Mirta Mittelstedt Leal de Sousa serves as a Senior Researcher in the Department of Clinical and Molecular Medicine at the Norwegian University of Science and Technology (NTNU), Faculty of Medicine and Health Sciences. Her laboratory is situated at Laboratoriesenteret, Øya campus in Trondheim, Norway. Her educational background includes a PhD in Molecular Medicine (2012) from NTNU's Department of Cancer Research and Molecular Medicine, an MSc in Molecular Biology (2003) from the University of Brasília, Brazil, and a BSc in Chemistry (2000) from the same institution. She completed extensive postdoctoral training at NTNU (2012-2020) and at Lawrence Berkeley National Laboratory/Joint Bioenergy Institute in California (2012-2013). Dr. Sousa's research spans proteomics, neuroscience, biochemistry, DNA repair mechanisms, and cancer biology. Her work consistently investigates how oxidative DNA damage impacts cellular function, with particular emphasis on base excision repair pathways, epitranscriptomic modifications, and their roles in neurodegenerative disorders, immunodeficiency, and oncogenesis. Recent publications demonstrate her pivot toward pandemic-related research, examining DNA repair activation in severe COVID-19 and epitranscriptomic alterations in critical illness. Analysis of her 15 most recent publications reveals strong thematic continuity in DNA damage response mechanisms while expanding into clinical applications including cancer therapeutics, neurodevelopmental disorders, and diagnostic nanotechnology. Her work frequently employs advanced proteomic and genomic techniques to elucidate molecular pathways in disease contexts. Her scientific contributions include development of NAxtra magnetic nanoparticles for nucleic acid isolation, characterization of OXR1's role in histone methylation, and mechanistic studies of DNA glycosylases in neurological dysfunction and cancer. Collaborative work spans international institutions including University of California, University of Oslo, and University of Brasília. Dr. Sousa maintains active research in multiple high-impact areas including oxidative stress response, epigenetic regulation, and translational applications of DNA repair knowledge. Her laboratory continues to produce significant findings in both fundamental molecular mechanisms and clinically relevant disease processes.
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Orazio SamperiView profile
Researcher
Orazio Samperi is a Researcher at the Centre for Materials Science and Nanotechnology Physics at the University of Oslo. His work bridges experimental and computational approaches in materials science, focusing on semiconductor physics and surface chemistry. Education : PhD (2021-2024), MSc (2019-2021), and BSc (2015-2019) in Materials Science/Nanotechnologies from the University of Catania, Italy. Research Focus : Radiation manipulation of point defects in wide-band gap semiconductors (e.g., silicon carbide), ion implantation, chemical etching, and electrical characterization for power electronics applications. Projects : Involved in the Diamond and Gallium Oxide Interfaces for Power Electronics Devices (DOPED) project, contributing to advancements in semiconductor defect profiling. Expertise : Combines experimental techniques (SIMS, DLTS, AFM) with computational tools to study defect dynamics and process control in semiconductors.