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James Briscoe is a Senior Group Leader at The Francis Crick Institute in London, where he leads a research group focused on developmental biology and morphogen signaling. He previously held positions at the Medical Research Council's National Institute for Medical Research, which later became part of the Francis Crick Institute. Education: BSc in Microbiology and Virology from the University of Warwick, UK PhD from Imperial Cancer Research Fund/King's College London Postdoctoral training at Columbia University with Thomas Jessell Dr. Briscoe's research focuses on the molecular and cellular mechanisms of graded signaling by morphogens and the role of transcriptional networks in cell fate specification. His laboratory employs a range of experimental and computational techniques using model systems including mouse and chick embryos and embryonic stem cells. His work has significant implications for understanding developmental processes and their relationship to disease. His recent publications demonstrate a continued focus on morphogen gradients, neural tube development, and computational approaches to understanding cell fate decisions. His research increasingly integrates single-cell technologies and computational modeling to unravel the complexities of developmental patterning. Scientific Awards and Honors: EMBO Young Investigator (2001) EMBO Gold Medal (2008) Elected to EMBO (2009) Fellow of the Academy of Medical Sciences (2019) Fellow of the Royal Society (2019) As Editor-in-Chief of the journal Development since 2018, Dr. Briscoe plays a significant role in shaping the field of developmental biology. His leadership extends to mentoring researchers and contributing to scientific policy discussions, as evidenced by his recent publication 'Science under siege: protecting scientific progress in turbulent times.' Dr. Briscoe's laboratory at the Crick Institute is well-equipped with access to advanced facilities including light microscopy, flow cytometry, genomics, and computational resources, enabling a multidisciplinary approach to developmental biology questions.

• Developmental Biology
• Molecular Signaling
• Transcriptional Networks
• +4 more

Professor Mark Coles serves as Professor of Immunology and Lead for Industrial Strategy and Entrepreneurship at the Kennedy Institute of Rheumatology, University of Oxford, holding concurrent roles as Kennedy Trust Senior Research Fellow, Official Fellow at Reuben College, and Affiliate Faculty at the Wolfson Centre of Mathematical Biology. His interdisciplinary work bridges immunology, computational modeling, and translational research to accelerate therapies for immune-mediated inflammatory diseases. His academic journey began with a BSc in Microbiology from Cornell University (1992), followed by a PhD in Molecular and Cell Biology at UC Berkeley under David Raulet, and postdoctoral training with Dimitris Kioussis at the National Institute of Medical Research. At the University of York (2006-2017), he pioneered stromal immunology research and co-founded the York Computational Immunology Laboratory. Coles' research centers on stromal and systems immunology, with core expertise in stromal cell biology, inflammatory disease mechanisms, and mathematical modeling of immune responses. He champions 3Rs-based approaches (Replacement, Reduction, Refinement) to reduce animal testing through in silico models, integrating spatial single-cell biology with multi-scale computational frameworks to dissect immune function in human tissues. His 2025 publications reveal a cohesive research trajectory applying interdisciplinary methods across diverse disease contexts—from cardiac fibrosis and vaccine responses to arthritis pathogenesis and CAR-T cell therapy—unified by focus on stromal-immune crosstalk and quantitative modeling to identify therapeutic targets. Key honors include: Fellow of the Royal Society of Biology Kennedy Trust Senior Research Fellow As former Director of Graduate Studies (2017-2024) at the Kennedy Institute, Coles mentored numerous graduate students while co-leading major initiatives including the Arthritis Therapy Acceleration Program and Human Cell Atlas medicalization. His entrepreneurial impact spans three co-founded ventures: Simomics Ltd (in silico disease modeling), Lightox Ltd (phototherapy for oral cancer), and Mestag Therapeutics (fibroblast-targeted therapies for cancer/inflammation). He directs the Laboratory of Stromal and Systems Immunology and Oxford Mathematical Immunology Group, fostering collaborations with Christopher Buckley, Calliope Dendrou, and Eamonn Gaffney to develop Quantitative Systems Pharmacology models that translate mechanistic insights into patient therapies.

