Sriram Subramaniam is a Professor in the Department of Biochemistry and Molecular Biology at the University of British Columbia (UBC) and holds the Gobind Khorana Canada Excellence Research Chair in Precision Cancer Drug Design. His research leverages cryo-electron microscopy (cryo-EM) to advance structural biology and drug design, focusing on protein dynamics and therapeutic target identification. Education: PhD in Physical Chemistry (1987) from Stanford University; MSc in Chemistry (1981) from Indian Institute of Technology, Kanpur. Subramaniam's interdisciplinary work combines cryo-EM with computational tools and molecular biology to study protein structures at atomic resolution. His lab has pioneered cryo-EM applications in precision medicine, including mapping small molecule drugs on patient-specific cancer mutants. Recent publications (2024-2022) highlight his contributions to understanding SARS-CoV-2 immune evasion, structural mechanisms of ATPases, and AI integration in structural biology. His research spans viral entry mechanisms, CRISPR systems, and neurodegenerative disease pathways. Scientific Awards: Gobind Khorana Canada Excellence Research Chair NIH Director’s Award for Scientific Excellence Fellow of the Biophysical Society Breakthrough Prize nomination Based at the Djavad Mowafaghian Center for Brain Health, Subramaniam leads the Program in Cryo-EM Guided Drug Design, contributing to over 177 peer-reviewed publications with a career h-index of 58 and citations exceeding 12,340.
Karen I. Winey serves as the Harold Pender Professor in the Department of Chemical and Biomolecular Engineering and Materials Science and Engineering at the University of Pennsylvania's School of Engineering and Applied Science. Her research group employs experimental and computational tools to investigate advanced polymers for energy applications, particularly focusing on proton and ion conductivity for fuel cells and batteries within the Laboratory for Research on the Structure of Matter (LRSM). Dr. Winey's research encompasses: Designing functional polymers to improve proton, hydroxide, and ion conductivity Studying polymer nanocomposites and nanoparticle dynamics in electrochemical devices Developing polymer-to-polymer upcycling methods to convert waste polyolefins to higher value polymers Revolutionizing understanding of ionomer morphologies beyond traditional spherical aggregate models Her recent publications reveal significant advances in sustainable energy materials, particularly fluorine-free alternatives to conventional polymer electrolytes. The research spans fundamental studies of ion transport mechanisms in precisely engineered polymers to practical applications in energy devices. A critical focus is understanding how nanoscale morphology affects macroscopic properties, with particular attention to structure-property relationships in ion-conducting polymers for fuel cells and batteries. Scientific recognition includes: 2025 Turner J. Alfrey Visiting Professor Harold Pender Professorship (endowed chair) NSF DMR Polymers grant awarded July 2025 Dr. Winey actively mentors a diverse research group including PhD students, postdoctoral researchers, and undergraduates. Her lab recently welcomed six summer undergraduates and has celebrated numerous student achievements including qualifying exam successes and award-winning presentations. Current major projects include the Port5 collaboration and the PolyUp project focused on polymer upcycling through dehydrogenation and functionalization strategies. The Winey Group operates within Penn's state-of-the-art Vagelos Laboratory for Energy Science and Technology (VLEST), maintaining active collaborations with institutions including the University of Konstanz in Germany, Florida State University, and Michigan State University. The group regularly hosts international visitors and participates in major conferences including the APS Global Physics Summit.
