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Yaojun ZhangView profile

Assistant Professor

• Biological Physics
• Biophysics
• Theoretical Physics
• +3 more

Yaojun Zhang is an Assistant Professor in the Department of Physics & Astronomy and the Department of Biophysics at Johns Hopkins University. She earned her PhD in Physics from the University of California, San Diego (2015), followed by postdoctoral fellowships at the Princeton Center for Theoretical Science (2015-2018) and the Princeton Center for the Physics of Biological Function (2018-2021). Her research focuses on biological physics, particularly the complex behaviors of biomolecules and their assemblies across scales—from single-molecule folding to intracellular transport and biomolecular phase separation. She employs theoretical, mathematical, and computational tools to bridge biological questions with physical principles. Education PhD in Physics, University of California, San Diego (2015) Postdoctoral Fellowships: Princeton University (2015-2021) Research Interests Her group studies biomolecular condensates and liquid-liquid phase separation, exploring how microscopic interactions determine macroscopic properties of cellular compartments. Key areas include: Biomolecular condensate formation and dynamics Phase separation in cellular environments Interactions between biomolecules and cellular components Biophysics of intracellular transport Collaborations & Tools Zhang collaborates with experimentalists to validate theoretical models and develops frameworks for understanding condensate functions, such as surface tension, stoichiometry, and phase diagrams. Her work addresses challenges like condensate stability, molecular exclusion, and biological function regulation. Labs & Resources She leads the Zhang Lab , which integrates experimental and computational approaches. Her team’s research is supported by resources at the Bloomberg Center for Physics and Astronomy.

Andre LevchenkoView profile

Professor

• Systems Biology
• Signal Transduction
• Cell Communication
• +5 more

Andre Levchenko is the John C. Malone Professor of Biomedical Engineering at Yale University, with secondary appointments in the Department of Neurosurgery and affiliations with the Cancer Signaling Networks, Immunology, and the Yale Program in Neurodevelopment and Regeneration. His research focuses on systems biology, signal transduction, and cell-cell communication, utilizing microfluidics and computational modeling to study cancer progression, stem cell behavior, and neurological disorders. PhD, Columbia University MEng, Moscow Institute of Physics and Technology Levchenko's work explores how cells process dynamic signals to make critical decisions, particularly in glioblastoma migration, organoid development, and cardiovascular tissue engineering. His lab develops innovative microfluidic platforms and mathematical models to dissect multicellular communication and signaling networks. Recent publications highlight his contributions to understanding YAP-driven cancer invasion , NOTCH signaling in angiogenesis , and metabolic regulation of hypoxia responses . He has pioneered methods for organoid modeling and single-cell analysis , advancing precision in biological signaling studies. Scientific Awards : Computational Molecular Biology Post-Doctoral Fellowship (Burroughs Wellcome Fund) National Academies Keck Futures Conference Invitee Distinguished Guest Lecturer, University of Virginia American Asthma Foundation Early Excellence Award Fellow, American Institute for Medical and Biological Engineering Levchenko leads the Levchenko Lab at the Yale Systems Biology Institute, collaborating with institutions like Mayo Clinic and Yale Cancer Center. His research has received recognition in Faculty of 1000 and multiple journal highlights.

Gert CauwenberghsView profile

Professor

• Neuromorphic Engineering
• Biomedical Integrated Circuits
• Neural Interfaces
• +7 more

Gert Cauwenberghs is a Professor of Bioengineering at the University of California San Diego (UCSD), affiliated with the Jacobs School of Engineering. He co-directs the Institute for Neural Computation and holds a visiting professorship at MIT. His research focuses on neuromorphic engineering, energy-efficient neural interfaces, and wearable biosensors. Key contributions include silicon-based adaptive neural circuits, implantable neural recording systems, and in-ear biosensing devices. Education: M.Eng. in Applied Physics (University of Brussels, 1988), M.S. and Ph.D. in Electrical Engineering (Caltech, 1989–1994). Prior roles include Professorships at Johns Hopkins University and Visiting Professor at MIT. Research Interests: Biomedical integrated circuits, neuromorphic computing, brain-machine interfaces, and energy-efficient neural systems. His work bridges neuroengineering and clinical applications, emphasizing adaptive intelligence and low-power designs. Recent Work: Development of femtojoule-efficient neural chips, high-density neural interfaces, and closed-loop wearable systems. Projects include neurobench benchmarking frameworks and RRAM-based neuromorphic hardware. Awards: NSF Career Award (1997), ONR Young Investigator (1999), PECASE (2000), IEEE Distinguished Lecturer (2003–2004). Grants & Labs: Active in NIH and DoD-funded projects, co-directs the UCSD Institute for Neural Computation. Collaborates with industry on neural interface technologies. Labs/Teams: Cauwenberghs Lab at UCSD focuses on integrated neuroengineering systems, including neural recording systems and neuromorphic computing architectures.

