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Amit R. Reddi is a Professor at the Department of Chemistry, Georgia Institute of Technology. His research focuses on metalloproteins, particularly the mechanisms of heme trafficking and redox signaling in relation to cancer, neurodegenerative disorders, and infectious diseases. He has received numerous awards for both research and teaching excellence. Education : B.A. from Carleton College (2003) Ph.D. from Columbia University (2008) NIH Postdoctoral Fellowship at Johns Hopkins University (2013) Research Interests : The Reddi laboratory investigates cellular mechanisms of metalloprotein activation and inter-biomolecular communication in metabolic and signaling pathways critical to human health. Key projects explore heme trafficking pathways and the role of Cu/Zn Superoxide Dismutase (SOD1) in redox signaling, with implications for cancer, neurodegenerative diseases, and microbial pathogenesis. Scientific Awards : Vasser Woolley Faculty Fellowship (2021) Student Recognition of Excellence in Teaching Class of 1934 Award (2021) CTL/BP Junior Faculty Excellence in Teaching Award (2019) Bergmann Memorial Award (2018) Blanchard Professorship (2016) NSF CAREER Award (2015) NIH NRSA Post-doctoral Fellowship (2008-2011) Grants & Fellowships : NSF CAREER Award (2015) Sigma Xi Grants-In-Aid-of-Research (2003) NIH Cancer Research Training Award Fellowship (1999-2001)

• Biochemistry
• Metalloproteins in biological regulation and disease
• Heme trafficking and signaling
• +4 more

Markus Babst is a Professor of Biological Sciences at the University of Utah, where he leads research at the Center of Cell and Genome Science. His work focuses on protein trafficking mechanisms in eukaryotic cells using Saccharomyces cerevisiae as a primary model system. His educational background includes: Diploma from Federal Institute of Technology, Switzerland Ph.D. from Federal Institute of Technology, Switzerland Dr. Babst's research centers on post-translational regulation of plasma membrane proteins through endocytosis and endosomal sorting. Key investigations include ESCRT-mediated protein sorting into multivesicular bodies for lysosomal degradation and eisosome-regulated storage of nutrient transporters. His work demonstrates how calcium signaling and proton gradients control eisosome disassembly and transporter endocytosis, revealing fundamental mechanisms of cellular stress adaptation. This research bridges membrane biophysics, metabolic regulation, and organelle dynamics. Analysis of his 15 most recent publications shows persistent thematic focus on membrane tension regulation, ESCRT complex dynamics, and nutrient transporter control. His work increasingly integrates mitochondrial metabolism with plasma membrane organization while maintaining yeast genetics as the core methodology. Recurring subfields include membrane contact sites, lipid domain organization, and stress-induced protein trafficking changes. Dr. Babst's scientific contributions are evidenced by his extensive publication record in high-impact journals, though specific awards are not documented in available sources. While student mentorship details are unavailable in the provided materials, his laboratory employs biochemical, genetic, and cell biological approaches to investigate membrane protein regulation. Grant funding specifics are not mentioned in the source text. His laboratory operates within the University of Utah's biological research ecosystem, utilizing S. cerevisiae to dissect conserved eukaryotic mechanisms. Current work emphasizes plasma membrane tension dynamics, ER-plasma membrane contact sites, and metabolic regulation of membrane protein trafficking, with implications for understanding cellular adaptation in changing environments.