Weiping Tang is a Professor of Pharmaceutical Sciences and Chemistry at the University of Wisconsin-Madison, holding the Janis Apinis Professorship in the School of Pharmacy and the Vilas Distinguished Achievement Professorship. He also serves as Director of the Medicinal Chemistry Center at the School of Pharmacy and maintains a faculty appointment with the Department of Chemistry in the College of Letters and Science. Janis Apinis Professor of Pharmaceutical Sciences Vilas Distinguished Achievement Professor Director of Medicinal Chemistry Center Faculty Appointment with Department of Chemistry Dr. Tang received his B.S. in Chemistry from Peking University in 1997, M.S. in Chemistry from New York University in 1999, Ph.D. in Organic Chemistry from Stanford University in 2005, and completed a postdoctoral fellowship in Medicinal Chemistry, Chemical Biology and Drug Discovery at Harvard University in 2007. Dr. Tang's research program focuses on drug discovery for cancer, infectious diseases, and neurodegenerative disorders through three interconnected areas: Organic Synthesis (advancing glycoscience through novel carbohydrate synthesis technologies), Medicinal Chemistry (developing small molecules that selectively remove disease-associated proteins), and Chemical Biology (dissecting biological pathways using novel small molecule probes). His group operates as an interdisciplinary team where chemists and biologists collaborate closely on drug discovery projects, with particular emphasis on developing novel degraders for disease-causing proteins. Analysis of Dr. Tang's publication record reveals a significant shift toward targeted protein degradation technologies, particularly PROTACs and molecular glues, while maintaining strong foundations in carbohydrate chemistry. His most impactful recent work includes developing degraders for extracellular and membrane proteins (previously considered 'undruggable'), creating rapid synthesis platforms like Rapid-TAC and Rapid-Glue, and advancing understanding of ternary complex formation for novel PROTAC design. His research spans both chemical methodology development and therapeutic applications across multiple disease areas. Vilas Distinguished Achievement Professorship Janis Apinis Professorship Numerous high-impact publications in leading chemistry and pharmacology journals Editor's pick and hot paper designations for significant contributions Dr. Tang mentors a diverse team of graduate students, postdoctoral fellows, and staff scientists with expertise spanning synthetic chemistry, medicinal chemistry, carbohydrate chemistry, computational chemistry, biochemistry, and cell biology. His group has developed innovative platforms for the rapid synthesis of protein degraders and has made significant contributions to understanding the mechanisms of action for these novel therapeutics. Current research includes developing selective degraders for cancer targets like RIPK1, BRD4, and CARM1, as well as advancing delivery systems for clinical translation. The Tang Research Group maintains state-of-the-art facilities within the School of Pharmacy at UW-Madison, equipped for comprehensive chemical synthesis, compound characterization, and biological evaluation. The group actively collaborates with researchers across campus and with industry partners to advance discoveries toward clinical applications, with particular focus on cancer therapeutics and protein degradation technologies.
Vadim Cherezov, the Ester Dornsife Chair in Biological Sciences and Professor at the University of Southern California (USC), leads groundbreaking research in membrane protein structure and function. Affiliated with the Bridge Institute, Department of Chemistry, and Michelson Center for Convergent Bioscience, his work focuses on GPCRs, ion channels, and transporters—critical targets for drug discovery. His team leverages advanced techniques like Lipidic Cubic Phase (LCP) and Serial Femtosecond Crystallography (SFX) at XFEL facilities to solve high-resolution structures under physiological conditions. Institutional Affiliations: Bridge Institute, USC Michelson Center, Department of Chemistry, Department of Pharmacology and Pharmaceutical Sciences. Key Collaborations: Katritch Lab, Kuhn Lab, NIH, European XFEL. His research explores the role of lipids in modulating GPCR function, addressing diseases like Alzheimer’s, diabetes, and cancer. By solving the structure of the A 2A adenosine receptor via sulfur SAD phasing at XFEL, Cherezov’s lab demonstrated de novo phasing without heavy atoms. This breakthrough enables structural studies of previously intractable membrane proteins. Scientific Awards & Grants: NIH R01 GM108635, U54 GM094618, U54 GM094599, R01 GM095583 Science Signaling Breakthroughs of the Year (2014) Cherezov mentors a dynamic team, including postdocs (e.g., Dong-Gyun Kim), graduate students (e.g., Behnaz Davoudinasab), and alumni (e.g., Benjamin Stauch at Eli Lilly, Nairie Michaelian at Genentech). His lab’s publications span Nature , Science , and Cell , with recent work on Science Advances (2025) addressing ABEL-FRET for GPCR dynamics.