• Immunology
• Translational Immunology
• Computational Immunology
• +4 more

Andrew Regan is a Senior Lecturer in the School of Chemistry at the University of Manchester, specializing in organic synthesis and drug discovery. He holds a B.A. (1981), M.A. (1985), and Ph.D. (1985) from the University of Cambridge. His career includes postdoctoral research at Columbia University and a lectureship at the University of Kent before joining Manchester in 1991. Research interests focus on synthesizing biologically active compounds, such as phosphinic acids for anticancer agents, and developing novel synthetic methods. His work contributes to drug discovery, green chemistry, and efficient chemical processes. He currently supervises two PhD students researching phosphinic acid analogues and simplified erythromycin analogues. Key achievements include the synthesis of epibatidine and advancements in macrolide antibiotic design. His research aligns with sustainable development goals through eco-friendly synthesis methods.

• Drug Discovery
• Organic Synthesis
• Biologically Active Compounds
• +5 more

Professor David Grainger is a faculty member at the University of Birmingham's School of Biosciences, specializing in Molecular Microbiology. He leads the Grainger Lab, focusing on bacterial chromosome biology, pathogenicity, and antibiotic resistance. His research integrates high-throughput techniques and single-molecule analysis to study gene regulation and bacterial pathogenesis. Education: PhD (2004), PGCE (2000), BSc (1999) in Biochemistry from the University of Birmingham. Affiliations: Part of the Institute of Microbiology and Infection (IMI), collaborating with experts in genomics, proteomics, and structural biology. Research Interests: Deciphering chromosome biology of pathogenic bacteria, including transcriptional regulation, toxin production control, and antibiotic resistance pathways. Utilizes cutting-edge methods like Hi-C for 3D chromatin analysis and single-molecule microscopy. Recent Articles: Focused on transposon capture mechanisms, bacterial promoter diversity, and quorum sensing signaling. Highlights include studies on Salmonella regulons and Vibrio cholerae biofilm suppression. Awards: Wellcome Trust Career Development Fellowship (2008), Runner-up in 'Science Snaps' competition for scientific communication. Grants: Career Development Fellowship-funded establishment of his research group at the University of Warwick (2008). Labs/Teams: Grainger Lab at the University of Birmingham, part of the IMI network. Engages in public science outreach via Twitter and lab website.

• Bacterial Chromosome Biology
• Pathogenicity
• Antibiotic Resistance Mechanisms
• +3 more

Professor Thomas Meier is a Visiting Professor at the Department of Life Sciences, Imperial College London (since 2015), and Director of the Centre for Structural Biology (2017–2021). He leads research on ATP synthase structure, drug targets for tuberculosis, and molecular mechanisms of disease. Previously, he was a Group Leader at the Max-Planck-Institute of Biophysics (2006–2015) and ETH Zurich's Institute of Microbiology. His work combines structural biology (X-ray crystallography, electron microscopy) with biochemical studies. Education: Dr. sc. nat. (2002) and Dipl. sc. nat. (1998) from ETH Zurich. Awards include the Wellcome Trust Investigator (2015–present). Research focuses on ATP synthase's role in energy conversion, drug development, and structural biology. His lab includes postdocs and students like Lisa Uhrig and Anthony Cheuk. Key affiliations: Centre for Structural Biology, Membrane Biology Group, and Bacterial Pathogenesis studies. Languages: German, English, French (fluent), Latin (read/write). Publications span structural biology, planetary science, and drug discovery. His work on ATP synthase inhibitors for TB has clinical implications, while astrophysical studies explore planetary formation via giant impacts.

