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Paul D. SchedlView profile

Professor

• Developmental Biology
• Gene Expression Regulation
• Chromatin Structure
• +7 more

Paul D. Schedl is a Professor in the Department of Molecular Biology at Princeton University, where he leads the Schedl Lab focused on understanding gene expression and early development in Drosophila melanogaster . His research investigates how genetic and epigenetic mechanisms regulate developmental pathways, including sex determination, chromatin architecture, and embryonic polarity. Position: Professor of Molecular Biology Institution: Princeton University Department: Department of Molecular Biology Lab: Schedl Lab Contact: pschedl@princeton.edu | 609-258-4979 His research centers on three major developmental systems in Drosophila : (1) The Sex-lethal gene in sex determination, examining how pathway choice, commitment, and differentiation are regulated through transcriptional and post-transcriptional mechanisms; (2) Chromatin structure and regulation of the Abd-B gene via cis-regulatory domains, Polycomb/Trithorax group proteins, and boundary elements like Fab-7 and Fab-8; and (3) mRNA localization in oocyte polarity, particularly the role of the orb gene in establishing anterior-posterior and dorsal-ventral axes. The 15 most recent publications reflect a consistent focus on chromatin boundaries, insulator function, gene regulation, and mRNA localization. Key themes include the functional dissection of boundary elements (e.g., Fab-7, Fab-8), the role of CTCF and GAGA factors in chromatin organization, the autoregulatory function of orb in oocyte specification, and the mechanisms of transcriptional quiescence in germ cells. The work spans molecular genetics, developmental biology, and epigenetics, often combining genetic screens with biochemical and imaging approaches. No scientific awards are explicitly listed in the provided texts. Dr. Schedl actively mentors graduate students and postdoctoral researchers, many of whom co-author his publications. His lab investigates fundamental questions in developmental gene regulation, including zygotic genome activation, germline-soma distinction, and chromatin domain organization. Research is supported by ongoing projects exploring the roles of insulator proteins, CPEB family members, and signaling pathways in cell fate determination. The Schedl Lab is a key contributor to understanding how chromatin architecture and RNA regulatory networks orchestrate development in Drosophila , serving as a model for higher eukaryotes.

Stanislav Y. ShvartsmanView profile

Professor

• Quantitative Biology
• Developmental Biology
• Systems Biology
• +11 more

Stanislav Y. Shvartsman is a Professor in the Department of Molecular Biology and a member of the Lewis Sigler Institute for Integrative Genomics at Princeton University. His research integrates experimental, theoretical, and computational approaches to understand the dynamics of living tissues during development. His primary research interests include: Quantitative modeling of signaling networks, particularly the ERK cascade Mechanisms of small cell cluster formation and function in Drosophila Developmental abnormalities arising from deregulated RAS signaling Metabolic control of embryogenesis Epithelial morphogenesis and tissue mechanics The Shvartsman Lab employs Drosophila and zebrafish as model systems, utilizing live imaging, optogenetics, genome editing, and dynamical systems theory. Recent work emphasizes the integration of physical principles with biological complexity to build predictive models of developmental processes. His recent publications reveal a strong trend toward quantitative, systems-level understanding of development, combining high-resolution imaging with mathematical modeling. Key themes include signal transduction dynamics, collective cell behaviors, nuclear organization, metabolic regulation, and mechanical forces in tissue patterning. The work spans molecular, cellular, and tissue scales, reflecting an integrative approach to developmental biology. Scientific contributions include: Development of optogenetic tools for controlling ERK signaling Quantitative models of germline cyst growth and synchronization Insights into the biophysics of intercellular bridges Elucidation of transcriptional repression dynamics by Capicua Analysis of scaling laws in collective cell growth Shvartsman actively mentors students and postdoctoral researchers, as evidenced by extensive collaborations with early-career scientists on publications. His lab receives funding for interdisciplinary research at the interface of biology, physics, and computation, supporting projects in live imaging, quantitative developmental biology, and systems modeling. The lab collaborates widely with groups at Princeton and beyond, including those led by Wieschaus, Toettcher, Fuchs, and others. The Shvartsman Lab is a hub for integrative research, combining wet-lab experiments with theoretical modeling. It focuses on uncovering fundamental principles that govern the self-organization of developing tissues, using Drosophila embryos and egg chambers as primary model systems. The team explores how genetic programs interact with physical constraints to produce robust developmental outcomes.