• Protein Trafficking
• ESCRT Complexes
• Eisosomes
• +5 more

Laura Dassama is an Assistant Professor at Stanford University with appointments in both the Department of Chemistry and Department of Microbiology & Immunology . She is actively affiliated with multiple interdisciplinary institutes including Bio-X , SPARK at Stanford , MCHRI , Sarafan ChEM-H , and Wu Tsai Neurosciences Institute . PhD in Biochemistry and Molecular Biology from Pennsylvania State University (2013) Postdoctoral training at Northwestern University (Molecular Biosciences, 2017) Research Associate position at Boston Children's Hospital/Harvard Medical School/Dana-Farber Cancer Institute (2018) Laboratory research focuses on chemical biology approaches to understand biomolecular interactions, particularly bacterial lipid trafficking and targeted protein degradation . Key methodologies include bioinformatic analyses , structural studies , and machine learning algorithms like SLiPP for lipid-binding pocket prediction. Recent publications emphasize antimicrobial resistance challenges and opportunities, protein delivery systems for erythroid cells, and structure-function relationships in lipid transport proteins. These studies demonstrate innovative approaches to address therapeutic limitations through chemical biology tools and interdisciplinary methods . MAC3 Impact Philanthropies Faculty Fellow (2023-2025) Terman Faculty Fellowship (2022-2025, 2018-2021) Hellman Faculty Scholar (2019-2020) Gabilan Junior Faculty Fellowship (2018-2021) Active advisor to multiple PhD candidates and postdoctoral researchers , with formal advising roles in Biophysics , Cancer Biology , and Microbiology & Immunology graduate programs. Laboratory located at Rm. W215 ChEM-H/Neuro Research Complex .

• Chemical Biology
• Bacterial Lipid Trafficking
• Antimicrobial Resistance
• +3 more

Matthew R. Dent is an Assistant Professor in the Department of Chemistry at Wayne State University’s College of Liberal Arts and Sciences. His research focuses on protein biochemistry, biophysical and bioinorganic techniques, and drug design. He holds a B.S. from James Madison University (2014), a Ph.D. in Chemistry from the University of Wisconsin–Madison (2019), and completed an NIH Postdoctoral Fellowship at the University of Pittsburgh (2019–2024). B.S., James Madison University, 2014 Ph.D. in Chemistry, University of Wisconsin–Madison, 2019 NIH Postdoctoral Research Fellow, University of Pittsburgh, 2019–2024 His research interests center on protein biochemistry, leveraging biophysical and bioinorganic methodologies, chemical computation, and bioinformatics. He investigates animal models of disease and drug design, particularly developing CO-sensing hemoproteins for medical applications and exploring heme-dependent signaling pathways in cellular contexts. Notable grants include NIH K99/R00 awards for optimizing hemoprotein-based CO antidotes and biosensors. His NIH postdoctoral fellowship supported studies on heme proteins and their medical applications. Additional grants focus on oxygen carrier development for hemorrhagic shock resuscitation. Though specific advisees are not listed, his research involves interdisciplinary collaborations. Grants emphasize CO poisoning treatments and oxygen delivery systems. His work bridges biochemistry, pharmacology, and medical applications. Labs or teams are not explicitly detailed in the provided information.

• Protein biochemistry
• Biophysical techniques
• Bioinorganic chemistry
• +4 more

David Antonetti, Ph.D., serves as Professor and Scientific Director at the University of Michigan's Kellogg Eye Center within the Department of Ophthalmology and Visual Sciences. His laboratory actively accepts new students and maintains dual appointments in Molecular & Integrative Physiology. Antonetti directs research focused on vascular barrier mechanisms with significant implications for diabetic complications and stroke. His research centers on the tight junction complex in blood-retinal and blood-brain barriers, investigating how diabetes and stroke compromise vascular integrity. Antonetti's lab pioneered the discovery that occludin phosphorylation regulates barrier properties, demonstrating that transgenic mice expressing phosphorylation-resistant occludin mutants preserve retinal vascular function during diabetes. Current work explores Norrin cytokine therapy for barrier restoration and occludin phosphorylation targeting for stroke treatment using biochemical, cell biological, and transgenic approaches. Award highlights include the Jules Francois Prize (2004), Hinkle Society Translational Research Award (2007), and Roger W. Kittendorf Research Professorship (2019). His publication trends reveal sustained focus on vascular permeability mechanisms, with recent emphasis on Norrin signaling, disheveled-claudin interactions, and therapeutic repurposing for diabetic retinopathy and stroke. Jules Francois Prize for Young Investigator in Ophthalmology (2004) Hinkle Society Mid-Career Translational Research Award (2007) Most Inspirational Teacher Award (2009) Jules and Doris Stein Professorship (2011) Roger W. Kittendorf Research Professorship (2019) Antonetti leads collaborative research with Dr. Dan Lawrence on blood-brain barrier mechanisms in stroke, and directs multiple institutional resources including the Michigan Research Experts Profile. His laboratory develops transgenic models and molecular techniques to translate barrier biology discoveries into novel therapeutics, with recent work focusing on controlled antibody delivery systems and repurposed drugs for vascular protection. The Antonetti lab operates within the Kellogg Eye Center's research infrastructure, utilizing advanced techniques including mass spectrometry, mutational analysis in endothelial cell culture, transgenic mouse modeling, and optical coherence tomography. Current projects investigate neurovascular unit interactions, occludin-dynein mechanics, and Norrin-based therapeutics for diabetic retinopathy, with strong translational emphasis on vision preservation.