• Structural Biology
• Biochemistry
• Microbiology
• +5 more

Professor Tim Williams is Professor of Veterinary Clinical Pathology at the Department of Veterinary Medicine, University of Cambridge, and Director of Studies in Veterinary Medicine at Fitzwilliam College. He is also a visiting research fellow in the Karet laboratory at the Cambridge Institute of Medical Research. His research focuses on extracellular vesicles in renal and urinary tract disorders, with particular emphasis on: The utility of extracellular vesicles as biomarkers for renal diseases The clinical significance of the bactericidal activity of urinary exosomes Novel biomarkers for chronic kidney disease in cats Potential biomarkers for urothelial cell carcinoma in dogs His work bridges veterinary clinical pathology, molecular biology, and translational medicine with applications in feline and canine medicine. Recent publications demonstrate his focus on identifying differentially expressed proteins and microRNAs associated with extracellular vesicles in disease states, spanning from fundamental bactericidal properties to clinical applications in companion animals. Professor Williams has received the Society for Comparative Endocrinology award for Excellence in the Advancement in Veterinary Endocrinology in both 2011 and 2015. He supervises multiple graduate students and maintains extensive collaborations across Cambridge departments and international institutions including Royal Veterinary College, Tufts University, and Shanghai Jiao Tong University. His research is supported by PetPlan Charitable Trust, BSAVA Petsavers, and the European College of Veterinary Clinical Pathology. As leader of the Extracellular Vesicle Research Group, Professor Williams investigates the role of extracellular vesicles in disease processes and their potential as diagnostic and therapeutic tools, with particular focus on translational applications from veterinary to human medicine.

• Extracellular vesicles
• Kidney disease
• Endocrinopathies
• +5 more

Isabella Guido is a Senior Lecturer in Experimental Soft Matter Physics at the University of Surrey's School of Mathematics and Physics. She holds a PhD from TU Berlin (2010) and has conducted postdoctoral research at Peking University and the Max Planck Institute for Dynamics and Self-Organization. Her research focuses on synthetic biology, active bioinspired systems, and microtubule-motor protein dynamics. Guido's work bridges active matter physics and synthetic biology, aiming to develop minimal systems mimicking natural cellular structures. Key projects include synthetic beating structures resembling cilia, 3D active nematics, and investigations into cellular symmetry breaking via biomimetic systems. Her education includes a PhD on dielectrophoretic effects in mammalian cells, followed by postdoctoral studies on cell mechanics, microfluidics, and electroporation. Guido's interdisciplinary approach combines experimental biophysics with synthetic biology to uncover principles governing living matter. She leads the Synthetic Active Systems group and collaborates internationally on projects such as light-powered artificial cells and motor-driven microtubule networks. Her work addresses sustainable development goals through bio-inspired material design and active matter applications. Publications highlight contributions to electrotaxis mechanisms, live-cell imaging techniques (e.g., MIET), and microtubule network dynamics under depletion forces. Guido's research has advanced understanding of ciliary beating patterns, synthetic axoneme models, and biopolymer self-organization under mechanical stress.

• Synthetic Biology
• Active Bioinspired Systems
• Active Matter
• +3 more

Dr. Megan Bergkessel is a Research Professor in Molecular Microbiology at the University of Dundee's School of Life Sciences. Her research focuses on understanding how bacteria like Pseudomonas aeruginosa regulate activities during growth arrest, particularly in resource-limited environments. This work addresses antibiotic tolerance mechanisms critical to chronic infections. Principal Investigator leading studies on non-growing bacterial physiology Recipient of a £900k UKRI Future Leaders Fellowship (2020) Expertise in antimicrobial resistance and microbial stress responses Current research explores regulatory pathways enabling protein synthesis in non-growing states, with implications for developing novel infection treatments. Supervises PhD projects investigating two-component signaling systems and environmental sensing in P. aeruginosa. Recognized for teaching excellence in Biological and Biomedical Sciences programs. PhD opportunities: Adaptive antimicrobial resistance mechanisms and environmental sensing roles Media commentary available via Corporate Communications

• Molecular Microbiology
• Antimicrobial Resistance
• Bacterial Physiology
• +3 more

Professor Lindsay Turnbull is a Professor of Plant Ecology at the University of Oxford's Department of Biology. Her research focuses on understanding the evolutionary and ecological basis of plant trait diversity and its consequences for ecosystems. Key interests include seed size variation, plant-soil interactions, and the impact of organic farming on biodiversity. She leads a research group exploring topics such as mutualism stability, species coexistence, and island conservation genetics. Turnbull's work integrates experimental, observational, and computational approaches to address fundamental questions in ecology. Her lab, based at the Department of Biology (Mansfield Road and South Parks Road campuses), has contributed to global understanding of biodiversity-ecosystem functioning relationships and plant-microbe symbioses. Notable projects include studies on Aldabra giant tortoises and coral reef connectivity in the Seychelles, highlighting her commitment to applied conservation science. Her research spans multiple scales—from molecular interactions in legume-rhizobia systems to large-scale biodiversity patterns in grasslands and tropical ecosystems. Recent work emphasizes the role of trait-based approaches in predicting ecological responses to environmental changes such as eutrophication and climate variability. Her publications frequently bridge theoretical and applied ecology, offering insights into both natural and human-managed ecosystems.

