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Jens S. Andersen is a Professor in the Department of Biochemistry and Molecular Biology at the University of Southern Denmark, where he leads research in Biomedical Mass Spectrometry and Systems Biology. His work is centered on the development and application of quantitative mass spectrometry and microscopy-based proteomics to study human cell biology, particularly the structure and function of organelles such as centrosomes, cilia, autophagosomes, and mitochondria. His research focuses on determining the protein composition and dynamic properties of cellular organelles, the roles of specific protein groups, and their contributions to biological processes and diseases. He investigates cell signaling mediated by post-translational modifications, especially within the DNA damage response, autophagy, and immune systems. His lab, the Jens S. Andersen Lab, is part of the Research Section of Biomedical Mass Spectrometry. The analysis of his recent publications reveals a strong interdisciplinary trend combining proteomics, structural biology, and cell signaling. His work spans cilia biology, RNA metabolism, DNA repair, and cancer mechanisms, with frequent use of advanced techniques like mass spectrometry, CRISPR, and live-cell imaging. The integration of systems biology approaches is evident across his research outputs. Professor, Department of Biochemistry and Molecular Biology, University of Southern Denmark Head of Research, Biomedical Mass Spectrometry and Systems Biology Principal Investigator, Jens S. Andersen Lab ORCID: 0000-0002-6091-140X While no specific scientific awards are mentioned in the provided texts, his extensive publication record in high-impact journals such as Science , Nature Communications , Molecular Cell , and EMBO Journal reflects significant scholarly contributions. He has supervised research projects and collaborated widely across Europe, though specific names of students are not listed. His research is supported by multiple ongoing projects, reflecting sustained funding and academic leadership. The Jens S. Andersen Lab operates at the intersection of proteomics and cell biology, contributing to fundamental understanding of organelle dynamics and disease mechanisms. The lab's work is highly collaborative, involving partnerships with groups in structural biology, RNA research, and cancer biology.

• Proteomics
• Quantitative Mass Spectrometry
• Cell Biology
• +11 more

Istvan Albert is a Research Professor of Bioinformatics at Pennsylvania State University , affiliated with the Department of Biochemistry and Molecular Biology . He leads the Bioinformatics Consulting Center and teaches BMMB 852: Applied Bioinformatics . Research Interests: Specializing in bioinformatics, large-scale biological data analysis, microarray and sequence analysis, scientific programming, algorithm development, and database-driven web development. His work spans gene ontology visualization , RNA-Seq analysis , and coronavirus research . Software Development: Created GeneScape for gene function visualization and bio for bioinformatics workflows. Maintains the Biostar Handbook series and the Biostars Q&A Forum , a leading bioinformatics resource.

• Bioinformatics
• Genomics
• Computational Biology
• +5 more

Professor Dario Alessi is a leading academic at the University of Dundee's School of Life Sciences, serving as the Director of the MRC Protein Phosphorylation Unit (MRC PPU) and Professor of Signal Transduction. He earned his BSc (1988) and PhD (1991) from the University of Birmingham. His research focuses on protein phosphorylation and ubiquitylation pathways, particularly the LRRK2 kinase pathway linked to Parkinson's disease. He has made groundbreaking contributions to understanding LRRK2's role in neurodegeneration, including its interaction with Rab proteins and scaffolding molecules like RILPL1. School of Life Sciences, University of Dundee MRC PPU Director since 2012 Signal Transduction Therapy Unit Director His work combines molecular biology, biochemistry, and collaborative industry partnerships to advance therapeutic strategies for Parkinson's disease. Key research areas include LRRK2 activation mechanisms, Rab protein phosphorylation, and lysosomal dysfunction. Alessi has trained over 30 graduate students and 40 postdocs, many now in academic and industry leadership roles. Notable awards include the EMBO Gold Medal (2005), the Robert A. Pritzker Prize for Leadership in Parkinson’s Research (2023), and an OBE (2023) for contributions to medical science. His lab promotes open science, sharing reagents and protocols globally through platforms like MRC Pure Agents and LRRK2.bio. Current projects include investigating novel mitochondrial and organelle biology in Parkinson’s, developing biomarkers, and advancing LRRK2 inhibitors through clinical trials. Collaborations span the Michael J. Fox Foundation, Aligning Science Across Parkinson’s, and the UK Dementia Research Initiative.

