Hypothalamic function Professors and Supervisors | ApplySharif

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Reilly T. EnosView profile

Assistant Professor

University of South CarolinaUnited States

Reilly T. Enos, PhD, is an Assistant Professor in the Department of Pathology, Microbiology & Immunology at the University of South Carolina School of Medicine. His research focuses on the molecular mechanisms of sex differences in obesity, particularly metabolic and inflammatory processes influenced by sex steroids. The Enos Lab employs rodent models and advanced metabolic phenotyping to investigate menopause-related metabolic dysfunction and complementary therapies. PhD, Exercise Science (Applied Physiology), University of South Carolina, 2013 Post-Doctoral, Complementary and Alternative Medicine in Cancer and Obesity, University of South Carolina School of Medicine, 2017 MS, Exercise Physiology, Baylor University, 2009 BS, Dietetics, University of Northern Colorado, 2010 BA, Spanish & Physical Education, College of Wooster, 2007 Dr. Enos’s research spans immunometabolism, obesity, cancer cachexia, and gut microbiota. His work explores how dietary components (e.g., quercetin, emodin), hormonal status (especially estrogen), and immune modulation (e.g., miR-155, macrophages) influence metabolic and oncological outcomes. He investigates sex-specific responses to high-fat diets, inflammation, and therapeutic interventions using transgenic and diet-induced mouse models. His recent publications highlight trends in metabolic physiology, inflammation, and cancer, often examining the interplay between adipose tissue, immune cells, and hormonal regulation. Key themes include the impact of vivarium conditions on reproducibility, the role of microRNAs in tumorigenesis, and the safety and efficacy of natural compounds. Dr. Enos has not been awarded any listed scientific prizes or fellowships in the provided texts. He advises a research team focused on metabolic and inflammatory disease models, frequently collaborating with researchers such as Erin A. Murphy and Kandy T. Velázquez. His lab receives funding for studies on obesity, cancer, and complementary medicine, though specific grants are not detailed. The lab is equipped for metabolic phenotyping and rodent model studies. The Enos Lab is dedicated to understanding sex-specific metabolic regulation and developing targeted therapies for obesity and cancer-related metabolic disorders, with a focus on translational relevance and experimental rigor.

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James CurleyView profile

Associate Professor

University of Texas at AustinUnited States

James Curley is an Associate Professor in the Department of Psychology at the University of Texas at Austin, part of the College of Liberal Arts. He is Co-Director of the Behavioral and Social Data Science Major and Principal Investigator of the Social Dynamics Lab. His research focuses on the neurobiological basis of social behavior, social hierarchies, and long-term physiological changes linked to social status. He earned his B.A. from the University of Oxford and a Ph.D. from the University of Cambridge, followed by postdoctoral work at Cambridge before joining Columbia University in 2012. At UT Austin since 2017, he has received awards including the Affordable Education Champion (2021), Dr. Wendy Domjan Excellence in Teaching Award (2021), and President’s Associates Teaching Excellence Award (2022). His teaching includes courses on statistics, R programming, and social behavior analysis. Curley’s lab investigates social dynamics through interdisciplinary approaches, combining behavioral studies with genomic, transcriptomic, and neuroendocrine analyses. He emphasizes open educational resources, co-authoring an open-access textbook for statistics and developing interactive learning tools. His work spans animal and human social systems, exploring how early life experiences shape behavior and how social hierarchy impacts neural and physiological processes. He has published extensively on topics like social dominance, gene expression, and the application of network models to understand social interactions. Teaching highlights include PSY 317L (statistics for behavioral sciences), PSY 120R (R programming), and UGS 302 (Being Social). His commitment to affordable education and innovative pedagogy has been recognized nationally. Research collaborations include studies on primate microbiota, stress vulnerability in depression models, and transgenerational epigenetic effects. He maintains affiliations with platforms like GitHub and Google Scholar, reflecting his embrace of open science principles.

