simulations, and free energy methods applied to nucleic acid structures, protein dynamics, and nanotechnology systems. She has contributed to the AMBER simulation package development, co-authoring versions from 10 to 14. Education: Doctorate in Physics, University of Toronto (1995) Licentiate degree, National University of San Luis, Argentina Research Interests: Sagui’s work explores DNA/RNA structure and phase transitions, electrostatic interactions, and methodologies for large-scale molecular simulations. Recent studies include nucleic acid hairpin instabilities linked to neurodegenerative diseases, polyglutamine aggregation mechanisms, and novel DNA motifs like the eGZ structure in Z-DNA. She employs quantum chemistry, density functional theory, and phase-field models to investigate systems ranging from biomolecules to nanomaterials. Publications: Her recent work emphasizes nucleic acid dynamics, free energy landscapes, and computational methods for studying diseases such as Friedreich’s ataxia and polyglutamine disorders. Key contributions include advancements in laser-driven simulations and infrared spectroscopy analysis of protein structures. Labs/Teams: Active in the Center for High Performance Simulation, focusing on high-throughput computational modeling and collaborative software development for biomolecular research.

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Steven A. CorcelliView profile

Professor

University of Notre DameUnited States

Steven A. Corcelli is a Professor and Interim Dean of the College of Science at the University of Notre Dame, with a research focus on Theoretical Chemistry and Molecular Dynamics Simulations . His work bridges Physical Chemistry and Biochemistry , targeting Energy Applications and Biomolecular Binding Mechanisms . He leads the Computational Molecular Science & Engineering Laboratory (CoMSEL). Ph.D., Chemistry, Yale University (2001) Sc.B., Chemistry, Brown University (1997) Research interests span ionic liquids for Carbon Capture , aqueous electrolytes in battery technologies , and molecular binding processes in immunology and DNA interactions . His group employs GPU-accelerated simulations and weighted ensemble methods to uncover structural and dynamic motifs. Recent publications highlight trends in vibrational spectroscopy , TCR-MHC binding , and CO2 solvation mechanisms . Awards include the Thomas P. Madden Award (2020) , ACS Fellowship (2016) , and NSF CAREER Award (2009) . Staff: Erin Brossard (Ph.D.), Nell Karpinski, Shuang Wu, Noah Vasconez, Kaitlyn Handy, Isabel Thompson

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Jacques ArchambaultView profile

Professor

McGill UniversityCanada

Dr. Jacques Archambault is a Professor in the Department of Microbiology and Immunology at McGill University , and an associate member of the Division of Experimental Medicine since 2016. His research focuses on the molecular biology and pathogenesis of human papillomaviruses (HPVs) and polyomaviruses (HPyVs), with an emphasis on their replication mechanisms as episomes in host cells. The Archambault laboratory employs functional genomics, proteomics, and chemical biology approaches to identify cellular pathways exploited by these viruses and develop high-throughput assays for screening small molecule inhibitors of viral replication. Analysis of his recent publications reveals a strong focus on HPV and HPyV replication machinery, including studies on the E1 helicase, UAF1-USP1 interactions, and structural characterization of viral proteins involved in DNA replication. His work bridges virology, oncology, and drug discovery, particularly targeting oncogenic HPV types implicated in anogenital and oropharyngeal cancers, as well as HPyVs like BKPyV and JCPyV that cause pathologies in immunosuppressed patients. Current efforts in the lab aim to elucidate the molecular mechanisms by which HPVs and HPyVs replicate their genomes and to develop antiviral therapies targeting these processes. Techniques such as fluorescence anisotropy, NMR spectroscopy, and crystallography are frequently employed to study protein-DNA and protein-protein interactions critical to viral replication.

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ZHANG YangView profile

Professor

National University of SingaporeSingapore

Dr. Yang Zhang is a Professor at the National University of Singapore (NUS), holding appointments in the Department of Computer Science (School of Computing) and the Department of Biochemistry (Yong Loo Lin School of Medicine). He also leads the Zhang Lab, which focuses on AI-driven computational methods for protein structure prediction and design. Previously, he was a Professor at the University of Michigan. His research integrates artificial intelligence, deep learning, and physics-based models to address challenges in computational biology. Affiliations: School of Computing; Yong Loo Lin School of Medicine; Cancer Science Institute of Singapore Key Roles: Principal Investigator of Zhang Lab; Developer of I-TASSER algorithm Research interests span AI-driven protein design, deep learning for RNA structure prediction, and drug discovery. Projects include the EvoDesign server for protein interaction design and TripletRes for coevolution-based contact prediction. Major contributions include the I-TASSER algorithm, ranked top in CASP experiments for protein structure prediction. Awards: Alfred P. Sloan Award, NSF CAREER Award, and seven-time Highly Cited Researcher (2015–2021).