Stefan SemrauView profile

Associate Professor

• Cell-fate Decision-making
• Single-cell Transcriptomics
• Stem Cell Biology
• +6 more

Dr. Stefan Semrau is an Associate Professor at the Leiden Institute of Physics (LION) within the Faculty of Science at Leiden University . His research focuses on quantitative single-cell biology, particularly studying cell-fate decision-making using embryonic stem cells as a model system. Develops single-cell RNA-seq and single-molecule FISH methods Applies machine learning and mathematical modeling to decode stem cell differentiation Investigates interplay of epigenetics, cell cycle, and signaling molecules His work addresses both fundamental biological dynamics and applications in regenerative medicine and cancer stem cell eradication . Recent publications emphasize single-cell transcriptomics and gene fusion quantification . The Semrau Lab maintains collaborations across disciplines and develops tools like fuseFISH for cancer research. Scientific Awards FOM-Projectruimte Grant (2016) for stem cell dynamics research Advising & Collaborations Current advisees include PhD students studying retinoic acid-induced differentiation and lineage priming. The lab integrates computational and experimental approaches through partnerships with biotech and physics teams.

• Bioprinting
• Tissue Engineering
• Hydrogel Engineering
• +5 more

Vasileios Trikalitis is a Researcher at the University of Twente's Advanced Manufacturing, Sustainable Products & Energy Systems department, specializing in cutting-edge bioprinting methodologies for tissue engineering and vascularization. His work bridges advanced manufacturing with regenerative medicine through innovative hydrogel and bioink development. Education: PhD in Tissue Bioprinting (University of Twente, 2024) MSc (institution unspecified) His research focuses on solving fundamental challenges in vascular network formation within engineered tissues, with particular expertise in embedded 3D printing techniques using granular baths and shear-thinning materials. He pioneers approaches like aptamer-based programmable bioinks and Magnetic Nozzle-Free Embedded 3D Printing to achieve precise microvascular morphogenesis. His work integrates principles from hydrogel engineering, growth factor delivery, and microfluidics to create biomimetic tissue constructs. Analysis of his 2023-2025 publications reveals a strategic progression from foundational embedded printing techniques toward increasingly sophisticated vascularization strategies. Key trends include the development of multi-material printing systems, dynamic bioink programming for 4D tissue evolution, and integration of biological cues like vascular endothelial growth factors. His research consistently targets clinical translation barriers in regenerative medicine through engineering-first solutions. Scientific Awards: No awards documented in provided materials While no formal advising relationships or grant awards are specified, his extensive collaborative network—evident in co-authorships with Rouwkema, Misra, and Schwach—demonstrates active participation in large-scale research initiatives. His conference presentations track methodological evolution from basic bioprinting (2018-2019) toward advanced vascularization techniques (2023-2025). Dr. Trikalitis operates within University of Twente's interdisciplinary biomanufacturing ecosystem, contributing to teams focused on sustainable advanced manufacturing applications in medical technology. His work particularly advances the intersection of granular mechanics, hydrogel science, and vascular tissue engineering through experimental innovation.

Roy SillitoeView profile

Professor

• Developmental Neuroscience
• Neurological Diseases
• Cerebellar Development
• +7 more

