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Brenda OgleView profile

Professor

• Cardiac Tissue Engineering
• 3D Bioprinting
• Stem Cell Differentiation
• +6 more

Brenda Ogle is a Professor in the Department of Biomedical Engineering at the University of Minnesota's College of Science and Engineering. She leads the System Regeneration Lab, where her research focuses on cardiac tissue engineering, stem cell differentiation, and advanced 3D bioprinting technologies. Her work bridges multiple disciplines including stem cell biology, extracellular matrix science, and engineering principles to develop novel approaches for cardiovascular regeneration. Dr. Ogle's research interests primarily center on understanding the mechanisms that govern stem cell fate, particularly in the context of the cardiovascular system. Her lab is pioneering 3D bioprinting for cardiac tissue engineering, creating complex model systems that go beyond simple geometric shapes. Key areas of investigation include the role of extracellular matrix proteins in guiding stem cell differentiation, the development of novel tools for analyzing stem cell behavior, and the delivery of stem cells or associated progeny to the body. Her work has led to breakthroughs in creating patch-like structures with micron-scale features that support cardiac cell organization and can be adhered to failing hearts. Dr. Ogle's research has resulted in significant scientific contributions, including the development of unique bioink formulations coupled with multiphoton-based 3D printing to create chambered heart structures based on digital templates. These engineered tissues can sustain flow profiles and exhibit pressure-volume dynamics characteristic of the native heart, making them valuable for studying cardiac disease progression and testing drug efficacy. Her work has received recognition including an NIH R01 award for Epicardial Regulation of Myocardial Function and being named a BMES Fellow. NIH R01 Awarded, Epicardial Regulation of Myocardial Function BMES Fellow (2021) Dr. Ogle mentors a diverse team of researchers including postdoctoral associates, graduate students, and undergraduate researchers. Her lab has produced numerous PhD graduates who have gone on to successful careers in academia and industry. Current research projects in her lab include heart organoid formation using hiPSC-derived cardiomyocytes, investigation of hypertrophic cardiomyopathy mechanisms, cardiomyocyte maturation studies, and development of ECM-based bioinks for cardiac constructs. The lab is also working on creating integrated platforms for high-throughput cardiac organoid production and developing models to study the impact of radiation exposure on cardiac function.

• Photonics
• Biophotonics
• Optical Microscopy
• +3 more

Dr. Wolfgang Hübner is a Researcher at the Faculty of Physics at University of Bielefeld, Germany, affiliated with the Biomolecular Photonics Group. His work focuses on advanced optical imaging techniques applied to cellular and molecular structures. He maintains an active research program as evidenced by numerous publications from 2023-2025. His research interests center on photonics, biophotonics, optical microscopy, super-resolution imaging techniques, cellular biophysics, and molecular imaging. Dr. Hübner's work bridges physics and biology, developing and applying cutting-edge microscopy methods to address biological questions at the nanoscale level. His recent publications demonstrate a strong focus on super-resolution microscopy techniques, particularly structured illumination microscopy, fluorescence lifetime imaging, and correlative imaging approaches. His research investigates cellular structures like liver sinusoidal endothelial cells, dystroglycan mutants, and mitochondrial dynamics, revealing how advanced optical methods can visualize biological processes at unprecedented resolution. Dr. Hübner's research shows consistent development in both methodological advances in optical imaging and biological applications. His work spans from fundamental optical engineering to biomedical applications, demonstrating interdisciplinary expertise across physics, engineering, and cell biology.