• Diabetic Retinopathy
• Stroke
• Blood-Retinal Barrier
• +5 more

Dr. Kelly Chacón is the Arthur F. Scott Associate Professor of Chemistry at Reed College, affiliated with the Chemistry Department within the Division of Mathematical and Natural Sciences. Her research focuses on understanding how metal ions are trafficked within cells, employing biochemical and spectroscopic techniques. Her lab investigates protein-to-protein metal ion transfers, particularly in newly discovered metalloproteins, utilizing bi-annual synchrotron lightsource experiments. At Reed, she teaches Introductory Chemistry, Metabolic Biochemistry (with a focus on metal ions), and Biochemical Methods. She is actively involved in promoting diversity in chemistry through institutional support frameworks for underrepresented groups. Additionally, she contributes to the bioinorganic chemistry community and enjoys outdoor activities. Research Interests Metalloprotein interactions and metal ion transfer mechanisms Bioinorganic chemistry of copper, iron, and zinc Structural and functional studies of bacterial metalloregulatory systems Role of mucin glycoproteins in copper management at mucosal surfaces Recent Research Trends Her recent work emphasizes bacterial metal sensing (e.g., Pseudomonas aeruginosa’s BqsR/CarR system), copper binding in intestinal mucins, and zinc transfer mechanisms via proteins like AztD. Studies often integrate structural biology, biophysics, and systems-level approaches to uncover metalloprotein functions. Grants and Advising While specific grant details are not listed, her collaborative projects (e.g., H-NOX homologues in biofilm formation) suggest active funding. She mentors students in lab research, though no named advisees are provided here. Labs and Teams Her lab at Reed College collaborates with synchrotron facilities for advanced spectroscopic analyses. She also participates in interdisciplinary teams within the bioinorganic chemistry community.

• Bioinorganic Chemistry
• Metalloprotein Research
• Metal Ion Trafficking
• +3 more

Dr. Angela Wilks is the Isaac E. Emerson Professor and Program Chair in Chemical & Biological Discovery at the University of Maryland School of Pharmacy, Department of Pharmaceutical Sciences. She leads an active research laboratory focused on bacterial heme metabolism and iron homeostasis in Pseudomonas aeruginosa , a major opportunistic pathogen. University: University of Maryland School: School of Pharmacy Department: Department of Pharmaceutical Sciences Rank: Professor Her research integrates bacterial genetics, metabolomics, proteomics, and biophysical methods to understand how pathogens acquire heme as an iron source during infection. Her work has elucidated mechanisms of heme uptake, trafficking, and regulation, leading to the structural characterization of key proteins and the development of novel antimicrobial strategies. The trends in her recent publications reveal a strong focus on molecular mechanisms of heme signaling, regulation by sRNAs and metabolites, structural enzymology of heme oxygenase, and the design of inhibitors targeting heme metabolism. These studies span biochemistry, microbiology, and medicinal chemistry, with implications for treating antibiotic-resistant infections. Isaac E. Emerson Chair of Pharmaceutical Sciences Dr. Wilks mentors a dynamic team of graduate students and postdoctoral researchers, including joint students with Professors Fengtian Xue and Maureen Kane. Her lab has secured competitive NIH fellowships (F31, Diversity Supplements) and industry partnerships (Genentech). She collaborates extensively and has contributed to major resources like the Pseudomonas aeruginosa Metabolome Database (PAMDB). She leads the Wilks Lab, which investigates intracellular heme trafficking, regulation of heme uptake systems (Has and Phu), and the development of antimicrobial inhibitors targeting heme sensing and utilization. The lab employs high-throughput screening, NMR, HDX-MS, and biochemical assays in its therapeutic development efforts.

