Find Academic Supervisors

Sriram SubramaniamView profile

Professor

• cryo-electron microscopy
• structural biology
• drug-design
• +4 more

Sriram Subramaniam is a Professor in the Department of Biochemistry and Molecular Biology at the University of British Columbia (UBC) and holds the Gobind Khorana Canada Excellence Research Chair in Precision Cancer Drug Design. His research leverages cryo-electron microscopy (cryo-EM) to advance structural biology and drug design, focusing on protein dynamics and therapeutic target identification. Education: PhD in Physical Chemistry (1987) from Stanford University; MSc in Chemistry (1981) from Indian Institute of Technology, Kanpur. Subramaniam's interdisciplinary work combines cryo-EM with computational tools and molecular biology to study protein structures at atomic resolution. His lab has pioneered cryo-EM applications in precision medicine, including mapping small molecule drugs on patient-specific cancer mutants. Recent publications (2024-2022) highlight his contributions to understanding SARS-CoV-2 immune evasion, structural mechanisms of ATPases, and AI integration in structural biology. His research spans viral entry mechanisms, CRISPR systems, and neurodegenerative disease pathways. Scientific Awards: Gobind Khorana Canada Excellence Research Chair NIH Director’s Award for Scientific Excellence Fellow of the Biophysical Society Breakthrough Prize nomination Based at the Djavad Mowafaghian Center for Brain Health, Subramaniam leads the Program in Cryo-EM Guided Drug Design, contributing to over 177 peer-reviewed publications with a career h-index of 58 and citations exceeding 12,340.

Vadim CherezovView profile

Professor

• Membrane Protein Structure and Function
• G Protein-Coupled Receptors (GPCRs)
• Lipid-Protein Interactions
• +3 more

Vadim Cherezov, the Ester Dornsife Chair in Biological Sciences and Professor at the University of Southern California (USC), leads groundbreaking research in membrane protein structure and function. Affiliated with the Bridge Institute, Department of Chemistry, and Michelson Center for Convergent Bioscience, his work focuses on GPCRs, ion channels, and transporters—critical targets for drug discovery. His team leverages advanced techniques like Lipidic Cubic Phase (LCP) and Serial Femtosecond Crystallography (SFX) at XFEL facilities to solve high-resolution structures under physiological conditions. Institutional Affiliations: Bridge Institute, USC Michelson Center, Department of Chemistry, Department of Pharmacology and Pharmaceutical Sciences. Key Collaborations: Katritch Lab, Kuhn Lab, NIH, European XFEL. His research explores the role of lipids in modulating GPCR function, addressing diseases like Alzheimer’s, diabetes, and cancer. By solving the structure of the A 2A adenosine receptor via sulfur SAD phasing at XFEL, Cherezov’s lab demonstrated de novo phasing without heavy atoms. This breakthrough enables structural studies of previously intractable membrane proteins. Scientific Awards & Grants: NIH R01 GM108635, U54 GM094618, U54 GM094599, R01 GM095583 Science Signaling Breakthroughs of the Year (2014) Cherezov mentors a dynamic team, including postdocs (e.g., Dong-Gyun Kim), graduate students (e.g., Behnaz Davoudinasab), and alumni (e.g., Benjamin Stauch at Eli Lilly, Nairie Michaelian at Genentech). His lab’s publications span Nature , Science , and Cell , with recent work on Science Advances (2025) addressing ABEL-FRET for GPCR dynamics.

