Xinshu XiaoView profile
Professor
Xinshu Xiao is a Professor in the Department of Integrative Biology and Physiology at the University of California Los Angeles, within the College of Letters and Science. She leads an active research laboratory focused on RNA biology and computational genomics, with significant contributions to understanding RNA editing, alternative splicing, and their roles in neurological disorders and cancer. Dr. Xiao earned her PhD in Health Sciences and Technology from the Massachusetts Institute of Technology in 2004. Her research career has been marked by continuous NIH funding and innovative methodological developments in transcriptome analysis. Her primary research interests center on RNA editing mechanisms, particularly A-to-I editing, and their implications in neurological disorders like schizophrenia and Alzheimer's disease, as well as cancer. She has developed several important computational tools for RNA analysis, including RASER, L-GIREMI, and dsRID. Her work bridges computational biology with molecular mechanisms, employing long-read RNA sequencing technologies to uncover novel aspects of RNA processing. Analysis of her recent publications reveals a strong focus on the intersection of RNA biology with neurological disorders, particularly schizophrenia and Alzheimer's disease, alongside significant work in cancer genomics. Her research increasingly incorporates long-read sequencing technologies to resolve complex aspects of RNA processing that were previously inaccessible with short-read approaches. Dr. Xiao currently serves as Principal Investigator on multiple NIH grants, including R01AG078950, R01CA262686, R01AG075206, and R01MH123177, demonstrating sustained funding success across multiple research domains. Her laboratory, the Xiao Lab, maintains active collaborations across multiple disciplines and institutions, as evidenced by her extensive publication record with diverse co-authors spanning computational biology, neuroscience, and cancer research fields.