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Henry LiangView profile

Professor

Texas Tech UniversityUnited States

Henry Liang, Ph.D., is a Professor in the Department of Cell Physiology and Molecular Biophysics at Texas Tech University Health Sciences Center (TTUHSC), with adjunct appointments in Chemical Engineering and Chemistry at Texas Tech University. His lab focuses on bridging biology with synthetic systems through membrane biophysics and bioengineering. Research Interests: Dr. Liang's work spans membrane protein reconstitution, nanodisc technology, antimicrobial nanoparticles, blood-brain barrier targeting, and immunotherapy platforms. Key areas include: Design of synthetic proteomembranes for protein function studies Development of environmentally responsive nanoantibiotics Nanoparticle-based theranostic systems for cancer Light-driven energy transduction in biohybrid materials Publication Trends: His 15 most recent articles (2011-2023) demonstrate consistent focus on nanotechnology solutions for biomedical challenges, with evolving emphasis on antimicrobial nanostructures (35%), membrane protein platforms (30%), cancer nanomedicine (20%), and sustainable nanomaterials (15%). Methodological strengths include polymer synthesis, X-ray scattering, and biomimetic system design. Training: The Liang Lab actively recruits graduate students and postdoctoral researchers for projects in membrane biophysics and bioengineering. Current research infrastructure includes capabilities for synchrotron small-angle X-ray scattering, molecular dynamics simulations, and nanomaterial characterization.

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Monica P. ColaiacovoView profile

Professor

Harvard UniversityUnited States

Dr. Monica P. Colaiacovo is a Professor of Genetics at Harvard Medical School, where she leads research in the Department of Genetics within the Blavatnik Institute. Her laboratory is located in the New Research Building in Boston, Massachusetts. Dr. Colaiacovo's research focuses on the molecular mechanisms of meiosis, chromosome dynamics, and DNA repair in the Caenorhabditis elegans model system. Her work examines how environmental toxicants impact germline function and reproductive health, with particular emphasis on chromosome segregation, recombination, and the synaptonemal complex. Her publications reveal a consistent research trajectory examining critical aspects of meiotic chromosome behavior, including double-strand break formation and repair, crossover designation, and chromosome movement during prophase I. Her laboratory has made significant contributions to understanding how environmental exposures like bisphenol A and phthalates disrupt normal meiotic progression and lead to germline dysfunction. Dr. Colaiacovo's work demonstrates strong interdisciplinary connections between basic chromosome biology, environmental health sciences, and reproductive medicine. Her research group employs advanced genetic, molecular, and imaging techniques to dissect the complex mechanisms ensuring accurate chromosome segregation during gamete formation. Her laboratory actively collaborates with researchers studying aging, DNA repair pathways, and environmental toxicology, as evidenced by publications spanning multiple high-impact journals including Nature, PLoS Genetics, and Genetics.

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Suliana ManleyView profile

Professor

Swiss Federal Institute of Technology in LausanneSwitzerland

Suliana Manley is a Full Professor at the École Polytechnique Fédérale de Lausanne (EPFL) , affiliated with the School of Basic Sciences and the Laboratory of Experimental Biophysics . She also holds teaching and research roles in EPFL's School of Life Sciences and Swiss Plasma Center , focusing on interdisciplinary biophysical studies. Education : PhD in Physics (2004), Harvard University Bachelor's in Physics & Mathematics (1997), Rice University Manley's research centers on super-resolution fluorescence imaging , single-molecule tracking , and quantitative biophysics . Key themes include: Understanding protein assembly dynamics at cellular membranes Elucidating viral assembly mechanisms (e.g., HIV-Gag) Developing 3D imaging algorithms and high-density data reconstruction tools like PALMsiever and FALCON Quantifying nanoscale organization in systems like telomeres and centrioles Her work bridges optical physics , computational image analysis , and cellular biology , with notable Nature and PNAS publications. Collaborations span bioengineering , genetics , and medical research . Scientific Awards : Featured in Nature Methods Research Highlights (3x) Very Important Paper and Cover Article (ChemBioChem, 2012) Postdoctoral Fellow, NIH and MIT Advising & Collaborations : Current PhD students in biophysics, cellular biology, and bioengineering Former students: Anna Archetti, Aleksandr Benke, Andrea Callegari, and others Co-founder of tools for high-density super-resolution microscopy and live-cell imaging Labs & Teams : Leads the Laboratory of Experimental Biophysics at EPFL, integrating physics-based methods into biological questions. The lab focuses on quantitative imaging , computational modeling , and software development for nanoscale analysis.

