Gavan McNallyView profile
Professor
Professor Gavan McNally is a distinguished behavioral neuroscientist at the University of New South Wales, where he serves as a Professor in the School of Psychology. He is actively engaged in research on the fundamental behavioral and brain mechanisms for learning and motivation, with applications to clinical conditions such as addictions, anxiety disorders, and mood disorders. McNally holds several prestigious editorial positions, including Editor-in-Chief of Neurobiology of Learning & Memory and Senior Editor of The Journal of Neuroscience. He also serves as President-Elect of the European Behavioral Pharmacology Society and is a Member of the Australian Research Council College of Experts. McNally's research interests span behavioral neuroscience, focusing on how fundamental brain mechanisms apply to clinical conditions. He employs a systems neuroscience approach, combining well-controlled behavioral approaches with optogenetics, chemogenetics, in vivo calcium imaging, and whole brain circuit mapping in both normal and transgenic animals. His work bridges basic science with clinical applications through collaborations with colleagues at University of Sydney, Sydney Local Health District, Monash University, and Turning Point. McNally's research particularly examines the cellular, circuit, and systems level mechanisms underlying learning, motivation, and their dysregulation in disorders like addiction. His laboratory investigates how these mechanisms translate to human conditions, with a strong emphasis on developing new treatments for psychological disorders. His extensive publication record demonstrates a clear trajectory in understanding punishment learning, addiction mechanisms, and the neural circuits underlying motivated behavior. Recent work has increasingly focused on the cognitive pathways to punishment insensitivity, the role of specific neural circuits in addiction, and translational approaches to understanding maladaptive behaviors. McNally's research bridges animal models with human studies, creating a comprehensive understanding of the neural mechanisms that govern learning and motivation, with particular attention to how these processes go awry in addiction and other psychological disorders. 2008 QEII Fellow, Australian Research Council 2009 Association for Psychological Science, International Rising Star 2010 Fellow, Association for Psychological Science 2010 UNSW Faculty of Science Staff Excellence Award for Research and Training 2011 Pavlovian Research Award, The Pavlovian Society 2012 Future Fellow (Level 3), Australian Research Council 2016 D.G. Marquis Behavioral Neuroscience Award, American Psychological Association 2017 Fellow, American Psychological Association 2019 Fellow of the Academy of Social Sciences in Australia 2021 D.G. Marquis Behavioral Neuroscience Award, American Psychological Association 2022 Ross Day Plenary Lecturer, Australasian Brain and Psychological Sciences 2023 European Behavioural Pharmacology Society Plenary Lecturer 2024 Elspeth McLachlan Plenary Lecturer, Australasian Neuroscience Society 2024 D.G. Marquis Behavioral Neuroscience Award, American Psychological Association Professor McNally actively supervises several students including Bixuan Lin, Si Yin Lui, Hannah Machet, Bart Cooley, Kelly Zhuang, and Alexandra Gregory. His current research is supported by significant funding including an Australian Research Council Discovery Project (2024-2026) on "Risky choices: From cells and circuits to computations and behaviour," another Discovery Project (2025-2028) on "Multimodal mapping of punishment learning," and NHMRC grants including a Synergy Grant on "Linking clinical and basic science discovery to find new treatments for alcohol-use disorder" and an Ideas Grant on "Novel pathways to abstinence from alcohol seeking." These projects reflect his commitment to both fundamental neuroscience and translational applications for treating psychological conditions. His teaching responsibilities include PSYC2081 Learning & Physiological Psychology and PSYC3051 Physiological Psychology. McNally's laboratory employs advanced techniques including optogenetics, chemogenetics, in vivo calcium imaging, and whole brain circuit mapping to investigate the neural mechanisms underlying learning, motivation, and their dysregulation in disorders. His team works at the intersection of basic neuroscience and clinical applications, with strong collaborations across multiple institutions to translate fundamental findings into potential treatments for addiction and other psychological disorders. The lab has made significant contributions to understanding the role of brain regions like the ventral pallidum, paraventricular thalamus, and nucleus accumbens in addiction, fear learning, and punishment sensitivity.
