Manu Sharma is an Associate Professor of Neuroscience at the Brain and Mind Research Institute , Weill Cornell Medical College (2024–present). His research focuses on the molecular mechanisms underlying neurodegenerative diseases, particularly tauopathies and synucleinopathies (e.g., Alzheimer’s and Parkinson’s diseases), synaptic transmission, and protein aggregation. Education: Ph.D., University of Toronto (2005) B.Sc., University of Toronto (1998) Research Interests: Dr. Sharma investigates how physiological and pathological modifications of tau and α-synuclein proteins contribute to neurodegeneration. His work explores synaptic vesicle dynamics, chaperone-mediated protein stabilization, and the role of lysosomal pathways in disease progression. Grants: He has secured major funding as Principal Investigator and Co-Investigator from the National Institute on Aging and National Institute of Neurological Disorders & Stroke (2024–2029) for studies on tau proteostasis, synucleinopathies, and small molecule inhibitors targeting neurodegenerative pathways. Labs & Teams: Affiliated with the Brain and Mind Research Institute, Dr. Sharma collaborates on multidisciplinary projects involving synaptic biology, protein quality control, and neurodegeneration models.
Michael J. Ragusa is an Associate Professor of Chemistry at the Department of Chemistry, College of Arts and Sciences, Dartmouth College , specializing in molecular mechanisms of selective autophagy . His research integrates structural biology , biochemical reconstitution , and cell biology to understand how cells degrade toxic components like damaged organelles. Education: B.S. in Chemistry from Siena College, Ph.D. in Biochemistry from Brown University His work focuses on autophagy , particularly the role of Atg proteins in membrane tethering and cargo selection. His lab has published extensively on mitophagy , ALFY , and Atg11 , linking defects in these pathways to cancer , neurodegeneration , and infectious diseases . Recent studies highlight mechanisms of vesicle clustering and dimerization-dependent membrane interactions . Dr. Ragusa teaches courses such as CHEM 5: General Chemistry , CHEM 42: Biological Chemistry II , and CHEM 95.05: Protein Crystallography . His lab employs techniques like X-ray crystallography , NMR spectroscopy , and membrane reconstitution to dissect protein-lipid interactions.
João F. Mano is a Full Professor at the Department of Chemistry, University of Aveiro, and Director of the Doctoral Program on Biotechnology. He leads the COMPASS Research Group and serves as Vice-Director at CICECO - Aveiro Institute of Materials. His academic appointments include Invited Professor at University of Lorraine (France), Visiting Professor at KAIST (South Korea), and Adjunct Professor at Ajou University (South Korea). Education: PhD in Chemistry (1996, Technical University of Lisbon); D.Sc. in Tissue Engineering, Regenerative Medicine and Stem Cells (2012, University of Minho) Research Interests focus on Biomaterials for Regenerative Medicine , integrating Nanotechnology , Microtechnology , and Biofabrication . His group develops Bioinspired Materials using polymer chemistry, Decellularized Extracellular Matrix , and 3D Bioprinting to engineer Cell Microenvironments for therapeutic applications. Recent Publications highlight advancements in Human-Derived Hydrogels , Photopolymerizable Scaffolds , Magneto-Responsive Biomaterials , and Programmable Bioinks . Trends show emphasis on Organ-on-a-Chip integration, Smart Living Materials , and Green Bioprinting methodologies. Scientific Awards include: European Research Council Advanced Grants (2015, 2020) Fellow at IUPAC, European Academy of Sciences, and American Institute of Medical and Biological Engineering ERC Proof of Concept Grants Doctor Honoris Causa from University of Lorraine and Utrecht UNESCO Chair on Biomaterials George Winter Award (European Society for Biomaterials) Supervisions & Collaborations encompass 74+ MSc, 26+ PhD students, and 40+ postdocs. He co-founded METATISSUE and CELLULARIS Biomodels , and serves as Editor-in-Chief of Materials Today Bio .