Jessica WilliamsView profile

Assistant Professor

• Neuroimmunology
• Multiple Sclerosis
• Astrocyte Biology
• +5 more

Jessica Williams, PhD is an Assistant Professor in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute (LRI) with additional faculty appointments at Case Western Reserve University, Kent State University, and Cleveland State University. She serves as the Cleveland Clinic liaison for Kent State University and represents the Clinic on the Executive Council for the Brain Health Institute and the Biomedical Sciences Graduate Program Executive Committee. Education: Postdoctoral Fellowship in Neuroimmunology, Washington University School of Medicine (2017) Ph.D. in Immunology, The Ohio State University (2011) M.S. in Physiology, Purdue University (2006) B.S. in Biology/Chemistry, Lindenwood University (2004) Dr. Williams' research focuses on neuroimmune interactions during multiple sclerosis, particularly examining regional responses of CNS glia to immune stimuli and astrocyte-immune crosstalk. Her lab employs murine MS models, primary human and murine cell analyses, and MS patient lesion assessment to investigate cytokine-mediated neuroprotection and CNS repair mechanisms. Recent work highlights protective astrocyte functions mediated by traditionally deleterious cytokines. Analysis of her 15 most recent publications reveals consistent focus on neuroimmune crosstalk in MS, with increasing emphasis on astrocyte heterogeneity, cytokine signaling (particularly IFNγ), and novel therapeutic targets like immunoproteasomes. Key themes include regional CNS differences in immune responses, glial cell repair mechanisms, and translating basic findings into potential MS therapies. Scientific Awards: Lerner Research Institute Excellence in Education Award (2022) Mentor of the Year Award (2023) Dr. Williams actively mentors the next generation of scientists as evidenced by her CIMER Trained Mentor certification and the graduation of PhD student Brandon Smith. Her research is supported by significant funding from the NIH, National MS Society, W.M. Keck Foundation, Brain Health Research Institute, and Neurological and Vision Impact Area. She regularly serves on study sections for the NIH, National MS Society, and Department of Defense. The Williams Laboratory investigates the interplay between immune and central nervous systems during MS, with current projects examining cytokine-mediated neuroimmune crosstalk for CNS repair and regionally distinct glial responses to inflammation. The lab employs advanced techniques including murine MS models and primary human cell analyses to identify novel therapeutic pathways for MS patients.

Mark WallaceView profile

Professor

• Membrane Biology
• Biophysics
• Optical Microscopy
• +3 more

Mark Wallace is a Professor of Chemistry at King's College London, affiliated with the Department of Chemistry and the Faculty of Natural, Mathematical & Engineering Sciences. He holds a Royal Society University Research Fellowship (2005–2016) and has been a lecturer at Oxford University before joining King's in 2016. His research focuses on membrane protein function and artificial membrane mimics, combining optical microscopy and nanotechnology. He earned a PhD from the University of Cambridge (2002) and postdoctoral training at Stanford University and the National Institute for Medical Research. Key research interests include membrane protein dynamics, lipid bilayer engineering, and single-molecule imaging. He has pioneered techniques like droplet interface bilayers and interferometric scattering microscopy. His work has led to patents and applications in molecular sensing and medical research. Awards include the 2002 Gregorio Weber Prize and the 2015 RSC Norman Heatley Award. He is actively involved in public outreach, including video podcasts and educational competitions. Recent publications emphasize artificial ion channels, nanoparticle formation monitoring, and mitochondrial protein dynamics. His lab collaborates with institutions like the London Centre for Nanotechnology and the Rosalind Franklin Institute. Over 30 students and researchers have been mentored, with active grants from EPSRC, Wellcome Trust, and BBSRC.

Oliver SeitzView profile

Professor

• Chemical protein synthesis
• DNA/RNA-templated reactions
• Bioorganic synthesis
• +6 more

