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Mårten HägglundView profile

Researcher

• Protein oxidation
• Mass spectrometry
• Protein cross-linking
• +5 more

Mårten Hägglund serves as a Special Consultant in the Department of Biomedical Sciences within the Faculty of Health and Medical Sciences at the University of Copenhagen. He maintains an active research profile through the Inflammation, Metabolism and Oxidation research group (Davies Group), focusing on protein oxidation mechanisms and advanced analytical methodologies. His laboratory is situated at Blegdamsvej 3B in Copenhagen N. Hägglund's research centers on understanding how oxidative modifications alter protein structure and function, with particular emphasis on supramolecular assemblies and protein aggregates. He has pioneered mass-spectrometry-based approaches for detecting intra- and intermolecular cross-links, while maintaining a longstanding investigation into thioredoxin systems and thiol-disulphide exchange reactions. His work bridges fundamental biochemistry with implications for inflammatory and metabolic diseases, utilizing cutting-edge proteomic techniques to map oxidative damage at molecular resolution. Analysis of his recent publications (2024-2025) reveals consistent methodological innovation in oxidative proteomics, with applications spanning mitochondrial metabolism, neutrophil biology, vascular systems, and lung tissue models. His research demonstrates particular expertise in singlet oxygen chemistry, hypochlorous acid modifications, and halogen speciation effects on protein function. Hägglund frequently collaborates with the Davies research group and international partners, publishing in high-impact journals including Free Radical Biology and Medicine and Redox Biology . Hägglund maintains active research collaborations across multiple countries as indicated by international co-authorship networks. His work receives recognition through citations in Wikipedia pages and academic platforms like Mendeley. The Davies Group laboratory environment provides the infrastructure for his mass spectrometry-based research on protein oxidation, with particular focus on the biochemical consequences of oxidative modifications in disease-relevant contexts.

• Soil Ecology
• Microbial Ecology
• Environmental Microbiology
• +3 more

Jonathan Donhauser serves as an Assistant Professor in the Department of Biology at the University of Copenhagen, specializing in Terrestrial Ecology. His research investigates soil-ecosystem interactions with a focus on microbial communities and environmental change. Research interests encompass: Soil ecology and biogeochemistry Microbial community responses to aridity and elevation Greenhouse gas fluxes and soil organic matter dynamics Bioinformatic tool development for microbial trait modeling Methodological innovations in soil DNA extraction His recent publications (2023-2025) emphasize methodological advances and climate change impacts on soil functions. Key themes include the development of the R package MicEnvMod, analysis of Europe-wide forest soils, and the role of soil properties in mediating microbial activity and ecosystem services. Scientific awards: None mentioned. Advising and grants: No information provided. Dr. Donhauser maintains active collaborations across European institutions, contributing to international research networks in soil science and ecology.

• Proteomics
• Epigenetics
• Molecular Biology
• +2 more

Jonas Walter is a Research Fellow at the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, working in the Choudhary Group led by Professor Chunaram Choudhary. His research focuses on proteomics and epigenetics, particularly investigating protein acetylation mechanisms and their role in gene regulation within chromatin dynamics. Walter's work spans molecular biology and disease modeling, with emphasis on histone/non-histone acetylation, enhancer activation by CBP/p300 enzymes, and transcriptional regulation. He applies stem cell technologies to model Parkinson's disease, examining RHOT1 gene mutations and Miro1 protein dysfunction. His interdisciplinary approach integrates proteomics, genomics, and cell biology to dissect fundamental regulatory processes. His recent publications (2021-2024) demonstrate consistent focus on acetylation-driven chromatin regulation, revealing how histone H2B marks identify active enhancers and how transcription machinery assembles at these sites. The work bridges basic epigenetic mechanisms with neurodegenerative disease modeling, particularly through induced pluripotent stem cell applications for Parkinson's research. No scientific awards were mentioned in the provided text. No information regarding student advising or research grants was provided in the source material. Walter operates within the Choudhary Group at the Novo Nordisk Foundation Center for Protein Research, a leading international hub for proteome-wide analysis of protein modifications, interactions, and functions in health and disease contexts.

• Molecular Imaging
• Cancer Diagnostics
• Peptide Therapeutics
• +5 more

Julie Maja Leth is a researcher at the Biotech Research & Innovation Centre (BRIC) within the University of Copenhagen, working in the Ploug Group. Her research focuses on the urokinase-type plasminogen activator receptor (uPAR) and its applications in cancer diagnostics and therapeutics. She maintains an active research profile with publications spanning molecular imaging, peptide engineering, and biochemical analysis of protein interactions. Her research interests center on developing molecular imaging techniques for cancer detection, particularly through uPAR-targeted approaches. This includes creating peptide-based imaging agents for fluorescence-guided surgery, optimizing radiolabeling techniques for PET imaging, and investigating the structural biology of uPAR interactions. Her work bridges biochemistry, oncology, and medical imaging to develop novel diagnostic and therapeutic strategies. Analysis of her publication record shows consistent contributions to molecular imaging techniques, with particular emphasis on uPAR-targeted applications across multiple cancer types. Her research demonstrates progression from fundamental biochemical studies of protein interactions toward translational applications in surgical oncology and diagnostic imaging. Dr. Leth actively collaborates with the Ploug and Kjaer research groups at BRIC, contributing to both basic science investigations of protein receptor biology and applied research in cancer diagnostics. Her work has been referenced in multiple patents, indicating translational potential of her research. Her laboratory work centers on the Ploug Group at BRIC, where she investigates uPAR receptor biology using biochemical, biophysical, and imaging approaches. The research environment supports both fundamental studies of protein interactions and applied development of imaging agents for clinical translation.

• Cancer Biology
• Cell Biology
• Molecular Biology
• +2 more

Kasper Johansen Mygind is an Assistant Professor in the Erler Group at the University of Copenhagen's Faculty of Health and Medical Sciences (SUND) and the Biotech Research and Innovation Centre (BRIC), based at Ole Maaløes Vej 5 in Copenhagen, Denmark. His research focuses on: Cancer metastasis and tumor microenvironment dynamics Integrin signaling and cell adhesion mechanisms ADAM metalloproteinase regulation of extracellular matrix Protein O-mannosylation in genetic disorders Analysis of his 2015-2024 publications reveals consistent investigation into how ADAM proteases (ADAM9, ADAM12, ADAM17) modulate $$\beta_1$$ integrin function, extracellular matrix remodeling, and cancer cell migration, with recent expansion into glycosylation enzymes like TMEM260 for rare syndromes. No scientific awards were mentioned in the source material. No information regarding student supervision or research grants was provided. Dr. Mygind conducts research within the Erler Group at BRIC, a specialized unit focused on molecular mechanisms of cancer metastasis and therapeutic development.