Silvia Cavagnero is a Professor in the Department of Chemistry at the University of Wisconsin–Madison, with a research focus on protein folding and misfolding in cellular contexts. Her work integrates biomolecular spectroscopy, chemical biology, and computational methods to address fundamental questions in structural biology. B.S., First University of Rome ‘La Sapienza’ (1988) M.S., University of Arizona (1990) Ph.D., California Institute of Technology (1996) Her research explores the role of molecular chaperones like Hsp70 in protein biogenesis, the development of laser-driven NMR techniques for enhanced sensitivity, and the implications of protein aggregation in neurodegenerative diseases. Key projects include cotranslational folding studies at ribosomal exit tunnels and hyperpolarization methods for low-concentration NMR analysis. The 15 most recent publications highlight interdisciplinary advances in NMR spectroscopy optimization Protein folding kinetics Cryo-EM structural analysis Chaperone-client interactions Hsp70 antimicrobial design Hydration dynamics in folding Scientific contributions include A Prize for Going in Vivo (2017) Recognition for Diversity and Inclusion Efforts Students from the Cavagnero Group have pursued careers in academia, pharmaceutical industries, and national laboratories. Her lab emphasizes interdisciplinary training, blending physical chemistry, biology, and computational analysis.
Anna G Orr serves as Nan and Stephen Swid Assistant Professor of Frontotemporal Dementia Research and Assistant Professor of Neuroscience at Weill Cornell Medical College's Brain and Mind Research Institute since 2016, leading pioneering research on astrocyte biology in dementia pathogenesis. Her educational background includes: Ph.D. from Emory University (2008) B.S. from Allegheny College (2002) Dr. Orr's research program centers on astrocytic-neuronal interactions , mitochondrial signaling , and neuroimmune mechanisms through three interconnected pathways: neuroimmune , oxidative , and G protein-coupled signaling . Her lab investigates how these mechanisms influence neuroinflammation, protein aggregation, synaptic function, and behavioral outcomes in dementia, with parallel therapeutic discovery efforts targeting astrocytic pathways for novel dementia treatments. Analysis of her 15 most recent publications (2025-2010) reveals escalating focus on astrocyte-specific dementia mechanisms , particularly mitochondrial ROS signaling, sex-dimorphic memory effects, TDP-43 pathology interactions with antiviral pathways, and lipid dysregulation in neurodegeneration. Her work consistently bridges molecular discoveries with therapeutic applications, demonstrating increasing NIH funding support for translational approaches. Key scientific recognitions include: NIH K99/R00 Pathway to Independence Award (2017) Leon Levy Fellowship in Neuroscience (2021) Nan and Stephen Swid Endowed Professorship (2021) Outstanding Neuroscience Teaching Award (2021) Dr. Orr actively mentors eight trainees across career stages, including Ph.D. candidates Evelyn Hardin and Constance Zhou, while securing major NIH grants as Principal Investigator for projects like Uncovering Dementia-Related Lipid Alterations in Astrocytes (NIA 2024-2026) and Mitochondrial Complex III Free Radicals in Dementia Pathology (NIA 2020-2026), alongside collaborative awards from the Alzheimer's Association. Her Orr Lab maintains a dual focus on mechanistic astrocyte biology and therapeutic translation, with current projects examining astrocytic TDP-43 dysregulation, mitochondrial complex III signaling, and sex-specific memory mechanisms using advanced in vivo techniques and disease models.
