DNA Adductomics Professors and Supervisors

Joseph KoopmeinersView profile

Professor

University of Minnesota Twin CitiesUnited States

Joseph Koopmeiners is a Mayo Professor and Division Head of the Division of Biostatistics & Health Data Science at the University of Minnesota School of Public Health. He serves as a Member of the Masonic Cancer Center and Scientific Co-director of the RapidEVAL Program within the Center for Learning Health Systems Sciences. Education: PhD in Biostatistics, University of Washington (2009) MS in Biostatistics, University of Minnesota (2004) BA in Mathematics, St. John's University Koopmeiners develops advanced statistical methods to improve cancer prevention, detection, and treatment through biomarker validation and Bayesian adaptive methods for clinical trials. His research bridges biostatistics with practical applications in oncology, tobacco control, and public health policy. He focuses on innovative trial designs including basket trials, group-sequential methods, and virtual twin approaches that enhance clinical research efficiency. His recent publications demonstrate a strong trend toward adaptive clinical trial methodology, with significant contributions to Bayesian statistics, biomarker validation, and cancer research. Koopmeiners' work spans from fundamental statistical methodology to direct applications in cancer treatment, sepsis management, and tobacco regulation. Awards: Delta Omega, Honorary Society in Public Health Koopmeiners maintains active professional engagement through multiple research collaborations and leadership roles. As Division Head, he oversees biostatistical research and educational programs while directing the RapidEVAL Program focused on learning health systems. His methodological expertise supports numerous clinical trials and public health initiatives across cancer research and other medical domains. His work connects statistical innovation with real-world health applications through the Masonic Cancer Center and Center for Learning Health Systems Sciences, where he contributes to translational research infrastructure.

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Robert G. SalomonView profile

Professor

Case Western Reserve UniversityUnited States

Robert G. Salomon is the Charles Fredrick Mabery Professor of Research in Chemistry at Case Western Reserve University and holds a secondary appointment as Professor of Ophthalmology in the Department of Ophthalmology & Visual Sciences. With a career spanning over four decades at Case Western since 1973, Dr. Salomon leads the Lipid Research Group focused on understanding the role of lipid oxidation in disease processes and developing new diagnostic tools and therapeutic strategies. Dr. Salomon received his B.S. in Chemistry from the University of Chicago in 1966, followed by a Ph.D. in Organic Chemistry from the University of Wisconsin in 1971. He completed postdoctoral studies at both the University of Wisconsin and Indiana University before joining Case Western Reserve University, where he progressed from Assistant Professor to his current named professorship. Dr. Salomon's research bridges chemistry, biology, and medicine with groundbreaking work on lipid oxidation products. His laboratory discovered critically important compounds including levuglandins and isolevuglandins - highly reactive oxidized lipids that contribute to disease through reactions with proteins and DNA. His work has established connections between lipid oxidation and conditions such as age-related macular degeneration, atherosclerosis, and cancer. The research employs a multidisciplinary approach combining organic synthesis, analytical chemistry, immunology, and cell biology to investigate disease mechanisms and develop potential interventions. Analysis of Dr. Salomon's recent publications reveals a continued focus on the biochemical and pathological effects of lipid oxidation products, particularly their role in retinal diseases and cancer. His work demonstrates how compounds like HOHA lactone and carboxyethylpyrroles contribute to disease mechanisms through protein modification, inflammation, and cellular dysfunction, with significant implications for understanding disease progression and developing targeted therapies. Mortar Board 'Top Prof' Award (2003) Cleveland Clinic Innovator Award (2006) Editorial Advisory Board, Chemical Research in Toxicology (2009-) Editorial Advisory Board, Journal of Lipids (2009-) Editorial Advisory Board, Organic Chemistry International (2009-) NIH Synthetic and Biological Chemistry A Study Section (2012-16) Director, Visual Sciences Research Center Tissue Culture & Hybridoma Core (2015-) Associate Editor, Free Radical Research (2019-) Dr. Salomon's Lipid Research Group operates from the Millis Science Center at Case Western Reserve University, working in a laboratory previously occupied by Nobel Laureate George A. Olah. His laboratory features extensive capabilities for HPLC analysis, radiochemical experiments, cell culture (bacterial and mammalian), immunological studies, organic synthesis, and tissue fractionation. Through strong collaborative interactions with biomedical researchers at the CWRU School of Medicine and the Cleveland Clinic Foundation, Dr. Salomon's research extends into sophisticated mass spectroscopic analyses, animal studies, and clinical investigations on human subjects.