Andrew SpakowitzView profile

Professor

• Chromosomal organization and dynamics
• Protein self-assembly
• Polymer membranes
• +7 more

Andrew Spakowitz is a Professor of Chemical Engineering, Materials Science and Engineering, and by courtesy, Applied Physics and Chemistry at Stanford University. He currently serves as the Senior Associate Dean for Research and Faculty Affairs and holds the Tang Family Foundation Chair of the Department of Chemical Engineering. His academic career at Stanford spans from Assistant Professor (2006-2014) to Associate Professor (2014-2020) and now Professor since 2020. Dr. Spakowitz earned his PhD in 2004, MS in 2001 from the California Institute of Technology, and his BS in Chemical Engineering from the University of Wisconsin, Madison in 1999. He completed postdoctoral training in Molecular and Cell Biology and Biophysics at UC Berkeley from 2004-2006. His research focuses on theoretical and computational approaches to understanding biological processes and complex materials. The Spakowitz lab addresses fundamental chemical and physical phenomena through four main research themes: chromosomal organization and dynamics, protein self-assembly, polymer membranes, and charge transport in conducting polymers. His group employs diverse theoretical and computational methods including analytical theory of semiflexible polymers, polymer field theory, continuum elastic mechanics, Brownian dynamics simulation, equilibrium and dynamic Monte Carlo simulations, and reaction-diffusion modeling. Analysis of his recent publications reveals a strong emphasis on epigenetics and chromatin dynamics, with significant work on DNA methylation patterns, nucleosome clustering, and chromosome organization. His research also extends to polymer physics applications in biological systems, particularly in respiratory diseases, water purification membranes, and bacterial phage interactions with human mucus. Tang Family Foundation Chair of the Department of Chemical Engineering Professor Spakowitz mentors several graduate students and postdoctoral scholars in the Chemical Engineering and Materials Science departments. His lab members work on diverse projects spanning from chromatin dynamics to polymer membranes for water purification. He teaches multiple courses including CHEMENG 120B (Energy and Mass Transport), CHEMENG 340 (Molecular Thermodynamics), CHEMENG 466 (Polymer Physics), and CHEMENG 467 (Physics of Biomacromolecules). The Spakowitz lab operates from Clark S295 at Stanford University, conducting theoretical and computational research that bridges chemistry, physics, biology, and engineering disciplines to address complex problems across multiple length and time scales.

David VocadloView profile

Professor

• Bioorganic Chemistry
• Chemical Biology
• Glycobiology
• +3 more

David Vocadlo is a Distinguished Professor of Chemistry and Molecular Biology & Biochemistry at Simon Fraser University (SFU), holding the Canada Research Chair in Chemical Biology. His research focuses on Chemical Glycobiology, investigating carbohydrate-processing enzymes and developing chemical tools to study glycan roles in health and disease. His lab explores O-GlcNAc signaling, neurodegenerative disorders (e.g., Alzheimer’s, Parkinson’s), and enzyme inhibitors for therapeutic applications. Education: PhD from University of British Columbia (UBC), followed by a CIHR postdoctoral fellowship at UC Berkeley. Key roles include E.W.R. Steacie Memorial Fellow and Royal Society Fellow. Research highlights include O-GlcNAcase inhibitors for neuroprotection, glycan structure-function relationships, and enzyme activity imaging tools. Collaborates globally with experts in glycobiology and employs cutting-edge techniques like chemical synthesis, mass spectrometry, and live-cell imaging. Awards: Distinguished Professor title, Canada Research Chair, Royal Society Fellowship. Active in training researchers through SFU’s graduate programs, emphasizing interdisciplinary approaches. Lab members work on topics ranging from enzyme mechanisms to disease modeling.

