Find Academic Supervisors

• Cancer Research
• Antibody-Drug Conjugates
• Molecular Oncology
• +5 more

Lars Henning Engelholm is a Professor in the Department of Biomedical Sciences at the University of Copenhagen's Faculty of Health and Medical Sciences. With 72 research outputs including 65 journal articles, 6 reviews, and 1 conference abstract, he maintains an active research program focused on cancer therapeutics and molecular biology. His work bridges basic science with clinical applications through innovative drug delivery approaches. Dr. Engelholm's research focuses on cancer therapeutics with particular emphasis on antibody-drug conjugates (ADCs), bioconjugation techniques, and targeted therapy development. His work spans multiple cancer types including breast cancer, pancreatic cancer, ovarian cancer, and malignant pleural mesothelioma. He has made significant contributions to understanding drug delivery mechanisms, tumor microenvironment interactions, and novel payload development for cancer treatment. His recent publications demonstrate a strong trend toward developing next-generation antibody-drug conjugates with improved targeting capabilities and novel payload systems. Research areas include bioconjugation chemistry, cancer stem cell targeting, immune microenvironment modulation, and organoid-based drug response profiling. His 2024 review in Cancers journal has received 40 Scopus citations, indicating significant impact in the field. Cited 40 times in Scopus for 2024 Cancers review article Patent Family Citation for Science Advances pancreatic cancer research Multiple news outlets have covered his research (6 outlets for the HER2 nanobody-drug conjugate work) Research referenced in patents and widely shared on social media platforms Dr. Engelholm maintains extensive collaborations across multiple institutions, with research picked up by numerous news outlets, blogged about, and widely shared on social media platforms including X (formerly Twitter) and Bluesky. His work demonstrates strong translational potential with several studies moving toward preclinical and clinical applications.

• germ cell development
• meiotic recombination
• DNA damage response and repair
• +3 more

Hannah Rebecca Schorle is a Postdoctoral Research Fellow in the Department of Cellular and Molecular Medicine at the University of Copenhagen's Faculty of Health and Medical Sciences, specializing in the Molecular Aging Program. Her research focuses on female germ line mechanisms, particularly the causes of aneuploidy and pathways linked to ovarian ageing. Her primary research interests include germ cell development , meiotic recombination , DNA damage response and repair , oogenesis , and ovarian ageing . She investigates the connections between DNA damage response pathways, meiotic recombination errors, and germ cell development abnormalities using advanced cellular models. Her collaborative work spans cancer biology and cellular migration mechanisms, as evidenced by her 2021 publication in Cancers . This research explored PTEN loss effects on durotaxis and RhoB-dependent amoeboid migration in 3D scaffolds. No scientific awards or formal advisees are documented in the available records. Her laboratory work operates within the Hoffmann Group's research framework at the University of Copenhagen.

• Genetic modification
• Mouse models
• CRISPR/Cas9
• +5 more

Javier Martin Gonzalez serves as a Doctor Research consultant and manager of the Transgenic Core Facility at the University of Copenhagen's Faculty of Health and Medical Sciences. With expertise in genetic modification and mouse model development, he leads a critical research support unit that provides essential services to the scientific community. His research interests center on genetic modification techniques, particularly CRISPR/Cas9 applications, mouse model development, embryonic stem cell culture and modification, and assisted reproduction technologies. The Transgenic Core Facility maintains an extensive cryobank with over 750 mouse strains, supporting researchers through embryo manipulation, stem cell derivation, and specialized breeding programs. His recent publication record demonstrates a strong focus on developmental biology, genome editing, and reproductive science, with multiple high-impact publications in 2024-2025 across journals including Cell Reports, Nature Communications, and Heliyon. His work spans from fundamental DNA repair mechanisms to applications in fertility and embryonic development. The Transgenic Core Facility under his management represents a vital resource for researchers at the University of Copenhagen, providing specialized expertise in mouse model generation and maintenance that supports numerous research projects across the institution.

• Cell Biology
• Genome stability
• DNA Damage Response
• +2 more

Saskia Hoffmann is an Associate Professor at the Novo Nordisk Foundation Center for Protein Research (CPR) at the University of Copenhagen, where she leads research in the Mailand Group. She has held this position since October 2019 and maintains dual affiliation as both Associate Professor and Guest Researcher at CPR. Her academic credentials include: PhD in Biochemistry (2013-2016) from the University of Copenhagen, CPR, under Professor Niels Mailand with thesis on 'Functions of ubiquitin ligases in responses to replication stress and DNA damage' Master's in Biochemistry (2010-2012) from the University of Copenhagen supervised by Associate Professor Claus Storgaard Sørensen Bachelor's in Biochemistry (2007-2010) from the University of Leipzig, Germany, supervised by Professor Kurt Engeland Dr. Hoffmann's research program focuses on cellular responses to DNA damage and replication stress, with particular emphasis on understanding how cells counteract genotoxic insults to maintain genome stability. Her current work investigates the molecular link between human proteases and cellular surveillance pathways, revealing critical implications for human health and disease. Her research spans: Cell Biology mechanisms underlying genome maintenance Genome stability preservation pathways DNA Damage Response systems DNA Replication processes under stress conditions Protease functions in cellular surveillance Analysis of her publication record demonstrates a consistent research trajectory focused on DNA damage response mechanisms, protein modification systems (particularly ubiquitination and SUMOylation), and their roles in maintaining genome integrity. Her work frequently explores how defects in these pathways contribute to human diseases including genetic disorders and cancer, with several publications appearing in high-impact journals such as Nature Structural and Molecular Biology, Nature Communications, and Molecular Cell. Dr. Hoffmann has established herself as a significant contributor to the field of genome maintenance research, with her work on proteases and DNA damage response pathways opening new avenues for understanding disease mechanisms and potential therapeutic approaches.