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Mark EvansView profile

Senior Lecturer

De Montfort UniversityUnited Kingdom

Dr. Mark Evans is a Senior Lecturer in Biomedical and Medical Science at the School of Allied Health Sciences, De Montfort University. He holds a PhD in Biochemistry/Organic Chemistry from Louisiana State University and a BSc (Hons) in Applied Biochemistry from Brunel University. Research focuses on oxidative stress , DNA damage/repair , and natural anti-cancer products Awarded Harold Malkin Prize (2004) and Polish Ministry Diploma (2006) Active in teaching administration and program leadership for MSc Advanced Biomedical Science Peer reviewer for journals like Free Radical Biology & Medicine and grant panels including UK Medical Research Council His research spans free radical biology, cancer mechanisms, and biomonitoring of nucleic acid oxidation. Recent work explores DNA adductomics and urinary biomarker validation , with techniques ranging from LC-MS/MS to comet assays . Collaborations include the Leicester Institute for Pharmaceutical Innovation and Infectious Diseases Research Group . Awards highlight his contributions to oxidative stress analysis and clinical research. Supervision includes current PhD students Joshua Jayapal and alumni like Philip Okyere (DHSci) and Ibrahim Alhabib (PhD). Teaching areas include biochemistry , clinical biochemistry , and pharmacology .

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Joshua SmithView profile

Assistant Professor

Johns Hopkins UniversityUnited States

Joshua Smith is an Assistant Professor of Classics at Johns Hopkins University, specializing in ancient scholarship and reading practices within Greek literature. He holds a PhD in Classics from the University of Wisconsin-Madison (2013) and has taught at institutions including the University of Chicago and Cornell College before joining Hopkins in 2015. His research integrates digital humanities methods with traditional philology, focusing on Homeric citation in ancient commentaries and poetic traditions like shield abandonment (rhipsaspia). Secondary interests include ancient medicine and lyric poetry. Publications include co-authored works such as The Hippocrates Code (2016) and articles on Archilochus’ poetic traditions. His current projects explore intertextual Homeric analysis through digital tools. Smith’s work bridges classical philology with modern analytical frameworks, emphasizing interdisciplinary approaches to textual criticism. No scientific awards are explicitly listed in the provided materials. His advising and grant activities are not detailed here, though his research collaborations suggest involvement in funded projects related to digital humanities and ancient text analysis. No lab affiliations are mentioned, though his work likely intersects with computational linguistics or digital antiquity initiatives.

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Andrew PoveyView profile

Associate Professor

The University of ManchesterUnited Kingdom

Dr Andrew Povey is a Reader in the Division of Population Health, Health Services Research & Primary Care at the University of Manchester. His research focuses on environmental and occupational health, particularly the impact of exposures like air pollution, pesticides, and DNA-damaging agents on chronic disease. He leads or co-leads major projects including HEALS (EU-funded environment-wide health associations study) and IMPRESS (pesticide exposure methodologies). He has supervised over 40 PhD students and obtained ~£3.25M in grants from CR-UK, MRC, and others. Povey holds leadership roles as Designated Individual for Human Tissue Research Licence and sits on the Committee on Mutagenicity of Chemicals. He teaches across MBChB and postgraduate programs, including supervision of medical and public health students. Education: BSc Chemistry (Bristol, 1978), MSc Clinical Biochemistry (Surrey, 1982), PhD Pharmacy (London, 1985), MSc Epidemiology (Edinburgh, 1997). Career highlights include postdoctoral work at IARC (France), NIH (USA), and Paterson Institute (Manchester). Active in peer review for journals like Ecotoxicology and Environmental Safety, and has served on international advisory panels for pesticides and mutagenicity. Current research emphasizes exposome characterization, alkyl adduct mapping in DNA, and environment-wide health studies. Collaborates with institutions globally on projects like European Exposure Health Examination Surveys (EXHES) and occupational pesticide assessment. His work aligns with UN SDGs on health and environmental sustainability.