Ehud Gazit is a distinguished Professor in the Department of Molecular Microbiology and Biotechnology at Tel Aviv University's Faculty of Life Sciences. He holds the Chair for Nano-Biology and serves as Vice President for Research and Development at Tel Aviv University. Professor Gazit has held numerous prestigious visiting appointments including at Umeå University, Fudan University, and Cambridge University. His academic journey began with a B.Sc. (summa cum laude) from Tel Aviv University's Special University Program for Outstanding Students in 1991, followed by a Ph.D. (with distinction) from the Weizmann Institute of Science in 1997, and postdoctoral training at MIT from 1997-2000. Professor Gazit's research focuses on molecular structure and self-assembly at the nano-scale, particularly examining protein folding, unfolding, and misfolding phenomena. His laboratory investigates the mechanisms and significance of protein unfolding and misfolding, with experimental systems including bacterial toxin-antidote systems, type II diabetes-related amyloidogenic proteins, and the VHL tumor suppressor protein. His work bridges fundamental biochemistry with nanotechnology applications, exploring how molecular self-assembly can be harnessed for technological innovation. His recent publications demonstrate a strong trajectory in peptide-based nanomaterials, with particular emphasis on amyloid formation mechanisms, peptide self-assembly for functional materials, and therapeutic applications targeting neurodegenerative diseases. His work spans multiple disciplines including biochemistry, nanotechnology, materials science, and biomedical engineering, showing increasing integration of fundamental research with practical applications. Professor Gazit has received numerous prestigious awards including: 2020 Landau Prize in Sciences and Arts in the Field of Healthy Aging 2019 Rappaport Prize for Excellence in Biomedical Research 2018 Foreign Fellow of the National Academy of Sciences, India 2016 ERC Advanced Grant from the European Research Council 2015 Elected Member of the European Molecular Biology Organization (EMBO) Professor Gazit has been actively involved in mentoring students and researchers, as evidenced by his extensive publication record with numerous collaborators. He has secured significant research funding including an ERC Advanced Grant. His professional activities include editorial board memberships for journals including Journal of Peptide Science, Nanoscience & Nanotechnology - Asia, and Amyloid. He previously served as Chief Scientist of the Ministry of Science and Technology (2012-2014). His laboratory has developed innovative approaches to studying molecular self-assembly, with particular expertise in peptide nanostructures. The research team has made significant contributions to understanding amyloid formation mechanisms while simultaneously developing novel biomaterials with applications ranging from electronics to medicine. They have established strong collaborations with research groups worldwide, creating a dynamic interdisciplinary research environment focused on the intersection of biology and nanotechnology.
Dr. Andrew Bassett serves as Head of the Cellular and Gene Editing Research group at the Wellcome Sanger Institute, where he develops cutting-edge genome engineering techniques using human pluripotent stem cells to investigate neurodegenerative diseases including Alzheimer's and Parkinson's. His work focuses on scaling genetic screening approaches and improving CRISPR specificity for modeling complex disease mechanisms. His academic training includes: PhD at the MRC Laboratory of Molecular Biology (MRC-LMB) with Andrew Travers on chromatin remodelling in heterochromatin formation Postdoctoral research with David Baulcombe at the University of Cambridge studying small RNA roles in chromatin modification Additional postdoctoral work with Chris Ponting at the MRC Functional Genomics Unit (MRC-FGU) in Oxford, where he pioneered CRISPR applications in Drosophila Bassett's research program centers on developing advanced genome engineering methodologies for precise modulation of gene expression networks during development and neurodegeneration. His group specializes in creating complex editing events (SNPs, paired knockouts, enhancer perturbations) within iPSC-derived models, with particular emphasis on epigenetic regulation and transcriptional control. Current projects integrate single-cell 'omics and phenotypic assays to decode genetic causes of neurodegenerative disorders through the OpenTargets consortium. Analysis of his 15 most recent publications reveals dominant trends in CRISPR technology development (35%), neurodegenerative disease modeling (30%), and single-cell functional genomics (25%). His work consistently bridges methodological innovation with disease mechanism studies, increasingly incorporating multi-omics approaches and expanding into cancer immunology and infectious disease applications since 2022. As group leader, Bassett mentors postdoctoral researchers and PhD students while securing major funding for genome engineering initiatives. His team operates within the Sanger Institute's Cellular Operations division and maintains critical partnerships with the OpenTargets consortium for therapeutic target validation. The laboratory specializes in high-throughput screening platforms using iPSC-derived neural and microglial models, with recent methodological advances including scSNV-seq and ONE-STEP tagging systems that significantly enhance precision genome editing capabilities.