Prof. Oliver Seitz leads the Bioorganic Synthesis research group at the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Humboldt University of Berlin. His lab focuses on cutting-edge chemical biology approaches for protein/nucleic acid interrogation, with recent work advancing DNA/RNA-programmed assemblies for cellular imaging and therapeutic applications. Research spans chemical protein synthesis, glycoprotein/phosphoprotein engineering, and nucleic acid-templated reactions. Key innovations include Forced Intercalation (FIT) probes for wash-free RNA imaging, loss-of-affinity principles for catalytic efficiency, and peptide-PNA conjugates for targeted cellular delivery. The group actively develops tools for live-cell protein labeling and biomolecular spatial screening. Recent publications (2021-2024) emphasize fluorescence-based detection systems, catalytic templated reactions, and therapeutic peptide synthesis. Trends show increasing sophistication in multi-dye probes, glycan engineering, and RNA-triggered pro-drug activation. Scientific awards include: Max Bergmann Award (2019) Prof. Seitz actively advises doctoral students, with recent graduates Marvin Björn Stutz (2023, magna cum laude ), Dino Gluhacevic von Krüchten (2023, summa cum laude ), and Sophie Schöllkopf (2023, magna cum laude ). Current PhD candidates include Ekaterina Kazakova (glycoprotein synthesis), Alina Herfort (phosphoproteins), and Lina-Marie Beck (peptide-nucleic acid conjugates), with postdocs like Dr. Mandana Oloub (viscosity sensors). The Bioorganic Synthesis lab operates within Berlin's vibrant chemical research ecosystem, utilizing specialized techniques for chemical protein synthesis and nucleic acid detection. Recent team growth reflects ongoing projects in RNA imaging, catalytic templated reactions, and therapeutic conjugate development, supported by open positions for new researchers.

Jana ShenView profile

Professor

• Molecular Simulation
• Data Science
• Kinases
• +12 more

Jana Shen is a Professor in the Department of Pharmaceutical Sciences at the University of Maryland School of Pharmacy, where she leads an interdisciplinary research group at the intersection of chemistry, biology, physics, and computer science. Her lab develops and applies advanced simulation and data science tools to understand biomolecular mechanisms and accelerate drug discovery. Education: Postdoc, The Scripps Research Institute (2003–2007) PhD, University of Minnesota at Twin Cities (1999–2003) MS, University of Calgary, Canada (1996–1999) Diplom-Chemie, Bergische Universität Wuppertal, Germany (1991–1995) Her research focuses on molecular simulation , data science , and computational biophysics , with applications in kinases , GPCRs , transmembrane transporters , and pH-responsive materials . She has pioneered the development of continuous constant pH molecular dynamics (CpHMD) methods and their applications in drug design and biomolecular mechanisms. The recent publications highlight a strong trend in computational drug discovery , particularly in covalent inhibitors , opioid receptor mechanisms , antiviral design , and the integration of machine learning with molecular dynamics . These works span high-impact journals such as eLife , JACS , Nature Communications , and ACS journals. Scientific Awards: National Science Foundation CAREER Award American Chemical Society HP Outstanding Junior Faculty Award Junior Faculty Research Award (University of Oklahoma, 2008, 2009) Phi Kappa Phi, University of Minnesota Louise T. Dosdall Graduate Fellowship Nova Graduate Fellowship Dr. Shen has mentored numerous PhD students and postdoctoral fellows, many of whom have gone on to successful careers in academia and industry. Her research is supported by major agencies including the National Institutes of Health , National Science Foundation , and FDA . She leads the Shen Lab, which actively develops open-source tools such as DeepCys , CpHMD , and PKAD-3 , and maintains databases for covalent ligandability and pKa predictions.

