Yoichi NakaoView profile
Professor
Yoichi Nakao is a Professor at the School of Advanced Science and Engineering, Faculty of Science and Engineering, Waseda University, specializing in natural products chemistry, chemical biology, and functional food chemistry. His research focuses on marine natural products, stem cell differentiation, and epigenetics, with significant contributions to understanding how natural compounds affect cellular processes. Dr. Nakao earned his Doctor of Agriculture from the University of Tokyo. His educational background includes undergraduate, master's, and doctoral studies all completed at the University of Tokyo between 1985 and 1994, followed by postdoctoral research at the University of Hawai'i Department of Chemistry from 1994-1996. His research spans multiple interdisciplinary fields with a particular emphasis on identifying bioactive compounds from natural sources. Nakao's work explores how marine organisms and traditional food sources produce compounds that influence stem cell differentiation, particularly neural stem cells into astrocytes, and how these processes relate to neurodegenerative diseases and depression. His laboratory investigates epigenetic modifications induced by environmental chemicals and natural products, with implications for developmental toxicology and disease prevention. A significant portion of his recent work focuses on sustainable applications, including serum-free cell culture systems using algal extracts for cultured meat production and regenerative medicine. Analysis of Nakao's recent publications reveals a strong focus on marine natural products chemistry, with numerous discoveries of novel compounds from sponges, cyanobacteria, and other marine organisms. His research increasingly integrates chemical biology approaches with stem cell technology, particularly using induced pluripotent stem cells to study epigenetic changes. There's also a growing emphasis on sustainable biotechnology applications, especially in developing alternatives to animal serum for cell culture, which has significant implications for cultured meat production and regenerative medicine. Dr. Nakao serves in various professional capacities, including as a committee member for the Natural Products Discussion Group (2011-present), the Japanese Society of Chemical Biology (2010-present), and the Chemical Ecology Research Group (2007-present). He is an active member of numerous professional societies including the American Chemical Society, Japanese Bioinformatics Society, and Japanese Society of Chemistry. His laboratory maintains active collaborations across multiple disciplines, working with researchers in microbiology, parasitology, and biomedical engineering. Current research directions include developing chemical probes for target identification, studying microbial interactions in marine environments, and exploring the therapeutic potential of natural compounds for neurological disorders and infectious diseases.