Brandon Weissbourd is an Assistant Professor in the Biology department at the Massachusetts Institute of Technology (MIT) and holds a joint appointment as an Investigator at the Picower Institute for Learning and Memory. He joined MIT in 2023 after completing a postdoctoral fellowship in the lab of David Anderson at the California Institute of Technology (Caltech). Prior to that, he earned his PhD in Biology from Stanford University in 2016 under the mentorship of Liqun Luo, and a BA in Human Evolutionary Biology from Harvard University in 2009. His research interests encompass systems neuroscience, evolutionary biology, and molecular biology. He uses jellyfish models, such as Clytia hemisphaerica, to study the evolution and functional mechanisms of nervous systems. His work combines computational techniques like single-cell RNA-seq and advanced microscopy with traditional genetic and anatomical approaches to dissect neural circuits and their roles in behaviors like feeding and social interaction. Additionally, he has explored serotonin and noradrenaline systems in mammals, focusing on their heterogeneity and functional connectivity. Recent publications emphasize the utility of non-traditional model organisms for evolutionary studies and underscore his expertise in computational methods for neurobiological analysis. Earlier work includes groundbreaking studies on the dorsal raphe serotonin system and basal forebrain circuits governing sleep-wake cycles. No scientific awards or honors have been explicitly mentioned in the provided text. Weissbourd’s academic trajectory reflects a strong emphasis on interdisciplinary research, merging evolutionary, molecular, and systems-level perspectives to understand neural systems across species. His advising record is not detailed here, though he has been affiliated with prestigious research labs during his training. Current affiliations include the MIT Biology department and the Picower Institute, where he likely contributes to collaborative projects in systems and evolutionary neuroscience. Weissbourd’s work is grounded in experimental models such as Clytia medusa and mouse brain studies, enabling him to investigate both ancient nervous system architectures and modern mammalian neural pathways. His lab’s focus on functional genomics and circuit mapping positions him at the forefront of studies on neural diversity and evolutionary innovation.
Ramanujan Hegde serves as a Professor and Group Leader at the MRC Laboratory of Molecular Biology (LMB), University of Cambridge, where he directs research on membrane protein biosynthesis and cellular quality control mechanisms. His work examines how membrane proteins are accurately targeted to organelles, inserted into lipid bilayers, folded, and assembled into functional complexes, with emphasis on the cellular pathways that eliminate defective proteins to prevent disease. Professor Hegde's research program focuses on fundamental questions in cell biology: How do cells ensure precise membrane protein localization? What molecular machinery governs protein insertion and folding? How do quality control systems detect and degrade misfolded proteins? His investigations reveal that biosynthetic failures are common, triggering degradation pathways linked to diseases like neurodegeneration. Key research areas include: Intramembrane chaperone mechanisms for multipass membrane proteins Orphan subunit recognition during complex assembly Ribosome-associated mRNA degradation in autoregulation Proteasome assembly quality control ER membrane protein complex functions Molecular basis of protein aggregation diseases His 2017-2023 publications in Cell, Nature, and Science demonstrate consistent innovation in protein quality control, with landmark discoveries including UBE2O's role in orphan subunit degradation, the EMC as a transmembrane domain insertase, and TTC5-mediated tubulin autoregulation. These works bridge basic cell biology with disease mechanisms through rigorous biochemical and structural approaches. Professor Hegde mentors a research team of 11 scientists: Christine Desroches Altamirano Zhong Yan Gan Dino Janssen Ryan Judy Jennifer Miao Elizabeth Miller Tim Stevens Julia Toplak Huping Wang Haoxi Wu Eszter Zavodszky His laboratory operates within the MRC LMB's world-class infrastructure, utilizing advanced techniques in biochemistry, structural biology, and cell imaging. Supported by Medical Research Council funding, the group maintains strong collaborations across Cambridge and internationally to dissect protein biogenesis pathways with implications for therapeutic development in protein-misfolding disorders.
David Latulippe is a Professor in the Department of Chemical Engineering at McMaster University. He joined McMaster in 2012 after postdoctoral work at Cornell University and a PhD at Penn State University, focusing on membrane filtration for DNA purification. His industrial experience includes roles at ZENON Environmental (now GE Water) in hollow-fiber membrane design for water treatment. Research interests include Membrane science and technology Bioprocessing of therapeutic viruses Microscale systems for biological applications Environmental engineering solutions for water treatment Current projects involve collaborations with industry partners like Ceapro and Aevitas, and the development of a biomanufacturing automation lab with Sartorius. Recent publications highlight advancements in Nanofiltration and microfiltration for viral vectors Conductive membranes for electrochemical applications Microfluidic systems for DNA analysis Environmental monitoring of biocides and microplastics Scientific recognition includes the Young Membrane Scientist Award (2014). Teaching activities focus on Fluid Mechanics (CHEMENG 2O04) and Industrial Separation Processes (CHEMENG 4M03).