Anna G OrrView profile

Assistant Professor

• Neuroscience
• Neurodegenerative Diseases
• Astrocyte Biology
• +5 more

Anna G Orr serves as Nan and Stephen Swid Assistant Professor of Frontotemporal Dementia Research and Assistant Professor of Neuroscience at Weill Cornell Medical College's Brain and Mind Research Institute since 2016, leading pioneering research on astrocyte biology in dementia pathogenesis. Her educational background includes: Ph.D. from Emory University (2008) B.S. from Allegheny College (2002) Dr. Orr's research program centers on astrocytic-neuronal interactions , mitochondrial signaling , and neuroimmune mechanisms through three interconnected pathways: neuroimmune , oxidative , and G protein-coupled signaling . Her lab investigates how these mechanisms influence neuroinflammation, protein aggregation, synaptic function, and behavioral outcomes in dementia, with parallel therapeutic discovery efforts targeting astrocytic pathways for novel dementia treatments. Analysis of her 15 most recent publications (2025-2010) reveals escalating focus on astrocyte-specific dementia mechanisms , particularly mitochondrial ROS signaling, sex-dimorphic memory effects, TDP-43 pathology interactions with antiviral pathways, and lipid dysregulation in neurodegeneration. Her work consistently bridges molecular discoveries with therapeutic applications, demonstrating increasing NIH funding support for translational approaches. Key scientific recognitions include: NIH K99/R00 Pathway to Independence Award (2017) Leon Levy Fellowship in Neuroscience (2021) Nan and Stephen Swid Endowed Professorship (2021) Outstanding Neuroscience Teaching Award (2021) Dr. Orr actively mentors eight trainees across career stages, including Ph.D. candidates Evelyn Hardin and Constance Zhou, while securing major NIH grants as Principal Investigator for projects like Uncovering Dementia-Related Lipid Alterations in Astrocytes (NIA 2024-2026) and Mitochondrial Complex III Free Radicals in Dementia Pathology (NIA 2020-2026), alongside collaborative awards from the Alzheimer's Association. Her Orr Lab maintains a dual focus on mechanistic astrocyte biology and therapeutic translation, with current projects examining astrocytic TDP-43 dysregulation, mitochondrial complex III signaling, and sex-specific memory mechanisms using advanced in vivo techniques and disease models.

Kristen PleilView profile

Associate Professor

• Neuroscience
• Pharmacology
• Neuropharmacology
• +4 more

Kristen Pleil is an Associate Professor at Weill Cornell Medicine in the Graduate School of Medical Sciences, affiliated with the Department of Pharmacology and Neuroscience. She serves as Co-director of the NIGMS-sponsored Training in Pharmacological Sciences (TIPS) predoctoral T32 program. Academic Appointments: Assistant Professor (2016), Associate Professor (2021) Education: BA in Psychology (Emory University, 2005), PhD in Neuroscience (Duke University, 2010), Postdoc at University of North Carolina School of Medicine Research Focus: The Pleil lab investigates how sex and stress hormones regulate alcohol/substance use, stress responsivity, and affective behavior through neuropeptidergic brain circuits and hormone-neuropeptide signaling. Key projects include estrogen's role in alcohol drinking and anxiety, opioid receptor signaling in reward/aversion learning, and sex-dependent thalamic control of stress responses. The lab uses in vivo and ex vivo mouse models to study synaptic/epigenetic plasticity across developmental stages. Publications Trends: Her work spans molecular pharmacology, neurophysiology, and addiction research with a focus on sex differences in neuropsychiatric diseases. Articles cover topics like estrogen signaling in binge drinking, opioid-context memory, thalamic circuits in stress response, and optogenetic tools for receptor imaging. Scientific Awards: President’s Young Investigator Award, ISBRA (2013) Elizabeth Young New Investigator Award, OSSD (2015) K99/R00 Pathway to Independence Award, NIAAA (2015) Kellen Foundation Junior Faculty Fellowship (2016) NARSAD Young Investigator Award (2017) Early Career Investigator Award, NIDA-NIAAA (2017) Training and Collaborations: As Co-director of the TIPS T32 program, she mentors graduate students in pharmacological sciences. Her collaborations include researchers at UNC, Duke, and Weill Cornell, with grants from NIAAA, NIMH, and NIGMS.