Christoph SchmidtView profile

Professor

• Biophysics
• Cell Mechanics
• Microrheology
• +5 more

Christoph F. Schmidt is the Hertha Sponer Distinguished Professor of Physics at Duke University with cross-appointments in the Thomas Lord Department of Mechanical Engineering and Materials Science, Biology, and Biomedical Engineering. He serves as Co-Director of the Duke Materials Initiative and leads an active research program at the intersection of physics and biology. His educational background includes a D.R. from the Technical University of Munich (Germany) in 1988. Schmidt has established himself as a leading researcher in biophysics through decades of innovative work. Professor Schmidt's research spans multiple scales of biological organization, from single molecules to whole organisms. His lab investigates cellular mechanics using advanced techniques including optical trapping, atomic force microscopy, and microrheology. A significant innovation from his group involves single-walled carbon nanotubes for high-bandwidth intracellular tracking. Current research focuses on cardiomyocyte mechanics, Drosophila tissue dynamics, and computational analysis of complex biological systems. His work on motor proteins like Eg5 and ncd has provided fundamental insights into cellular division mechanics. His recent publications (2021-2025) demonstrate increasing integration of computational approaches with experimental biophysics, particularly in analyzing cardiac tissue mechanics and Drosophila sensory systems. The work shows progression from fundamental biophysical measurements toward applications in understanding disease mechanisms and biological function. Professor Schmidt teaches several courses including PHYSICS 995 (Graduate Training Internship), PHYSICS 493 (Research Independent Study), PHYSICS 415 (Biophysics II), PHYSICS 174 (Introduction to Frontiers of Biophysics), and BIOLOGY 425 (Biophysics II). He has successfully mentored numerous graduate students to completion, including recent PhD graduates Dr. Mingru Li and Dr. Xiaoxuan Jian. The Schmidt Lab, part of Duke's Physics Department and the Duke Soft Matter Center, maintains state-of-the-art equipment for optical trapping, atomic force microscopy, and advanced light microscopy. The lab participates in the Triangle Soft Matter Workshop, fostering collaborations with researchers from Duke, UNC Chapel Hill, and NC State University. Current research directions include mechanical responses of suspended cells, tracking non-equilibrium cellular fluctuations, nuclear mechanics, and bacterial membrane mechanics under turgor pressure.

Waldemar KolanusView profile

Professor

• Molecular Immunology
• Cell Signaling
• Signal Transduction Pathways
• +4 more

Prof. Waldemar Kolanus leads the Molecular Immunology and Cell Biology department at the University of Bonn's Life & Medical Sciences Institute (LIMES) . His research bridges immunoregulation , stem cell dynamics , and metabolic stress responses in immune cells. Unit 2 member at LIMES Principal investigator in SFB 704 and ImmunoSensation Cluster Leads a multidisciplinary lab with postdocs, PhD students, and technical staff His work focuses on intracellular signaling pathways connecting immune activation to tissue homeostasis, particularly through: Cytohesin proteins in integrin-mediated adhesion and migration TRIM71 in stem cell regulation and congenital hydrocephalus High-salt environments affecting macrophage function Publication trends show expertise in immune cell migration , genetic models , and chemical inhibition , with frequent use of mice and zebrafish for in vivo studies. Key articles explore: TRIM71's dual role in auditory development and germ cell maintenance Cytohesin family's Golgi regulation and insulin signaling Ruxolitinib's off-target migration inhibition of dendritic cells Contact details: Address: LIMES Institute, Carl-Troll-Straße 31, Bonn Email: kolanus.sekretariat@uni-bonn.de Phone: +49 228 73-62788

• Stem Cell Mechanobiology
• Bone Tissue Engineering
• Regenerative Medicine
• +3 more

