Posttranslational Modification Professors and Supervisors in Denmark

Ole Nørregaard JensenView profile

Professor

University of Southern DenmarkDenmark

Ole Nørregaard Jensen is a Professor in Biomedical Mass Spectrometry and Systems Biology at the Department of Biochemistry and Molecular Biology, University of Southern Denmark . His research integrates advanced mass spectrometry, proteomics, and bioinformatics to study chromatin biology, post-translational modifications, and cellular signaling networks. He is actively involved in major research initiatives funded by Novo Nordisk Foundation and Lundbeck Foundation. His research interests include Mass Spectrometry, Proteomics, Posttranslational Modification, Histone Biology, Chromatin Biology, Bioinformatics, Systems Biology, Lipidomics, and Protein Chemistry . He employs cutting-edge techniques such as tandem mass spectrometry and ion mobility spectrometry to analyze protein isomers and dynamic modifications. His work has significant implications for understanding gene regulation, DNA replication, and disease mechanisms. His recent publications demonstrate a strong trend in chromatin dynamics, epigenetics, and integrated omics approaches , combining proteomics with transcriptomics and lipidomics to unravel complex biological systems. His research spans from fundamental molecular mechanisms to translational applications in biomedicine and food science. He has been recognized with several prestigious awards: MCP Lectureship Award Juan Pablo Albar Proteomics Pioneer Award 2019 EliteForsk 2009 prize Knight Order of Dannebrog (Ridder af Dannebrogordenen) Jensen is deeply involved in academic service, including peer review for journals like Nature Communications and Molecular and Cellular Proteomics , organizing conferences, and supervising students. He teaches courses such as Biomedical Mass Spectrometry - Principles and Applications and coordinates the Computational Biomedicine international Master’s program. He leads multiple active research projects, including PLATO and INTEGRA, focusing on health data, imaging, and protein networks. He is a key member of a vibrant research environment in biomedical mass spectrometry at SDU, contributing to both national and international scientific collaborations. His lab is at the forefront of developing and applying novel mass spectrometry methodologies for systems biology.

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Daan van AaltenView profile

Professor

Aarhus UniversityDenmark

Daan van Aalten is a Professor at Aarhus University, affiliated with the Department of Molecular Biology and Genetics - Neurobiology within the Faculty of Natural Sciences. His research focuses on protein O-GlcNAcylation, a critical posttranslational modification linked to intellectual disability (OGT-CDG). He leads studies using model systems (mESCs, Drosophila, mice) to dissect molecular mechanisms underlying OGT-CDG phenotypes. Notable contributions include defining OGT-CDG as a congenital disorder of glycosylation and identifying therapeutic targets. He has secured major grants, including a Novo Nordisk Foundation Laureate Grant (DKK 50M) and a Villum Investigator Grant (DKK 40M), supporting work on protein modifications and fungal pathogenesis. Key research areas include enzymology, structural biology, and neurobiology. His lab explores O-GlcNAc signaling dynamics, fungal cell wall synthesis, and genetic disorders. Recent studies highlight neurodevelopmental defects in mouse models and human stem cell systems. Collaborative projects with international teams advance drug discovery for fungal pathogens and intellectual disability syndromes. Publications span molecular mechanisms of OGT mutations, enzyme inhibitors, and structural biology. Awards include recognition for his transformative work in glycobiology and neurodevelopment. His lab actively engages in training scientists and welcomes inquiries about OGT-CDG studies via ogtcdg@au.dk.

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Veit Stefan SchwämmleView profile

Associate Professor

University of Southern DenmarkDenmark

Veit Stefan Schwämmle is an Associate Professor at the Department of Biochemistry and Molecular Biology, University of Southern Denmark. His work focuses on biomedical mass spectrometry and systems biology, with expertise in proteomics, bioinformatics, and computational modeling of multivalent histone modifications in gene regulation. Research Interests: His research combines statistical data analysis, Monte Carlo simulations, and advanced mass spectrometry techniques to study proteomics, posttranslational modifications, and their applications in biomedical contexts. Key areas include liquid chromatography-mass spectrometry, bottom-up proteomics, and privacy-preserving data analysis methods. Projects: He participates in EU Horizon Europe initiatives like ELIXIR-STEERS and ELIXIR-STREERS, focusing on research infrastructure and bioinformatics. His involvement in projects such as PROTEIN and Elixir Hub highlights his contributions to multicenter proteomics and data standardization. Activities: A seasoned lecturer, he has delivered presentations on computational proteomics, statistics, and bioinformatics in both academic and industry settings since 2012, emphasizing large datasets and analytical rigor.