Dr. Steven G. Clarke is a Distinguished Professor at UCLA Department of Chemistry & Biochemistry and director of research at the Molecular Biology Institute . His work bridges protein chemistry , methylation biology , and aging research through studies of spontaneous protein damage and its repair mechanisms. Education: BA in Chemistry and Zoology, Pomona College (magna cum laude, Phi Beta Kappa) PhD in Biochemistry and Molecular Biology, Harvard University (NSF Fellow) Postdoctoral Fellowship at UC Berkeley (Miller Fellow) Dr. Clarke's research focuses on protein isoaspartyl repair via PCMT1/PIMT enzymes , ribosomal protein methylation in Saccharomyces cerevisiae , and PRMT family characterization including PRMT7 and PRMT9. His lab combines biochemical assays , genetic models , and structural analysis to investigate aging mechanisms and disease implications. Recent publications highlight: COQ5 structure-function analysis in coenzyme Q biosynthesis PCMTD1 ubiquitin ligase interactions PRMT7 substrate specificity in histone H2B Protein isoaspartyl impacts on T cell function in lupus Novel PRMT inhibitors for cancer therapy Methionine addiction in osteosarcoma malignancy Major scientific awards: American Chemical Society Ralph F. Hirschmann Award in Peptide Chemistry NIH MERIT Award Ellison Medical Foundation Senior Scholar Award William C. Rose Award, ASBMB UCLA Distinguished Teaching Award (Eby Award winner) Current lab members include PhD candidates Eric Pang (UCSB) and Sining "Cindy" Wang (UCLA), while undergraduates Celeste Medina-Seymoure , Elizabeth Oroudjeva , Olivia Pacheco , and Jasmine Winter contribute to ongoing proteostasis studies. Collaborations with Profs. Jose Rodriguez and Catherine Clarke demonstrate interdisciplinary research approaches.
Ralph H. Colby serves as Professor of Materials Science and Engineering and Chemical Engineering at Pennsylvania State University's College of Earth and Mineral Sciences, holding the Corning Faculty Fellowship. His research focuses on molecular-level dynamics in complex fluids, particularly polymers, ionomers, and liquid crystalline systems. With over 130 publications and authorship of the textbook Polymer Physics (2003), he directs an active research program examining structure-property relationships in soft matter. B.S. in Materials Science and Engineering, Cornell University (1979) M.S. in Chemical Engineering, Northwestern University (1983) Ph.D. in Chemical Engineering, Northwestern University (1985) Professor Colby's research spans polymer physics, rheology, and materials for energy applications. His group employs mechanical rheology, dielectric spectroscopy, and scattering techniques to investigate ion transport in single-ion conductors for batteries, dynamics of glass-forming liquids, and self-assembly in polyelectrolyte systems. Current work emphasizes structure-property relationships in ionomers, liquid crystalline polymers, and branched architectures. Analysis of recent publications reveals consistent focus on ionomer membranes for energy applications, processing-structure relationships in advanced polymers, and fundamental dynamics of complex fluids. Key trends include increasing integration of computational modeling with experimental characterization, expansion into sustainable materials processing, and growing emphasis on applications in battery technology and biomedical materials. Penn State Faculty Scholar Medal for Outstanding Achievement (2022) Bingham Medal, Society of Rheology (2012) American Chemical Society Fellowship Corning Faculty Fellowship in Materials Science and Engineering Professor Colby leads multiple federally funded projects including NSF's 'Fundamental Studies of Flow-Induced Polymer Crystallization' and DOE's 'Conduction mechanisms and structure of ionomeric single-ion conductors'. His group maintains strong industry partnerships with Corning Incorporated and participates in interdisciplinary initiatives like the Penn State Intercollege Graduate Degree Program in Materials Science and Engineering. Current research includes collaborations on breast cancer adherence interventions in Rwanda and conjugated polymer development for flexible electronics. The Colby Research Group operates specialized facilities for rheological characterization, dielectric spectroscopy, and X-ray scattering at Penn State's Materials Research Institute. The team maintains active collaborations with national laboratories and international research groups, focusing on translating fundamental polymer physics discoveries into practical applications for energy storage and advanced manufacturing.
