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Chris MeierView profile

Professor

• Nucleoside Chemistry
• Nucleotide Chemistry
• Pronucleotide Development
• +5 more

Prof. Chris Meier is a distinguished Professor of Organic Chemistry at the University of Hamburg, Germany, where he leads the research group AG Meier within the Institute of Organic Chemistry, Department of Chemistry, Faculty of Mathematics, Informatics and Natural Sciences (MIN Faculty). With over two decades of academic leadership, he serves as Co-Speaker of Collaborative Research Center 1648 "Emerging Infections" and has held significant roles including Scientific Director of the Centre for Structural Systems Biology (CSSB) and President of the International Society for Nucleosides, Nucleotides and Nucleic Acids (IS3NA). Dr. Meier's educational background includes a Chemistry degree (Dipl. Chem.) from the University of Marburg/Lahn (1982-1987), followed by his doctorate in Organic Chemistry from the same institution (1987-1989). He completed postdoctoral research at the Pasteur Institute in Paris (1990-1991) and habilitated at Goethe University Frankfurt (1996) before his appointment as C4/W3 Professor at the University of Hamburg in 1999. Professor Meier's research program focuses on nucleoside and nucleotide chemistry, with particular emphasis on pronucleotide development, antisense oligonucleotide chemistry, and stereoselective synthesis of carbocyclic nucleoside analogs. His laboratory investigates molecular mechanisms of chemical carcinogenesis through synthesis of arylamine-modified oligonucleotides and develops innovative organic synthesis methods based on solid support. The group's work bridges fundamental organic chemistry with biomedical applications, particularly in antiviral and anticancer drug development. Recent publications highlight advancements in TriPPP ro -technology for nucleoside triphosphate delivery and metabolic labeling applications. 2018: Antonín Holý Memorial Award from the International Society for Antiviral Research (ISAR) 2007: William Prusoff Award from ISAR 1995: Adolf-Messer Prize for Interdisciplinary Research 1992-1996: Habilitation Scholarship from the German Research Foundation (DFG) 1990-1992: Liebig Postdoctoral Fellowship Professor Meier has successfully mentored numerous doctoral students and postdoctoral researchers, many of whom have gone on to establish independent research careers. His laboratory maintains active collaborations with virology and immunology groups across Europe, particularly with institutions in France (Pasteur Institute, University of Aix-Marseille) and Belgium (KU Leuven). The group has secured substantial funding through multiple Collaborative Research Centers (SFBs) and has developed several patented technologies related to pronucleotide delivery systems. The Meier laboratory operates state-of-the-art organic synthesis facilities within the Institute of Organic Chemistry and maintains close ties with the Centre for Structural Systems Biology (CSSB), where they utilize advanced imaging and structural biology techniques to characterize their compounds. The research group actively participates in the International Society for Antiviral Research and contributes to the development of novel antiviral strategies through both basic research and translational applications.

• Medicinal Chemistry
• Cancer Research
• Prostate Cancer
• +7 more

Daniel A Harki , Professor of Medicinal Chemistry at the University of Minnesota, is a leading researcher in cancer biology and molecular virology. Affiliated with the Institute for Molecular Virology , his work focuses on developing novel protein degraders for RET-positive cancers, targeting APOBEC mutagenesis in breast cancer, and creating antiviral compounds for RNA viruses. Current projects include NIH-funded studies on Neuroendocrine Prostate Cancer and Cancer Center Support Active member of multidisciplinary collaborations across the University of Minnesota's medical and molecular research divisions His research portfolio spans biochemistry, enzymology, and chemical biology , with recent publications examining: Allosteric binding site targeting in NF-κB signaling Structure-activity relationships in Aurora kinase A degraders Sugar conformation effects on APOBEC3A/3B activity SARS-CoV-2 nucleocapsid protein inhibition West Nile/Zika virus nucleoside prodrugs Key collaborations include co-investigator roles in 20 major projects and principal investigator positions on APOBEC Mutagenesis grants. His work contributes to UN Sustainable Development Goals through cancer research and antiviral development.