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Moniek de MaatView profile

Professor

• Biochemistry of Haemostasis
• Thrombosis
• Fibrinogen Variants
• +7 more

Prof. Moniek de Maat is a leading researcher in the Biochemistry of Haemostasis and Thrombosis at the Erasmus University Medical Center (Rotterdam, Netherlands) and a Visiting Professor at the University Hospital of South West Denmark. Her work focuses on fibrinogen variants , fibrin network architecture , and their roles in thrombosis , stroke outcomes , and coagulation disorders . Education: PhD in Biochemistry (1995, Erasmus University), Chemistry (Biochemistry) at Utrecht University (1987-1991). Career: Senior researcher at TNO (1991-1999, 1999-2003), Associate Professor (2003-2018), and Professor (2018-present) at Erasmus MC, Head of Hemostasis Lab (2008-2023). Research Focus: Her work explores how genetic and protein variation in fibrinogen affects clot stability , fibrinolysis , and thrombosis risk . She investigates biomarkers for acute ischemic stroke and NETosis (neutrophil extracellular traps) in cardiovascular and infectious diseases like COVID-19 . Her team studies fibrin network properties under flow and in biofilms , aiming to optimize patient treatment. Publication Trends: Recent articles (2023-2025) highlight her expertise in fibrinogen variants , NETs , and stroke biomarkers , with collaborations in diabetes , COVID-19 coagulopathy , and biofilm-related thrombosis . Key journals include J Thromb Haemost , Acta Biomater , and TH Open . Scientific Awards: Outstanding Investigator Award, International Fibrinogen Research Society (2010) Advising: She mentors PhD students (Aarazo Barakzie, Hande Eyisoylu) and postdocs (Charlene Jacqmarcq), with alumni (Tirsa Koopman). Her lab collaborates with departments in epidemiology , cardiology , pediatric hematology , microbiology , and neurology across institutions like TU Delft and MUMC+ .

Carmen CataláView profile

Assistant Professor

• Plant Biology
• Fruit Development
• Auxin Signaling
• +4 more

Carmen Catalá serves as an Assistant Professor in the Section of Plant Biology within Cornell University's School of Integrative Plant Science. Her laboratory investigates molecular mechanisms governing tomato fruit development, with particular focus on auxin synthesis, translocation, and signaling networks. Based in offices 315/316 at Cornell, she maintains an active research program integrating genetic, genomic, and biochemical approaches to study fruit set and growth processes. Her research centers on elucidating auxin homeostasis during tomato fruit development, examining how spatial and temporal control of auxin levels regulates ovary growth post-fertilization and coordinates cell expansion. Key investigations include transcriptional mapping of PIN and AUX/LAX gene families controlling auxin transport, analysis of IAA biosynthesis pathways, and cell-specific transcriptome profiling using Laser Capture Microdissection. Recent work extends into drought stress adaptation mechanisms and utilization of wild tomato species for genetic diversity studies. Publications reveal consistent focus on auxin-mediated developmental processes, with increasing emphasis on environmental stress responses and genomic approaches. Her work demonstrates strong integration of transcriptomic, proteomic, and physiological methodologies to address fundamental questions in fruit biology. The 2018 Tomato Expression Atlas represents a significant community resource for plant researchers. No scientific awards were explicitly mentioned in the source materials. Her laboratory engages in mentoring through the Boyce Thompson Institute internship program, where students investigate molecular mechanisms underlying fruit set, development, and drought stress responses in tomato systems. The Catalá Lab operates at the intersection of plant physiology, molecular genetics, and genomics, utilizing tomato as a model system to address fundamental questions in fruit development. Research activities include hormone signaling analysis, transcriptome profiling, and investigation of wild tomato species for stress adaptation traits.