Roy Sillitoe, Ph.D. is a Professor in both the Department of Pathology and the Department of Neuroscience at Baylor College of Medicine in Houston, Texas. His research is conducted at the Duncan Neurological Research Institute, where he leads the Sillitoe Lab focused on understanding brain circuit development and neurological disorders. Dr. Sillitoe received his Ph.D. from the University of Calgary in 2003, followed by postdoctoral fellowships at the University of Oxford (2004), New York University School of Medicine (2006), and Memorial Sloan-Kettering Cancer Center (2008). Dr. Sillitoe's research focuses on the developmental origins of neurological diseases, particularly examining how precise neural circuitry is established during brain development and how disruptions lead to conditions like ataxia, dystonia, and autism spectrum disorders. His lab uses the cerebellum as a model system due to its well-organized architecture and established circuit connections. The Sillitoe Lab employs an interdisciplinary approach combining mouse molecular genetics, high-resolution neuroanatomy, and in vivo electrophysiology to study how genes and neural activity interact to establish functional neural circuits that control complex behaviors. Their work has revealed how cerebellar patterning cues control the precise targeting of neural connections required for smooth purposeful movements. Analysis of Dr. Sillitoe's recent publications reveals a strong focus on cerebellar development, neural circuit mapping, and the genetic basis of neurological disorders. His work has made significant contributions to understanding the zonal organization of the cerebellum, the role of specific genes (particularly engrailed homeobox genes) in neural circuit formation, and the relationship between cerebellar dysfunction and motor coordination disorders. The research employs advanced techniques including multicolor neural circuit mapping, whole-mount immunohistochemistry, and analysis of gene expression patterns in mouse models. Dr. Sillitoe is actively involved in research funding, with support from NINDS grant #NS089664 for his project 'Synaptic origins of cerebellar disease.' His lab includes research assistants, associates, and collaborators working on various aspects of cerebellar development and function. The Sillitoe Lab maintains a strong presence in the neuroscience community, with members participating in professional organizations including the Society for Neuroscience, American Physiological Society, and Society for Research on the Cerebellum and Ataxias. The lab has developed numerous protocols for studying cerebellar development and function, including specialized techniques for immunohistochemistry, tissue processing, and neural circuit mapping. Their ultimate goal is to uncover the developmental mechanisms affected by disease-linked genes, with the hope of identifying novel therapeutic targets to improve quality of life for individuals with neurological disorders.

Katrina AdamsView profile

Assistant Professor

• Neuroscience and Behavior
• Development and Regeneration
• Cellular and Molecular Biology
• +12 more

Katrina Adams is the Gallagher Assistant Professor in the Department of Biological Sciences at the University of Notre Dame, where she leads a research laboratory focused on brain development and regeneration. Her work bridges cellular and molecular neuroscience with regenerative medicine, particularly in the context of demyelinating diseases such as Multiple Sclerosis. Her research interests center on glial cell biology, neural stem cells, and white matter regeneration. She investigates how glial progenitor cells respond to injury and disease, with a focus on oligodendrocyte development and myelination. Her lab uses mouse models of demyelination, human tissue analysis, single-cell transcriptomics, and advanced genetic tools to uncover conserved molecular pathways that could serve as therapeutic targets for brain repair. The recent publications highlight a consistent trajectory in understanding endogenous repair mechanisms in the central nervous system. Her work spans developmental neurobiology, injury response, glial heterogeneity, and regenerative signaling pathways, with strong emphasis on translational relevance for neurodegenerative conditions and perinatal brain injury. Selected Scientific Contributions: Investigated Sirt2 in white matter oligodendrogenesis and neonatal hypoxia Explored Endothelin-1 signaling in postnatal glial progenitor proliferation Examined environmental enrichment effects on white matter recovery Elucidated the complexity of glial scar formation Developed stem cell models of motor neuron differentiation Katrina Adams mentors trainees in her lab and utilizes interdisciplinary approaches combining developmental biology, molecular signaling, and regenerative neuroscience. Her research is supported by institutional and likely federal funding, though specific grants are not listed. She collaborates with experts in neuroscience and stem cell biology, as evidenced by her co-authorships with prominent researchers like Vittorio Gallo and Bennett Novitch. Her laboratory is located in the Galvin Life Science Center (Lab: Galvin 044, Office: Galvin 049), and she is actively contributing to the neuroscience research community through high-impact publications and innovative experimental models.