Virgil Percec is the P. Roy Vagelos Professor of Chemistry at the University of Pennsylvania, affiliated with the School of Arts & Sciences and the Department of Chemistry. His research focuses on organic, supramolecular, and macromolecular chemistry, with an emphasis on self-assembly, drug delivery systems, and biomimetic nanosystems. He holds a B.S. and Ph.D. from institutions in Jassy, Romania, and conducted postdoctoral research at the University of Freiburg and the University of Akron. Research Interests: Percec’s work integrates synthetic methods, catalysis, and structural biology to design functional nanosystems. Key areas include hierarchical folding, supramolecular chirality, and synthetic mimics of biological membranes. His lab explores mRNA delivery systems using Janus dendrimers and studies self-organized structures like helical columns and quasicrystals. Recent Articles: His recent publications highlight advancements in mRNA delivery mechanisms, supramolecular architectures, and polymer synthesis innovations. The group’s work often involves interdisciplinary collaborations, bridging chemistry, materials science, and bioengineering. Awards: Percec was elected a Foreign Member of the Academia Europaea (2020) and delivered the inaugural ACS Kavli Lecture (2011). His lab has trained numerous students and postdocs, including Juncheng Lu (Master’s Capstone Award recipient) and Devendra Maurya (SET-LRP research). Labs & Teams: The Percec Research Laboratory at Penn develops cutting-edge biomaterials and supramolecular systems. The group collaborates globally, with projects funded by grants exploring nanotechnology and drug delivery.
James Van Etten is the William Allington Distinguished Professor of Plant Pathology at the University of Nebraska-Lincoln, affiliated with the School of Biological Sciences and Nebraska Center for Virology. His research focuses on chloroviruses—large dsDNA viruses infecting Chlorella-like algae—with emphasis on DNA replication, restriction systems, and membrane transport proteins. Key research themes include: Viral DNA modification systems Host-virus interactions Structural virology Evolution of organellar genomes Recent work analyzed: SMRT sequencing of viral methylation patterns Chlorovirus cryopreservation methods Potassium channel biophysics Host chemical signaling mechanisms Lab webpage: vanettenlab.unl.edu
Martin Burke is the May and Ving Lee Professor for Chemical Innovation and Professor of Chemistry at the University of Illinois Urbana-Champaign , with additional appointments in Biochemistry, Biomedical & Translational Sciences, and multiple campus institutes including the Beckman Institute and the Carl R. Woese Institute for Genomic Biology. Education B.S. Johns Hopkins University , 1998 Ph.D. Harvard University , 2003 M.D. Harvard Medical School , 2003 Research Interests Burke’s program centers on molecular prosthetics : the design, synthesis and application of small molecules that replicate or replace missing or dysfunctional proteins. His group pioneered iterative cross-coupling (ICC) using MIDA-protected haloboronic acids to automate the construction of complex natural products and function-oriented small molecules. Current projects target ion-channel replacement in cystic fibrosis, iron-transport restoration in anemia, and non-toxic antifungals that overcome drug resistance. Scientific Awards & Honors National Academy of Medicine (2021) AAAS Fellow (2021) ASCI Member (2021) iCON Award (2019) Mukaiyama Award, Japan (2019) ACS Nobel Laureate Award for Graduate Education (2017) Thieme-IUPAC Prize in Synthetic Organic Chemistry (2014) Elias J. Corey Award (2013) Arthur C. Cope Scholar Award (2011) Research Output & Impact Burke has authored >120 peer-reviewed articles, >30 patents, and his work has been cited >20,000 times. High-impact publications in Nature , Science , and Angewandte Chemie have advanced automated synthesis, molecular prosthetics, and cystic fibrosis therapeutics. Laboratory & Training The Burke Laboratories house a multidisciplinary team of graduate students, post-doctoral researchers, and physician-scientists developing next-generation molecular prosthetics. The group is supported by NIH, NSF, private foundations, and industry partnerships aimed at democratizing molecular innovation.