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Paula GoforthView profile

Assistant Professor

University of Michigan-Ann ArborUnited States

Paula Goforth is an Assistant Professor at the University of Michigan Medical School , affiliated with the Department of Pharmacology and the Caswell Diabetes Institute . Her research focuses on the intersection of neuropharmacology and metabolic disease, particularly leptin signaling, orexin regulation, and hypothalamic circuits controlling glucose homeostasis and energy balance. Education: Postdoctoral training at Virginia Commonwealth University School of Medicine (2000-2004), specializing in Pharmacology under Dr. Satin LS. Her work explores neuron-specific metabolic regulation , including calcium channel modulation in obesity, orexin-glucose axis dynamics, and GABA-independent hypothalamic signaling. She employs techniques such as cell-type-specific circuit dissection and synaptic physiology to study these mechanisms. Recent publications highlight her expertise in leptin-regulated pathways , area postrema neuron function , and traumatic brain injury-related receptor changes , with implications for diabetes, obesity, and neurodegenerative diseases. Scientific Awards: NIH grants spanning 2013-2029, including dual awards for leptin action and gut-brain axis research Industry collaborations with Eli Lilly, Pfizer, and MedImmune LLC University of Michigan institutional support for diabetes/metabolic research Dr. Goforth's laboratory investigates metabolically coupled ion channels and neuronal population dynamics in metabolic disease models, with a strong emphasis on translational neuroscience applications.

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Sharmili Edwin ThanarajahView profile

Researcher

Max Planck Institute for Empirical AestheticsGermany

Sharmili Edwin Thanarajah is a researcher at the Goethe University Frankfurt , affiliated with the Faculty of Medicine and the Department of Psychiatry, Psychosomatics and Psychotherapy . Her work focuses on the intersection of peripheral metabolism, brain signaling, and mental health, utilizing advanced neuroimaging and intervention studies. Research Interests Impact of dietary factors on brain function Metabolism-neurocircuitry interactions Neuromodulation via vagus nerve stimulation Intranasal insulin's effects on cognition Translational psychiatry Key Publications Her research spans multidisciplinary areas including: Modulating midbrain activity through metabolic interventions Anti-inflammatory effects of vagus nerve stimulation Linking reward processing to habitual dietary patterns Neuroimaging-based studies of eating behavior Clinical applications of neuromodulation techniques Methods & Expertise She employs functional MRI , structural MRI , and intervention studies to explore these domains, with recent work addressing emotional processing and metabolic influences on mental health.

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Rui ChangView profile

Associate Professor

Yale UniversityUnited States

Rui Chang is an Associate Professor at Yale University School of Medicine , jointly appointed in the Department of Neuroscience and Department of Cellular and Molecular Physiology . His research focuses on organ-to-brain circuits and neurocardiology with specific interest in Parkinson's disease . He completed his B.S. in Biological Sciences at Tsinghua University (2005) Ph.D. in Neuroscience at University of Southern California (2011) Postdoctoral training in the lab of Stephen Liberles at Harvard Medical School (2017) Research Highlights: The Chang lab employs single-cell gene expression profiling , virus-based anatomical mapping , and optogenetics to investigate vagal interoceptive systems and their roles in cardiovascular regulation and gut-brain axis dysfunction in neurodegenerative diseases. Their work has revealed a multidimensional coding architecture for visceral sensory signals. Notable Scientific Awards: McKnight Neurobiology of Brain Disorders Award (2021) NIH Director’s New Innovator Award (2019) Kavli Faculty Innovative Research Award (2019) NIH K01 Mentored Research Scientist Award (2017) Keystone Symposia Future of Science Scholarship (2016) Collaborative Network: Chang collaborates with experts in neurodegeneration (David A. Hafler, MD), biostatistics (Hongyu Zhao, PhD), and neural imaging (Le Zhang, PhD). His work intersects with the Stephen & Denise Adams Center for Parkinson’s Disease Research and Kavli Institute for Neuroscience .

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Sangwon LeeView profile

Assistant Professor

Yale UniversityUnited States

Sangwon Lee is an Assistant Professor of Pharmacology at Yale University’s Yale School of Medicine. He holds primary appointments in Pharmacology and affiliations with the Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS) program, Janeway Society, and Molecular Medicine department. His academic journey includes a PhD in Chemistry and Biochemistry from the University of California, San Diego (2007), and earlier degrees from Konkuk University (MS 1998, BS 1996). Dr. Lee’s research focuses on structural biology and molecular mechanisms of FGF signaling pathways, particularly the role of β-Klotho and α-Klotho co-receptors in endocrine regulation. He designs novel protein-based inhibitors targeting oncogenic receptors and explores therapeutic applications of FGF pathway modulation. His work bridges computational protein engineering, cryo-EM structural analysis, and translational medicine. Key research trends include isoform-specific FGFR inhibition, structural oncology of KIT mutants, and bivalent interactions in FGF ligand systems. His lab collaborates extensively on projects involving designed oligomeric assemblies for vascular differentiation and drug delivery. Current efforts emphasize translating structural insights into therapeutic strategies for cancer and metabolic disorders. Dr. Lee’s academic contributions include leadership in the Yale Combined Program in the Biological and Biomedical Sciences (BBS), mentoring trainees, and serving on committees for academic promotion and interdisciplinary research. His laboratory is located at Sterling Hall of Medicine, Room 395F.