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Vladimir GorshkovView profile

Researcher

University of Southern DenmarkDenmark

Vladimir Gorshkov is a Lab Manager at the Department of Biochemistry and Molecular Biology, University of Southern Denmark, specializing in Biomedical Mass Spectrometry and Systems Biology . His research focuses on Proteomics , Mass Spectrometry , and Posttranslational Modification , with applications in neurodegenerative diseases, cancer therapy, and cultural heritage analysis. Lab Manager, Biomedical Mass Spectrometry and Systems Biology, SDU 46+ publications spanning 2010–2025 Research Trends : His recent work emphasizes ultra-fast proteomic analysis , MS/MS-free quantification , and neuroprotection mechanisms in Parkinson’s and chemotherapy-induced neuropathy. Collaborations span Denmark , Brazil , and International Partners . Scientific Activities : Presented at the 2023 EuBIC-MS conference on Negative Ion Mode Proteomics .

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Magnus KjærgaardView profile

Associate Professor

Aarhus UniversityDenmark

Magnus Kjærgaard is an Associate Professor at the Department of Molecular Biology and Genetics and affiliated with DANDRITE and the Interdisciplinary Nanoscience Center (INANO-MBG) at Aarhus University . His work bridges neurobiology, structural biology, and protein biophysics. Research Focus: Intrinsically disordered proteins, biomolecular condensates, enzyme mechanisms, and neurodegenerative diseases. Recent Work: Investigating phase separation in metabolic pathways, designing disordered proteins for controlled assembly, and characterizing kinase regulation via linker domains. Techniques: NMR spectroscopy, single-molecule FRET, X-ray crystallography, and computational modeling of protein interactions. Publications: His 2025 ChemBioChem paper quantified small molecule partitioning in condensates, while 2024 studies explored antibody-oligomer interactions in Parkinson's disease and kinase docking principles. Earlier work (2015-2021) established frameworks for understanding tau aggregation and ATPase function. Collaborations: Regularly works with teams across Denmark and internationally, particularly in molecular neuroscience and structural enzymology projects.

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Pia JensenView profile

Researcher

University of Southern DenmarkDenmark

Pia Jensen is an academic staff member at the Department of Biochemistry and Molecular Biology at the University of Southern Denmark, specializing in Biomedical Mass Spectrometry and Systems Biology. Her research focuses on proteomics, post-translational modifications, and their roles in neurodegenerative diseases such as Parkinson's and Alzheimer's. Dr. Jensen's research spans several interconnected areas including proteomics, dopaminergic neuroscience, posttranslational modification analysis, glycoprotein and glycopeptide characterization, and neural stem cell biology. Her work particularly examines how protein modifications contribute to conditions like Parkinson's and Alzheimer's diseases, with emphasis on glycosylation patterns, neural differentiation, and cellular signaling pathways. Her recent publications demonstrate a strong focus on applying advanced proteomics techniques to understand neurodegenerative processes. Jensen's work connects protein modifications with neuronal function and disease mechanisms, particularly in Parkinson's and Alzheimer's diseases. She frequently collaborates with researchers across multiple institutions to investigate the molecular basis of these conditions using mass spectrometry and systems biology approaches. Scientific awards include: Årets unge forsker 2012 (Young Researcher of the Year 2012) from Parkinsonforeningen Travel Award for abstract submission to ASNTR meeting (2012) Travel Award for abstract submission to ASNTR meeting (2009) Dr. Jensen has served as a peer reviewer and participated extensively in academic activities including conference presentations and workshops. She led a project funded by A. P. Møller og Chastine Mckinney Møllers Fond in 2016 focused on insulin release signaling mechanisms in beta cells. Her research activities span neural transplantation, stem cell research related to Parkinson's disease, and molecular mechanisms of neurodegenerative disorders. As part of the Biomedical Mass Spectrometry and Systems Biology group at the University of Southern Denmark, Jensen applies advanced proteomics techniques to study neurodegenerative diseases and cellular signaling pathways. Her work integrates mass spectrometry with systems biology approaches to understand protein modifications in neurological conditions.