• Mitochondrial Disease
• Genetics
• Genomics
• +5 more

Professor Robert Taylor is a leading academic in mitochondrial disease research at Newcastle University. His work focuses on genetic and molecular mechanisms underlying mitochondrial disorders, with contributions to understanding complex I and IV deficiencies, neurodevelopmental syndromes, and clinical-genetic correlations. He collaborates widely, publishing on topics like proteomics-based diagnostics, cerebellar degeneration mechanisms, and novel genetic variants. His research integrates clinical, biochemical, and genomic data to advance diagnostic guidelines and treatment strategies. Education/Training: Not explicitly stated in provided text. Affiliations: Newcastle University, multiple international collaborations. Research Interests: Professor Taylor’s work spans mitochondrial genetics, metabolic disorders, and translational research. Key areas include mitochondrial tRNA mutations, complex assembly defects, and applications of proteomics in variant prioritization. He investigates clinical manifestations of genetic variants, such as in RYR1, PTPMT1, and NDUFA13, and their impacts on neurological and metabolic systems. Articles Trends: Recent work emphasizes proteomic approaches for rapid variant identification, cerebellar degeneration mechanisms, and multi-omics analysis of mitochondrial dysfunction. Studies highlight clinical heterogeneity in cohorts like pediatric Egyptian patients and African populations with King-Denborough syndrome. Advising/Grants: Leads multidisciplinary teams and participates in large-scale studies like the UK National Registry of Rare Kidney Diseases. Co-authors include prominent researchers in mitochondrial medicine, indicating collaborative grant activities. Labs/Teams: Likely part of Newcastle’s Mitochondrial Research Group, contributing to diagnostic guideline development (e.g., UK Best Practice Guidelines).

• Human Genetics
• Health Sciences
• Genomics
• +5 more

Mads Kaern is an Associate Professor in the Department of Cellular and Molecular Medicine, specializing in synthetic biology, gene regulation, and systems biology. His research integrates computational modeling with experimental approaches to understand cellular processes and design genetic circuits for biomedical applications. Key areas of focus include epistasis analysis, gene expression variability, and the development of educational programs in BIOSTEM. Research interests span molecular mechanisms of gene regulation, synthetic biology applications, and quantitative analysis of genetic interactions. His work emphasizes interdisciplinary methods combining genomics, bioinformatics, and engineering principles to address complex biological questions. Publications highlight contributions to understanding cellular heterogeneity, improving DNA assembly techniques, and advancing therapeutic strategies through synthetic biology. Educational efforts include initiatives like iGEM-inspired programs to enhance undergraduate research and skill development in biotechnology.

Elizabeth VargisView profile

Associate Professor

• Biophotonics
• Raman Spectroscopy
• Retinal Tissue Engineering
• +5 more

Elizabeth Vargis is an Associate Professor in Biological Engineering at Utah State University's College of Engineering. She serves as the faculty advisor for the Society of Women Engineers and maintains an active research laboratory focused on biomedical engineering applications. Her work bridges engineering principles with biological systems to address significant medical challenges. Dr. Vargis received her educational training from prestigious institutions: BS in Bioengineering from UC Berkeley MS in Biomedical Engineering from Vanderbilt University PhD in Biomedical Engineering from Vanderbilt University Postdoctoral training at Oak Ridge National Lab and UT Knoxville Her research spans three primary domains with significant clinical relevance. In biophotonics, she develops Raman spectroscopy applications for disease detection, including work on cervical cancer screening and bacterial identification. Her retinal tissue engineering research focuses on creating in vitro models to understand age-related macular degeneration and diabetic retinopathy, with particular emphasis on the role of mechanical stress and cell detachment. Additionally, her work on muscular atrophy investigates the effects of microgravity on muscle tissue, with applications for both space travel and terrestrial medical conditions. Her lab employs a combination of experimental techniques and computational modeling to advance these research areas. Analysis of her recent publications reveals a strong trend toward increasingly sophisticated in vitro models of retinal diseases, with growing integration of microfluidic technologies and biomimetic materials. Her work has evolved from basic characterization studies to complex disease modeling systems that incorporate mechanical, biochemical, and structural components of retinal pathologies. The interdisciplinary nature of her research is evident in the diverse range of journals where she publishes, spanning biomedical engineering, ophthalmology, and space medicine. Dr. Vargis has received numerous prestigious awards recognizing both her research and mentorship excellence: Outstanding Graduate Mentor of the Year (2018, USU College of Engineering) Outstanding Researcher of the Year (2018, Department of Biological Engineering) Ralph E. Powe Junior Faculty Enhancement Award (2015, ORAU) Multiple Research Catalyst Awards from Utah State University National Science Foundation recognition and NIH fellowships She has successfully mentored numerous graduate students to completion of their degrees, with many going on to successful careers in industry and academia. Her research has been supported by diverse funding sources including the Nuclear Regulatory Commission, NIH, Oak Ridge Associated Universities, NASA Space Grant Consortium, and private foundations like the BrightFocus Foundation and Knights Templar Eye Foundation. She actively promotes undergraduate research opportunities through USU's URCO program and the College of Engineering's EURP program. The Vargis Lab operates as a dynamic, interdisciplinary research environment with multiple concurrent projects. Current work includes developing microfluidic platforms for retinal disease modeling, creating biomimetic materials using spider and hagfish silk proteins, and investigating the combined effects of microgravity and radiation on biological systems. The lab maintains strong collaborations with researchers in Electrical and Computer Engineering, particularly with Dr. Zhen Zhang on computational modeling of blood vessel growth. Lab meetings are held weekly during academic terms, fostering a collaborative environment where students present their work and receive feedback.

