Mohamed AbdelsalamView profile
Researcher
Mohamed Abdelsalam is a researcher in the Department of Medicinal Chemistry at the Institute of Pharmacy, Faculty of Natural Sciences I - Biosciences, Martin Luther University Halle-Wittenberg. He is actively involved in designing novel chemical probes and PROTACs targeting HDACs and FLT3-ITD in leukemia. His research focuses on medicinal chemistry , epigenetic drug discovery , and targeted cancer therapy . He specializes in the design and synthesis of selective HDAC inhibitors, prodrugs, and protein degraders with applications in acute myeloid leukemia and pancreatic cancer. His work integrates synthetic chemistry, biological evaluation, and computational modeling. The recent publications highlight a consistent trend in developing class I HDAC-selective inhibitors , particularly pyrazine-anilinobenzamide derivatives, with strong emphasis on structure-activity relationships and biological testing in cancer models. Additional work explores therapeutic repurposing of HDAC inhibitors for parasitic diseases like schistosomiasis. He collaborates with Prof. Dr. Oliver Krämer from the Institute of Toxicology at the University of Mainz. Contact: Email: mohamed.abdelsalam@pharmazie.uni-halle.de Phone: ++49 345 55 25188 Scientific Contributions: Design and synthesis of bioreductive prodrugs for targeted leukemia therapy Development of HDAC1-3 selective inhibitors Computational and in vitro validation of novel HDAC inhibitors Exploration of HDAC inhibitors for schistosomiasis treatment Synthesis of terephthalamide-based molecular hybrids He has no listed scientific awards or students at this time. His ORCID identifier is 0000-0001-6559-2527 .
