Gioele La MannoView profile
Assistant Professor
Gioele La Manno is an Assistant Professor (tenure track) at the École Polytechnique Fédérale de Lausanne (EPFL), affiliated with the School of Life Sciences (SV) and the Department of Life Sciences Engineering. He leads the Unité du Prof. La Manno (UPLAMANNO) and holds roles in teaching and doctoral education within the SSV-ENS and Programme doctoral Biologie computationnelle et quantitative . His research focuses on single-cell genomics, cellular heterogeneity, and systems biology approaches to study developmental and neural systems. La Manno’s educational background includes a strong foundation in computational and quantitative biology, reflected in his teaching of courses like Biological data science I: statistical learning and Scientific literature analysis in neuroscience . His lab explores interdisciplinary methods combining genomics, epigenomics, and machine learning to dissect cell fate decisions and tissue organization. He actively contributes to doctoral programs, supervising over a dozen PhD students and advising theses on topics ranging from nervous system development to drug sensitivity profiling. His work bridges basic research with translational applications, such as clinically compliant cell cryopreservation for regenerative medicine. La Manno collaborates across EPFL’s Life Sciences Engineering ecosystem, leveraging state-of-the-art technologies like mass spectrometry imaging and single-cell RNA velocity modeling. His lab’s recent studies address lipidome dynamics, glial diversity in the CNS, and the molecular regulation of midbrain dopaminergic neurons.