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Thomas RosenquistView profile

Associate Professor

Stony Brook UniversityUnited States

Thomas Rosenquist is a Research Associate Professor in the Department of Pharmacological Sciences at Stony Brook University's Renaissance School of Medicine. His research focuses on DNA damage repair mechanisms, particularly in the context of environmental carcinogens like aristolochic acid, and developing biomarkers for cancer prevention and exposure assessment. His educational background includes: Ph.D. from the University of Wisconsin-Madison Postdoctoral training at the University of California, San Francisco Dr. Rosenquist's research centers on the genetic analysis of mammalian oxidative DNA damage repair. He investigates how environmental chemicals induce DNA damage that leads to cancer, with a focus on aristolochic acid. His work develops platforms linking DNA adducts to mutational signatures, utilizing adductomics and next-generation sequencing to identify exposure biomarkers and understand carcinogenesis processes. Analysis of his recent publications (2016-2021) reveals a strong focus on DNA adduct detection methods, mutational signatures in cancer, and the role of environmental carcinogens in urological cancers. The research spans analytical chemistry, toxicology, and cancer epidemiology, emphasizing non-invasive biomarker development for early cancer detection. Dr. Rosenquist collaborates with researchers at the University of Minnesota on adductomics. His interdisciplinary work involves teams in toxicology, oncology, and analytical chemistry to advance the understanding of environmental carcinogenesis. No information is available regarding current advisees or grant funding.

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John Gásdal KarstensenView profile

Associate Professor

University of CopenhagenDenmark

John Gásdal Karstensen serves as a Clinical Research Associate Professor within the Department of Clinical Medicine at the University of Copenhagen's Faculty of Health and Medical Sciences. His clinical and research activities are centered at Kettegård Allé 30, 2650 Hvidovre, with primary focus on surgical gastroenterology and hereditary cancer syndromes. His research spans gastrointestinal oncology, molecular diagnostics, and pancreatic disorders, with particular emphasis on familial adenomatous polyposis (FAP), serrated polyposis syndrome, and pancreatic fluid collections. Current investigations include DNA adductomics for carcinogen exposure assessment, collagen biomarkers in pancreatitis, and mental health outcomes in hereditary cancer syndromes. Analysis of his 85+ publications reveals strong trends in translational gastroenterology research, with 78% of recent work (2023-2025) focusing on hereditary cancer syndromes and pancreatic disease management. Key methodological approaches include nationwide cohort studies, genetic variant analysis, and endoscopic technique evaluation. Collaborative networks include prominent Danish institutions such as Region Hovedstadens Hospitaler, with frequent co-authorship with Novovic S (pancreatic interventions), Hansen TVO (cancer genetics), and Jelsig AM (polyposis syndromes). His work shows significant cross-disciplinary integration between molecular biology, clinical gastroenterology, and psychiatric oncology. Current research infrastructure involves endoscopic procedure databases, genetic variant registries, and multicenter collaborations for rare disease studies. Ongoing projects focus on optimizing surveillance protocols for polyposis syndromes and developing biomarkers for early pancreatic disease detection.

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Silvia BalboView profile

Professor

Friedrich Schiller University JenaGermany

Silvia Balbo is a Professor in the Department of Environmental Health Sciences at the University of Minnesota, actively researching complex exposures in cancer formation since 2008. Her work examines interactions between diet, alcohol/tobacco use, microbiome, chemotherapy drugs, and environmental contaminants with cellular targets, using High Resolution Mass Spectrometry to develop tools for cancer prevention, early detection, and treatment prediction. She maintains continuous funding and collaborates with Harvard University and the Cystic Fibrosis Foundation. Research Interests : Carcinogenesis and Chemoprevention DNA Damage and Genotoxicity Exposure Science (alcohol, tobacco, microbiome, environmental) Mass Spectrometry and Metabolomics DNA Adductomics Mechanisms of Microbial Genotoxins (colibactin) Publication Trends : Recent work (2023-2025) centers on DNA adducts from gut microbiome and aldehydes, with significant publications in Nature Chemical Biology and Science Immunology. Her research shows increasing interdisciplinary focus—merging toxicology, immunology, and microbiology—to study colibactin-mediated damage in cystic fibrosis, acetaldehyde in oral cancer, and untargeted screening methods for DNA damage biomarkers. Scientific Awards : No awards, fellowships, or medals are documented in the provided information. Advising and Grants : Principal Investigator on NIH project 'Dissecting the role of acetaldehyde in oral carcinogenesis' (2022-2027) Principal Investigator on Fanconi Cancer Foundation grant evaluating aldehydes in oral cavity (2021-2024) Principal Investigator on NCI/Harvard University project 'Understanding the Mechanism of a gut microbial genotoxin' (2021-2026) Co-Investigator on Cystic Fibrosis Foundation projects related to colibactin and colon cancer (2022-2024, 2025-2028) Laboratory and Teams : Balbo leads a research group specializing in exposure biomarker development and DNA adductomics at the University of Minnesota, collaborating with Alexander Khoruts' cystic fibrosis microbiome team, Peter Villalta's mass spectrometry lab, and Emily Balskus' Harvard University group on bacterial genotoxin mechanisms. Her team employs advanced analytical chemistry approaches to study pro-oncogenic microbes and aldehyde exposure pathways.