• Plant Ecology
• Biodiversity
• Ecology
• +3 more

Philip Burnet is a Professor of Neuroscience at the University of Oxford, affiliated with the Department of Psychiatry . He serves as the Director of Graduate Studies for Psychiatry , teaches on the MSc Neuroscience and MRCPsych courses, and sits on the editorial board of Nutrition and Aging . His research bridges neuroscience and psychiatry, focusing on neurotransmitter modulation and brain health. Research interests: Burnet investigates the regulation of serotonin and glutamic acid systems in aging and psychiatric disorders. Key projects include exploring D-amino acid oxidase (DAO) inhibition to restore cognition in schizophrenia, analyzing the microbiome-gut-brain axis , and testing dietary interventions like probiotics and ketogenic diets for mental health applications. His work combines molecular techniques with behavioral studies in preclinical and clinical contexts. Article trends reveal a focus on neurotransmitter dynamics , microbiome-brain interactions , and metabolic interventions . Notable methods include RNA interference , animal models , and clinical trial protocols . Professional activities: Collaborates across Oxford and with industry partners, contributes to academic editing, and engages in graduate education leadership.

• Neuroscience
• Psychiatry
• Neurotransmitter Modulation
• +5 more

Professor Gideon James Grogan is a distinguished academic at the University of York, holding a position in the Department of Chemistry within the Faculty of Sciences. With expertise spanning structural and applied enzymology, he leads research at the intersection of chemistry and biology, developing novel biocatalysts for sustainable chemical synthesis and pharmaceutical applications. Professor Grogan's research focuses on the identification, characterization, and application of enzymes with biotechnological potential. His work encompasses: Oxygenases including P450s, flavoprotein monooxygenases, and peroxygenases Reductases such as ketoreductases (KREDs), imine reductases (IREDs), and reductive aminases (RedAms) Lyases catalyzing asymmetric hydration of alkenes Ligases for amide bond formation His multidisciplinary approach integrates synthetic chemistry, microbiology, molecular biology, and X-ray crystallography to engineer enzymes using in vitro evolution techniques. Recent research has yielded significant advances in biocatalytic pathways for chiral pharmaceutical precursors and renewable material processing. Professor Grogan's publication record demonstrates consistent innovation in biocatalysis, with recent work focusing on peroxygenase applications, reductive amination technologies, and enzyme engineering for improved catalytic properties. His research shows strong trends in developing sustainable enzymatic routes for pharmaceutical synthesis, with particular emphasis on stereoselective transformations and cascade reactions. Professor Grogan has received significant research funding through major grants from: BBSRC (Biotechnology and Biological Sciences Research Council) EPSRC (Engineering and Physical Sciences Research Council) He actively supervises PhD students and collaborates extensively both within the University of York and internationally. His work bridges the Departments of Chemistry and the York Structural Biology Laboratory (YSBL), leveraging state-of-the-art facilities for organic synthesis, protein expression, and structural analysis. Professor Grogan maintains strong industry connections, translating fundamental research into practical applications for pharmaceutical and chemical manufacturing. His current projects include sustainable production of menthol enantiomers, development of native amine dehydrogenases for chiral amine synthesis, and discovery of securinine alkaloid biosynthesis pathways.

• Structural and Applied Enzymology
• Biocatalysis
• Enzyme Engineering
• +9 more

Rachel Sippy is a Research Fellow at the University of Cambridge , specializing in epidemiology and infectious disease dynamics within the Department of Psychiatry . Her work bridges public health, climate science, and computational methods.