Peter Van Puyvelde is a Full Professor at KU Leuven's Faculty of Engineering Sciences, where he leads research at the Soft Matter, Rheology and Technology (SMaRT) unit within the Department of Chemical Engineering. He is an active member of the Applied Rheology and Plastics Processing Division and the Leuven.AM Institute for Additive Manufacturing. His academic responsibilities include membership in the Faculty Council of Engineering Sciences and departmental committees. His core research focuses on: Polymer processing and complex fluid dynamics In-situ characterization of flow-microstructure relationships Flow-induced crystallization phenomena Development of sustainable polymer materials Additive manufacturing technologies Professor Van Puyvelde's recent publications (2023-2025) demonstrate strong emphasis on sustainable polymer systems including lignin-based materials, humins valorization, bioplastics, and green additives. His work frequently employs advanced characterization techniques like fast-scanning calorimetry and synchrotron X-ray scattering to study crystallization kinetics and microstructure development in complex polymer systems. He currently supervises PhD students working on nanofiltration membranes and reinforced polymer parts. His extensive research portfolio includes leadership roles in multiple ongoing projects: Polylactic acid bioplastics development (Co-promoter) Lignin-based flame retardants (Co-promoter) Humins valorization for functional polymers (Co-promoter) Ionic liquids for enhanced oil recovery (Promoter) Competition between crystallization and crosslinking (Promoter) Additive manufacturing of polymer composites (Co-promoter)
Graham Dobereiner is an Associate Professor and Robert L. Smith Early Career Professor in the Department of Chemistry at Temple University's College of Science and Technology. He received his Ph.D. from Yale University (2011) and completed postdoctoral research at MIT (2012-2014) after earning his B.S. from Brandeis University (2007). His research group develops novel homogeneous transition metal catalysts for synthetic chemistry applications spanning fine chemicals manufacturing, petrochemical processing, and drug discovery. The work integrates organometallic chemistry principles, combining organic molecular diversity with inorganic compound reactivity. Research areas include catalytic isomerization, oxidative synthesis, ligand design, and mechanistic studies of transition metal complexes. Analysis of his recent publications demonstrates strong emphasis on reaction mechanism elucidation, catalyst design for stereoselective transformations (particularly Z-selective isomerizations), and development of novel catalytic systems for sustainable synthesis. His group employs computational and experimental approaches to advance synthetic methodology.
Dr. Michael J. Katz is a Professor in the Department of Chemistry at Memorial University in St. John's, Newfoundland and Labrador, Canada. He leads an active research group focused on porous materials, particularly metal-organic frameworks (MOFs), with applications in gas storage, chemical separation, and catalysis. His work is well-recognized in the field of materials chemistry, with numerous publications in high-impact journals spanning from 2005 to 2025. Dr. Katz's primary research interests lie in the synthesis, properties, and applications of porous materials. His work specifically focuses on: Metal-Organic Frameworks (MOFs) design and synthesis Gas storage technologies, particularly low-pressure methane storage Chemical separation processes including removal of harmful molecules from air Catalysis using porous materials Adsorption properties of various porous frameworks Environmental applications of porous materials Analysis of Dr. Katz's publication record from 2017-2025 reveals a strong emphasis on zirconium-based MOFs, particularly the UiO-66 family. His research spans fundamental characterization techniques like NMR spectroscopy to practical applications in carbon capture, gas separation, and environmental remediation. A notable trend is the increasing focus on real-world implementation of MOFs, including biochar-based materials for CO 2 capture and frameworks for air pollutant removal such as nitrous acid. His work demonstrates a progression from fundamental materials science toward practical environmental applications. Dr. Katz actively supervises graduate students and postdoctoral researchers in his research group. His laboratory at Memorial University is equipped for the synthesis and characterization of novel porous materials, with particular expertise in metal-organic framework development. His research is supported by various grants that enable the exploration of structure-property relationships in porous materials and their practical applications.