Juan BotasView profile

Professor

• Neurodegenerative Disorders
• Genetic Research
• Molecular Neuroscience
• +3 more

Juan Botas is a Professor at Baylor College of Medicine with joint appointments in the Department of Molecular and Human Genetics and Molecular & Cellular Biology . His research focuses on neurodegenerative disorders , particularly Huntington's, Parkinson's, and Alzheimer's diseases, using Drosophila and mice models to dissect molecular mechanisms and identify therapeutic targets. Botas's lab specializes in high-throughput genetic screens , integrating robotic instrumentation with multi-omics datasets to uncover gene networks driving pathogenesis. Key themes include proteolysis impairment , neuronal compensatory mechanisms , and cross-species validation for drug discovery. Their work has identified critical modifiers like TRIM28 and NUAK1 for tau and huntingtin toxicity. Recent publications highlight studies on glial gene regulation in Huntington's disease, APOE allele interactions in Alzheimer's, and lipid signaling pathways as therapeutic targets. The lab's interdisciplinary approach bridges computational analysis with in vivo models , emphasizing genome-scale screens and neuroprotective strategies .

• Metabolic Health
• Skeletal Muscle Physiology
• Alcohol Misuse
• +5 more

Danielle Levitt, PhD, CSCS*D, serves as an Assistant Professor in the Department of Kinesiology & Sport Management at Texas Tech University and is actively affiliated with the Institute for One Health Innovation. Her research program focuses on metabolic health, investigating how lifestyle factors contribute to dysfunction in health and disease while developing targeted intervention strategies to improve clinical outcomes. Dr. Levitt's core research interests include: Skeletal muscle physiology and bioenergetics Alcohol misuse and its metabolic consequences Glycemic control mechanisms Inter-organ crosstalk in disease states Cardiometabolic risk in vulnerable populations (e.g., people living with HIV, first responders) Exercise physiology interventions Analysis of her recent publications reveals dominant themes in alcohol-pathogen interactions, skeletal muscle regeneration under metabolic stress, and cardiometabolic risk modulation. Her work frequently employs SIV-infected macaque models to study HIV-alcohol comorbidities, explores mTOR signaling pathways in muscle adaptation, and investigates dietary impacts on viral pathogenesis including SARS-CoV-2 susceptibility. Methodologically, she integrates molecular biology, exercise physiology, and epidemiological approaches across diverse populations. No scientific awards were mentioned in the provided documentation. Information regarding Dr. Levitt's graduate student advising, grant funding history, or specific laboratory resources was not included in the source materials. Her research appears to operate through collaborative frameworks within the Institute for One Health Innovation. Dr. Levitt maintains active research operations at Texas Tech University's Institute for One Health Innovation, where she contributes to interdisciplinary initiatives addressing complex health challenges at the human-animal-environment interface through metabolic and physiological research.

