Find Academic Supervisors

• Developmental Biology
• Genetics
• Molecular Biology
• +4 more

Sanna Maria Vuoristo is an Academy Research Fellow at the University of Helsinki, affiliated with the STEMM - Stem Cells and Metabolism Research Program. She serves as a supervisor for the Doctoral Programme in Biomedicine and collaborates with institutions including Karolinska Institutet and University of Cambridge. Education: Kantasolu- ja kehitysbiologia, Dosentti (University of Helsinki) Her research focuses on developmental biology, genetics, and molecular mechanisms in human embryogenesis. Key areas include non-coding genomic elements, transcription factors like DUX4, and hormone signaling in reproductive and metabolic systems. Recent publications highlight her work on: Transcriptional priming during embryonic genome activation Role of DUX4 in developmental processes Modeling hormone receptor mutations using stem cells Transcriptional changes induced by NR5A1 during gonadal differentiation Scientific recognition includes: People's Choice for Breakthrough of the Year 2016 (Science magazine) Active in academic leadership, she: Serves on the board of the Finnish Society for Developmental Biology Presents at international conferences like Signaling through Chromatin Secures funding from the Academy of Finland and Sigrid Jusélius Foundation

Hani GoodarziView profile

Associate Professor

• Computational Biology
• RNA Biology
• Cancer Genomics
• +3 more

Hani Goodarzi, PhD , is an Associate Professor in the Department of Biochemistry and Biophysics at the University of California, San Francisco (UCSF), with dual affiliation to the Arc Institute and Helen Diller Cancer Center. His laboratory employs a systems biological framework integrating computational and experimental approaches to investigate metastatic progression in cancer and neurodegenerative diseases. Princeton University PhD in Quantitative & Computational Biology Postdoctoral Fellow, Rockefeller University (Cancer Systems Biology) NIH R01 Grants (2016–2026) Research Themes : Machine learning for in silico functional genomics Evolutionary dynamics of oncRNA regulatory modules in cancer Post-transcriptional control via tiRNA fragments and RNA methylation RNA structural element discovery using pyPAGE algorithms Scientific Recognition : Vilcek Prize for Creative Promise (2022) NIH K99/R00 Award (2015) Tri-Institutional Breakout Prize (2014) Blavatnik Regional Award (2015) Laboratory Impact : Developed Deep Generative AI for early-stage lung cancer detection Identified ENPP1 as innate immune checkpoint in breast cancer Created pyPAGE framework for gene-set enrichment analysis

• Genomics
• Non-coding RNA research
• Phenotype-genotype relationships
• +7 more

Professor Marcel Dinger is a prominent academic and researcher currently serving as Professor and Head of School for Biotechnology and Biomolecular Sciences at UNSW Sydney. With over 20 years of experience in genomics, he has established himself as a leading figure in both academic and entrepreneurial spheres within the field. He has published 153 papers with over 24,000 citations and maintains an h-index of 61 on Google Scholar. His leadership extends beyond academia as he serves as President of the Australasian Genomics Technologies Association (AGTA) and holds director positions at Pryzm Health and the National Centre for Indigenous Genomics (NCIG). Professor Dinger's research laboratory focuses on establishing new links between phenotype and genotype, particularly examining rare and complex diseases in relation to underexplored regions of the genome including pseudogenes, repetitive elements, non-canonical DNA structures, and noncoding RNAs. His work harnesses population-scale genomic datasets and sophisticated data science methods to bring an objective perspective to understanding how the genome stores information and how it is transacted in biology. His research interests span genomics, non-coding RNA biology, clinical applications of genomic medicine, and the development of computational approaches for analyzing complex genomic data. Analysis of Professor Dinger's recent publications reveals a strong emphasis on non-coding RNA research, particularly long noncoding RNAs and their roles in disease mechanisms. His work spans cancer genomics, neurological disorders, and fundamental genomic mechanisms including DNA secondary structures like i-motifs and G-quadruplexes. His research combines experimental approaches with advanced bioinformatics to address fundamental questions in genomic medicine and has significant translational implications for disease diagnosis and treatment. Highly Cited Researcher in Cross-Field category (2019, 2020, 2021) Fellow of the Faculty of Science (Research), Royal Society of Pathologists of Australasia (2016) NHMRC Career Development Award (2010) Queensland Government Smart Futures Fellowship (2009) Foundation of Research, Science and Technology New Zealand Postdoctoral Fellowship (2005) Professor Dinger has been instrumental in establishing and leading several significant research initiatives including Genome.One, one of the first companies globally to provide clinical whole genome sequencing services, and the Kinghorn Centre for Clinical Genomics at the Garvan Institute of Medical Research. His entrepreneurial experience includes founding four biotechnology and IT startups. He serves on multiple governance boards including the National Centre for Indigenous Genomics, focusing on using genomics to improve health outcomes for Australia's First Peoples. His laboratory at UNSW continues to advance our understanding of genomic regulation and its implications for human health and disease.