• Protein Phosphorylation
• Ubiquitylation Pathways
• Parkinson's Disease
• +3 more

Nathalie Katsonis is a Professor of Chemistry at the University of Groningen, affiliated with the Faculty of Science and Engineering and the Molecular Active Systems department within the Stratingh Institute of Chemistry. Her research focuses on understanding and designing active molecular systems inspired by biological mechanisms, emphasizing the transmission of movement across molecular to macroscopic scales, particularly in liquid crystals, supramolecular chemistry, and molecular machines. She holds a Ph.D. in Chemistry from Sorbonne Université (2004), followed by postdoctoral research at the University of Groningen (2004–2007) and a Veni Fellowship (2009–2011). Prior to her current position, she held academic roles at the University of Twente, including Professor, Associate Professor, and Assistant Professor from 2011–2020. Her research explores molecular motion mechanisms, chirality control, and the creation of functional materials like light-responsive polymers and self-actuating systems. Key contributions include studies on rotaxane-based liquid crystal switches and macroscopic motion driven by molecular dynamics. She leads an international research group and chairs committees such as the Binding Study Advice Commission (FSE) and the Van't Hoff Foundation. Notable awards include the Professor-Werdelmann Award (2022), Koninklijke Hollandsche Maatschappij der Wetenschappen membership (2021), and an ERC Consolidator Grant (2017). Her work bridges fundamental science and applications in soft robotics, smart materials, and origins-of-life research.

• Chemistry
• Liquid Crystals
• Supramolecular Chemistry
• +7 more

Paul O'Callaghan is a Researcher at Uppsala University's Department of Medical Cell Biology within the Faculty of Medicine. His work spans multiple disciplines at the intersection of cell biology, neuroscience, and biomedical engineering. Based at the BMC campus in Uppsala, he maintains an active research program with publications spanning from 2008 to the present, demonstrating sustained scholarly productivity. Dr. O'Callaghan's research interests focus on cellular mechanisms relevant to neurodegenerative diseases, particularly Alzheimer's disease, with emphasis on amyloid-beta pathology, heparan sulfate proteoglycans, and glial cell biology. His recent work has expanded into biomedical engineering applications including bioprinting, microfluidics, and biomaterials for neural applications. His publication record reveals a trajectory from fundamental cell biology toward translational applications, with consistent focus on cellular signaling mechanisms. O'Callaghan's recent publications (2021-2024) demonstrate a shift toward more engineering-focused approaches to biological problems, including 3D bioprinting, microfluidic cell culture systems, and biomaterial testing. His work maintains strong connections to both fundamental cell biology questions and potential clinical applications, particularly in neurodegenerative disease and cancer research. He leads his own research group within the Department of Medical Cell Biology, collaborating extensively with colleagues across Uppsala University including Johan Kreuger, Olle Eriksson, and other researchers in related fields. His work appears in high-impact journals across cell biology, neuroscience, and biomaterials disciplines.

• Cell Biology
• Neuroscience
• Alzheimer's Disease Research
• +7 more

Wei-Chung Allen Lee, PhD, is an Associate Professor of Neurology and Neurobiology at Harvard Medical School. His research focuses on understanding how neural circuits enable behavior through functional connectomics, combining advanced imaging, machine learning, and computational modeling. The Lee Lab develops tools like X-ray holographic nanotomography and GridTape for high-resolution neural structure analysis. Key interests include circuit principles in Drosophila, cerebellar interneurons, and synaptic wiring in decision-making regions. His work explores structural-functional relationships in networks, conservation across species, and developmental constraints on neural architecture. Recent studies highlight connectomic reconstructions in Drosophila, cerebellar disinhibition mechanisms, and blood-brain barrier heterogeneity. Methodological innovations in microscopy and image restoration underscore his lab’s interdisciplinary approach. The Lee Lab is located at 220 Longwood Avenue, Boston, MA, and collaborates on large-scale neuroimaging pipelines like the Open Connectome Project.

• Neuroscience
• Connectomics
• Neural Circuits
• +3 more

David Agard is a Professor in the Department of Biochemistry and Biophysics at the University of California San Francisco (UCSF), where he leads a research group focused on uncovering the structural basis of biological function at the molecular and cellular levels. His lab specializes in advanced cryo-electron microscopy (cryo-EM) and fluorescence light microscopy, developing novel imaging technologies to study dynamic cellular processes. His research interests span structural biology , molecular chaperone function (particularly Hsp90 and its role in disease), microtubule nucleation , centrosome and cilium structure , and the structure of phage-encoded tubulins . He is deeply involved in methodological innovations in cryo-EM data processing , including deconvolution, heterogeneous reconstruction, and tomography, enabling atomic-level insights into complex biological systems. Recent publications highlight his lab’s work on the structural mechanisms of Hsp90-client regulation, microtubule organization, phage nucleus formation, and high-resolution imaging techniques using functionalized graphene-oxide grids. His work increasingly integrates AI-driven structural modeling and in situ approaches to understand macromolecular complexes in their native cellular context. Dr. Agard has made seminal contributions to understanding the ATPase cycle of Hsp90, the architecture of the gamma-tubulin complex, and the structural dynamics of viral and cellular tubulins. His research bridges biochemistry, biophysics, and cell biology, with implications for cancer, neurodegeneration, and antimicrobial strategies.

