Kathleen MulvaneyView profile
Assistant Professor
Kathleen Mulvaney is an Assistant Professor at the Fralin Biomedical Research Institute at Virginia Tech and in the Department of Biomedical Sciences and Pathobiology at the Virginia-Maryland College of Veterinary Medicine. Her laboratory is located at the Children's National Research & Innovation Campus in Washington, D.C., where she leads research efforts focused on cancer biology and therapeutic development. Dr. Mulvaney's educational background includes: Ph.D. in Cell Biology from the University of North Carolina, Chapel Hill B.S. in Biology from the University of Rochester Dr. Mulvaney's research program centers on understanding and disrupting protein-protein interactions and protein modifications in cancer, with particular focus on pancreatic cancer and pediatric and adult brain cancers. Her laboratory investigates tumor dependencies - the specific enzymes and pathways that cancers rely on for survival - with the goal of translating these findings into meaningful clinical improvements for patient care. A significant portion of her recent work has focused on PRMT5, an enzyme found in approximately 15% of human cancers, exploring how to target this enzyme for therapeutic benefit. Her research employs CRISPR gene editing, molecular biology techniques, and biochemical approaches to identify vulnerabilities in cancer cells. Her laboratory has made significant contributions to understanding the molecular basis of substrate recruitment to the PRMT5 methylosome and has discovered first-in-class inhibitors of the PRMT5-substrate adaptor interaction. Recent work published in Cancer Research demonstrates a promising combination therapy approach for hard-to-treat cancers that lack specific tumor suppressor genes. These cancers, which include certain lung, brain, and pancreatic tumors, become dependent on PRMT5 for survival, making it a potential therapeutic target. Dr. Mulvaney has received numerous scientific awards and honors, including: National Institutes of Health F32 Ruth L. Kirschstein Postdoctoral Individual National Research Service Award (2018-2021) National Institutes of Health LRP Award (2019-2021) Sigma Xi Research Society Graduate Student Travel Award (2015) National Science Foundation Graduate Research Fellowship Honorable Mention (2011, 2012) Dr. Mulvaney actively mentors graduate students and postdoctoral researchers in her laboratory at the Children's National Research & Innovation Campus. Her research is supported by grants from the National Institutes of Health, including an R35 grant to examine cancer-related enzymes. She collaborates extensively with researchers across Virginia Tech and Children's National Hospital to advance cancer research and therapeutic development, participating in the Virginia Tech Cancer Research Alliance which brings together scientists and physicians to develop innovative approaches to cancer treatment. The Mulvaney Lab is part of the Cancer Research Center - D.C. at the Children's National Research & Innovation Campus, where they work alongside other researchers in the Children's Cancer and Immunobiology Center. This collaborative environment allows for interdisciplinary approaches to understanding cancer biology and developing novel therapeutic strategies, with particular emphasis on translating basic science discoveries into clinical applications for hard-to-treat cancers.