• Signal Regulated Transcription
• Chromatin and Gene Regulation
• Nuclear Receptors
• +7 more

W. Lee Kraus is a Professor and Director at the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center, where he also holds leadership roles including Vice Chair for Basic Sciences in the Department of Obstetrics and Gynecology, Assistant Director for Basic Research at the Simmons Comprehensive Cancer Center, and Assistant Dean for Research Development. He is also a member of the Board of Directors of the Endocrine Society (2023–2026). Ph.D., University of Illinois at Urbana-Champaign (1994) Postdoctoral Research, University of California, San Diego B.S., Cornell University (1989) Dr. Kraus's research centers on signal-regulated transcription, chromatin and gene regulation, nuclear receptors, PARPs, and NAD+ metabolism and signaling. His work has elucidated the roles of ADP-ribosylation in transcriptional control, enhancer function, and cancer biology. He has published over 150 peer-reviewed articles in top journals such as Science , Cell , and Molecular Cell . His recent publications reveal a strong focus on PARP enzymes, enhancer RNAs, NAD+ compartmentalization, and the interplay between metabolism and gene regulation. Themes across his work include the functional roles of ADP-ribosylation in transcription, splicing, translation, and cancer, with implications for therapeutic development. Scientific honors include: Endocrine Society’s Richard E. Weitzman Memorial Award (2007) Endocrine Society’s Ernst Oppenheimer Award (2014) Cornell University Teaching Excellence Award (2004) Cornell University Mentoring Excellence Award (2008) Dr. Kraus has been a successful mentor, training 22 doctoral students, 26 postdocs, and 16 clinical fellows, most of whom have secured faculty or research positions in academia or industry. His research has been supported by grants from the NIH, American Cancer Society, Burroughs Wellcome Fund, CPRIT, and NSF. He is also active in biotech, having co-founded Ribon Therapeutics and ARase Therapeutics, and serves on scientific advisory boards for startup companies. He leads the Kraus Lab at UT Southwestern, which continues to pioneer research in transcriptional regulation and metabolic signaling.

Jean (Jiayu) WenView profile

Associate Professor

• RNA Biology
• Computational Biology
• MicroRNA Regulation
• +5 more

Associate Professor Jean (Jiayu) Wen holds positions at The Australian National University (ANU), including Group Leader of The Wen Group, ARC Future Fellow, and Deputy Director of The Shine-Dalgarno Centre for RNA Innovation. She specializes in computational and molecular biology, focusing on RNA regulation, gene expression, and cancer genomics. Her affiliations include ANU’s Division of Genome Sciences and Cancer, and the Centre for Computational Biomedical Sciences. Education: BEng in Electronic Engineering (Beijing), MSc in Computer Science (Lakehead University), PhD in Computational Biology (ANU). Postdoctoral training at Copenhagen University and Memorial Sloan-Kettering Cancer Center. Research interests span RNA structures, microRNA biogenesis, transcriptome dynamics, and epigenetic regulation. Her work addresses intragenomic conflicts, cancer mechanisms, and neural development. Notable projects include RNA-based machine learning models for RNA-RNA interactions and immune cell differentiation studies. Publications highlight contributions to RNA interference pathways, tumor development, and Drosophila genetics. Awards include the ARC Future Fellowship. She leads interdisciplinary teams advancing computational and experimental approaches in genomics and systems biology.