Ingrid SpanView profile

Professor

• Bioinorganic Chemistry
• Sustainable Energy Production
• Bioremediation
• +7 more

Ingrid Span is a Professor of Bioinorganic Chemistry at the Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nuremberg (FAU). Her research group investigates the chemistry of biocatalysts, focusing on sustainable energy production, bioremediation, and strategies to combat bacterial/viral infections. The team employs multidisciplinary approaches spanning molecular biology, spectroscopy, and macromolecular crystallography. Research areas include Bioinorganic Chemistry , Sustainable Energy , and Antimicrobial Development . Key methods: Protein Crystallography , Spectroscopy , and Biophysical Analysis . Contact: ingrid.span@fau.de , Room A2.37, Egerlandstr. 1, 91058 Erlangen.

Philipp LangeView profile

Associate Professor

• Precision Oncology
• Proteomics
• Genomics
• +5 more

Dr. Philipp Lange is an Associate Professor at the University of British Columbia (UBC) in the Faculty of Medicine , Department of Pathology & Laboratory Medicine. He serves as a Canada Research Chair in Translational Proteogenomics of Pediatric Malignancies and as an Investigator in the Michael Cuccione Childhood Cancer Research Program at BC Children’s Hospital and BC Cancer Research Institute. His work bridges proteomics, genomics, and bioinformatics to advance pediatric precision oncology . Research Focus : Precision oncology, proteomics, post-translational protein modification, cell signaling in childhood cancers, and targeted therapeutics. Educational Background : PhD in Biochemistry (Free University Berlin), MSc in Molecular Biology, Microbiology, and Computer Sciences (University of Hamburg). Dr. Lange leads the Lange Lab , which develops proteomics platforms for molecular pathology in pediatric cancers. He co-leads Canada’s PROFYLE precision oncology consortium and chairs the Canadian Pediatric Cancer Consortium (ACCESS) Cancer Biology group. His work emphasizes translational research to reduce treatment side effects and improve survival. Scientific Awards CIHR Early Career Investigator in Cancer Award Great Canadian Innovation Award (Canadian Cancer Society) Recent Publications His research spans proteomics methodology (e.g., ASAP/SQuAPP for FFPE tissue analysis, positional proteomics), pediatric cancer proteoforms, and clinical translation of proteogenomics. Key studies include PDX models for therapy selection in progressive malignancies and proteome-wide analysis of drug resistance mechanisms. Graduate Student Supervision Dr. Lange mentors students in the Bioinformatics , Cell and Developmental Biology , and Genome Science and Technology programs at UBC. Lab members include graduate students, postdoctoral fellows, and senior research technicians working on proteomic tools, childhood cancer biology, and drug development.

Kimon LemonidisView profile

Researcher

• Biochemistry
• Molecular Biology
• Structural Biology
• +5 more

Kimon Lemonidis is a Researcher at the University of Glasgow, affiliated with the College of Medical, Veterinary and Life Sciences and the Department of Molecular Biosciences. He is currently based in the Jarrett Building (Lab 260/Office 261) at the Garscube campus. His research spans multiple biochemical and molecular mechanisms, including Structural characterization of ubiquitination events in the Fanconi Anemia DNA repair pathway Mechanistic studies of the Scar/WAVE regulatory complex in actin protrusion and cell migration Protein S-acylation mediated by zDHHC enzymes Antibiotic action of DNA minor groove-binding molecules Genomic instability in differentiated cells The 15 most recent publications reveal a focus on Ubiquitination and deubiquitination in DNA repair (4 articles) S-acylation of signaling proteins (3 articles) Antibiotic modes of action (2 articles) Membrane protein trafficking mechanisms (3 articles) Structural biology of protein complexes (3 articles)