Yan JieView profile

Professor

• Biophysics
• Molecular Biology
• Mechanobiology
• +3 more

Professor Yan Jie is a distinguished academic at the National University of Singapore, holding faculty positions at the Mechanobiology Institute and the Department of Physics. He also maintains an affiliation with the Centre for BioImaging Sciences under the Department of Biological Sciences. Professor, Mechanobiology Institute (MBI), NUS Professor, Department of Physics, NUS Professor, Centre for BioImaging Sciences, NUS Dr. Yan's research lies at the intersection of biophysics, molecular biology, and mechanobiology. His work focuses on understanding how mechanical constraints influence biomolecular stability, including: Force-dependent conformations and interactions of nucleic acids and proteins Mechanosensing at cell-ECM adhesion and cell-cell junctions Chaperone-mediated protein folding mechanisms Chromosome packaging and DNA damage repair dynamics His recent publications highlight advancements in: Mechanical stabilization of biomolecular complexes via energy landscape modeling Multi-domain interactions in cytoskeletal proteins Force-transducing mechanisms in bacterial membranes Calcium signaling in stem cell mechanical properties Dr. Yan has mentored a diverse team including PhD students Kayo Kumadaki, Lin Yueying, Guo Yanyu, Sun Yuze, Liu Jingzhun, Dasvit Shetty, and former student Pang Si Ming. His lab integrates single-molecule biophysical methods with theoretical modeling to explore mechanical regulation at the molecular and cellular level.

Rachelle CrosbieView profile

Professor

• Duchenne muscular dystrophy
• Protein biochemistry
• Muscle physiology
• +5 more

Rachelle Crosbie is a Professor and Department Chair at the University of California, Los Angeles (UCLA), specializing in Integrative Biology and Physiology. Her research focuses on Duchenne muscular dystrophy (DMD), sarcospan, and extracellular matrix interactions in muscle health and disease. She earned her B.S. in Biochemistry from Texas A&M University (1989) and her Ph.D. in Biochemistry from UCLA (1994). Postdoctoral work was conducted at the University of Iowa Carver College of Medicine, supported by the Muscular Dystrophy Association. Her lab investigates sarcospan's role in ameliorating dystrophic muscle by activating compensatory mechanisms. Research includes developing small molecule therapies, in vitro platforms for fibrosis studies, and multi-omics approaches to cytoskeletal remodeling. She leads an NIH T32 training grant for muscle research. Scientific awards include the UCLA Chancellor’s Distinguished Teaching Award, Coalition Duchenne Lotus Award, and National Academies Education Scholar recognition. She developed an online DMD course for UC campuses and contributed to education research on student engagement in asynchronous learning.

• Biosensors
• Tissue Engineering
• Muscular Dystrophies
• +3 more

Juanma Fernandez Costa is a Researcher at the Institute for Bioengineering of Catalonia (IBEC), leading the Biosensors for Bioengineering research group. His work focuses on advancing bioengineering solutions for muscular dystrophies through innovative 3D in vitro models and tissue engineering platforms. Key contributions include developing xeno-free skeletal muscle tissues, functional Duchenne muscular dystrophy models, and organ-on-a-chip systems to study disease mechanisms and therapeutic interventions. Research interests span biosensor integration in tissue models, regenerative medicine applications, and translational research bridging bench and clinical settings. Notable projects include muscle-atrophy studies linked to non-alcoholic fatty liver disease, drug testing platforms for steroid myopathy, and miRNA-based therapies for myotonic dystrophy type 1. Collaborations involve multi-organ systems to explore metabolic interactions, such as muscle-exercise effects on insulin secretion. His lab pioneered plasmonic biosensors for real-time fibrosis monitoring and functional skeletal muscle models enabling preclinical drug evaluation. Current efforts emphasize scalable bioengineered tissues and systems integration for complex disease modeling.