Chao Liu is an Associate Professor at the Department of Biomedical Engineering , Southern University of Science and Technology (2024.11–present). Previously, he served as an Assistant Professor at the same institution (2019–2024.11) and completed a Postdoctoral Fellowship at New York University (2016–2019) with joint appointments in the Department of Biomedical Engineering and Orthopedics at NYU Langone Health . He holds a PhD in Biomedical Engineering (2016) and MASc in Mechanical Engineering (2010) from University of Toronto , following a BASc in Engineering Science (2008). Education : PhD (IBBME, U of Toronto, 2016), MASc (Mechanical Engineering, U of Toronto, 2010), BASc (Engineering Science, U of Toronto, 2008) His research focuses on mechanobiology of stem cells , bone tissue engineering , and functional implants . He investigates how mechanical forces modulate osteogenic and angiogenic stem cells, designs implants with micro-geometry to enhance cellular activity, and develops 3D real-time imaging modalities for bone repair processes. His work spans biomechanics , regenerative medicine , and cellular mechanotransduction . The selected publications from 2022 to 2010 reveal trends in mechanical force applications for bone regeneration, pharmacological impairments in healing, nanostructured biomaterials for stem cell differentiation, and microfluidic platforms for osteocyte studies. These works are published in journals like Bone , FASEB Journal , and ACS Applied Materials & Interfaces . Scientific Awards : International Conference BME Young Investigator Award (2019), IFMRS Travel Grant (2017), ASBMR Young Investigator Grant (2016), CIHR Travel Awards (2010–2014), Ontario Graduate Scholarship (2011–2013), Barbara and Frank Milligan Fellowship (2008, 2010) Chao Liu mentors graduate students, including Zhang Jianing (2022 Master’s graduate). His lab ( https://abtrl.bme.sustech.edu.cn/ ) recruits postdocs and research assistants for projects in mechanical force applications , micro-geometric implants , and 3D imaging . He has contributed to 14 journal articles with 714 citations and presented at 6 international conferences in the past three years.

Raffaele MezzengaView profile

Professor

• Self-Assembly Processes
• Biopolymers
• Protein-Based Materials
• +6 more

Prof. Raffaele Mezzenga is a Full Professor at ETH Zürich's Department of Health Sciences and Technology and Head of the Institute of Food, Nutrition, and Health. He earned his master's from Perugia University (Italy) and a PhD in Polymer Physics from EPFL, followed by postdoctoral work at UC Santa Barbara. His career includes roles at the Nestlé Research Center and the University of Fribourg before joining ETH in 2009. His research focuses on self-assembly processes in polymers, biopolymers, and colloidal systems, with applications in environmental remediation, bioplastics, and biomedical materials. Key contributions include pioneering protein-based materials and advancing understanding of amyloid fibrils. Education: Master's, Materials Science & Engineering, Perugia University PhD, Polymer Physics, EPFL Research Interests: Self-assembly, biopolymers, amyloid materials, sustainable technologies, food colloids, and soft condensed matter. Awards: 2011 AOCS Award, 2017 APS Fellowship, and 2013 Biomacromolecules Young Investigator Award. Visiting Roles: Held visiting professorships at Aalto University, RMIT, Monash University, Nanyang Technological University, and others. Labs/Teams: Leads the Institute of Food, Nutrition, and Health at ETH, focusing on interdisciplinary research in food science and biomaterials. His work bridges fundamental science and applied innovation, addressing global challenges in sustainability and health through materials science. Recent projects include creating bioplastics from food waste, developing amyloid-based water purification systems, and advancing targeted drug delivery via lipidic mesophases.

• Biomaterials
• Tissue Engineering
• Regenerative Medicine
• +12 more

Professor Hala Zreiqat AM is a leading biomedical engineer at The University of Sydney , serving as the Director of the ARC Training Centre for Innovative BioEngineering . A Fellow of all major Australian academies (AAS, ATSE, FAHMS, FRSN), she develops 3D printed bioceramics for bone regeneration while championing diversity through initiatives like the IDEAL Society and BIOTech Futures mentorship program. Her work bridges academia, clinical practice, and industry in musculoskeletal research . Research Focus: Her lab creates synthetic bone scaffolds that mimic natural bone architecture, strength, and porosity, enabling non-rejected bone regeneration via patient-matched implants. Key applications include orthopaedic, dental, and maxillofacial repair , with over $18M in competitive funding and multiple patents. Current projects explore AI-driven scaffold performance prediction and anti-senescence strategies for aging-related bone loss. Scientific Trends: Recent publications highlight 3D printed nanovoxelated ceramics , antisenescence biomaterials , and multifunctional theranostic platforms . Her team integrates machine learning for scaffold design, atom probe tomography for interface analysis, and two-photon imaging for cellular monitoring in 3D environments. 2021-2022 Fulbright Senior Scholar 2018 NSW Premier's Woman of the Year 2019 Eureka Prize for Innovative Use of Technology Fellow of Australian Academy of Science (2021) Over $18M in research funding Teaching & Leadership: She designed core courses like Tissue Engineering and Nanomaterials in Medicine , mentoring 158 students in 2020 alone. As Chair of CAAR (2020-2023), she strengthens Australia-Arab collaborations. Her lab trains early-career researchers , with alumni now in academia and industry.

