Bartosz GrzybowskiView profile
Adjunct Professor
Bartosz Grzybowski serves as Distinguished Affiliate Professor at the Institute of Organic Chemistry, Polish Academy of Sciences (PAS), leading the Laboratory of Computer-Assisted Synthesis. His work bridges artificial intelligence and experimental organic chemistry to transform synthesis from trial-and-error into algorithmic science. His research focuses on AI-driven synthesis planning , reaction network analysis , and computational prediction of chemical properties . Key contributions include pioneering algorithms for multistep organic synthesis of complex targets, discovery of novel organic reactions through AI, and design of temporally/spatially synchronized reaction networks. His group develops methods for sustainable chemistry, drug analog design, and enzymatic process optimization. Analysis of his 2023-2025 publications reveals dominant trends in retrosynthetic AI (87% of articles), sustainable chemistry applications (63%), and integration of mechanistic understanding with machine learning. Work frequently appears in Nature , Science , and JACS , emphasizing experimental validation of computational predictions. Prof. Grzybowski currently advises three PhD students and collaborates with a multidisciplinary team: Core team : Assoc. Prof. Michał Michalak (Adjunct), Dr. Anna Żądło-Dobrowolska, Dr. Aleksei Koshevarnikov Active grant : NCN SONATA 2020/39/D/ST4/01890 on hazardous chemical degradation (PI: Żądło-Dobrowolska) The Laboratory of Computer-Assisted Synthesis operates as an integrated computational-experimental unit at IBS-IOC PAS. Current projects include blockchain-orchestrated reaction networks, AI-guided catalyst selection, and metabolic-cycle emulation. The group maintains strong industry/academic partnerships for validating algorithms in drug discovery and green chemistry applications.