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Chuna Ram ChoudharyView profile

Professor

University of CopenhagenDenmark

Dr. Chuna Ram Choudhary is a Professor and Group Leader at the Novo Nordisk Foundation Center for Protein Research (CPR) within the Faculty of Health and Medical Sciences at the University of Copenhagen , Denmark. His academic journey includes a PhD in Biochemistry (University of Münster, Germany, 2001–2006) and postdoctoral training at the Max Planck Institute for Biochemistry (2007–2009). He leads a research group focused on protein posttranslational modifications (PTMs) —particularly lysine acetylation and ubiquitylation —using quantitative mass spectrometry to map their roles in cell signaling networks and DNA repair . Research interests center on systems-wide analysis of PTMs, emphasizing their dynamic regulation of protein activity, stability, and localization in health and disease. His lab has pioneered methods for site-resolved acetylation stoichiometry and ubiquitylation dynamics , revealing connections between metabolism , transcription , and genome integrity . Collaborations span national and international institutions , including groups at CPR and beyond. Research output trends show a focus on ubiquitin and acetylation signaling , DNA repair mechanisms , and enhancer-promoter compatibility . His work has significant implications for cancer biology , cardiovascular diseases , and developmental processes . Scientific awards include: 2015: ERC Consolidator Grant 2014: Junior Researcher Prize (Danish Cancer Society) 2014: Hallas Møller Investigator Grant (NNF) 2013: EMBO Young Investigator 2012: Sapere Aude Grant (Danish Research Council) 2009: Artur Pappenheim Prize (German Society of Hematology and Oncology) Lab activities involve cutting-edge proteomics and mass spectrometry , with a strong emphasis on translational research and therapeutic target identification .

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Chiara FrancavillaView profile

Associate Professor

Technical University of DenmarkDenmark

Chiara Francavilla is an Associate Professor at the Technical University of Denmark (DTU) , Department of Biotechnology and Biomedicine. She holds an external position as Honorary Senior Research Fellow at the University of Manchester (since 2023) and earned her PhD in Molecular Medicine from the AIRC Institute of Molecular Oncology in 2009.

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Christian Adam OlsenView profile

Professor

University of CopenhagenDenmark

Christian Adam Olsen is a Professor at the Department of Drug Design and Pharmacology , University of Copenhagen. With a foundation in chemical synthesis, his research group develops peptidomimetic secondary structures and chemical tools to investigate human lysine deacylase enzymes, HDAC inhibitors, and quorum sensing modulators.

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Martin Røssel LarsenView profile

Professor

University of Southern DenmarkDenmark

Martin Røssel Larsen is a Professor in the Department of Biochemistry and Molecular Biology at the University of Southern Denmark, specializing in Biomedical Mass Spectrometry and Systems Biology. His research focuses on proteomics and post-translational modifications, with significant contributions to understanding cellular processes in health and disease. Dr. Larsen's research interests span several key areas in biochemistry and molecular biology. His primary focus is on Proteomics , where he has developed advanced methodologies for protein analysis. He has made significant contributions to Phosphoproteomics , studying protein phosphorylation and its role in cellular signaling. His work in Mass Spectrometry has advanced the field of biomedical analysis, and his research on Posttranslational Modifications has provided insights into disease mechanisms. He also investigates Glycosylation patterns and their biological significance. The recent publications of Dr. Larsen demonstrate a strong focus on applying proteomic approaches to understand disease mechanisms. His work spans cancer biology (particularly glioma), metabolic disorders including liver disease and diabetes, and neurological conditions. There's a clear trend toward system-wide proteomic analysis to understand complex biological processes and disease states, often combining multiple analytical approaches to gain comprehensive insights. Paul Dudley White International Scholar of the American Heart Association (2018) Eliteforsk prisen (2014) Dr. Larsen has supervised numerous PhD students (12 listed) and has been involved in multiple significant research projects. His current projects include 'DEVELOPNOID - Characterizing early brain development in health and disease using brain organoids' funded by Lundbeckfonden (2021-2025), collaborations with pharmaceutical companies including AstraZeneca and Leo Pharma, and international research initiatives. His work has attracted substantial research funding from both public and private sources. Dr. Larsen leads research in Biomedical Mass Spectrometry and Systems Biology, with laboratory facilities equipped for advanced proteomic analysis. His team collaborates extensively with researchers across Denmark and internationally, as evidenced by the global nature of his publications and projects.

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