• Genomics
• Epigenetics
• Bioinformatics
• +3 more

Dr. Gary Hon is an Assistant Professor at UT Southwestern Medical Center affiliated with the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Lyda Hill Department of Bioinformatics. He leads a research program focused on decoding the complexity of the human genome through two primary directions: understanding the molecular basis of cell state for regenerative medicine applications, and elucidating how non-coding variants contribute to development and disease. His lab employs integrative techniques at the interface of gene regulation, epigenetics, genome engineering, single-cell genomics, and bioinformatics. His research interests span genomics, epigenetics, bioinformatics, gene regulation, stem cell biology, and disease mechanisms. Dr. Hon earned his graduate degree from UC San Diego's Bioinformatics and Systems Biology Program and completed post-doctoral training in Dr. Bing Ren's lab before joining UT Southwestern in 2015. Dr. Hon has received significant recognition including the CPRIT Scholar award and NIH Director’s New Innovator Award. His recent publications demonstrate a focus on advanced genomic techniques including Perturb-Seq optimization, single-cell transcriptomics in cancer and reproductive biology, enhancer network mapping, and stem cell modeling of human development.

John A. PulikkanView profile

Assistant Professor

• Chromatin Dynamics
• Hematopoiesis
• Leukemia Biology
• +3 more

John A. Pulikkan, PhD, is an Assistant Professor in the Department of Cell Biology, Neurobiology and Anatomy at the Medical College of Wisconsin. His research focuses on deciphering the interplay between transcription factors and chromatin dynamics in normal and malignant hematopoietic stem cells, with a particular emphasis on acute myeloid leukemia (AML). He leads the Pulikkan Lab, dedicated to identifying novel therapeutic targets for leukemia treatment through genetic, epigenetic, and biochemical approaches in mouse models and human primary leukemic cells. Dr. Pulikkan earned his PhD from Ludwig Maximilian University of Munich, Germany, where his work elucidated mechanisms of C/EBPα in hematopoiesis. His postdoctoral research at the University of Massachusetts Medical School led to the discovery of AI-10-49, a small molecule inhibitor targeting CBFβ-SMMHC in leukemia. This work demonstrated the feasibility of targeting 'undruggable' oncogenic transcription factors, with AI-10-49 now advancing toward clinical development. His research interests span three key areas: (1) transcription factor-chromatin dynamics in hematopoiesis, (2) transcriptional deregulation in AML, and (3) functional roles of non-coding RNAs in leukemia. Notable contributions include insights into MYC chromatin dynamics inhibition and SWI/SNF/PRC axis disruption in cancer. Awards: ASH Scholar Award, Alex's Lemonade Stand Foundation Young Investigator Award, Lauri Strauss Leukemia Foundation Discovery Grant Lab Focus: Translational research bridging basic science and clinical leukemia therapy Key Findings: Role of ADAR2 RNA editing in AML, hijacking of PU.1 antisense promoters by CBF fusions, and N-MYC survival pathways in inv(16) AML

Jinchuan XingView profile

Professor

• Mobile Elements
• Human Genomic Variation
• Evolutionary Genetics
• +14 more

Jinchuan Xing is a Professor at Rutgers, The State University of New Jersey, where he leads the Xing Lab of Genomics. His research focuses on human genomic variation, mobile DNA elements, evolutionary and population genetics, and their implications for human disease. He integrates computational and experimental methods to study genome-wide variation, with applications in disease gene identification and genomic technology development. His research interests include: Mobile DNA element biology Human demographic history and population diversity Disease gene identification using whole-exome and whole-genome sequencing High-altitude adaptation genetics Transposable element regulation and expression piRNA and small RNA pathways His recent publications highlight a strong trend in reproductive genomics, particularly in identifying genetic risk factors for embryo aneuploidy in IVF patients, using advanced sequencing technologies. Other work spans evolutionary genomics in diverse species (bats, moths, Drosophila), structural variation in neurodevelopmental disorders, and proteogenomic discovery. His lab actively develops and applies bioinformatic tools for variant analysis and gene prioritization. Scientific awards and honors are not explicitly mentioned in the provided text. Jinchuan Xing advises several graduate students, including Nan Wang, Siqi, Ellie Lu, and Tongji Xing. His lab has received significant funding, including an R01 grant from NICHD on aneuploidy risk, a grant from the Center for Human Evolutionary Studies, and a Life Sciences Alliance Pilot Seed Funding grant in collaboration with the Department of Statistics. These grants support research in fertility genomics, disease gene discovery, and genomic tool development. The Xing Lab of Genomics is an active research group conducting interdisciplinary studies combining genomics, bioinformatics, and molecular biology. The lab welcomes new members regularly, including master’s and PhD students, and collaborates across departments. Current projects include understanding the genetic basis of meiosis, fertility, and high-altitude adaptation, as well as developing Markovian gene networks for disease gene discovery.