Kumar Varoon Agrawal is an Associate Professor at École Polytechnique Fédérale de Lausanne (EPFL), holding the Gaznat Chair for Advanced Separations. He is affiliated with the School of Basic Sciences (SB), the Institute of Chemical Sciences and Engineering (ISIC), and the Laboratory of Advanced Separations (LAS) in Sion, Switzerland. Additionally, he contributes to the Swiss Doctoral School in Chemical and Bioengineering (SCGC) and serves as Vice President of the Confédération des Chimistes et des Génie Chimique (CCE). Research Focus: Material Chemistry & Engineering at the Ångström scale for high-performance inorganic and hybrid membranes, emphasizing energy-efficient molecular separations. Teaching: Courses include Fundamentals of separation processes , Diffusion and mass transfer , and Chemical engineering product design . Scientific Contributions: His 15 most recent publications (2025-2020) span topics like graphene pore engineering , 2D material synthesis , carbon capture , and gas separation membranes , with keywords such as Nanotechnology , Materials Science , and Molecular Transport . Subfields include Atomic-Scale Pores , Membrane Stability , and Industrial Scalability . Students and Collaborations: He advises 10 current PhD students and has mentored 9 past PhD candidates in areas like graphene membranes , ion separation , and MOF films . He is an Academic Referent for the EPFL Carbon Team and a committee member for the EDCH Doctoral Program in Chemistry and Chemical Engineering.
Simon Sharpe is a Professor in the Department of Biochemistry at the University of Toronto and a Senior Scientist at The Hospital for Sick Children. His research focuses on the structural and dynamic properties of self-assembling proteins, particularly those involved in degenerative diseases, elastomeric proteins, and biological phase separation. The Sharpe Lab utilizes advanced biophysical techniques such as NMR spectroscopy, X-ray scattering, and electron microscopy to investigate these phenomena. BSc: Memorial University of Newfoundland (Cell Biology and Biochemistry, 1997) PhD: University of Western Ontario (Biochemistry, 2002) Postdoctoral Training: NIH (Solid-State NMR, 2002-2006) Research interests include: Protein self-assembly mechanisms Amyloid formation in neurodegenerative diseases Elastin and resilin biophysics Lipid-protein interactions Biological phase separation Structure-function relationships Lab members include Research Associate Dr. Sean Reichheld and PhD students James Otis, Asal Nady, and Robert Lu. The lab has dedicated access to 600 and 700 MHz NMR spectrometers and collaborates with SickKids facilities including the SBC Facility and Imaging Facility. Scientific awards: Canada Research Chair (2006-2016) Ontario Early Researcher Award (2010) Dr. Sharpe has taught courses including BCH374Y1 (Research Project in Biochemistry) and BCH425H (Structural Biology: Principles and Practice). His recent publications examine topics ranging from serum amyloid A structure to bacterial phase separation defenses, with methodologies combining solid-state NMR, fluorescence microscopy, and computational approaches.
James C. Gumbart is an Adjunct Professor in the School of Physics at Georgia Institute of Technology, with additional affiliation to the School of Chemistry and the Institute for Bioengineering and Bioscience . His research leverages molecular dynamics simulations to decode the atomic-level mechanisms of bacterial proteins and cellular structures. B.S., Physics and Mathematics, Western Illinois University, 2003 Ph.D., Physics, University of Illinois at Urbana Champaign, 2009 Dr. Gumbart's work bridges computational biophysics and biochemistry to understand: Mechanisms of bacterial membrane protein insertion and nutrient import Structural dynamics of cell wall mechanics SARS-CoV-2 spike protein interactions with ACE2 Free-energy calculations for protein-ligand binding Applications of machine learning in biomolecular simulations His publications reflect trends in membrane protein biophysics , viral dynamics , and computational drug design , with a strong emphasis on interdisciplinary techniques. Awards include multiple fellowships and grants from NSF , DOE , and NIAID . He has mentored numerous PhD students, including Zijian Zhang , David Ryoo , and Andrew Pang , whose work has advanced understanding of bacterial systems and viral proteins. The Gumbart Lab integrates high-powered supercomputing and advanced software to model biomolecular processes, fostering collaborations with institutions like the National Institutes of Health and Argonne National Laboratory .
