Sai ZhangView profile
Assistant Professor
Sai Zhang is an Assistant Professor in the Department of Epidemiology at the University of Florida (UF), holding affiliations with the College of Public Health & Health Professions and College of Medicine. He is also an Affiliate Faculty in the J. Crayton Pruitt Family Department of Biomedical Engineering at the Herbert Wertheim College of Engineering. Previously, he was an Instructor at Stanford University School of Medicine and a Research Associate at the VA Palo Alto Epidemiology Research and Information Center (ERIC). Dr. Zhang completed his Ph.D. in Computer Science and Technology at Tsinghua University, followed by postdoctoral training in Dr. Michael Snyder’s lab at Stanford Genetics. His research integrates machine learning, genomics, and precision medicine to uncover genomic bases of complex diseases. Key focuses include developing algorithms for multiomic data analysis, modeling genotype-phenotype relationships, and leveraging deep learning for biological sequence analysis. His work emphasizes cell-type-specific mechanisms in diseases like ALS, coronary artery disease, and neurodegenerative disorders. Notable contributions include frameworks for polygenic risk scoring (e.g., PRS-Net), biomarker discovery for ALS, and tools for time-to-event prediction in neurological diseases. He leads the Zhang Laboratory, advancing computational systems for precision health applications.