Stacy M. HornerView profile

Associate Professor

• RNA Biology
• Cell Biology
• Antiviral Innate Immunity
• +3 more

Stacy M. Horner is an Associate Professor in the Department of Integrative Immunobiology at Duke University School of Medicine. Her research focuses on the intersection of RNA biology, cell biology, and immunology within the context of Flaviviridae virus infections, including dengue, Zika, and hepatitis C viruses. She holds multiple academic appointments across Duke's Basic Science Departments and is affiliated with the Duke Cancer Institute and Duke Initiative for Science & Society. Her research interests center on understanding how RNA modifications regulate virus-host interactions, particularly through mechanisms involving m6A methylation and UFMylation pathways . Her work explores both viral replication strategies and host antiviral innate immune responses. Recent publications highlight her contributions to mapping post-translational modifications in orthoflaviviruses, with specific focus areas including RNA regulatory controls, mitochondrial antiviral signaling, and interferon response modulation. Her work appears in journals such as J Virol , Nat Biotechnol , and Cell Host Microbe . Horner has secured significant research grants from the National Institute of Allergy and Infectious Diseases and other NIH divisions for projects investigating RNA modifications and intestinal immune regulation.

Lukasz JoachimiakView profile

Professor

• Protein Misfolding
• Neurodegenerative Diseases
• Tau Protein Aggregation
• +7 more

Łukasz Joachimiak, Ph.D. is a faculty researcher at UT Southwestern Medical Center where he leads the Joachimiak Lab within the Center for Alzheimer's and Neurodegenerative Diseases. His work focuses on deciphering the structural and biochemical mechanisms of protein misfolding in neurodegenerative disorders, with particular emphasis on tau protein aggregation in Alzheimer's disease and related tauopathies. Dr. Joachimiak employs innovative hybrid approaches integrating cross-linking mass spectrometry with structural, computational, and biochemical methodologies to uncover fundamental principles of protein conformation and pathological assembly. Dr. Joachimiak's academic background includes: B.S. in Biochemistry from University of Wisconsin-Madison (2000) Ph.D. from University of Washington (2007) under David Baker, developing computational tools for protein-protein interactions Postdoctoral training with Judith Frydman at Stanford University studying eukaryotic chaperonin TRiC/CCT His research program centers on understanding how conformational changes in intrinsically disordered proteins drive pathological aggregation. The lab's landmark discovery of two distinct tau monomer states—an inert form (Mi) and a seed-competent form (Ms)—revolutionized understanding of tau aggregation mechanisms. Current investigations focus on how disease-causing mutations near tau's six-amino acid amyloid motif perturb local structure to promote pathological assembly, and how molecular chaperones like DnaJC7 recognize and regulate these conformational states. The lab employs advanced techniques including XL-MS, NMR, and Rosetta-based computational modeling to characterize protein structural dynamics in neurodegeneration. Analysis of Dr. Joachimiak's publication record reveals consistent contributions to understanding protein misfolding mechanisms, with recent work emphasizing chaperone-substrate interactions, tau conformational states, and structural determinants of amyloid formation. His research bridges fundamental biophysics with translational applications, aiming to develop early detection methods for pathological protein conformations before clinical symptom onset. Dr. Joachimiak mentors a diverse research team comprising postdoctoral researchers (Chad Dashnaw, Klaudia Jaczynska, Ruhar Singh), graduate students (Daniel Kieffer, Simran Rastogi, Paweł Wydorski, Victoria Wiernikouskaja), and research staff (Nabil Morgan). His laboratory operates within UT Southwestern's collaborative research environment dedicated to scientific rigor, creativity, and interdisciplinary approaches to neurodegenerative disease research. The Joachimiak Lab maintains active collaborations across UT Southwestern, particularly with Marc Diamond's group on tau seeding mechanisms and Rui Sousa's laboratory on chaperone biochemistry. Current research directions include developing diagnostic tools targeting conformation-specific tau epitopes, investigating how post-translational modifications regulate aggregation, and exploring therapeutic strategies to stabilize non-pathological protein conformations.