Daniel RoxburyView profile

Associate Professor

• Nanoscience
• Carbon Nanotubes
• Nanomaterials
• +4 more

Dr. Daniel Roxbury is an Associate Professor and Graduate Director at the Department of Chemical, Biomolecular and Materials Engineering within the University of Rhode Island's College of Engineering. With expertise in nanoscience and carbon nanomaterials, his research focuses on nano-bio interactions, developing functionalized nanotubes for biomedical applications and environmental monitoring through his NanoBio Engineering Laboratory. His work spans multiple disciplines including: Biomedical nanosensors Smart wearable biomaterials Targeted drug delivery systems Environmental nanotechnology Single-molecule imaging Nanotoxicology Recent publications emphasize machine learning-enhanced spectral analysis, coral reef conservation nanotechnology, and wearable stress monitoring textiles. His 2024 ACS Nano study introduces AI-driven macrophage phenotyping, while 2023 Nature Nanotechnology work explores coral reef restoration strategies using nanomaterials. Awarded the 2019 NSF CAREER grant for cellular nanometrology, he leads multiple NIH-funded projects including: $820,000 NSF CAREER: Spectral Imaging for Sub-Cellular Nanometrology $140,000 Miriam Hospital COBRE: Cortisol Detection Textiles $700,000 NSF EAGER: Multiplexed Wound Biomarker Detection His laboratory houses state-of-the-art equipment including: Near Infrared Hyperspectral Microscope Custom NIR Fluorescence Spectrometer Jasco UV/VIS/NIR Spectrophotometer Biosafety Cabinet Cell Culture Incubator Cryo-Storage System

• Neuroscience
• Synaptic Plasticity
• Neural Circuit Formation
• +4 more

Colin J Akerman is Professor of Neuroscience and Group Leader in the Department of Pharmacology at the University of Oxford, concurrently serving as Corange Fellow and Medical Tutor at Corpus Christi College. His research investigates fundamental mechanisms of synaptic circuit formation and plasticity, with direct implications for epilepsy, dementia, and schizophrenia through multidisciplinary approaches integrating electrophysiology, optical imaging, and computational modeling. His primary research interests encompass Synaptic Plasticity, Neural Circuit Formation, and Excitatory-Inhibitory Balance, with specific focus on neuronal progenitor influences on connectivity, chloride dynamics in inhibitory transmission, and learning mechanisms in disease contexts. The lab employs custom-built equipment and molecular tools to probe synaptic function across in vivo , in vitro , and in silico platforms, emphasizing how activity-dependent processes shape neural networks during development and disease. Recent publications (2023-2025) reveal strong thematic convergence on intracellular chloride regulation in sleep-wake cycles, cortical circuit assembly from embryonic progenitors, and innovative optical tools for neural monitoring. This work bridges molecular neuroscience with systems-level understanding of synaptic plasticity, particularly regarding ionic mechanisms in epilepsy and sleep homeostasis. No scientific awards or fellowships are explicitly documented in the source materials. Professor Akerman currently mentors four PhD students (Vourvoukelis, Selfe, Wang, Gemayel) and multiple postdoctoral researchers, having previously trained scientists now leading independent groups in Toronto, Edinburgh, Cape Town, Oxford, and London. His research is funded by the European Research Council, Innovative Medicines Initiative, and Wellcome Trust, supporting investigations into synaptic mechanisms underlying neurological disorders. The Akerman Group, established in 2008, operates as an integrative neuroscience hub within Oxford's Pharmacology Department. The 10-member team combines expertise in patch-clamp electrophysiology, optogenetics, multiphoton imaging, and computational modeling, with current projects spanning neuronal progenitor biology, inhibitory synaptic plasticity, and learning rule implementation in neural networks. The lab emphasizes technical innovation, regularly developing custom instrumentation and molecular tools for neural observation and manipulation.