• Heme Metabolism
• Bacterial Pathogenesis
• Iron Homeostasis
• +7 more

Dr. Iqbal Hamza is a Professor holding joint appointments at the University of Maryland's Department of Animal & Avian Sciences (College Park) and the Department of Pediatrics at the University of Maryland School of Medicine (Baltimore). He leads groundbreaking research on heme trafficking mechanisms in eukaryotes, using C. elegans and parasitic nematodes as models. His work established foundational discoveries about heme import/export pathways and their relevance to human health. Key affiliations include the Center for Blood Oxygen Transport and Hemostasis (CBOTH), Biological Sciences Graduate Program, and collaborations with NIH institutes. He has held visiting roles at the University of Torino and NIH branches. Research focuses on heme's role in disease, particularly targeting parasitic infections and genetic disorders. Notable achievements include identifying conserved heme transporters in humans and parasites, leading to potential therapeutic applications. Awards include AAAS Fellowship and NIH career awards. Professional activities span grant review panels (NIH, NSF, international agencies), editorial roles at PNAS and eLife , and founding Rakta Therapeutics Inc. to commercialize heme-related therapies.

• Heme Trafficking
• Cell Biology
• Molecular Genetics
• +5 more

F. Wayne Outten is a Professor in the Department of Chemistry and Biochemistry at the University of South Carolina, affiliated with the McCausland College of Arts and Sciences. He holds the Guy F. Lipscomb, Sr. Professorship of Biochemistry. His research focuses on microbial metal metabolism, particularly Fe-S cluster biogenesis under stress conditions and metal homeostasis in bacteria. He has authored over 40 peer-reviewed publications and secured significant NIH and NSF funding. Education: B.S. in Biology (College of William and Mary, 1995); Ph.D. in Biochemistry (Northwestern University, 2001); Postdoctoral Fellowship at NIH (2001–2005). Awards include the Cottrell Scholar Award and Ada B. Thomas Advisor Award. Research Interests: Iron and copper homeostasis, oxidative stress responses, bacterial pathogenesis, and Fe-S cluster assembly pathways (Suf system). Key contributions include defining roles of SufBCD and SufE proteins in Fe-S cluster formation under iron starvation and oxidative stress. Grants: Current NIH support for studying Fe-S cluster dynamics and NSF funding for membrane biogenesis integration with metal metabolism. Collaborative projects include designing pH-responsive ferritin nanocages for drug delivery. Labs: GSRC 303, 304, 320, 321. Active in professional societies (ASBMB, ACS) and conference organization (Iron-Sulfur Biogenesis). Mentored 23 undergraduates, 16 Ph.D. students, and 3 postdocs. Military service includes roles in U.S. Army Reserve and National Guard.

• Microbial Metal Metabolism
• Bioinorganic Chemistry
• Microbial Physiology
• +7 more

Julia Kardon is an Assistant Professor of Biochemistry at Brandeis University . Her research focuses on the molecular mechanisms governing mitochondrial protein activity, quality control, and proteome adaptation to cellular demands. Research Areas: Mitochondrial protein regulation, heme biosynthesis, AAA+ unfoldases, lysosomal degradation, proteomics, and stress response. Education: Ph.D. from the University of California, San Francisco; B.S. from Yale University. Her work investigates how mitochondrial chaperones like ClpX interpret substrate signals to determine outcomes ranging from activation to degradation. Recent studies highlight ClpX's role in heme biosynthesis regulation and disease pathogenesis. Scientific awards include: National Science Foundation Pre-doctoral Fellowship (2004-2007) Ruth L. Kirschstein Postdoctoral Fellowship (NIDDK), NIH (2012-2015) Her publications span microbiology, structural biology, and cell biology, revealing insights into protein degradation mechanisms and mitochondrial-cytoplasmic interactions.

