Laurence ChapuyView profile
Adjunct Professor
Laurence Chapuy, MD, PhD is an Associate Investigator at the Research Institute of the McGill University Health Centre (RI-MUHC) and an Adjunct Professor in the Department of Pediatrics, Faculty of Medicine and Health Sciences at McGill University. He is affiliated with the Infectious Diseases and Immunity in Global Health Program and the Centre for Translational Biology at RI-MUHC. Dr. Chapuy's research focuses on immunological mechanisms underlying inflammatory bowel diseases (IBD). His work specifically examines the role of innate immune cells, particularly mononuclear phagocytes, in the inflammatory and fibrotic processes of patients with Crohn's disease and ulcerative colitis. His laboratory employs advanced techniques including single-cell RNA sequencing, transcriptomic analysis, and high-dimensional phenotypic mapping to characterize immune cell populations in intestinal mucosa and mesenteric lymph nodes. Analysis of Dr. Chapuy's recent publications reveals a consistent focus on cellular immunology in IBD, with particular emphasis on mononuclear phagocytes, CD14+ subsets, and Th17/Th1 responses. His work demonstrates significant differences in immune cell profiles between Crohn's disease and ulcerative colitis, providing insights into disease mechanisms and potential therapeutic targets. His research spans both adult and pediatric IBD populations, with recent work examining very early onset and early onset IBD in pediatric cohorts. As an Associate Investigator at RI-MUHC, Dr. Chapuy leads a research program investigating mucosal immunology in inflammatory bowel diseases. His work bridges basic immunology with clinical applications, aiming to translate findings into improved understanding and management of IBD. His research is conducted in collaboration with multiple investigators at McGill University and the McGill University Health Centre.