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Jaswant SinghView profile

Professor

University of SaskatchewanCanada

Jaswant Singh is a Professor at the Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine (WCVM), University of Saskatchewan. He serves as Associate Dean of Academic Excellence and Innovation at the College of Graduate and Postdoctoral Studies (CGPS). His work bridges veterinary reproductive biology with human health research, focusing on ovarian function and oocyte competence using bovine models. BVSc and AH (1983, Punjab Agricultural University, India) MVSc (1986, Punjab Agricultural University, India) PhD (1997, University of Saskatchewan, Canada) His research explores the molecular and endocrine control of ovarian follicles, with applications in cattle breeding and human reproductive disorders like endometriosis. He pioneered the use of GnRH antagonists for follicle synchronization and ultrasound biomicroscopy for in vivo oocyte imaging. His lab maintains specialized facilities for molecular and live-cell imaging. Dr. Singh’s work spans basic and applied research, including field studies on ergot alkaloids in cattle feed and domestic animal models for human prostate and endometrial disorders. He has authored over 135 peer-reviewed articles and secured 21 consecutive NSERC Discovery Grants. He mentors extensively, co-directed 13 reproductive ultrasonography workshops, and contributes to university governance as a University Council member and Chair of the Biomedical Engineering Division.

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Ali D. GülerView profile

Associate Professor

University of VirginiaUnited States

Ali D. Güler is an Associate Professor of Biology at the University of Virginia, leading the Güler Lab. His research focuses on neural circuits regulating feeding behavior and sleep, particularly how modern societal factors like food availability disrupt these processes. He holds a B.A. from Bowdoin College (1999), a Ph.D. from Johns Hopkins School of Medicine (2006), and completed postdoctoral training at Johns Hopkins University (2006–2008) and the University of Washington (2008–2013). Research interests include: Neural pathways linking reward centers and circadian clocks Metabolic disorders such as obesity and type 2 diabetes Pharmacological mechanisms of weight-loss drugs Alzheimer’s disease and circadian rhythm disruption Recent work highlights discoveries like the GLP-1 satiety circuit and dopamine’s role in hedonic feeding. His lab uses advanced tools such as optogenetics and real-time neurophysiology in mouse models. Advising and training include mentoring over 30 graduate and undergraduate students. Current projects explore circadian therapy for neurodegenerative diseases and molecular mechanisms of food anticipation. The lab is located in Gilmer Hall, Room 414.

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Matt VijayanView profile

Professor

University of CalgaryCanada

Matt Vijayan is a Professor in the Department of Biological Sciences at the University of Calgary, holding the NSERC Canada Research Chair (CRC I) in Environmental Physiology and Toxicology, and serving as Associate Head (Research). His research focuses on cellular and molecular mechanisms of stress tolerance, particularly corticosteroid regulation and environmental toxicant impacts on fish physiology. Education: B.F.Sc. (Fisheries Science, Tamil Nadu Agricultural University, 1982), M.F.Sc. (Fish Production, University of Agricultural Sciences, India, 1984), Ph.D. (Animal Physiology, University of Guelph, 1990), and postdoctoral studies at the University of Ottawa (1993). Research interests include stress signaling pathways, endocrine disruption by contaminants, and developmental programming. Current projects explore maternal stress effects, exosome-mediated intercellular communication, and long-term impacts of pollutants like bisphenol A and venlafaxine on fish growth and behavior. His work employs genomic/proteomic approaches, CRISPR-Cas9 knockout models in zebrafish, and field studies with Alberta native fish species. He teaches courses on energy flow in biological systems and animal physiology. Key contributions include identifying non-genomic cortisol signaling mechanisms, characterizing stress axis gene knockouts, and developing behavioral biosensors for environmental contaminants.