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Christopher LawsonView profile

Assistant Professor

University of TorontoCanada

Christopher Lawson is an Assistant Professor in the Department of Chemical Engineering and Applied Chemistry at the University of Toronto, affiliated with the Faculty of Applied Science and Engineering. He serves as Principal Investigator of the Microbiome Engineering Lab and is part of BioZone – the Centre for Applied Bioscience and Bioengineering. His research focuses on engineering anaerobic microbiomes for resource recovery from waste streams using systems biology, synthetic biology, and machine learning approaches. B.A.Sc., M.A.Sc. (University of British Columbia) Ph.D. (University of Wisconsin-Madison) Postdoctoral Training (Berkeley Lab) Lawson's work addresses the challenge of controlling complex microbial interactions in engineered systems to enable scalable biotechnologies for renewable energy, chemicals, and materials. His lab develops high-throughput methods integrating automation and computational tools to optimize microbiome assembly and metabolic fluxes. Recent publications highlight advancements in metabolic modeling , isotope tracing , and systems-level analysis of anaerobic microbiomes, with applications in wastewater treatment , anammox granules , and bioenergy production . His research bridges fundamental microbiology with industrial-scale bioprocess engineering. Scientific Awards ISME/IWA BioCluster Rising Star Award (2022) Jacobs Engineering Group/AEESP Outstanding Doctoral Dissertation Award (2020) Wesley Eckenfelder Graduate Research Award (2019) WEF Canham Graduate Studies Scholarship (2018) NSERC Post-Graduate Scholarship – Doctoral (2014) Lawson actively mentors students and postdocs, emphasizing technical rigor, communication skills, and independence. His lab collaborates within BioZone and with industry partners to advance "team science" principles. Current projects focus on creating engineered microbiomes for commercial-scale waste valorization.

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Helma WennemersView profile

Professor

ETH ZurichSwitzerland

Prof. Dr. Helma Wennemers serves as a Full Professor at ETH Zurich's Department of Chemistry and Applied Biosciences, leading the Laboratory for Organic Chemistry. Her research group operates from HCI H 313 at Vladimir Prelog Way 1-5/10 in Zurich, Switzerland, with active teaching responsibilities including Organic Chemistry I and Chemical Biology - Peptides for the Fall 2025 semester. Her research program centers on the intersection of organic chemistry and chemical biology , with particular emphasis on collagen triple helix engineering , peptide-catalyzed asymmetric synthesis , and development of chemical tools for tissue remodeling diagnostics . Key focus areas include designing hyperstable collagen heterotrimers for fibrosis monitoring, creating fluorophore-based probes for collagen cross-linking visualization, and pioneering organocatalytic methodologies for complex heterocycle synthesis. Her group actively explores how hydrophobic modifications and proline derivatives influence collagen stability and cellular uptake mechanisms. Analysis of her 15 most recent publications (2024-2025) reveals three dominant research trajectories: (1) collagen structural engineering for biomedical applications, (2) innovative peptide/organocatalysis enabling stereoselective transformations, and (3) chemical probe development targeting tissue remodeling processes. These works consistently integrate synthetic chemistry with biological validation, demonstrating translational potential in fibrosis diagnostics and regenerative medicine. While specific grant details aren't provided in available sources, her research program clearly supports advanced laboratory infrastructure including peptide synthesis facilities and photochemical reaction systems like the ETHos photoreactor. Her group maintains strong industry and clinical collaborations evident in applications targeting liver cancer cells and prostate cancer diagnostics. The Laboratory for Organic Chemistry functions as an interdisciplinary hub where synthetic organic chemists collaborate with biologists to develop collagen-based diagnostic platforms and catalytic systems. Current projects focus on lysyl oxidase-responsive probes for real-time tissue monitoring and engineered peptide catalysts for sustainable chemical synthesis under environmentally relevant conditions.

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Jian PengView profile

Assistant Professor

University of LausanneSwitzerland

Jian Peng is an Assistant Professor in the Department of Computer Science at the University of Illinois at Urbana-Champaign. His research focuses on computational biology, machine learning, and their applications to protein structure prediction, drug design, and molecular modeling. He has contributed to advancements in antibody engineering, protein-ligand docking, and generative models for biological systems. Key research areas include: Machine Learning for Molecular Modeling Protein Structure Prediction Antibody and Peptide Design Genomics and Single-Cell Analysis Structure-Based Drug Discovery His work emphasizes integrating deep learning techniques with biological datasets to address challenges in precision medicine, drug development, and systems biology. Notable achievements include developing the FastFold system to accelerate AlphaFold training and pioneering flow-based methods for antibody design. Awards include the Overton Prize (2020), recognizing contributions to computational biology. His research has been published in top journals and conferences, spanning topics from protein mutation prediction to geodesic-based immune complex modeling.

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