John McCarreyView profile

Professor

• Epigenetic regulation
• Mammalian germ cells
• Stem cells
• +12 more

John McCarrey is a Professor and the Kleberg Distinguished University Chair in Cellular and Molecular Biology at The University of Texas at San Antonio (UTSA), where he is also Co-Director of the Institute of Regenerative Medicine. He is affiliated with the Department of Neuroscience, Developmental and Regenerative Biology in the College of Sciences and holds joint appointments with the Department of Cell Systems & Anatomy and the Department of Obstetrics & Gynecology at UT Health San Antonio. He leads the McCarrey Laboratory, which focuses on epigenetic regulation in mammalian germ cells and stem cells. Ph.D. in Genetics, University of California, Davis M.S. in Genetics, University of California, Davis B.S. in Animal Science, University of California, Davis Dr. McCarrey's research centers on epigenetic mechanisms governing germ cell and stem cell function, including epigenomic reprogramming, genomic imprinting, and transgenerational epigenetic inheritance. His lab investigates how assisted reproductive technologies and environmental exposures affect epigenetic programming and genetic integrity. He is pioneering the use of the baboon as a nonhuman primate model for translational stem cell research and regenerative medicine. His work integrates molecular, genomic, and epigenomic approaches across mouse, human, and primate models. The recent publications of Dr. McCarrey reflect a strong focus on epigenetic regulation in spermatogenesis, stem cell biology, and transgenerational inheritance. His research combines cutting-edge techniques such as single-cell RNA-seq, epigenomic profiling, and in vitro reprogramming to understand cell fate decisions, germ cell development, and the impact of environmental exposures. A recurring theme is the comparison of epigenetic states across cell types and species, particularly in the context of pluripotency and germline transmission. Kleberg Distinguished University Chair in Cellular and Molecular Biology Dr. McCarrey mentors graduate students and postdoctoral researchers through UTSA’s Developmental and Regenerative Sciences PhD program, Biology Masters program, and Biotechnology Masters program. His research is supported by collaborations with institutions such as the Southwest National Primate Research Center, Washington State University, UCLA, and international partners. He is actively involved in the National Centers for Translational Research in Reproduction and Infertility (NCTRI), contributing to community education on male reproductive epigenomics. He leads a multidisciplinary team within the McCarrey Laboratory, which includes current and former members engaged in high-impact research. The lab also contributes to seminars and graduate training initiatives at UTSA.

Holm ZaehresView profile

Senior Lecturer

• Stem Cell Engineering
• Induced Pluripotent Stem Cells (iPS)
• Neural Differentiation
• +3 more

Holm Zaehres is a Senior Lecturer at the Max Planck Institute for Molecular Biomedicine in Münster, Germany, leading the Stem Cell Engineering Laboratory . His work focuses on reprogramming somatic cells to pluripotency using transcription factors like OCT4, SOX2, and KLF4, with significant contributions to induced pluripotent stem (iPS) cell generation from neural and hematopoietic progenitors. Key Research Areas: Stem cell engineering, iPS cell differentiation, genome editing, and disease modeling (including Frontotemporal Dementia and Duchenne Muscular Dystrophy). Publications: Authored 10+ seminal works in Nature , Cell , and Stem Cells , establishing methods for efficient cellular reprogramming and organoid-based disease studies. Collaborations: Partnered with institutions like University of Bonn, German Cancer Research Center (DKFZ), and academic hospitals in neurology and hematology.

David Greg FitzharrisView profile

Professor

• Reproductive Biology
• Developmental Biology
• Cell Biology
• +3 more

David Greg Fitzharris is a Full Professor associated with the Université de Montréal and practices at the CRCHUM (Montreal University Hospital Research Center) in the Viger Tower. His research focuses on the mechanisms of conception, specifically the impact of maternal age on egg and embryo quality, and its implications for fertility. Education: Bachelor of Science in Physiology and Pharmacology, University College London (2000) PhD in Physiology, University College London (2004) Postdoctoral Fellow at Ottawa Health Research Institute (2007) His current projects investigate motor protein roles in age-related oocyte aneuploidy, chromosome segregation errors in early embryos, and centriole biogenesis regulation. He utilizes live-cell microscopy to study these processes. Scientific Contributions: Dr. Fitzharris has published extensively on reproductive aging, embryo development, and cellular dynamics in mouse models. His work addresses critical challenges in fertility decline associated with maternal age.