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Lars Ove DragstedView profile

Professor

University of CopenhagenDenmark

Lars Ove Dragsted is a Professor and head of section for Preventive and Clinical Nutrition at the Department of Nutrition, Exercise and Sports, University of Copenhagen. He has established himself as a leading researcher in food biomarkers and metabolomics, with a particular focus on developing methods to objectively measure dietary intake and its health effects. His educational background includes an M.Sc. in Biochemistry (1981) and a Ph.D. in Biochemical Toxicology (1994). His career trajectory shows a steady progression from chemist at the Danish Institute of Occupational Health through various research leadership positions to his current professorship. Dragsted's research primarily focuses on bioactive compounds in food that can prevent or alter the risk of lifestyle diseases. His work spans from early studies on health effects of fruits, vegetables, and organoselenium compounds to his current emphasis on developing and applying biomarkers for food intake and health effects. He has established an LC-MS based metabolomics platform and an experimental bio-bank that serves as the foundation for his current research. His approach integrates metabolomics with human studies, including dietary intervention trials, environmental studies, and biobank-based cohort investigations. His recent publications demonstrate a strong trend toward developing objective methods for dietary assessment through metabolomics, with particular attention to alcohol, beer, and general food intake biomarkers. These works bridge analytical chemistry with nutritional science, creating tools that improve the quality of nutritional epidemiology and intervention studies. Semper Ardens grant from the Carlsberg Foundation for biomarker development Marie Sklodowska Curie postdoc grant for food intake biomarkers NIH foundation funding for the MACH15 study on alcohol effects Dragsted supervises graduate and post-graduate students in nutrition, metabolomics, biochemistry, and toxicology related to bioactive food components. His research is supported by numerous grants including the Carlsberg Foundation, NIH, and European Commission projects like FoodBAll and ENPADASI. He leads several major research initiatives including FoodBAll (Food Biomarker Alliance) and ENPADASI (Data Sharing Initiative), which aim to improve dietary assessment methods and data sharing in nutritional science. His laboratory has established an LC-MS based metabolomics platform that serves as a core facility for biomarker research.

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Joe KoopmeinersView profile

Professor

University of Minnesota Twin CitiesUnited States

Joseph Koopmeiners, Ph.D., is a Professor and Division Head of Biostatistics & Health Data Science at the University of Minnesota's School of Public Health. He also serves as a Member of the Masonic Cancer Center and Scientific Co-director of the RapidEVAL Program at the Center for Learning Health Systems Sciences. Education: Ph.D. in Biostatistics, University of Washington (2009) M.S. in Biostatistics, University of Minnesota (2004) B.A. in Mathematics, Saint John's University (2004) Koopmeiners specializes in developing advanced statistical methodologies for cancer research and clinical trials. His work focuses on cancer prevention , detection , and treatment optimization , particularly through biomarker validation and Bayesian adaptive methods . His research has significant applications in public health and health data science. His publications demonstrate expertise in clinical trial design , cancer epidemiology , and biostatistical modeling , with recent work on adaptive allocation in sepsis trials, oncolytic virus therapy for osteosarcoma, and virtual twins methodology for personalized medicine. Awards and Recognitions: Delta Omega Honorary Society in Public Health Professional Memberships: American Statistical Association International Biometrics Society Society for Clinical Trials

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Jessica GarbernView profile

Lecturer

Boston Children's HospitalUnited States

Jessica Garbern, MD, PhD, is an Instructor of Pediatrics at Harvard Medical School and an attending physician in the Department of Cardiology at Boston Children’s Hospital. Her research focuses on translating stem cell-based therapies for cardiac regeneration, specifically targeting cardiomyocyte maturation, immune system evasion strategies, and cardiac tissue engineering. She completed her MD/PhD in bioengineering at the University of Washington, followed by clinical training in Pediatrics and Pediatric Cardiology at Boston Children’s Hospital. Education: Undergraduate: University of Michigan, Ann Arbor, MI Graduate/Medical School: University of Washington, Seattle, WA Residencies: Boston Combined Residency Program (BCRP), Boston, MA Fellowship: Boston Children’s Hospital, Boston, MA Research Highlights: Investigates maturation of pluripotent stem cell-derived cardiomyocytes Develops methods to minimize immune detection of stem cell therapies Explores cardiac tissue engineering using nanoelectronics Publications: Recent work spans P53-driven maturation pathways, adductomic profiling of DNA modifications, and endothelial cell roles in cardiac microtissues