• Gene Transcription
• Epigenetic Regulation
• RNA Regulation
• +1 more

Huanhuan CUI is a Research Associate Professor in the Department of Biology within the School of Life Sciences at Southern University of Science and Technology (SUSTech) in Shenzhen, China. She joined SUSTech in December 2018 and serves as a master's supervisor, contributing to both research and graduate education in molecular biology and genetics. Educational Background: PhD in Biology, Free University of Berlin (2011.09-2016.04) MS in Animal Genetics, Northwest A&F University (2008.09-2010.06) BE in Bioengineering, Northwest A&F University (2004.09-2008.06) Dr. CUI's research focuses on the mechanisms and method development of gene transcription and epigenetic regulation, with particular emphasis on RNA translation control. Her work spans multiple biological systems including cancer biology, developmental biology, and cardiovascular research, demonstrating a strong interdisciplinary approach that integrates molecular biology, genomics, and bioinformatics techniques. She has made significant contributions to understanding chromatin remodeling, transcriptional regulation, and RNA processing mechanisms. Dr. CUI's publication record shows a consistent trajectory of high-impact research, with publications in prestigious journals including Nature Communications, Nucleic Acids Research, and Cellular & Molecular Immunology. Her work demonstrates expertise in CRISPR-based technologies, epigenetic regulation, and multi-omics approaches to studying complex biological processes. Before joining SUSTech, Dr. CUI held positions as a Clinical Research Manager at BGI Genomics (2017.09-2018.11), a PostDoc at Charite Universitaetsmedizin Berlin (2016.05-2017.06), and a Research Assistant at Humboldt University of Berlin (2010.09-2011.08), building a diverse research background that bridges basic science and clinical applications.

• Geriatrics
• Cardiovascular Medicine
• Hypertension
• +3 more

Philip A. Kithas, MD, PhD, serves as Clinical Professor of Internal Medicine and Adjunct Associate Professor of Family & Preventive Medicine at the University of Utah School of Medicine, where he directs geriatric care at the Madsen Health Center in Salt Lake City. With 25 years of prior service at the George E. Wahlen Salt Lake Veterans Health Care System—including leadership as General Medicine Section Chief from 1999 to 2006—he transitioned to his current academic-clinical role after retiring from the VA system. His educational background includes: BA in Biology from the University of Utah BS in Human Biology from the University of South Alabama PhD in Pharmacology from the University of South Alabama College MD from the University of South Alabama Residency and Chief Medical Residency at the University of Utah School of Medicine Dr. Kithas' research centers on geriatric cardiovascular medicine, with deep expertise in hypertension management, hyperlipidemia, and anticoagulation protocols for elderly patients. His work addresses the complex interplay of multiple chronic conditions in aging populations, emphasizing patient education and partnership in care. Early career research investigated molecular mechanisms of cardiac function, particularly phosphodiesterase enzyme systems, while recent publications focus on practical clinical approaches for geriatric hypertension. His publication record reveals a clear evolution from foundational molecular cardiology studies in the 1980s-1990s to applied geriatric cardiovascular research in the 2000s-2020s. The 2010-2020 period features significant contributions to hypertension management guidelines for older adults, including considerations for chronic kidney disease and vascular stiffness, while earlier work established critical insights into cardiac enzyme regulation during development. Dr. Kithas has received exceptional patient feedback (5.0/5 from 19 reviews), with testimonials highlighting his compassionate care, thorough explanations, and unprecedented personal follow-up—including evening phone calls to ensure patient compliance. His administrative contributions include quality improvement initiatives across VA clinics and community-based outpatient facilities. As an educator, he has trained generations of medical providers in geriatric care principles, though specific mentee names are not documented. His current work continues to bridge clinical practice, education, and research at the University of Utah's Madsen Geriatric Clinic, with ongoing focus on optimizing cardiovascular outcomes for aging patients.

Anthony AlbertView profile

Associate Professor

• Medical Education
• Cardiovascular Physiology
• Ion Channel Regulation
• +4 more

Anthony Albert is an Associate Professor in Medical Education at Norwich Medical School , University of East Anglia, where he leads the development of the Graduate Entry Medicine course (2024–present). With over 25 years of research experience, he investigates receptor-ion channel coupling in vascular smooth muscle, focusing on therapeutic targets for cardiovascular diseases like hypertension and pulmonary artery hypertension. Education: BSc Human Biology (Oxford Brookes University, 1990) MSc Neuroscience (University of Edinburgh, 1991) PhD Neurophysiology (Royal Free Hospital Medical School, 1997) PgCert Healthcare and Biomedical Education (St George's, 2008) Senior Fellow, Higher Education Academy (2023) His research spans ion channel regulation in vascular cells, with funding from the British Heart Foundation and BBSRC. He pioneered studies on MARCKS , TRPC1 , and calcium-sensing receptors , linking these to vascular contractility and drug development. His educational impact includes curriculum design , student engagement , and advocacy for equality in higher education . Recent publications highlight his work on Na/H exchanger inhibition in diabetes drug-induced vascular relaxation and sex-dependent Kv7 channel regulation . His ORCID profile lists 80+ research outputs. He actively mentors PhD students and has received multiple teaching excellence awards (2018, 2020, 2024) for his student-centered approach and pastoral care. Scientific Awards: Excellence in Education Award (2018) Excellence in Education Award (2020) Excellence in Education Award (2024) Prof Albert's administrative roles include chairing promotion committees, mentoring leadership programs, and advocating for mental health as a First Aider and Think Tank member. His work bridges basic science and medical education reform , addressing curriculum coloniality and student transition challenges.

