Genhong ChengView profile
Professor
Genhong Cheng is a Professor in the Department of Microbiology, Immunology, and Molecular Genetics (MIMG) at the University of California Los Angeles (UCLA). His research focuses on understanding the molecular mechanisms of host-pathogen interactions, particularly in viral infections such as Zika virus, SARS-CoV-2, and influenza. Dr. Cheng has made significant contributions to the field of innate immunity, especially in interferon signaling pathways and NF-kappaB regulation. Dr. Cheng's research interests span across virology, immunology, and molecular biology. He has extensively studied how viruses interact with host immune responses, with a particular focus on interferon signaling pathways. His work has revealed critical mechanisms by which viruses evade host defenses and how host cells mount effective antiviral responses. Key areas of investigation include: NF-kappaB signaling in immune responses Interferon-stimulated gene functions Host metabolic changes during viral infection Mechanisms of viral replication and evasion Development of broad-spectrum antiviral strategies Analysis of Dr. Cheng's recent publications reveals a strong focus on emerging viral threats, including SARS-CoV-2 and monkeypox virus. His research consistently explores how host metabolic pathways intersect with immune responses to viral infection. A notable theme is the identification of host factors that can be targeted for broad-spectrum antiviral therapies, particularly those involving lipid metabolism and interferon-stimulated genes. Recent work has emphasized translational applications of basic discoveries in viral pathogenesis. Dr. Cheng's laboratory has been instrumental in advancing our understanding of host-pathogen interactions at the molecular level. His team employs a multidisciplinary approach combining virology, immunology, molecular biology, and systems biology to unravel complex host-virus relationships. Current research directions include exploring novel antiviral strategies targeting host factors that are essential for viral replication.