Justin EnglishView profile

Assistant Professor

• Directed Evolution
• Protein Engineering
• Molecular Tool Development
• +5 more

Justin English serves as Assistant Professor of Biochemistry at the University of Utah School of Medicine, where he develops molecular tools to investigate human health and disease mechanisms through directed evolution and protein engineering approaches. Education: B.A. from Cornell University Ph.D. from University of North Carolina at Chapel Hill Research Focus: Dr. English's laboratory specializes in Directed Evolution and Protein Engineering to create molecular tools for studying G-protein Coupled Receptors (GPCRs) , cell signaling pathways , and neuroscience applications . His work integrates synthetic biology with classical pharmacology to develop innovative platforms like VEGAS for mammalian cell evolution and TRUPATH for GPCR transducerome analysis, with significant implications for drug discovery and therapeutic development. Publication Trends: Analysis of his 2019-2025 publications reveals consistent focus on GPCR biology, featuring breakthroughs in biosensor development (nanobody-based receptor monitoring), chemogenetic tools (BioTAC system), and high-throughput screening platforms. His research demonstrates strong translational potential in neuroscience, particularly through engineered mouse models for psychedelic drug studies and molecular tools for mapping small-molecule interactomes. Research Environment: Dr. English leads an active laboratory within the University of Utah's Department of Biochemistry, leveraging institutional core facilities for biochemical and molecular studies. His research program maintains strong collaborative ties with neuroscience and pharmacology groups, with ongoing projects focused on advancing molecular engineering techniques for biomedical applications as detailed on his lab website.

Craig MorrellView profile

Professor

• Platelet Biology
• Vascular Inflammation
• Thrombosis
• +5 more

Craig Morrell is a Professor at the University of Rochester School of Medicine and Dentistry , with joint appointments in the Departments of Medicine , Microbiology and Immunology , and Pathology and Laboratory Medicine . He serves as Associate Director of the Aab Cardiovascular Research Institute . Education: Sc.B. in Biology, Brown University (1995) D.V.M. , Tufts University School of Veterinary Medicine (2000) Ph.D. in Pathobiology, Johns Hopkins University (2005) His research examines the interface between platelets, vascular biology, and immune cells , focusing on platelet roles in thrombosis, inflammation, and immune regulation. Using advanced mouse models , his lab investigates platelet-derived mediators like β2M and PF4 in diseases such as malaria, stroke, and myocardial infarction. Article trends highlight platelets' dual roles in thrombosis and immune modulation , with recurring themes in vascular inflammation , ERK5 signaling , and age-related immune dysfunction . Scientific Awards: Kenneth M. Brinkous Young Investigators Prize (2008) Deans Gift research award (2006) Multiple travel scholarships and fellowships (2003-2005) Pathology Award-Excellence in Pathology (2000) Mentoring and Teaching : He has mentored 8 doctoral students , 7 undergraduates , and 6 postdoctoral fellows , with a focus on diversity. He serves on thesis committees and the URMC MSTP (MD/PhD) admissions committee . Labs and Collaborations : Leads the Morrell Lab at the Aab Cardiovascular Research Institute, collaborating with institutions like Johns Hopkins and Medical College of Wisconsin.

Nathaniel NucciView profile

Associate Professor

• Protein Biophysics
• Spectroscopy
• Drug Development
• +11 more

Nathaniel Nucci is an Associate Professor at Rowan University's College of Science & Mathematics, jointly appointed in the Department of Biological & Biomedical Sciences and Physics & Astronomy. His research bridges biophysics, structural biology, and nanotechnology to understand protein behavior in confined environments. Education Ph.D., Biochemistry and Molecular Biophysics, University of Pennsylvania M.S., Biochemistry and Molecular Biology, University of New Hampshire B.S., Biochemistry and Molecular Biology, University of New Hampshire Research Interests Dr. Nucci's lab focuses on: Protein biophysics in crowded/confining environments Reverse micelle technology for biomolecular studies Hydration dynamics of proteins (NMR-based methods) Structural biology of disease-related proteins (PHDs, p53) Drug delivery systems for protein therapeutics Nanoparticle synthesis with protein conjugation Research Trends His recent publications demonstrate expertise in using reverse micelles to study: Protein structural stability under confinement Hydration dynamics of therapeutic proteins Microenvironmental effects on phase-separating proteins Conformational changes in GPCRs Interfacial interactions in biomolecular systems Scientific Awards Gary J. Hunter Excellence in Mentoring Award (2024) College of Science and Mathematics Excellence in Academic Student Support (2022) Teaching Philosophy Emphasizes applied and experiential learning, integrating recent scientific discoveries into classroom practice and promoting hands-on scientific investigation.