• Mitochondrial Protein Regulation
• Heme Biosynthesis
• AAA+ Protein Unfoldases
• +3 more

Dr. Andrea Galmozzi is an Assistant Professor in the Division of Endocrinology, Diabetes, and Metabolism at the University of Wisconsin-Madison School of Medicine and Public Health. His research focuses on understanding adipose tissue dysfunction in metabolic diseases, including obesity, type 2 diabetes, and cancer-associated cachexia. He employs a multidisciplinary approach integrating physiology, chemical biology (chemoproteomics, metabolomics), molecular biology, and in vivo models. Education: B.S. in Pharmaceutical Biotechnology, University of Milan, Italy Ph.D. in Biochemistry, University of Milan, Italy Postdoc in Chemical Physiology, Scripps Research, La Jolla, CA Key research areas include heme biosynthesis's role in adipocyte function, cancer cachexia mechanisms, and intracellular metabolite trafficking. His lab collaborates on advanced techniques like Orbitrap mass spectrometry for phosphoproteome analysis. Current projects explore heme's role in thermogenesis, tumor-adipose crosstalk in cachexia, and nuclear receptor ligand trafficking. Dr. Galmozzi's team includes postdoctoral fellows and graduate students specializing in cellular and molecular biology, nutritional sciences, and biochemistry. He actively seeks motivated researchers to join his lab, emphasizing expertise in mass spectrometry, metabolism, and coding.

• Metabolic Disorders
• Cell Biology
• Chemical Biology
• +4 more

Carla Marie Koehler is a Professor in the Department of Chemistry and Biochemistry at the University of California, Los Angeles (UCLA), affiliated with the College of Letters and Science. Her research program focuses on mitochondrial biology, including protein import machinery, RNA trafficking, redox regulation, and dynamics in health and disease contexts such as cancer and neurodegeneration. Her research investigates mitochondrial protein translocation pathways, redox-controlled folding mechanisms, RNA import/processing, calcium signaling, and metabolic reprogramming. Key areas include the development of small-molecule probes targeting mitochondrial import and the role of mitochondrial dynamics in cellular homeostasis. Her recent publications emphasize mitochondrial membrane potential imaging, calcium flux regulation, RNA trafficking, and mitochondrial network reorganization in diseases like lung cancer. Studies utilize advanced techniques including in vivo imaging, structural biology, and chemical screens, highlighting trends in mitochondrial bioenergetics and therapeutic targeting. Dr. Koehler has secured substantial NIH funding, including: R01NS120690: Control of calcium flux and mitochondrial fission by Mfn2 (2020-2025) R01DK101780: Small Molecule Probes for Primary Hyperoxaluria 1 (2015-2020) R01GM073981: RNA trafficking in mitochondria (2006-2025) R21HL082801: Cardiolipin remodeling in Barth Syndrome (2006-2009) She leads an active laboratory at UCLA specializing in mitochondrial biochemistry and collaborates extensively with researchers across institutions. Her team employs multidisciplinary approaches including genetics, chemical biology, and live-cell imaging to dissect mitochondrial functions.

• Mitochondrial Biology
• Protein Translocation
• RNA Trafficking
• +4 more

Ping-Xia Zhang, MD, PhD, is an Associate Research Scientist in the Department of Laboratory Medicine at Yale School of Medicine. She holds an MD from Henan Medical University (1983), a PhD in Immunology from Beijing Medical University (1995), and completed postdoctoral training at Yale University School of Medicine (1999). Dr. Zhang is affiliated with the Bruscia Lab, conducting research in pulmonary inflammation mechanisms. Her research focuses on molecular pathways underlying inflammatory responses in cystic fibrosis, including monocyte/macrophage adaptation, hematopoietic stem cell regulation, and signaling pathways like AKT/microRNA-199a-5p/CAV1. Key interests include lung microenvironment interactions, protein trafficking defects, and therapeutic modulation of hyperinflammation. Dr. Zhang's publications reveal consistent focus on cystic fibrosis pathogenesis, with recent work exploring ezrin-mediated monocyte adaptation in inflamed lungs and CDK9/RUNX1 mechanisms in hematopoietic differentiation. Her foundational studies established macrophage contributions to CFTR-related inflammation.

