Fletcher PaulView profile
Professor
- Neurobiological mechanisms of psychosis
- Computational psychiatry
- Appetite control and disordered eating
- +1 more
Professor Paul Fletcher holds the Bernard Wolfe Professorship of Health Neuroscience at the University of Cambridge and serves as Clinical Director of the Cambridge Neuroscience Interdisciplinary Research Centre. He is also a Wellcome Trust Investigator and Honorary Consultant Psychiatrist with NHS trusts. His research bridges clinical psychiatry and neuroscience, focusing on brain mechanisms underlying psychosis, appetite disorders, and decision-making. Graduating in medicine (1998), he has pioneered theories linking prediction-error signals to psychotic symptoms, published in Nature Reviews Neuroscience , and contributed to influential computational psychiatry frameworks. Education: Medical degree from University College London (1998), specialization in psychiatry. Research interests emphasize neurobiological mechanisms of psychosis, computational modeling in psychiatry, and the neural basis of eating disorders. His work on the game Hellblade: Senua’s Sacrifice earned a BAFTA award for its portrayal of mental illness. Awards include the James Bull Medal (2017) and Fellowship in the Academy of Medical Sciences (2012). Publications span translational neuroscience, with over 240 papers cited ~50k times. His lab integrates neuroimaging, pharmacology, and computational methods to study brain processes in health and disease, particularly schizophrenia, anorexia nervosa, and stress-related disorders.