Fadia KamalView profile

Associate Professor

• Osteoarthritis Research
• Chondrocyte Biology
• Cartilage Homeostasis
• +5 more

Fadia Kamal, PharmD, PhD is an Associate Professor holding dual appointments in the Department of Orthopaedics and Rehabilitation and the Department of Cell and Biological Systems. She leads research at the Center for Cannabis and Natural Product Pharmaceuticals (CCNPP) with a strong publication record including 33 research outputs and an h-index of 18 based on Scopus data. Dr. Kamal's research focuses on cellular pathways that control chondrocyte homeostasis in healthy tissue and the pathological processes leading to cartilage damage in osteoarthritis. Her work investigates how chondrocytes transform into pathological cells that cause cartilage degradation, with particular interest in discovering new pathways and drugs to control chondrocyte behavior and potentially reverse osteoarthritis progression. Her laboratory also explores the therapeutic potential of non-euphorigenic cannabis compounds for bone fracture pain management and healing. Her recent publications demonstrate a strong trend toward interdisciplinary research combining orthopedics, molecular biology, immunology, and pharmacology. The work spans from fundamental cellular mechanisms in osteoarthritis to applied therapeutic development, with particular emphasis on cannabis-based treatments, immune responses in fracture healing, and novel imaging techniques. Her research shows increasing collaboration across multiple institutions and disciplines. Scientific Awards: Samuel Hinkle Junior Faculty Research Scholar Award (2022) - widely recognized with coverage by 5 news outlets, blogged by 1 source, posted by 38 X users, and shared on 1 Facebook page with 33 Mendeley readers Dr. Kamal serves as Principal Investigator on significant research projects, most notably the NIH-funded 'Therapeutic targeting of GPCR Gbetagamma-GRK2 in osteoarthritis' project (2019-2023) from the National Institute of Arthritis and Musculoskeletal and Skin Diseases. Her mentorship is evident through numerous co-authored publications with junior researchers who appear to be her students and postdoctoral fellows. She maintains active collaborations across immunology, bone healing, and natural product pharmacology research areas. Her work contributes to UN Sustainable Development Goals related to health and well-being, with research spanning osteoarthritis, heart failure progression, chondrocyte biology, and G protein-coupled receptor research. The Kamal lab maintains strong connections with the Center for Cannabis and Natural Product Pharmaceuticals, indicating a specialized research focus on natural compounds for musculoskeletal conditions.

Iwan de EschView profile

Professor

• Drug Design
• Fragment-Based Drug Design (FBDD)
• Computer-Aided Drug Design (CADD)
• +5 more

Prof. Iwan de Esch is a Full Professor in the Department of Chemistry and Pharmaceutical Sciences at VU University Amsterdam, leading the Drug Design & Synthesis division and serving as Head of Department. He holds dual appointments in the Faculty of Science and AIMMS (Amsterdam Institute for Molecular and Life Sciences). His research focuses on understanding molecular interactions for drug discovery, employing CADD and FBDD approaches. He co-founded three biotech companies (De Novo Pharmaceuticals, IOTA Pharmaceuticals, Griffin Discoveries) and coordinates the EU-funded FRAGNET network. PhD from VU University (1998) Postdoc at University of Cambridge (Drug Design Group) Recipient of the 2011 Galenus Research Prize Received grants from EU-FP7, IMI, and Dutch STW Research interests span fragment-based drug design, receptor-ligand interactions, and pre-clinical drug candidate development. His work impacts GPCRs, PDEs, kinases, and protein-protein interactions. He teaches courses on drug discovery methodologies and computational tools. Over 200 peer-reviewed publications and 8 datasets/software contributions highlight his impactful career.