Emília SantosView profile

Assistant Professor

• Evolutionary Biology
• Developmental Genetics
• Population Genetics
• +4 more

Dr. Emília Santos is an Assistant Professor and NERC Independent Research Fellow in the Department of Zoology at the University of Cambridge. Her research focuses on the genetic and developmental mechanisms underlying morphological diversity in Lake Malawi cichlid fishes, integrating evolutionary biology, genetics, and developmental biology. Research themes include pigmentation pattern evolution, neural crest cell development, and adaptive radiation. Utilizes genome editing tools (CRISPR, Tol2 transgenesis) and comparative genomics to link cellular biology to macroevolutionary patterns. Investigates whether micro- and macroevolutionary processes share common genetic pathways. Her recent work examines transposable element dynamics, visual system adaptation, and neural crest divergence across cichlid species. She leads the Cichlid Eco-evo-devo Group, accepting PhD applications. Scientific Awards: NERC Independent Research Fellowship Contact: es754@cam.ac.uk , Room 2.01, Downing St, Cambridge CB2 3EJ.

Leo van GrunsvenView profile

Professor

• Liver Cell Biology
• Hepatic Stellate Cells
• Liver Fibrosis
• +5 more

Leo van Grunsven is a Professor at the Vrije Universiteit Brussel (VUB) where he serves as head of the Liver Cell Biology research group, a position he has held since 2009. His research is situated within the Basic (bio)medical sciences faculty, specifically in the Translational Liver Cell Biology department. With over 239 research outputs and 60 active projects, his work has significantly contributed to the understanding of liver biology and disease mechanisms. Dr. van Grunsven obtained his PhD in life sciences from the Ecole Normale Supérieure de Lyon (France, 1996), following postdoctoral training at the NINDS/NIH (Bethesda, USA, '96-'98) and KU Leuven (Belgium, '98-'06). His laboratory specializes in studying molecular mechanisms driving liver homeostasis, fibrosis, and regeneration, with particular expertise in hepatic stellate cells and in vitro disease modeling. His research interests focus on understanding hepatic stellate cell biology and developing innovative in vitro models for chronic liver disease. His group was the first to identify autophagy, AGE- and Hippo-signaling as key mechanisms in hepatic stellate cell activation during liver fibrogenesis. They also established the first hepatocyte-injury dependent in vitro liver fibrosis model using organoid cultures of human hepatocytes and iPSC-derived hepatic stellate cells. Current research focuses on refining these models and investigating stress pathway regulation in liver cells during acute and chronic injury. Analysis of Dr. van Grunsven's recent publications reveals a strong focus on liver fibrosis mechanisms, with particular emphasis on hepatic stellate cell activation, liver organoid models, and the molecular pathways driving liver disease progression. His work bridges basic science with translational applications, developing novel in vitro models that better recapitulate human liver pathologies. Dr. van Grunsven actively supervises research, with 43 supervised works documented in his profile. He leads multiple significant research projects including B-LIVER 2.0 (Brussels Alliance for Liver Research & Valorization, 2025-2029), CATCH (CAR-T cell immunotherapy against chronic liver disease, 2024-2028), and 3D-CELLMAP (advanced imaging of cell interactions in tissues, 2024-2028). His laboratory, the Liver Cell Biology Laboratory, maintains active collaborations across multiple institutions and continues to advance the field of liver research through innovative approaches to modeling liver disease and identifying potential therapeutic targets.

Rhett P. KetterlingView profile

Professor

• Molecular Cytogenetics
• Fluorescence In Situ Hybridization (FISH) Assays
• Hematologic Malignancies
• +2 more

Dr. Rhett P. Ketterling is a Professor at the Mayo Clinic College of Medicine and Science and a key member of the Mayo Clinic Comprehensive Cancer Center and Department of Laboratory Medicine and Pathology . With over two decades of leadership roles in clinical and research committees, he specializes in molecular cytogenetics and fluorescence in situ hybridization (FISH) assays for hematologic and solid tumor malignancies. MD from Mayo Medical School (1996) Residency and Fellowship in Anatomic & Clinical Pathology and Clinical Cytogenetics at Mayo Clinic His research focuses on: Development of molecular cytogenetic/FISH assays for myeloid and lymphoid malignancies Genomic characterization of solid tumors Discovery of novel chromosomal rearrangements in hematologic cancers The 15 most recent publications highlight his work in myeloproliferative neoplasms , genomic instability , and molecular diagnostics , with collaborations spanning Italy, the United States, and international consortia. Articles demonstrate expertise in: Mutation-driven prognostic models Fluorescence in situ hybridization techniques Genetic subtyping of lymphomas Translational research in blood cancers Scientific awards include: Howard Hughes Medical Student Fellowship (1993, 1996) Joseph Collins Scholarship (1992) Howard W. Alkire Scholarship (1991) Professional memberships encompass leadership roles in the Division of Laboratory Genetics and Genomics at Mayo Clinic, the College of American Pathologists , and societies including the American Society of Hematology and American College of Medical Genetics and Genomics .