• Glycobiology
• Chemical Biology
• Glycosylation
• +5 more

Jennifer Kohler is an Associate Professor in the Department of Biochemistry at UT Southwestern Medical Center. She leads the Kohler Lab, which focuses on developing chemical biology tools to study glycosylation in biological systems. Her research has significant implications for understanding fundamental biology, cancer metastasis, and infectious diseases. Dr. Kohler completed her undergraduate degree in Chemistry at Bryn Mawr College. She earned her Ph.D. in the Chemistry Department at Yale University, where she studied the kinetics of protein-DNA interactions under Prof. Alanna Schepartz. From 2000-2004, she was an American Cancer Society postdoctoral fellow with Prof. Carolyn Bertozzi at the University of California, Berkeley. Dr. Kohler's research focuses on understanding the roles of glycoconjugates in biological systems. Her lab develops innovative chemical biology methods to address challenges in glycoscience, particularly through the creation of photocrosslinking sugar analogs that can be metabolically incorporated into cellular glycoconjugates. These tools enable the identification of transient glycan-mediated interactions that would otherwise be difficult to capture. Her work spans multiple areas including: Development of photocrosslinking reagents for sialic acid and GlcNAc Investigation of glycan-mediated host-pathogen interactions, particularly with cholera toxin Exploration of O-GlcNAc's role in nuclear transport Creation of methods to discover glycoprotein substrates of sialidases Understanding glycosylation in intestinal epithelial tissue Analysis of Dr. Kohler's recent publications (2021-2024) reveals a consistent focus on glycobiology with particular emphasis on sialic acid and O-GlcNAc modifications. Her work bridges chemical biology and disease mechanisms, with applications in infectious disease (particularly cholera), metabolism, and cancer. She frequently collaborates with other researchers worldwide and shares her innovative photocrosslinking reagents with the scientific community. Dr. Kohler was an American Cancer Society postdoctoral fellow during her time at UC Berkeley. While specific awards aren't detailed in the provided text, her sustained research program and numerous high-impact publications suggest recognition within her field. Dr. Kohler advises graduate students in the Biochemistry and Cell Regulation programs at UT Southwestern. Her research is supported by grants that enable her lab to develop and implement new tools for studying glycosylated molecules, with applications spanning fundamental biology, cancer metastasis, and infectious disease. She has mentored numerous students and postdoctoral fellows who have contributed to her extensive publication record. The Kohler Lab is dedicated to advancing glycoscience through innovative chemical biology approaches. The lab actively develops and shares photocrosslinking sugar analogs that have been adopted by research groups worldwide. Current research focuses on understanding glycosylation in intestinal epithelial tissue and its implications for host-pathogen interactions. The lab maintains strong collaborations with other research groups both within UT Southwestern and internationally.

Christopher ToepferView profile

Associate Professor

• Cardiovascular Science
• Cardiology
• Genetic Disorders
• +3 more

Christopher Toepfer is an Associate Professor of Cardiovascular Science at the University of Oxford , focusing on inherited and acquired heart diseases within the Medical & Health domain. His work bridges molecular mechanisms with therapeutic applications in cardiomyopathies. Research spans hypertrophic cardiomyopathy , sarcomere biology , and genetic disorder therapies Develops hiPSC-based models and automated analysis tools (CalTrack, SarcTrack) Investigates protein dysregulation , metabolic pathways , and CRISPR/Cas9 applications His recent publications highlight advancements in ALPK3 truncation therapies , titin enhancer function , and EGFR-mediated stromal activation in cardiomyopathies. He explores myosin dynamics , calcium signaling , and hypoxia-inducible factor roles using innovative imaging and genetic techniques. Current trends in his work include precision medicine approaches for sarcomere-related diseases, cross-species muscle physiology comparisons, and non-linear optical microscopy applications for cardiovascular diagnostics.