Prof. Dr. Roderick Lim is an Associate Professor at the Biozentrum, University of Basel , where he leads a research group since 2014. His work bridges biophysics, nanotechnology, and molecular biology , focusing on the nuclear pore complex (NPC) and mechanobiology of cells . He develops biomimetic systems for selective molecular transport and ARTIDIS , a nanomechanical tissue diagnostic platform commercialized for breast cancer prognosis . Education : BSc (UNC Chapel Hill), PhD (NUS/IMRE Singapore), Postdoc (Swiss Nanoscience Institute) Positions : Argovia Professor (2014–present), Tenure Track Asst. Prof. (2009–2013), Postdoc (2004–2008) His research on NPC transport selectivity reveals how karyopherins modulate the FG Nup barrier via multivalent interactions, with implications for viral entry and Alzheimer’s disease . His ARTIDIS platform uses atomic force microscopy to detect cancer via tissue softness, linking hypoxia to metastasis . Recent 2025 publications explore bacterial nanoharpoon defense mechanisms and DNA origami-based NPC mimics . Scientific Awards : Pierre-Gilles de Gennes Prize (2008), A*STAR Fellowship (2004) Collaborations : NCCR Molecular Systems Engineering, NanoTera, KTI He mentors PhD students in institutions across Switzerland, Singapore, Sweden, and the UK , with alumni working on polymersome delivery, mechanotransduction, and pathogen transport . His lab pioneered high-speed atomic force microscopy for real-time NPC dynamics and plasmonic nanopores for synthetic biology applications.
Magnus Richardson is a Professor at the University of Warwick, affiliated with the Mathematics for Real-World Systems Centre for Doctoral Training (CDT), where he previously served as Director (2016–2020) and currently acts as Deputy Director. His research focuses on theoretical neuroscience, mathematical modeling of neural systems, and neurodegenerative diseases. He has led significant grants, including the UKRI-funded £5M renewal for the CDT, extending its operations until 2028. Richardson has supervised numerous doctoral students, including Alice Wang, Ivana Del Popolo, and alumni such as Dr. Emily Hill and Dr. Robert Gowers. His work bridges computational neuroscience and experimental biology, investigating topics like synaptic plasticity, adenosine signaling, and the impact of protein aggregates (e.g., tau, α-synuclein) on neuronal function. Richardson’s teaching includes modules on mathematical biology and machine learning. His GitHub repositories reflect his computational contributions, including neural modeling frameworks for integrate-and-fire neurons. Key research themes include understanding how synaptic inputs and neuromodulators influence neuronal dynamics, and developing mathematical tools to analyze neural systems under pathological conditions. Richardson’s grants and collaborations highlight his role in advancing interdisciplinary research at the intersection of mathematics, neuroscience, and computational biology.
Dr. Wael M. Rabeh is an Associate Professor of Chemistry at New York University Abu Dhabi (NYUAD), affiliated with the Division of Science. He holds a PhD in Biochemistry from the University of Oklahoma and conducted postdoctoral research at the Structural Genomic Consortium (University of Toronto) and McGill University. His research focuses on protein structure-function relationships, particularly in disease-relevant proteins such as CFTR (cystic fibrosis transmembrane conductance regulator) and human Hexokinase 2, leveraging X-ray crystallography and biophysical techniques. Key areas include cystic fibrosis mechanisms, cancer metabolism, drug discovery, and bioluminescence. Dr. Rabeh’s work has contributed to understanding CFTR misfolding and functional correction, as well as the role of Hexokinase 2 in tumor growth. His lab collaborates internationally (e.g., with McGill University) and has secured funding from institutions like Al Jalila Foundation, Terry Fox Research Foundation, and NYUAD. He teaches courses in biochemistry and structural biology, emphasizing hands-on experimental approaches. Notable research highlights include the discovery of a dual-step correction mechanism for the ∆F508 CFTR mutation and structural studies of antiviral drugs like Tamiflu. His lab’s bioluminescence research aims to elucidate color-producing mechanisms in luciferases. Dr. Rabeh actively contributes to structural biology education through innovative laboratory curricula and public engagement.
