Marieke KlijnView profile
Assistant Professor
Dr. Marieke Klijn is an Assistant Professor at the Department of Biotechnology, Faculty of Applied Sciences, Delft University of Technology. Her research focuses on data-driven bioprocess development, leveraging process analytical technology (PAT) to enhance real-time monitoring and control of bioprocessing strategies across industries. She leads the Marieke Klijn Group, which develops frameworks for integrating data from process analyzers to improve process understanding and product quality in continuous and intensified bioprocessing environments. Her work emphasizes flexibility in bioprocessing approaches, including monitoring, control, and technology development. Recent studies highlight applications in stem cell culture bioreactors, synthetic co-culture systems, and PAT miniaturization for biopharmaceuticals. She advises multiple PhD candidates researching topics like CFD modeling, off-gas measurements, and microbial cell factories for cellular agriculture. Key research directions include optimizing bioreactor designs, enhancing Raman spectroscopy models for fermentation monitoring, and predicting protein behavior in chromatography. Her group collaborates on projects funded by industry and academic partnerships, addressing challenges in bioprocess scalability and real-time quality assessment.