Surl-Hee AhnView profile

Assistant Professor

• Molecular Dynamics Simulations
• Enhanced Sampling Methods
• Drug Discovery
• +7 more

Surl-Hee Ahn is an Assistant Professor in the Department of Chemical Engineering at the University of California, Davis. Her research focuses on using molecular dynamics (MD) simulations and enhanced sampling methods like the weighted ensemble (WE) to study biological systems, including proteins, nanocrystals, and drug discovery for tuberculosis and other diseases. She leads the Ahn Lab, which develops cutting-edge computational tools, such as ParGaMD and DeepWEST, to advance kinetic and thermodynamic sampling in simulations. Education: Ph.D. in Chemistry (Chemical Physics), Stanford University M.S. in Chemistry, University of Pennsylvania M.A. in Mathematics, University of Pennsylvania B.A. in Biochemistry and Mathematics, University of Pennsylvania (Magna Cum Laude, Vagelos Scholar) Research Interests: Molecular dynamics simulations, enhanced sampling methods, computational drug discovery, vaccine design, protein interactions, and nanomaterial dynamics. Her work bridges computational biology, materials science, and pharmacology, with applications to infectious diseases and neurodegenerative disorders. Awards and Recognition: 2020 ACM Gordon Bell Prize Winner (SC20) for SARS-CoV-2 spike dynamics simulations 2021 Chancellor’s Outstanding Postdoctoral Scholar Award Finalist MIT Rising Stars in Mechanical Engineering (2018) ACS PHYS Division Young Investigator Award (2021) Grants & Collaborations: Her research is supported by grants from SC20/SC21 and leverages high-performance computing for multiscale modeling. She collaborates on projects like #COVIDisAirborne, combining AI with computational microscopy. Labs & Teams: The Ahn Lab at UC Davis emphasizes interdisciplinary training in computational methods and their application to real-world biomedical challenges.

Graham LaddsView profile

Professor

• Pharmacology
• G protein-coupled receptors
• Signal Bias
• +5 more

Professor Graham Ladds is a Professor of Receptor Pharmacology at the University of Cambridge's Department of Pharmacology and Fellow of St John's College. He serves as Co-Director of the Cambridge Academy of Therapeutic Science and Director of Studies for Pharmacology. His academic journey includes a BSc in Biochemistry from the University of Birmingham and PhD in yeast pheromone signalling from the University of Warwick, where he progressed to Associate Professor before joining Cambridge in 2015. His research focuses on G protein-coupled receptor (GPCR) pharmacology, specializing in: Agonist bias mechanisms and signaling dynamics Mathematical modeling of receptor-ligand interactions RAMPs (Receptor Activity-Modifying Proteins) in Class B1 GPCRs Intracellular calcium signaling pathways Development of biosensors for receptor activity screening He employs multidisciplinary approaches combining pharmacological assays, computational modeling, and machine learning. His recent publications demonstrate strong focus on adenosine receptor pharmacology, GPCR signaling bias, and therapeutic applications for metabolic/cardiovascular disorders. Research frequently appears in high-impact journals with significant industry collaboration themes. Honors include: Fellow of the British Pharmacological Society (2020) Royal Society Industry Fellowship for collaboration with AstraZeneca He leads a 17-member research group investigating GPCR signaling dynamics and maintains active industry partnerships with GSK, Takeda, and AstraZeneca. His teaching includes lectures on drug-receptor interactions and diabetes therapeutics for medical/natural sciences students. Laboratory activities focus on: BRET-based molecular probing of GPCR interactions Development of computational models for receptor activation Calcium signaling studies continuing legacy of Professor Colin Taylor Industry-linked drug discovery projects