Jonathan BohlenView profile
Researcher
Jonathan Bohlen serves as a Research Group Leader at the Gene Center, Ludwig Maximilian University of Munich (LMU), within the Department of Biochemistry. His laboratory focuses on mRNA translation mechanisms in human immunity, bridging molecular biology with clinical immunology to understand fundamental cellular processes. His educational background includes: Doctorate (2017-2020) at the German Cancer Research Center (DKFZ), Heidelberg M.Sc. in Molecular Biology (2015-2017) at Karls-Ruprecht University, Heidelberg B.Sc. in Biotechnology (2011-2015) at Hochschule Mannheim, Mannheim Dr. Bohlen's research centers on translational regulation in immune cells, with three primary focus areas: Translational Regulation in T Cells, Monogenic Ribosomopathies and Immunodeficiency, and tRNA Metabolism, Biogenesis, and Autoinflammatory Disease. His work explores how mRNA translation mechanisms affect leukocyte function and how disruptions in these processes lead to immunological disorders. By utilizing primary human leukocytes as a model system, his laboratory addresses the critical gap in understanding translational control in human physiology, which has been historically limited by the scarcity of live primary samples. Analysis of his recent publications reveals a consistent focus on the intersection of mRNA translation mechanisms and human immunity, particularly regarding IFN-γ responses to mycobacterial infections. His work demonstrates how specific translation factors (MCTS1, PRRC2) regulate critical immune proteins like JAK2, providing mechanistic insights into how translational defects lead to immunodeficiency. The publications span high-impact journals including Cell, Journal of Clinical Investigation, and Nucleic Acids Research, reflecting the significance of his contributions to understanding inborn errors of immunity through the lens of translational regulation. His scientific achievements have been recognized with prestigious awards: Marie Skłodowska-Curie Actions (MSCA) Postdoc Fellowship (2022) EMBO Postdoc Fellowship (2021) DFG Walter Benjamin Postdoc Stipendium (2021) RNA Society/Scaringe Graduate Student Award (2020) Dr. Bohlen actively mentors students and seeks motivated Master's students for internships and thesis projects focusing on molecular biology of mRNA translation. His laboratory aims to achieve three significant outcomes: enhanced understanding of ribosome and mRNA biology in leukocytes, insights into leukocyte involvement in genetic diseases of mRNA translation, and identification of pathomechanisms underlying severe genetic diseases. The research has direct clinical relevance to understanding and potentially treating immunological disorders with translational defects. The Bohlen Lab operates within the Gene Center Munich, a central scientific institution at LMU that fosters interdisciplinary research in genome biology, immunology, virology, and oncology. The lab's work exemplifies the institution's mission of advancing science beyond traditional disciplinary boundaries.