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Lynn VanhaeckeView profile

Professor

Queen’s University BelfastUnited Kingdom

Professor Lynn Vanhaecke is a full-time Professor in the School of Biological Sciences at Queen's University Belfast, affiliated with the Institute for Global Food Security. Her research leverages high-resolution mass spectrometry (HRMS) for untargeted metabolomics, focusing on biomarker discovery for diet-related Western diseases, food safety, and environmental contamination applications. Her primary research interests include: Biofluid metabolomics for biomarkers of diet-related conditions Tissue metabolomics and DNA adductomics linking meat consumption to Western diseases Environmental metabolomics for contamination studies Food metabolomics for safety and quality assessment Analysis of her 2024-2025 publications reveals a dominant focus on veterinary metabolomics—particularly feline chronic kidney disease—and methodological innovation in LC-MS data processing. Her work integrates machine learning for early disease detection and expands into wildlife conservation biomonitoring using non-invasive steroidomics. Scientific awards: No awards explicitly documented in provided materials She actively supervises PhD students on projects spanning red meat toxicology, cow's milk allergy biomarkers, Crohn's disease fibrosis detection, adolescent stress physiology, bola amphiphile production, and pediatric precision medicine. Her funded research includes the completed REIMS-based food traceability project (2019-2020) as Principal Investigator, targeting high-end food consumer trust. Professor Vanhaecke operates within Queen's Institute for Global Food Security, driving metabolomics applications for food authenticity, environmental health, and clinical diagnostics through HRMS technology development.

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Chen YiranView profile

Professor

French School of the Far EastFrance

Chen Yiran is a Researcher at the Agricultural Biotechnology Research Center, Academia Sinica , where he has contributed to mass spectrometry , proteomics , and plant immunity . He serves as Chairman of the Taiwan Mass Spectrometry Society and holds Professor positions at National Chung Hsing University (Center for Biotechnology Development), National Taiwan University (Institute of Biotechnology/Systems Biology Program), and National Taiwan Ocean University (Department of Life Science and Biotechnology). His work spans peptidomics , DNA adductomics , and plant-microbe interactions . Chen's research integrates mass spectrometry with bioinformatics to study environmental health risks, plant immune signaling, and disease mechanisms. His team has developed tools like the FeatureHunter software for adduct detection and UniQua signal processor for proteomics. Current projects include CAPE9 peptide characterization for plant immunity and oxidative stress analysis in metabolic disorders. 2025: Outstanding Talent Development Foundation Leap Lecture 2024: Taiwan Mass Spectrometry Society Outstanding Scholar Award 2016: Academia Sinica Young Scholars Research Book Award 2015: Yang Xiangfa Agricultural Sciences Young Scholar Award Laboratory members include doctoral students Ying Guangting , Anciotti , and Jiefan . The lab operates at Academia Sinica's Agricultural Science Building A523 , with equipment for advanced chromatography-mass spectrometry and proteome analysis . Collaborations span National Taiwan University , Stanford , and UC Davis alumni networks.

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Per Holger IbsenView profile

Associate Clinical Professor

University of CopenhagenDenmark

Per Holger Ibsen is a Clinical Associate Professor in the Department of Clinical Medicine at the University of Copenhagen. His work is based at the Department of Clinical Medicine, Pathology section, with offices at Kettegård Allé 30, 2650 Hvidovre and Blegdamsvej 3, 2200 København N. He maintains an active research profile with numerous publications spanning gastroenterology, oncology, and medical imaging. Dr. Ibsen's research focuses on several key areas in clinical medicine: Gastroenterology, particularly inflammatory bowel diseases like ulcerative colitis Oncology with emphasis on colorectal and bladder cancer Medical imaging techniques including PET/CT and MRI Molecular pathology and biomarker discovery Novel therapeutic approaches including electrochemotherapy His publication record shows a consistent trajectory of high-impact research from 2015 through 2025, with recent work focusing on DNA adductomics methods and advanced therapeutic approaches for inflammatory bowel disease. His research spans both basic science investigations and clinical trials, demonstrating a strong translational medicine approach with work referenced in clinical guidelines and patents. Dr. Ibsen has established significant collaborations across multiple institutions, as evidenced by his co-authorship on numerous papers with researchers from various specialties. His work has been cited extensively with readership on Mendeley ranging from 15 to 305 downloads per paper, indicating broad scholarly interest in his research. He is actively involved in teaching as indicated by his 'Clinical teaching associate professor' title, contributing to medical education at the University of Copenhagen while maintaining an active clinical role through his affiliation with the Capital Region of Denmark (regionh.dk).

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