• Structural Biology
• Molecular Biophysics
• Cryo-Electron Microscopy
• +9 more

Gregory C. Rogers is a Professor in the Department of Cellular and Molecular Medicine at the University of Arizona, with additional appointments in the BIO5 Institute, Cancer Biology GIDP, and Genetics GIDP. He specializes in molecular mechanisms governing centriole duplication and centrosome instability in cancer progression. Education: BA in Biology from the University of Rochester PhD in Cell and Developmental Biology from University of California, Davis Postdoctoral training at Albert Einstein College of Medicine and University of North Carolina, Chapel Hill His research focuses on centriole duplication control, centrosome amplification/loss in prostate cancer, and the role of Polo-like kinase 4 (Plk4) in mitotic errors. Articles from 2010-2025 highlight his work on centrosome dynamics, cancer-related chromosomal instability, and Drosophila model applications. Recent studies (2023-2025) explore PIM kinase inhibition in immunotherapy, Plk4 regulation, and centrosome loss as a driver of prostate malignancy. Earlier work (2010-2019) established foundational knowledge of centriole assembly and condensin II function.

• Centriole Duplication
• Centrosome Instability
• Chromosomal Instability (CIN)
• +6 more

Professor Hannah Mitchison is a leading academic at University College London (UCL) , where she serves as Professor of Molecular Medicine in the Genetics & Genomic Medicine Department at the UCL Great Ormond Street Institute of Child Health. She is Head of the department (2022–present) and has held leadership roles in the Ciliopathy Alliance and UK Cilia Network . Her research focuses on ciliopathies and genetic mutations in rare diseases, particularly Primary Ciliary Dyskinesia (PCD) . PhD in Biochemistry (University of Birmingham, 1991) BSc (Hons) in Biochemistry (University of Sussex, 1986) Her research spans genetic discovery , functional studies of ciliary proteins , and translational genetic therapies for PCD and related disorders. Recent work includes large-scale genomic analyses with the 100,000 Genomes Project and developing the CiliaVar database for motile ciliopathy variants. She also explores genotype-phenotype correlations in PCD cohorts across the UK, Finland, and Palestine. Her teaching roles include supervising PhD and MSc students, lecturing on UCL’s MSc Cell & Gene Therapy and Genomic Medicine programs, and leading the module Genomics of Common and Rare Inherited Diseases . She is co-lead for UCL on the Health Education England-supported MSc Genomic Medicine course. Scientific contributions include over 170 journal articles, with recent high-impact publications in Nature , Science , and European Respiratory Journal , emphasizing genomic approaches and novel therapies for ciliopathies. Collaborations with clinical teams and patient advocacy groups like the Ciliopathy Alliance underscore her translational focus. Funding comes from organizations including the Medical Research Council (MRC), Biotechnology and Biological Sciences Research Council (BBSRC), and NIHR Great Ormond Street Hospital Biomedical Research Centre.

• Genetics
• Genomic Medicine
• Rare Diseases
• +5 more

Kelly Sutherland is a Professor of Biology at the University of Oregon , affiliated with both the College of Arts and Sciences and the Oregon Institute of Marine Biology (OIMB) in Charleston. She holds a Ph.D. from MIT/Woods Hole Oceanographic Institution (2009), an M.S. from the University of South Alabama (2004), and a B.S. from Tufts University (1999). Her research bridges biology and physics, focusing on biomechanics and fluid-environment interactions in marine organisms, particularly gelatinous zooplankton. Education: B.S., Tufts University (1999) M.S., University of South Alabama (2004) Ph.D., MIT/Woods Hole Oceanographic Institution (2009) Sutherland’s lab investigates ecological and evolutionary roles of gelatinous plankton, which are understudied yet critical to marine food webs. Her work emphasizes predator-prey dynamics , multi-jet propulsion , and microbial-grazing interactions , employing in situ video, kinematic analysis, and flow visualization. Recent studies explore colonial salp swimming efficiency, appendicularian particle selection, and ctenophore ecological impacts in open oceanic ecosystems. Research Trends: Recent publications highlight Salp colonial architecture , multi-jet propulsion , microbial prey dynamics , particle surface properties , and hydrodynamic advantages in pelagic organisms . Collaborative themes span biomechanics , ecosystem impacts , and evolutionary adaptations . Advising & Outreach: Dr. Sutherland mentors undergraduate, MSc, and PhD students at both the Eugene campus and OIMB, with lab opportunities in lab/field studies and summer research. She encourages external funding applications and collaborates with environmental studies programs. Outreach includes partnerships with journalists, filmmakers, and artists to communicate science to broader audiences.