Simone D. CastellarinView profile

Professor

• Viticulture
• Berry Crop Physiology
• Plant Genomics
• +2 more

Simone D. Castellarin is a Professor in the Department of Applied Biology at the University of British Columbia's Faculty of Land and Food Systems, and holds the Canada Research Chair Tier 2 in Viticulture. His research focuses on the molecular and physiological mechanisms governing berry ripening and composition in grapes, blueberries, and raspberries, with emphasis on genomic regulation under environmental stressors like heatwaves and drought. PhD in Plant Biology from the University of Udine (2007) Postdoctoral training at Hochschule Geisenheim University and University of California Davis Research areas include terpene biosynthesis, jasmonate signaling, cuticular wax dynamics, and agronomic strategies for climate change mitigation. Key projects involve remote sensing for vineyard zoning , hormone application effects , and genetic studies of berry quality traits . His work spans collaborations with industry bodies like the BC Wine and Grape Council and academic partners including the Cantu Lab at UC Davis. Recent publications highlight genomic analyses of terpene synthases, water deficit impacts on metabolites, and postharvest quality assessments. Awards include the 2009 Rudolf Hermanns Prize for viticultural research. He supervises numerous PhD and Master's students, and leads the Castellarin Lab at UBC's Wine Research Centre.

Angelika RamboldView profile

Assistant Professor

• Immunology
• Cell Biology
• Metabolism
• +3 more

Dr. Angelika Rambold is a Group Leader at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany, heading the Laboratory for Metabolic Organelle Networks in Immunology within the Department of Developmental Immunology. Previously affiliated with the University of Münster's Center for Molecular Biology of Inflammation (ZMBE) and Institute of Medical Biochemistry until January 2025, she investigates how intracellular organelle networks regulate immune cell function during inflammation, infection, and metabolic stress. Her research centers on dynamic interactions between mitochondria, lysosomes, lipid droplets, and autophagosomes during cellular adaptation to nutrient deprivation and pathogen challenge. Key interests include organelle communication mechanisms in immune cell activation, metabolic reprogramming in T cells and macrophages, and how defects in organelle networks drive primary immunodeficiencies like Chediak-Higashi syndrome. She employs advanced live-cell microscopy, super-resolution imaging, metabolomics, and single-cell transcriptomics to dissect these processes in primary immune cells and human disease models. Analysis of her publication record reveals consistent focus on mitochondrial dynamics as a central regulator of immune cell metabolism and fate determination. Landmark studies demonstrate TFEB-mediated itaconate synthesis for bacterial control in macrophages and coordinated organelle network responses during starvation, establishing critical links between organelle communication, immunometabolism, and disease pathogenesis across multiple immune cell types. Dr. Rambold serves as a supervisor in the Cells in Motion International Max Planck Research School (CiM-IMPRS) Graduate Programme, mentoring PhD students in interdisciplinary research. Her laboratory maintains active collaboration with the Center for Chronic Immunodeficiency (CCI) at the University of Freiburg to translate basic findings on organelle-mediated immune defects into clinical insights for patient-oriented research.

Hillel AdesnikView profile

Professor

• Neuroscience
• Neural Circuits
• Optogenetics
• +6 more

Dr. Hillel Adesnik is a Professor in the Department of Neuroscience at the University of California, Berkeley, and a leading researcher in the neural basis of sensory perception. His lab focuses on cortical microcircuits, optogenetics, and neural coding, with emphasis on visual processing and memory formation. Key Research Areas: Cortical Microcircuits Optogenetic Tools Gamma Band Rhythms Neural Coding Mechanisms Dr. Adesnik has pioneered high-speed optical methods like 3D-MAP and 3D-SHOT to manipulate neural activity. His work spans cortical dynamics, synaptic plasticity, and cortical layer interactions, with applications in understanding learning algorithms and sensory inference. Selected Trends from Publications: Recent preprints and papers highlight advancements in cortical VIP neuron function, channelrhodopsin structures, and inter-areal computations. His team utilizes two-photon holography, cryo-EM, and computational modeling to decode perception-related neural codes. Scientific Awards: NIH Director's New Innovator Award (2013) Dr. Adesnik's lab collaborates with institutions like NIH and develops tools for awake animal studies. Funding includes grants from the Beckman Young Investigator Program and NIH.