Daryl Armstrong ScottView profile

Professor

• Medical Genetics
• Developmental Biology
• Genomics
• +4 more

Daryl Armstrong Scott, Professor at Baylor College of Medicine in the Department of Molecular and Human Genetics , is a leading researcher in identifying genetic causes of congenital defects. His work focuses on congenital diaphragmatic hernia (CDH) , 1p36 deletion syndrome , and neurodevelopmental phenotypes . Education: BS (Brigham Young University, 1993), PhD (University of Iowa, 2000), MD (University of Iowa, 2000) Certifications: American Board of Pediatrics (General Pediatrics), American Board of Medical Genetics (Clinical Genetics) Research Interests: Identifying genes for CDH and cardiovascular malformations (CVM) Investigating RERE gene mechanisms in 1p36 deletion syndrome Studying esophageal atresia/tracheoesophageal fistula (EA/TEF) via machine learning Global collaborations on neurodevelopmental disorders (autism, intellectual disability) Scientific Awards: Spriestersbach Dissertation Prize (1999) Fulbright and Jaworski Faculty Excellence Award (2013) Outstanding Graduate Teaching Award (2011) Research Trends (2022-2019): Recent publications highlight his use of exome sequencing , mouse models , and DECIPHER data to link genes like GATA4 , RERE , and FGFRL1 to congenital defects, with a strong focus on genotype-phenotype correlations and neurodevelopmental syndromes .

• Human Anatomy and Embryology
• Neurogenesis
• Neuroregeneration
• +3 more

Anibal de la Mano Bonin is a Professor at the Universidad de Valladolid, affiliated with the Department of Anatomy and Radiology under the Castile and Leon Institute of Neuroscience (1FA). His research focuses on developmental neurobiology, including neurogenesis, neuroregeneration, and neuroendocrine mechanisms in embryonic systems. Education: PhD from Universidad de Valladolid (2006) Research Group: Development and Teratology of the Central Nervous System and Organs of the Senses His work explores interleukin signaling in spinal cord proliferation/differentiation during embryogenesis, with cross-disciplinary implications for teratology and regenerative medicine.

• Ecotoxicology
• Marine Ecology
• Environmental Pollution
• +6 more

Elisa BERGAMI is an Associate Professor at the Department of Life Sciences, University of Modena and Reggio Emilia, Italy, specializing in Ecotoxicology and Marine Pollution research. She teaches courses such as Anthropogenic alterations of ecosystems , Coding in R for data analysis , and Management of bioresources and ecosystem services , with a focus on Nanoparticle Toxicity , Marine Biodiversity , and Data Analysis in ecological contexts. Her work addresses environmental challenges through the lens of the UN Sustainable Development Goals . Teaches Ecotoxicology with case studies on plastic pollution, heavy metals, and climate change Directs Experimental Biology Laboratory modules on marine organism analysis and nanoparticle interactions Her research interests include: Environmental impacts of nanoplastics and engineered nanomaterials Ecotoxicological effects on marine invertebrates Development of bioindicators for pollution Ecological risk assessment methodologies Antarctic ecosystem contamination Recent publications highlight her work on: Nanoplastic interactions with marine immune systems Toxicity mechanisms in polar and Mediterranean species Plastic colonization by microbial communities Combined chemical-nanoparticle stressors She leads the SCAR Plastic in polar environment Action Group and emphasizes hands-on laboratory training in courses covering DNA barcoding, microbiological testing, and biochemical analysis using marine models like Mytilus galloprovincialis and Paracentrotus lividus.