• Genomics
• Transcriptomics
• Network Biology
• +7 more

Pasquale Luca Curci is a Researcher at the Institute of Biosciences and BioResources (IBBR), part of the National Research Council of Italy (CNR) in Bari. His work focuses on integrating large-scale genomic and transcriptomic datasets to uncover biological mechanisms in plants, particularly in crops like durum wheat and artichoke. His research interests span genomics, transcriptomics, and network biology, with a strong emphasis on nitrogen use efficiency, gene regulatory networks, and plant stress responses. He employs systems biology approaches to identify key genes and regulatory elements involved in plant development and adaptation. The analysis of his recent publications reveals a consistent focus on plant genomics, particularly in durum wheat and Cynara species. His work integrates omics data to understand gene function, stress responses, and evolutionary relationships. Key themes include nitrogen metabolism, microRNA regulation, chloroplast genomics, and cross-species network analysis. He has led and coordinated multiple national and international research collaborations with institutions in Belgium, Sweden, Spain, France, and Italy, focusing on gene function discovery, nitrogen efficiency, and germplasm characterization. Integrative network analysis for gene function discovery in wheat (with BASF Agricultural Solutions, Belgium) Cross-species network biology in plants (with SweTree Technologies, Sweden) Transcriptomics and regulatory networks in durum wheat (with Sequentia Biotech SL, Spain) Phenotypization and genomic analysis of durum wheat (with Alma Mater Studiorum, Bologna) Asparagine synthetase genes in durum wheat (with INRA-CNRGV, France) He has contributed to the development of genomic resources for Cynara and has published extensively on chloroplast genomics, transcriptomics under nitrogen stress, and genetic diversity in vegetable crops. His work supports crop improvement and sustainable agriculture through advanced molecular tools.

• Microbial Genetics
• Genomics
• Bioinformatics
• +4 more

Dr. Madhusudan Choudhary is a Professor in the Department of Biological Sciences at Sam Houston State University. He holds a Ph.D. from McMaster University and completed post-doctoral training at Duke University. His research laboratory focuses on microbial genetics, genomics, and bioinformatics using Rhodobacter sphaeroides as a model organism to study bacterial cell-cycle regulation, metabolic innovations through gene duplication, and the evolution of genomic complexity in prokaryotes. Key investigations include chromosome replication origins, duplicate gene expression patterns, and the functional specialization of multipartite genomes. Dr. Choudhary's research spans diverse areas including bacterial responses to microgravity, CRISPR-Cas systems, heavy metal resistance mechanisms, and nanoparticle interactions. He directs studies on transcriptomics under stress conditions and develops computational methods for genome analysis. His work has significant implications for understanding microbial evolution and environmental adaptation.