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Chang-Chun LingView profile

Professor

University of CalgaryCanada

Dr. Chang-Chun Ling is a Professor in the Department of Chemistry at the University of Calgary, affiliated with the Arnie Charbonneau Cancer Institute. He holds a PhD from the Université de Paris Sud (1991) and completed postdoctoral research in Dublin, Paris, and Edmonton. His research focuses on bioorganic chemistry, carbohydrate-based vaccines, glycosyltransferase inhibitors, and neuroinflammation modulation. He leads projects at the Alberta Glycomics Centre targeting infectious diseases and cancer. Education: B.S. Chemistry, University of Lanzhou, 1986 PhD Chemistry, Université de Paris Sud, 1991 Research interests include carbohydrate-protein interactions, synthetic carbohydrate chemistry, and glycoconjugate vaccines. His lab explores inhibitors for tumor-associated enzymes, conjugate vaccine design, and ECM-driven neuroinflammation in multiple sclerosis and stroke. Key achievements include developing fluorinated glycans for myelin regeneration and cyclodextrin-based liquid crystal electrolytes. Notable awards include the Alberta/Pfizer Translational Research Fund Award (2013) and Alberta Ingenuity New Faculty Award (2007). Current projects involve multidisciplinary approaches to combat multidrug-resistant infections and autoimmune conditions.

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Tony TiganisView profile

Professor

Monash UniversityAustralia

Tony Tiganis is a Professor in the Department of Biochemistry and Molecular Biology at Monash University, where he also serves as Laboratory Head and leads the Metabolism, Diabetes and Obesity Program at the Monash Biomedicine Discovery Institute. He holds a joint appointment as Laboratory Head at the Peter MacCallum Cancer Centre and is an Adjunct Professor at Yale School of Medicine. His multidisciplinary research focuses on protein-tyrosine-phosphatases (PTPs) and their roles in metabolism, cancer, and immunity. Ph.D. in Biochemistry, University of Melbourne (1990–1994) B.Sc. (Hons) in Pharmacology, University of Melbourne (1986–1989) Professor Tiganis’s research centers on tyrosine-phosphorylation-dependent signaling, with a focus on PTPs. His work has challenged long-standing misconceptions about PTPs being 'undruggable' and has revealed their critical roles in obesity, type 2 diabetes, cancer, and immune regulation. His lab has made seminal contributions to understanding redox balance in metabolic health, T cell tolerance mechanisms, and central control of energy balance. These discoveries have significant translational potential, including intranasal therapies for obesity and genetically engineered CAR T cells for solid tumors. His recent publications span high-impact journals such as Journal of Clinical Investigation , Nature Communications , and Cell Metabolism , highlighting trends in redox signaling, immunometabolism, and therapeutic targeting of PTPs in cancer and metabolic disease. His work is frequently cited and has garnered attention from news outlets, social media, and the pharmaceutical industry. Melbourne University Postgraduate Scholarship (1990) C.J. Martin Fellowship, NHMRC (1995) AMRAD Post-Doctoral Award (1998) St. Vincent’s Hospital Research Week, Senior Investigator Prize (1999) Deans Award in Excellence in Research (2009) NHMRC Principal Research Fellowships (2010–2015, 2016–2020) Tony Tiganis actively supervises PhD students and leads multiple research projects funded by the National Breast Cancer Foundation and Cancer Council Victoria. He serves as an editor for FEBS Journal , Molecular & Cellular Biology , and Science Advances . His lab operates the Monash Metabolic Phenotyping Facility and collaborates with clinicians and chemists on translational programs. He is also a Scientific Advisory Board Member at DepYmed Inc. and a Consultant for Regeneron Pharmaceuticals. He leads a multidisciplinary team exploring the intersection of metabolism, immunity, and cancer, with ongoing projects investigating the impact of obesity on anti-tumor immunity and phosphatase roles in cancer pathogenesis.

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Shuibing ChenView profile

Professor

Memorial Sloan Kettering Cancer CenterUnited States

Shuibing Chen is a Professor of Chemical Biology in Surgery at Weill Cornell Medical College, holding additional roles such as Kilts Family Professor of Surgery. She specializes in manipulating stem cell fate using chemical and biological approaches to generate functional tissues for translational research. Her work focuses on human pluripotent stem cells, including embryonic and induced pluripotent stem cells. Dr. Chen earned her PhD from The Scripps Research Institute (2006), and MS (2002) and BS (1999) degrees from Tsinghua University. Her research interests span bioactive small molecules, high-throughput screening, and chemical genetics, with therapeutic applications in cancer, cardiovascular diseases, and diabetes. Awards include the NIH Director’s New Innovator Award. Notable grants include studies on diabetes genetics, pancreatic beta cell biology, and AI-driven pancreas knowledge integration. She advises students in chemical biology and stem cell research, and collaborates with industry partners like Vesalius Therapeutics and iOrganBio INC. Dr. Chen’s lab develops scalable differentiation protocols for neurons and tissues, leveraging stem cells to model diseases such as diabetes and metabolic disorders. Her work bridges basic science with clinical applications, emphasizing regenerative medicine and drug discovery.