Dr. Shelley Wickham is an Associate Professor and ARC DECRA Fellow at the University of Sydney, holding joint appointments in the Schools of Chemistry and Physics. She serves as a Westpac Research Fellow and leads the DNA Nanotechnology Group at the Sydney Nano Institute. Dr. Wickham is also co-Champion of the Sydney Nano Institute Grand Challenge project in Molecular Nanorobotics for Health, co-lead of the School of Physics Grand Challenge on Nanoscale brain navigation for targeted drug delivery, and faculty mentor of the University of Sydney BIOMOD team. Bachelor of Science and Master of Science in Physics from University of Sydney PhD in Condensed Matter Physics from University of Oxford Postdoctoral Fellow at Harvard Medical School, Dana-Farber Cancer Institute, and Wyss Institute Dr. Wickham's research focuses on self-assembling nanotechnology and molecular robotics, particularly in the design and assembly of programmable nanostructures out of DNA. Her work spans applications in cell biology, materials science, and nanomedicine. Current research projects include design and synthesis of self-assembling DNA nanostructures, proto-cells made of DNA gels that move under flow, new plasma fabrication methods for biomolecule micropatterning, and DNA computation circuits for navigating the brain using machine learning. Her research aligns with the Faculty of Science Research Strengths in Molecules to Materials, Preventing and Treating Disease & Disorder, and Next Generation Materials. Analysis of Dr. Wickham's recent publications reveals a consistent focus on DNA nanotechnology with increasing sophistication in structural complexity and biological applications. Her work has evolved from fundamental DNA origami structures to increasingly complex multi-component systems with practical applications in nanomedicine and biomimetic engineering. Recent publications show strong interdisciplinary collaboration across chemistry, physics, biology, and engineering disciplines, with emphasis on real-world applications including drug delivery systems and biomolecular sensors. ARC DECRA Fellow Westpac Research Fellow BIOMOD World Champions (2019) Dr. Wickham actively mentors PhD students and postdoctoral researchers in her DNA nanotechnology group. She has secured significant research funding including ARC Discovery Projects, Westpac Scholarships, and NSW Health grants. Her current grants support projects such as '3D Bio-Nanomaterial Displays with Designer Architectures and Functions' and 'RNA aptamer sensing devices for rapid detection of blood clotting.' Dr. Wickham encourages applications from diverse backgrounds and maintains active collaborations with researchers at Harvard, Oxford, and other international institutions. Dr. Wickham leads the DNA Nanotechnology Group at the University of Sydney, which is part of the Sydney Nano Institute. Her lab focuses on building tools from DNA origami - including tweezers, spanners, wrenches and springs - to better understand biological processes at the nanoscale. The group has achieved notable success with the BIOMOD team winning world championships in 2019, and continues to develop innovative approaches to molecular robotics for healthcare applications.
Gábor Magyarfalvi is an Assistant Professor and Lecturer at Eötvös Loránd University, affiliated with both the Institute of Chemistry and the Department of Inorganic Chemistry. His office is located at 1117 Budapest, Pázmány Péter sétány 1/a. (Room 542), and he can be contacted via email at gmagyarf@elte.hu or phone extension 6587. His research focuses on physical and inorganic chemistry, with specialization in spectroscopy, astrochemistry, and computational methods. Key areas include matrix isolation techniques for studying interstellar molecule formation (e.g., H 2 catalysis via polyaromatic hydrocarbons), photochemical generation of reactive intermediates, and conformational dynamics of biomolecules. His work extensively employs low-temperature matrix isolation coupled with laser spectroscopy and quantum chemical calculations. Magyarfalvi's publications demonstrate consistent themes: 60% focus on low-temperature photochemistry and spectroscopy of small molecules (e.g., nitrogen/sulfur compounds, amino acids), 30% on peptide/protein conformational analysis using vibrational circular dichroism (VCD) and NMR, and 10% on methodological developments in computational chemistry. Recent works increasingly explore astrochemistry and quantum tunneling phenomena.