Joshua HameyView profile

Lecturer

• Proteomics
• Protein Post-Translational Modifications
• Mass Spectrometry
• +3 more

Joshua Hamey is a Lecturer at the School of Biotechnology and Biomolecular Sciences, University of New South Wales, affiliated with the research group of Professor Marc Wilkins. His work focuses on protein post-translational modifications, particularly methylation and phosphorylation, using mass spectrometry and yeast/human models. 2021 School of BABS Early Career Researcher Grant 2020 UNSW Science ECAN Seed Grant Research interests include: protein methylation networks, ribosomal modifications, biomolecular condensates, and cross-talk between phosphorylation and methylation in chromatin regulation. Publications span high-impact journals like Cell Reports and Trends in Biochemical Sciences , with methodological advancements in mass spectrometry techniques. Scientific awards highlight recognition as a young investigator in proteomics, including the Australasian Proteomics Society Ken Mitchelhill Award (2021) and multiple travel scholarships. His work bridges fundamental yeast biology with implications for human diseases and epigenetic regulation.

Sean O'DonoghueView profile

Professor

• Bioinformatics
• Structural Biology
• Systems Biology
• +3 more

Sean O'Donoghue is a Conjoint Professor at the School of Biotechnology and Biomolecular Science, University of New South Wales (UNSW). He concurrently serves as a Laboratory Head and Senior Faculty Member at the Garvan Institute of Medical Research and a Visiting Scientist at CSIRO Data61. He holds a B.Sc. (Hons) and Ph.D. in Biophysics from the University of Sydney. His research integrates bioinformatics, structural biology, and data visualization to decode complex biological systems. Key interests include: Development of computational tools for protein structure/function analysis Visual analytics for genomics and multiomics data Mechanisms of viral protein assembly (e.g., SARS-CoV-2) Epigenetic dynamics and cancer transcriptomics Recent publications (2018–2022) demonstrate a strong focus on: Protein annotation frameworks and dark proteome characterization SARS-CoV-2 structural mechanisms Single-cell transcriptomics in breast cancer Innovations in biological data visualization tools He leads the VIZBI initiative (advancing bioinformatics visualization) and VizbiPlus (public science outreach). No awards or student advisories are detailed in the source material.

Jeff JonesView profile

Researcher

• Proteomics
• Mass Spectrometry
• Bioinformatics
• +4 more

Jeff Jones is a Senior Proteomics Bioinformatician at the Roukes Group within the Division of Physics, Mathematics and Astronomy at California Institute of Technology (Pasadena, CA). He holds a Ph.D. in Analytical Chemistry (2005, University of Arkansas) and dual BS degrees in Biochemistry and Microbiology (2001, Cal Poly). Expert in proteomics, mass spectrometry, and data science Developed algorithms for single-cell proteomics and spatial proteomics Created open-source tools: tidyproteomics , msfastar Recipient of patents for tandem identification engines and sample workflow systems Research interests span ultra-sensitive mass spectrometry , machine learning , and infectious disease proteomics . Current projects include NEMS for drug-target interactions , spatial proteomics of tuberculosis , and single-cell proteome analysis . His scientific contributions include: Over 20 years of experience in proteomics and bioinformatics Commercial development of colorectal cancer biomarker tests Collaborations with Prof. Steyn (AHRI)

