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Yasuhiro ArimuraView profile

Assistant Professor

• Chromatin Structure
• Chromosome Biology
• Structural Biology
• +3 more

Yasuhiro Arimura, PhD, serves as Assistant Professor in the Basic Sciences Division at Fred Hutchinson Cancer Center, where he investigates chromatin structure and regulation using advanced cryo-electron microscopy techniques. His research focuses on understanding how molecular cues on chromatin control gene expression and chromosome segregation, with direct implications for cancer biology where chromatin dysregulation causes aneuploidy. Education PhD in Structural Biology, Waseda University (2015) Dr. Arimura's research centers on the structural basis of chromatin function across cellular differentiation and cell cycle stages. He examines specialized chromatin regions including euchromatin, heterochromatin, telomeres, and centromeres, investigating how their local architectures enable transcriptional regulation, DNA repair, and chromosome stability. His innovative cryo-EM approaches reveal mechanisms underlying chromatin dysregulation in diseases, particularly cancer. His recent publications demonstrate a cohesive trajectory in developing high-resolution structural methods for native chromatin complexes. The work spans nucleosome architecture in different cell cycle phases, centromere assembly mechanisms, and cancer-associated histone mutations, consistently bridging structural biology with chromosome dynamics and disease pathology. These studies employ cutting-edge cryo-EM and biochemical reconstitution to visualize chromatin in near-native states. Scientific Awards No scientific awards were mentioned in the provided documentation. Advising and Funding Dr. Arimura leads an active research laboratory focused on chromatin structure, though specific student names and grant details are not documented in the provided materials. His work requires substantial funding for cryo-EM infrastructure and biochemical reconstitution systems, suggesting support from major biomedical research agencies. The lab trains researchers in structural biology techniques with applications to cancer mechanisms. Laboratory Focus The Arimura Lab develops novel cryo-EM/ET methodologies combined with Xenopus egg extract systems to reconstitute functional chromosomes. Current projects target structural analysis of centromeres, telomeres, and cell cycle-dependent chromatin states, aiming to elucidate how specific chromatin architectures regulate transcription, DNA replication, and chromosome segregation in health and disease.

• G protein coupled receptors (GPCR) signaling
• Neuroscience
• Basal ganglia research
• +5 more

Kirill Martemyanov serves as Professor and Chair of the Department of Neuroscience at the University of Florida, where he leads the Martemyanov Laboratory. His research program focuses on fundamental principles of G protein coupled receptor (GPCR) signaling pathways and their critical roles in nervous system function. Martemyanov's research interests center on GPCR signaling mechanisms in neuronal systems, particularly in the basal ganglia (where they mediate reward behavior and movement coordination) and in the retina (where they control light response and visual processing). His laboratory investigates RGS (Regulator of G protein Signaling) proteins as key regulators of GPCR pathways, with implications for neurological disorders including Parkinson's disease, Huntington's disease, and vision pathologies like macular degeneration. His laboratory employs multidisciplinary approaches including proteomics, enzyme kinetics, cellular signaling analysis, and behavioral characterization of genetic mouse models. The research has significant implications for drug development targeting GPCR signaling pathways. Martemyanov's scientific achievements have been recognized with prestigious awards: John J. Abel Award (2018) ASPET Cogan Award (2014) Association for Research in Vision and Ophthalmology McKnight Land-Grant Professorship (2008) European Academy Prize in Biology (1998) His extensive publication record demonstrates leadership in GPCR signaling research, with recent work focusing on RGS proteins, orphan GPCRs, and molecular mechanisms underlying neurological disorders. Martemyanov also contributes significantly to scientific publishing as an editor for the British Journal of Pharmacology, where he has published guidance on experimental design and drug development. The Martemyanov Laboratory represents a major research hub for GPCR signaling studies, with investigations spanning from molecular mechanisms to behavioral outcomes in neurological disease models.

• G protein coupled receptors (GPCR) signaling
• Neuroscience
• Vision research
• +6 more

Kirill Martemyanov is a distinguished Professor at the University of Minnesota leading the Martemyanov Laboratory, with extensive research focused on G protein coupled receptor (GPCR) signaling pathways and their critical roles in neuronal systems. His work spans neuroscience, pharmacology, and vision research, with particular emphasis on understanding GPCR signaling in basal ganglia and retinal function. Dr. Martemyanov's research interests center on the fundamental principles regulating GPCR signaling, with specific focus on basal ganglia where G proteins mediate reward behavior and movement coordination, and in the retina where G protein signaling systems enable visual processing. His laboratory investigates Regulator of G protein Signaling (RGS) proteins, which promote G protein inactivation and serve as central control points in GPCR signaling cascades. His multidisciplinary approach combines proteomics, enzyme kinetics, cell culture studies, and behavioral characterization of genetic mouse models. Analysis of his recent publications reveals a strong focus on neurodevelopmental disorders, opioid signaling mechanisms, visual processing, and structural characterization of GPCRs. His work demonstrates consistent innovation in understanding G protein pathways, with increasing emphasis on therapeutic applications for movement disorders, vision pathologies, and addiction. John J. Abel Award 2018 ASPET Cogan Award 2014 McKnight Land-Grant Professorship 2008 European Academy Prize in Biology 1998 Dr. Martemyanov serves as Principal Investigator on multiple NIH-funded grants focusing on GPCR signaling in neuronal systems, opioid receptor mechanisms, and retinal biology. His laboratory employs cutting-edge techniques including cryo-EM, in vivo protein labeling, and genetic mouse models to investigate fundamental signaling mechanisms with therapeutic implications. Current research directions include discovery of novel G protein regulators, protein-protein interactions, and feedback mechanisms in signaling pathways. The Martemyanov Laboratory operates at the intersection of neuroscience and pharmacology, investigating how GPCR signaling pathways influence critical biological processes from cellular reception to synaptic transmission. The lab's research has significant implications for understanding and treating neurological disorders including Parkinson's disease, Huntington's disease, Tourette syndrome, tardive dyskinesia, and various ocular pathologies.