• Ecology
• Evolution
• Marine Biology
• +5 more

Dr. Emily Gibson is an Associate Professor in the Department of Bioengineering at the University of Colorado School of Medicine. She holds a PhD from the University of Colorado Boulder (2004) and a BS from the Colorado School of Mines (1997). Her multidisciplinary research focuses on developing advanced optical technologies for neuroscience applications. Her primary research interests include: Development of implantable miniature microscopes for two-photon brain imaging in freely behaving animals Superresolution STED microscopy for subcellular imaging of protein dynamics Optical interfaces for neural modulation and sensing in central and peripheral nervous systems Applications in brain mapping, neural circuit analysis, and bioelectronic medicine Dr. Gibson's recent publications demonstrate a strong focus on neurophotonic tool development, including miniature microscopes, fiber-optic imaging systems, and superresolution techniques. Her work consistently applies these technologies to study neural coding, learning mechanisms, and neurodegenerative processes. She leads the Biophotonics Lab at CU Anschutz, which actively develops open-source neurophotonic tools. Current projects include BRAIN Initiative-funded work on voltage imaging and NSF-supported research on odor navigation. Her lab maintains active collaborations with neuroscientists and clinicians to translate optical technologies into neuroscience research and clinical applications.

• Neurophotonics
• Biomedical Optics
• Neural Imaging
• +4 more

Michael J. Caplan is the C.N.H. Long Professor of Cellular and Molecular Physiology and Professor of Cell Biology at Yale School of Medicine, where he also serves as Chair of the Department of Cellular and Molecular Physiology. He has been a faculty member at Yale since 1988, following the completion of his M.D. and Ph.D. degrees from Yale University in 1987. His academic journey began with a bachelor's degree in Biology from Harvard University in 1980. Dr. Caplan's research program focuses on understanding how membrane proteins are sorted in polarized epithelial cells, with particular emphasis on the Na,K-ATPase (sodium pump) in renal epithelial cells. His laboratory has made significant contributions to understanding the mechanisms responsible for Autosomal Dominant Polycystic Kidney Disease (ADPKD), particularly through studies of the polycystin-1 and polycystin-2 proteins. His work has revealed that polycystin-1 undergoes proteolytic cleavage to release its C-terminal tail, which enters the nucleus and modulates signaling pathways including Wnt signaling. His research also explores connections between renal cilia and olfactory signaling pathways in kidney function. Analysis of Dr. Caplan's recent publications reveals a strong focus on the molecular mechanisms underlying polycystic kidney disease, with particular attention to protein trafficking, membrane contact sites, transcriptional regulation in cystic cells, and novel therapeutic approaches. His work spans multiple disciplines including cell biology, molecular physiology, and translational medicine, with increasing integration of advanced imaging techniques and nanotechnology approaches. Dr. Caplan has received numerous prestigious awards including: Fellow of the American Association for the Advancement of Science (2023) Carl W. Gottschalk Distinguished Lectureship from the American Physiological Society (2012) Young Investigator Award from the American Society of Nephrology (1998) National Young Investigator Award from the National Science Foundation Fellowships from the Helen Hay Whitney Foundation and David and Lucille Packard Foundation As an educator and mentor, Dr. Caplan has received Yale's Postdoctoral Mentoring Prize (2010) and Bohmfalk Award for Excellence in Basic Science Teaching (2000). He currently serves as Editor-in-Chief of the journal Physiology and on the Board of Directors of the American Physiological Society. His laboratory continues to be at the forefront of research on kidney cell biology and polycystic kidney disease pathogenesis, with ongoing investigations into novel therapeutic targets and mechanisms of disease progression.