Kajsa PaulssonView profile

Professor

• Cancer Genomics
• Leukemia Research
• Genetics
• +3 more

Kajsa Paulsson is a Professor of Medical Genetics at Lund University, where she runs the Aneuploidy in Cancer research group at the Division of Clinical Genetics. She serves as a Principal Investigator at the Lund University Cancer Centre (LUCC) and manages the research team focused on aneuploidy in cancer. Dr. Paulsson is an expert in cancer genomics with extensive experience in classic genetic techniques including chromosome analysis and fluorescence in situ hybridization, as well as state-of-the-art methodologies such as SNP array analysis and next generation sequencing (NGS). Her research primarily focuses on understanding how aneuploidy (aberrant chromosome numbers) arises in somatic cells, how it affects tumorigenesis, and its correlation with prognosis and treatment response in cancer. Her specialized studies concentrate on high hyperdiploid and hypodiploid childhood acute lymphoblastic leukemia, with the ultimate goal of improving cancer patient survival through insights into tumorigenesis mechanisms. Analysis of Dr. Paulsson's publication record reveals a strong focus on the genomic architecture of pediatric acute lymphoblastic leukemia, with particular attention to chromosomal abnormalities, mutational signatures, and regulatory mechanisms. Her work spans from fundamental research on aneuploidy development to clinical applications examining treatment outcomes in specific leukemia subtypes. The research demonstrates increasing methodological sophistication with integration of multi-omics approaches including proteogenomics, Hi-C chromatin conformation analysis, and single-cell genomics, reflecting the evolving landscape of cancer genomics research. Dr. Paulsson has received significant recognition for her work, including the prestigious Samfundet Folkhälsan Albert de la Chapelle Prize in Medical Genetics in 2022 and the Senior Investigator Award from Cancerfonden in 2015. Her publications have been widely disseminated, with multiple papers highlighted by news outlets, referenced in clinical guidelines, and extensively read on academic platforms, demonstrating the translational impact of her research. As a supervisor and mentor, Dr. Paulsson leads active research projects including 'Non-coding mutations in pediatric acute lymphoblastic leukemia' (2021-2025), where she serves as the primary supervisor. She has been involved in the Epigenetics Theme at Pufendorf IAS, demonstrating her commitment to collaborative, interdisciplinary research that spans basic science and clinical applications. Her work contributes to UN Sustainable Development Goals related to health and well-being. Dr. Paulsson actively participates in the Lund University Cancer Centre (LUCC) ecosystem, regularly organizing and speaking at seminars and conferences including the LUCC Blood, Lymphoma & Myeloma series and the Swedish Cancer Research Meeting. Her laboratory focuses on the molecular mechanisms of aneuploidy in leukemia, particularly investigating how chromosomal abnormalities develop and impact treatment outcomes in childhood cancers, with direct implications for risk stratification and therapeutic decision-making in pediatric oncology.

• Genetics and Genomics
• Physics
• Natural Resource Management
• +7 more

Rune Andreassen is a Professor at the Faculty of Health Sciences , Department of Life Sciences and Health at OsloMet - Storbyuniversitetet. His research spans interdisciplinary domains including Genetics and Genomics, Forensic Genetics, miRNA regulation, and environmental stress responses in aquatic species like Atlantic salmon ( Salmo salar ). Specializes in method development for deep sequencing and characterization of genes. Active in studying epigenetic regulation by miRNAs in Atlantic salmon, particularly in disease response and osmotic stress adaptation. Collaborates on databases such as MicroSalmon , integrating miRNA target transcripts and cis-regulatory elements. Research Trends: Recent publications focus on miRNAome analysis, transcriptome profiling, and splice variants in salmonids. His work bridges molecular biology and aquaculture, with applications in fish health and conservation genetics. Education and Affiliations: Affiliated with OsloMet since at least 2002, Rune has contributed to projects involving CRISPR methodology, wildlife DNA sampling, and salmonid genomics.

Đorđević MarkoView profile

Associate Professor

• Computational Biology
• Systems Biology
• Infectious Diseases
• +7 more

Marko Djordjevic is an Associate Professor at the Faculty of Biology, University of Belgrade. His research spans computational biology of infectious diseases, bacterial immune systems (CRISPR/Cas and restriction-modification systems), and quantitative understanding of infection progression with applications to SARS-CoV-2 and computational physics of quark-gluon plasma. Diploma in Physics, Faculty of Physics, University of Belgrade, Serbia. PhD in Biophysics and Bioinformatics, Department of Physics, Columbia University, USA. Postdoctoral training at the Mathematical Biosciences Institute, Ohio State University, USA. Djordjevic's research focuses on nonlinear regulatory dynamics of bacterial immune systems, their role in horizontal gene transfer, and modeling infection progression under social mitigation measures. His secondary interest in computational physics examines quark-gluon plasma dynamics via high-p⊥ observables and tomography. His recent publications address CRISPR/Cas regulation, restriction-modification systems, and SARS-CoV-2 transmissibility drivers. Grants from the Serbian Ministry of Science, Science Fund of Serbia, EU Marie Curie IRG, and Swiss National Science Foundation support his work.