• Molecular Biology
• Microbiology
• Biochemistry
• +4 more

Stefan Irniger serves as a faculty member at a German-speaking academic institution, where he has supervised numerous doctoral candidates between 2004 and 2014. His academic position as a Privatdozent (PD) indicates he has completed the habilitation process, the highest academic qualification in the German system. Dr. Irniger's research spans multiple areas of molecular and cellular biology, with particular emphasis on: Microbial pathogenesis and host-pathogen interactions Fungal and yeast molecular genetics Protein regulation and post-translational modifications Enzyme structure and function Cellular metabolism and signaling pathways His doctoral students have published work examining diverse biological systems including Toxoplasma gondii, Saccharomyces cerevisiae, Aspergillus nidulans, and various plant-pathogen interactions. The publications demonstrate a consistent focus on molecular mechanisms underlying cellular processes, with particular attention to protein regulation, metabolic pathways, and host-microbe interactions. His students' work appears across multiple subdisciplines including parasitology, fungal genetics, enzymology, and membrane biology. Dr. Irniger has guided 18 doctoral students to completion, with dissertation topics spanning from 2004-2014. His students have investigated fundamental biological questions with implications for infectious disease, agricultural pathology, and basic cellular mechanisms. While specific awards are not documented in the available records, the breadth and quality of supervised research indicates significant scholarly contribution to his fields of expertise.

Mark Monroe RichView profile

Professor

• Neuromuscular Disease
• Electrophysiology
• Neuromuscular Junction
• +7 more

Mark Monroe Rich is a Professor in the Department of Neuroscience, Cell Biology & Physiology and Professor of Clinical Neuroscience at Wright State University School of Medicine, with over 25 years of combined clinical and research expertise in neuromuscular diseases. His MD/PhD background includes specialized fellowship training in neuromuscular disorders, positioning him at the intersection of patient care and laboratory investigation. Dr. Rich's research program centers on electrophysiologic defects across the neuromuscular axis, with particular emphasis on peripheral nerve pathologies, neuromuscular junction dysfunction, and skeletal muscle excitability disorders. His lab actively investigates disease mechanisms in myasthenia gravis, Lambert-Eaton syndrome, critical illness neuropathies, spinal muscular atrophy, ALS, Huntington's disease-related myopathies, and chemotherapy-induced sensory deficits. Current work focuses on identifying druggable targets for rapid therapeutic translation, especially regarding muscle excitability dysregulation in genetic muscle diseases. Analysis of his 15 most recent publications reveals a consistent trajectory toward mechanistic studies of action potential abnormalities in disease models, with growing emphasis on Huntington's disease, myotonia congenita, and periodic paralysis. His work increasingly integrates transverse tubule ultrastructure, ion channel dysfunction, and neuromuscular junction plasticity to explain pathological phenotypes. Dr. Rich's contributions have been recognized through significant honors: Wright State Academy of Medicine Outstanding Senior Faculty Achievement Award (2019) University Professor designation (2019) Teaching excellence award, School of Medicine (2020 and 2022) His laboratory maintains continuous NIH funding exceeding 25 years, supporting both basic science investigations and therapeutic development. While specific student mentorship isn't detailed in available records, his extensive publication record (110+ articles) indicates active training of researchers through collaborative projects. The lab employs advanced electrophysiological and ex vivo preparation techniques to model disease states and evaluate potential interventions, operating within Wright State's neuroscience research infrastructure.