• Epidemiology
• Vector-Borne Diseases
• Dengue Fever
• +4 more

Dame Fiona Powrie is a Professor of Musculoskeletal Sciences at the University of Oxford and Director of the Kennedy Institute of Rheumatology . She leads the Mucosal Immunology Research Group and serves as Director of the Oxford Centre for Microbiome Studies (OCMS) and Cluster Lead in the MRC National Mouse Genetics Network Microbiome Cluster . Roles: Director of Kennedy Institute, Professor, Research Group Leader Relevant Affiliations: Wellcome Trust Governor (2018–present), Deputy Chair (2022), Royal Society Fellow (2011) Research Interests : Fiona specializes in the interplay between the intestinal microbiota and the host immune system, focusing on how dysregulation leads to inflammatory bowel disease (IBD) . Her work has elucidated the role of regulatory T cells in maintaining gut homeostasis and identified the IL-23 pathway as critical in chronic intestinal inflammation. Current efforts aim to translate these findings into clinical therapies for IBD patients. Scientific Awards and Fellowships : Ita Askonas Award (European Federation of Immunological Societies) Louis-Jeantet Prize for Medicine (2012) Honorary Lifetime Membership (British Society of Immunology, 2021) Fellow of the Royal Society (2011), EMBO (2013), Academy of Medical Sciences (2014) International Fellow of the National Academy of Sciences (2020) Advising and Leadership : Fiona leads the Mucosal Immunology group at the Kennedy Institute, mentors researchers, and contributes to national and international scientific governance. She has been instrumental in advancing microbiome and immunology research through leadership roles at the Oxford Centre for Microbiome Studies and the MRC National Mouse Genetics Network . Labs and Teams : Fiona's research group at the Kennedy Institute of Rheumatology investigates mucosal immunity and microbiome interactions, combining experimental and clinical approaches to address inflammatory diseases.

• Mucosal Immunology
• Intestinal Microbiota
• Host-Immune System Interaction
• +3 more

Colin Cooper is a Professor of Cancer Genetics at the Norwich Medical School, University of East Anglia. He is also a member of the Metabolic Health and Cancer Studies research groups. His work focuses on genomic evolution, tumor microbiome dynamics, and biomarker development for prostate cancer and musculoskeletal health. Cooper’s recent research explores the interplay between cancer genetics and microbial communities, emphasizing their role in prognosis and treatment outcomes. He investigates clonal evolution in tumors, mutational signatures, and non-invasive diagnostic tools like urinary extracellular vesicles. His collaborations span genomics, microbiology, and clinical applications. 2025: Causes of evolutionary divergence in prostate cancer (Genomics, Precision Medicine) 2024: Applications of urinary extracellular vesicles... (Biomarker Development, Liquid Biopsy) 2023: Caution regarding pan-cancer microbial structure (Methodological Considerations, Microbiome Analysis) In 2022, Cooper received the European Urology Oncology SoMe Award for his contributions. His work is frequently cited and has been featured in media outlets globally, highlighting his impact on cancer and aging research.

• Cancer Genetics
• Prostate Cancer
• Genomic Evolution
• +5 more

Dr. Rebecca Clark is an Associate Professor in the Department of Biosciences at Durham University. Her research focuses on understanding intestinal function in health and disease using the Drosophila model. She investigates how the intestinal epithelium balances barrier function, nutrient absorption, microbial symbiosis, and cell turnover, particularly during aging and disease states. Key research questions include mechanisms of intestinal barrier failure and the interplay between nutrition and intestinal homeostasis. Her work integrates genetic, microbiological, and physiological approaches to explore aging-related pathologies. Current projects aim to identify molecular pathways linking intestinal health to longevity. Supervised postgraduate students include Ale Acevedo Marcelin, Beñat Yanez, and Fanila Shahzad. Dr. Clark’s lab uses Drosophila as a model system due to its powerful genetic tools and evolutionary relevance. Research has implications for understanding human conditions such as inflammatory bowel disease and age-related metabolic disorders. Recent findings highlight microbiota-independent aging mechanisms and the role of tricellular junctions in stem cell regulation. No scientific awards are explicitly listed in the provided materials. Her research has been published in journals like Cell , Nature Cell Biology , and Proceedings of the National Academy of Sciences .

• Intestinal Homeostasis
• Aging Biology
• Microbial Ecology
• +3 more