Jillian SimonView profile

Assistant Professor

• Redox Biology
• Cardiovascular Sciences
• Cardiac Signaling
• +4 more

Jillian Simon, PhD is an Assistant Professor in the Department of Cardiovascular Sciences at the Lewis Katz School of Medicine, Temple University. She leads the Simon Lab, which focuses on understanding integrated signaling dynamics between the heart's redox environment and calcium handling, and how pathogenic changes in these processes drive cell death and cardiac dysfunction. Dr. Simon earned her BS in Exercise and Health Science (with Chemistry minor) from Alma College in 2006, followed by a PhD in Physiology and Biophysics from the University of Illinois at Chicago in 2013. She completed a Postdoctoral Fellowship at the University of Oxford's Division of Cardiovascular Medicine & British Heart Foundation Centre for Research Excellence in 2022. Her research centers around the redox environment of the heart - how it varies with disease, whether these variations protect or injure the myocardium, and to what extent protective mechanisms can be leveraged to design novel therapeutics. The lab utilizes cutting-edge techniques in high-resolution cellular imaging, proteomics, and biochemistry to study redox patho-biology, integrating findings with studies in animal models and human cells/tissue. A major focus is understanding how stress-induced oxidation of PKA (a master kinase in the heart) leads to improved cell adaptation and survival following ischemia, with potential therapeutic applications for ischemic heart disease. Analysis of Dr. Simon's recent publications reveals a strong emphasis on redox signaling in cardiovascular disease, particularly focusing on how oxidation of protein kinases like PKA affects cardiac function during ischemia-reperfusion injury. Her work bridges basic molecular mechanisms with translational applications, with significant contributions to understanding nitroso-redox balance in atrial fibrillation, endothelial function in diabetes, and calcium handling abnormalities in cardiac disease. American Heart Association, Melvin L Marcus Early Career Investigator Award Finalist, 2020 British Cardiovascular Society, Young Publications Dr. Simon actively mentors a diverse research team including an MD/PhD student, undergraduate researchers, and a research scientist. Her lab is recruiting PhD students, MD/PhD students, and postdocs. She is a member of the American Heart Association (Council on Basic Cardiovascular Sciences), International Society of Heart Research, and European Society of Cardiology. Her research is supported by grants from organizations including the American Heart Association and British Heart Foundation. The Simon Lab at Temple University's School of Medicine is dedicated to understanding integrated signaling dynamics between the heart's redox environment and calcium handling. The lab leverages innovations in biosensor development, cellular imaging, proteomics and biochemistry, prioritizing robust and highly reproducible data. They recognize the value of diversity in driving innovation and discovery, striving to foster an inclusive environment for all researchers.

Edwin MooreView profile

Professor

• Cardiac Physiology
• Excitation-Contraction Coupling
• Calcium Signaling
• +3 more

Dr. Edwin Moore is Professor and Head of the Department of Cellular and Physiological Sciences at the University of British Columbia Faculty of Medicine. His research focuses on excitation-contraction coupling mechanisms in cardiac and smooth muscle cells. B.Sc. and M.Sc. in Physiology from the University of Toronto Ph.D. in Pharmacology from the Mayo Clinic Research Interests: Dr. Moore's laboratory investigates the type-2 cardiac ryanodine receptor (RyR2) that regulate cardiac contractile force through calcium release dynamics. His team examines RyR2 position/function in normal and diseased tissue using: Transmission electron microscopy Electron tomography 3D superresolution immunofluorescence Transgenic mouse models Ca 2+ spark/transient analyses Biochemical approaches Scientific Collaborations: The lab collaborates with Dr. Keng Chou (Chemistry Dept.) for dSTORM system development and is part of UBC's Cardiovascular Research Group . Current projects include: Investigating RyR2 variants' pathogenicity using iPSC-derived cardiomyocytes Studying dynamic RyR2 interactions through post-translational modifications Developing novel correlative microscopy techniques Lab Members: The interdisciplinary team includes Dr. Parisa Asghari (Research Associate), Dr. David Scriven (Research Associate), and Saif Dababneh (MD/PhD student).

Chia-wei LinView profile

Researcher

• glycosylation
• mass spectrometry
• glycoproteomics
• +4 more

Chia-wei Lin is a researcher at the Functional Genomics Center Zurich within ETH Zurich , specializing in proteomics. Her work focuses on advancing glycosylation research through mass spectrometry, with expertise in glycoproteomics, structural carbohydrate analysis, and quantitative glycoprotein assessments. Her research involves analyzing intact glycoproteins and characterizing post-translational modifications (PTMs) using techniques like Orbitrap analysis amino acid analysis intact protein analysis .