Caroline Schild-PoulterView profile

Professor

• Molecular Biology
• Genetics
• DNA Repair
• +3 more

Caroline Schild-Poulter is a Professor and Scientist at the Robarts Research Institute, affiliated with the Schulich School of Medicine & Dentistry at Western University in London, Ontario, Canada. She leads research in the Molecular Medicine department, specifically within the Vascular and Brain Health Group, focusing on DNA damage response mechanisms and their implications in cancer development. Education: Undergraduate in Biology at the University of Lausanne, Switzerland (Major in Molecular Biology) Master's and PhD at the University of Lausanne (Topic: Mechanisms regulating gene expression) PhD training included a 2-year stage at the National Institutes of Health, Bethesda, USA Dr. Schild-Poulter's research program centers on DNA repair/signaling pathways activated by double-stranded DNA breaks, one of the most dangerous forms of DNA damage. Her work specifically investigates how DNA gets repaired and how apoptosis is activated when repair is not completed. Her research has significant implications for understanding cancer development, stroke, and aging processes. She has made notable contributions to understanding the roles of RanBPM in controlling apoptosis in response to DNA damage and how the DNA repair factor Ku functions to repair and signal from double-stranded DNA breaks. Analysis of her publication record shows consistent focus on DNA repair mechanisms, with recent work expanding into RNA-mediated immunity and protein degradation pathways. Scientific Awards: Natural Sciences and Engineering Research Council Canada (NSERC) Discovery Accelerator Award (DAS) Post-doctoral Fellowship, Medical Research Council of Canada and the Arthritis Society Post-doctoral Fellowship, Association pour la Recherche sur le Cancer (France) Fellowship, Centre National de la Recherche Scientifique (France) Post-doctoral Fellowship, Swiss National Science Foundation (Switzerland) Dr. Schild-Poulter has received significant research funding through competitive grants, including the prestigious NSERC Discovery Accelerator Award which supports her innovative work in DNA repair mechanisms. Her research program has led to numerous publications in high-impact journals and has contributed significantly to our understanding of genomic instability and cancer development. While specific students aren't listed in the available information, her position as a Professor suggests she mentors graduate students and postdoctoral fellows in her laboratory, contributing to the next generation of molecular biologists and cancer researchers. Dr. Schild-Poulter is a key member of the Molecular Medicine research group at Robarts Research Institute, where she maintains an active laboratory investigating DNA damage response pathways. Her work bridges basic molecular mechanisms with potential clinical applications in cancer treatment and prevention, particularly focusing on the critical balance between DNA repair and programmed cell death that prevents malignant transformation.

James SchnableView profile

Professor

• Plant Genomics
• Crop Phenomics
• Quantitative Genetics
• +3 more

James Schnable serves as the Charles O. Gardner Professor of Agronomy in the Department of Agronomy and Horticulture at the University of Nebraska-Lincoln. His research integrates genomic, phenomic, and environmental data to advance crop breeding methodologies for maize and sorghum, with particular emphasis on climate-resilient varieties. Dr. Schnable's research program spans plant genomics , high-throughput phenomics , and quantitative genetics , focusing on genetic dissection of nitrogen use efficiency, photosynthetic traits, and stress tolerance mechanisms. His laboratory pioneers UAV- and satellite-based phenotyping systems, machine learning applications for image analysis, and genomic prediction models that bridge genotype-phenotype gaps under variable environmental conditions. Key innovations include nighttime fluorescence phenotyping to reduce environmental noise and spectral feature extraction for accelerated trait assessment. Analysis of his 2021-2025 publications reveals consistent leadership in genotype-environment interaction studies and computational phenotyping , with dominant themes including transcription factor binding site variation explaining heritability, nonphotochemical quenching kinetics in stress responses, and scalable satellite-based yield prediction methods. His work frequently employs the Genomes to Fields Initiative infrastructure for multi-state field validation. Charles O. Gardner Professorship Dr. Schnable directs an active research program involving advanced sensor networks, genomic selection pipelines, and multi-institutional field trials. His team develops computational frameworks like PlantSegNet for 3D plant reconstruction and SPARC-LoRa for agricultural IoT applications. While specific grant details aren't provided in source materials, his extensive publication record in high-impact journals indicates sustained funding from major agricultural research programs. The laboratory maintains cutting-edge phenotyping infrastructure including UAV fleets, hyperspectral imaging systems, and gas sensor networks for early stress detection. Current projects focus on nitrogen-responsive growth trajectories, chilling tolerance mechanisms in panicoid grasses, and gut microbiome interactions with grain composition, reflecting an integrative approach from molecular mechanisms to field performance.