• Cell Biology
• Epithelial Cell Physiology
• Membrane Protein Trafficking
• +5 more

Professor Takashi Ishikawa is a distinguished researcher and Group Leader at the Paul Scherrer Institute (PSI) in Switzerland, where he heads the Laboratory for Multiscale Bioimaging within the PSI Center for Life Sciences. His work focuses on the structural biology of eukaryotic flagella and cilia using advanced electron cryo tomography and microscopy techniques. Dr. Ishikawa's research program centers on understanding the 3D molecular architecture and functional mechanisms of flagellar/ciliary components, particularly dynein motor proteins. His laboratory employs cutting-edge cryo-EM methodologies to visualize biological macromolecules and organelles in their native hydrated states, enabling three-dimensional reconstructions at increasingly higher resolutions. The team's work has revealed critical insights into the molecular arrangement of dyneins and other proteins on microtubule doublets, the structural basis of dynein power stroke, and the mechanisms underlying flagellar/ciliary bending motion. His research has significant implications for understanding ciliopathies—diseases caused by defects in flagella/cilia—which affect multiple organ systems including respiratory tracts, reproductive systems, and the brain. The fundamental insights gained from studying these natural nanomachines also inform the development of artificial nanoscale devices and systems. Dr. Ishikawa has established numerous collaborative research projects with groups across various disciplines, including biochemistry, biophysics, and medical research. His laboratory serves as a hub for structural biology research at the intersection of cell biology and nanotechnology, training the next generation of scientists in advanced imaging techniques.

• Structural Biology
• Cryo-electron Tomography
• Flagella/Cilia Research
• +4 more

Jonathan Eggenschwiler is an Associate Professor in the Department of Genetics at the University of Georgia (UGA), affiliated with the UGA Developmental Biology Alliance. His research focuses on molecular mechanisms governing tissue patterning during mammalian embryonic development, particularly through Hedgehog and Nodal signaling pathways. B.A., Biology, University of California, Santa Cruz (1988) Ph.D., Genetics and Development, Columbia University (1998) Postdoctoral Research, Sloan-Kettering Institute (2003) Using mouse models, his lab investigates how Hedgehog signaling controls cell fate specification in the central nervous system and explores Nodal signaling in left-right axis patterning. Current NIH/NICHD grants support studies on Hedgehog transcriptional responses linked to the cell cycle and TGF-beta regulation by Rab23 and Megf8. He also co-leads an NSF-funded project to develop genome-editing tools in Anolis lizards. His scientific contributions are highlighted by awards such as the March of Dimes Basil O’Connor Starter Scholar Award and his role on editorial advisory boards for journals like Cilia and Development. He teaches courses including GENE4310 (Genetic Approaches to Developmental Neuroscience) and mentors graduate students.

• Developmental Biology
• Genetics
• Hedgehog Signaling Pathway
• +3 more

Dr. Steven J. Jones is a Professor in the Department of Medical Genetics at the University of British Columbia (UBC) and Associate Director/Head of Bioinformatics at the Genome Sciences Centre, BC Cancer Research Centre. He serves as Director of the CIHR/MSFHR Bioinformatics Training Program and the UBC Bioinformatics Graduate Program, with associate memberships at the Peter Wall Institute for Advanced Studies and Michael Smith Laboratories. Dr. Jones' research focuses on computational genomics and cancer bioinformatics , analyzing mutational landscapes and epigenetic targets in oncology. His work includes next-generation sequencing , structural variant detection , and long-read sequencing applications for resolving complex genomic architectures. He has extensive experience with transcriptome analysis , gene regulation , and comparative genomics across diverse organisms including C. elegans , conifers, and human pathogens. His 15 most recent publications highlight expertise in long-read sequencing for cancer genomics , imprinting disorders , and structural variation analysis. Key contributions include developing the Circos visualization tool for comparative genomics and pioneering bioinformatics approaches for epigenetic modifier discovery in oncology. Scientific Awards : Spencer Award for IT innovation (2005) 2007 Medical Genetics teaching award (UBC) 2011 Fellow of the Royal Society of Canada 2012 UBC Killam teaching prize 2014 Distinguished Achievement Award (UBC Faculty of Medicine) 2014 Fellow of the Canadian Academy of Health Sciences Clarivate Analytics Highly Cited Researcher (2016, 2018) Dr. Jones actively advises graduate students and serves as a data analysis center for the Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC). He co-founded Ifowonco Bioinformatics Inc. and Alamya Health, PBC, and consults for Apotheca Systems Inc.

• Bioinformatics
• Gene Expression
• Gene Regulation
• +7 more