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Jaap KeijerView profile

Professor

Wageningen University & ResearchNetherlands

Jaap Keijer is a Full Professor and Chairholder in the Department of Human and Animal Physiology at Wageningen University & Research. His research focuses on metabolic physiology, particularly energy metabolism, mitochondrial function, and the interplay between diet, aging, and chronic metabolic diseases. He leads projects investigating nicotinamide nucleotide transhydrogenase (NNT) in energy metabolism, galactose's effects on metabolic programming, and the role of environmental factors like hypoxia in muscle physiology. He serves on the editorial board of Molecular Nutrition and Food Research and advises the German Institute of Human Nutrition. His work integrates molecular, cellular, and whole-organism approaches to understand health and disease mechanisms. Key research themes include metabolic adaptations in obesity, mitochondrial dysfunction in aging, and translational biomarker development for physical activity and metabolic health. Dr. Keijer teaches courses on molecular nutritional physiology, model organisms for lifespan research, and dissection-free human/animal physiology. His projects address clinical challenges such as sarcopenia, atrial fibrillation, and nutrient interventions for metabolic disorders. Recent studies explore dietary galactose's programming effects on intestinal metabolism and the impact of NNT deficiency on cardiac health. His lab employs advanced techniques like single-cell transcriptomics and Seahorse extracellular flux analysis to study metabolic pathways in humans and animal models. Publications emphasize mitochondrial dysfunction, metabolic biomarkers, and translational models for aging and disease. His work bridges basic research and clinical applications, aiming to improve metabolic health through dietary and lifestyle interventions. Current initiatives include developing a human gut-on-a-chip model and validating integrative biomarkers for physical activity in adolescents.

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Alex KeeneView profile

Professor

Texas A&M UniversityUnited States

Alex Keene is a Professor & Department Head at Texas A&M University, leading the Keene Lab focused on neural mechanisms underlying sleep, metabolism, and evolutionary adaptations. His research uses Mexican cavefish as a model to study sleep-metabolism interactions and evolutionary changes in nutrient-poor environments. Key contributions include genetic screens, brain atlases, and functional imaging of cavefish neural circuits. Education: B.Sc., University of Massachusetts-Amherst, 2002 Ph.D., Biomedical Sciences, University of Massachusetts Medical School, 2006 Research Interests: Dr. Keene explores how sleep and metabolism are genetically and neurologically integrated, particularly in extreme environments. His lab investigates cavefish adaptations, such as sleep intensity changes and hypothalamic reorganization, to uncover conserved mechanisms in sleep regulation and metabolic survival strategies. Publications: Recent work highlights sleep’s role in glial function, circadian rhythm disruption in cancer, and cavefish sensory evolution. His studies bridge genetics, neurobiology, and ecology to address fundamental questions in sleep physiology and evolutionary biology. Labs/Teams: The Keene Lab is located in Butler Hall (Office Rm 100, Lab Rm 201) and collaborates on projects involving comparative genomics, behavioral profiling, and neural imaging in model organisms.

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Adrienne M. AntonsonView profile

Assistant Professor

University of Illinois Urbana-ChampaignUnited States

Adrienne M. Antonson is an Assistant Professor in the Department of Animal Sciences at the University of Illinois Urbana-Champaign, affiliated with the College of Liberal Arts & Sciences Neuroscience Program. She leads the Antonson Developmental Neuroimmunology Lab, focusing on immunology, microbiology, and developmental neuroscience. Education: PhD in Immunophysiology and Behavior (University of Illinois Urbana-Champaign, 2018), Postdoctoral Fellow at Ohio State University (2018-2021) Affiliations: Microbial Systems Initiative, Carl R. Woese Institute for Genomic Biology (Environmental Impact on Reproductive Health Theme), Interdisciplinary Environmental Toxicology Program Her research investigates how prenatal maternal immune activation—via viral infections or stress—alters fetal microglial function and neurodevelopmental outcomes. Using translational animal models, she examines inflammatory pathways linking maternal insults to behavioral abnormalities and mental health disorders in offspring. Recent publications reveal critical insights into influenza A virus impacts on maternal-fetal immunity, epigenetic disruptions in hypothalamic development, and microbiome-mediated neuroinflammatory mechanisms. Her work emphasizes the maternal-fetal interface as a key regulator of neurodevelopmental trajectories. Contact: aantnsn2@illinois.edu , Edward R. Madigan Laboratory, 1201 W Gregory Drive, Urbana, IL 61801

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