• Immunology
• Cystic Fibrosis
• Lung Inflammation
• +3 more

Li Zhang is Professor of Pharmacology & Physiology at the University of Maryland School of Medicine, with a secondary appointment in Surgery. She serves as Associate Director of Research and Acting Director of the Center for Vascular and Inflammatory Diseases (CVID), leading NIH-funded research on leukocyte biology and inflammatory diseases. Dr. Zhang earned her PhD in Biochemistry and Molecular Biology from the University of Notre Dame, completing postdoctoral training there. Prior to joining UMB, she held positions at the Cleveland Clinic Foundation's Lerner Research Institute and the American Red Cross's Holland Laboratory. Her research focuses on integrin CD11b/CD18 (Mac-1) mechanisms in macrophage migration, inflammation resolution, and immune regulation. Key projects examine how Mac-1 coordinates with LRP1, tPA, and PAI-1 for leukocyte trafficking in fibrin-rich environments, and its role in suppressing Th17 differentiation to maintain immune tolerance. Her work spans cardiovascular diseases, autoimmunity, and stem cell biology using CRISPR, single-cell RNAseq, and murine models of atherosclerosis, stroke, and multiple sclerosis. Recent publications reveal CD11b's dual roles: promoting macrophage migration via fibrin-VLDL receptor interactions while suppressing inflammatory pathways in obesity and arthritis. Her studies increasingly highlight tissue-specific macrophage functions—particularly resident vs. inflammatory subsets—in disease progression and resolution, with therapeutic implications for targeting Mac-1 in atherosclerosis and MS. No specific scientific awards are documented, though her 2010 JCI paper was highlighted by Faculty of 1000 Biology. Continuous NIH funding since the 1990s underscores her research impact. Dr. Zhang mentors postdoctoral fellows and leads multiple NIH R01 projects: R01NS082607 (2013-2019) on Mac-1/PDGF-CC in stroke; AHA 18TPA34170550 (2018-2021) on CD11b + leukocytes in atherosclerosis; R01HL142909 (2019-2023) targeting Mac-1 for atherosclerosis; and R01NS110630 (2019-2024) on CD11b in multiple sclerosis. She serves on NIH study sections and as editorial board member for Current Drug Targets . Her laboratory employs advanced techniques including live-cell imaging, CRISPR, and single-cell RNAseq to dissect macrophage heterogeneity in vascular and inflammatory diseases. Current projects investigate resident macrophage origins in atherosclerosis and microglial CD11b functions in blood-brain barrier integrity during stroke.

• Cardiovascular diseases
• Autoimmunity
• Inflammation
• +7 more

Dr. Jianli Zhao is an Assistant Professor and Physiological Core Director of Animal Models in the Department of Biomedical Engineering at the University of Alabama at Birmingham, jointly affiliated with the School of Engineering and Heersink School of Medicine. His research focuses on cardiovascular complications of diabetes, molecular mechanisms of ischemic injury, and adipokine signaling pathways. Primary research interests include: Molecular basis of diabetic cardiovascular complications Cellular mechanisms of ischemia-reperfusion injury Adiponectin signaling in cardioprotection Nicotine-induced vascular dysfunction Therapeutic strategies for heart failure Dr. Zhao's recent publications (2021-2023) demonstrate consistent focus on molecular cardiology, diabetic vasculopathy, and cardiac protection mechanisms. Key themes include adipokine regulation, oxidative stress pathways, exosome-mediated intercellular communication, and novel therapeutic targets for ischemic heart disease. As director of the Physiological Core of Animal Models, he oversees preclinical research infrastructure supporting cardiovascular investigations across the institution.

• Cardiovascular Disease
• Diabetic Complications
• Molecular Cardiology
• +2 more