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Philippe CampeauView profile

Associate Clinical Professor

• Medical Genetics
• Bone Dysplasias
• Skeletal Dysplasias
• +12 more

Dr. Philippe Campeau is an Associate Clinical Professor in the Department of Pediatrics at the Faculty of Medicine, Université de Montréal. He is affiliated with CHU Sainte-Justine, a major pediatric hospital in Montreal, Quebec, where he works in the Medical Genetics Service. His clinical and research work focuses on genetic disorders affecting children, particularly in the areas of skeletal development and neurogenetics. Dr. Campeau obtained his Doctorate in Medicine from Laval University in Quebec (1998-2003) followed by specialty training in medical genetics at McGill University (2003-2008). He completed postdoctoral training at Baylor College of Medicine (2008-2013), which further developed his expertise in genetic research methodologies. His primary research interests include bone dysplasias , skeletal dysplasias , epilepsy , and epigenetic diseases . Dr. Campeau's laboratory identifies disease-causing genes, deciphers disease pathophysiology, and works to improve the management of children affected by these conditions. His work encompasses exome analysis , functional studies with cell lines and mouse models , and investigations into urea cycle abnormalities . He has made significant contributions to understanding genetic causes of conditions such as Genitopatellar syndrome (KAT6B), osteopetrosis, dysosteosclerosis (SLC29A3), osteogenesis imperfecta, early-onset osteoporosis (WNT1), Yunis-Varón syndrome (FIG4), and DOORS syndrome (TBC1D24). Dr. Campeau's publication record demonstrates a strong trajectory in medical genetics research, with numerous high-impact publications spanning from fundamental genetic discovery to translational research. His work spans skeletal disorders, neurodevelopmental conditions, and epigenetic mechanisms. Recent publications indicate an expanding focus on chromatin modifiers, DNA methylation patterns, and spliceosome function in neurodevelopmental conditions, reflecting the evolution of his research interests toward more complex molecular mechanisms. Dr. Campeau has received several research grants in recent years (6 starting in 2014) from organizations including the Fonds de la recherche en santé du Québec, Canadian Institutes of Health Research, and Fondation Grand Défi Pierre Lavoie. While specific students are not mentioned in the available information, as a clinical professor, he mentors medical students, residents, and research trainees in the Department of Pediatrics. His research is conducted as part of the 'Musculoskeletal Diseases and Rehabilitation' axis at CHU Sainte-Justine Research Center, where he collaborates with international research teams to identify disease-causing genes and develop better management strategies for children with genetic disorders.

Philip BooneView profile

Academic

• Medical Genetics
• Genomics
• Pediatric Genetics
• +4 more

Philip Boone, MD, PhD, is an Attending Physician in the Division of Genetics and Genomics at Boston Children's Hospital and an Instructor of Pediatrics at Harvard Medical School. He specializes in medical genetics with particular expertise in rare disorders, medical mysteries, deletion and duplication syndromes, and Cornelia de Lange syndrome. Dr. Boone sees patients at Boston Children's Brookline location (2 Brookline Place, 7th Floor) and provides comprehensive genetic care including diagnostics, counseling, and individualized management. Stanford University (Undergraduate, 2006) Baylor College of Medicine (Graduate & Medical School, 2013-2014) Boston Combined Residency Program (Internship & Residency, 2016-2020) Harvard Medical School Genetics Training Program (Fellowship, 2020) Dr. Boone's research focuses on neurodevelopmental disorders, chromatin regulation, and genetic diagnostics. His work spans from fundamental genetic mechanisms to clinical applications, with particular emphasis on cohesinopathies including Cornelia de Lange syndrome. He has contributed significantly to understanding genetic variants associated with growth disorders, developmental features, and structural chromosomal abnormalities. His research combines advanced genomic technologies with clinical insights to improve diagnosis and management of rare genetic conditions. Analysis of Dr. Boone's publication record reveals a strong focus on medical genetics with emphasis on neurodevelopmental disorders, chromatin regulation, and genetic diagnostics. His work spans basic research on gene function and regulation to clinical applications in rare disease diagnosis. A notable trend is his investigation of cohesin complex disorders, particularly SMC3 variants and their relationship to Cornelia de Lange syndrome. His publications demonstrate expertise in both traditional genetic analysis and cutting-edge genomic technologies including long-read sequencing and telomere-to-telomere assembly. Dr. Boone actively contributes to medical education through publications on genetic diagnostics and distance learning resources for medical genetics. He has co-authored educational materials that help advance the field's knowledge base and training capabilities. As an attending physician in the Division of Genetics and Genomics at Boston Children's Hospital and a research fellow in the Center for Genomic Medicine at Massachusetts General Hospital, Dr. Boone works within one of the largest pediatric genetics practices in the country. The division includes over 30 board-certified clinical geneticists, genetic counselors, dieticians, and nursing staff who provide comprehensive care for patients with both common and extremely rare genetic conditions.

Yukiko GotohView profile

Professor

• Neural Development
• Neural Stem/Progenitor Cells
• Epigenetics
• +7 more

Yukiko Gotoh is a Professor at the Department of Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, The University of Tokyo. She serves as the Deputy Director and Principal Investigator at the International Research Center for Neurointelligence (IRCN). Her research focuses on understanding the mechanisms that regulate neural stem/progenitor cell fate during embryonic brain development and in the adult brain. Dr. Gotoh's research interests include: Genetic and epigenetic regulation of neural stem/progenitor cell fate Neuronal maturation processes Genesis and maintenance of adult neural stem cells Relevance of neural stem/progenitor cell dysregulation in neurodevelopmental disorders such as autism spectrum disorders Investigation of mechanisms regulating neural stem-progenitor cell fate during neocortical development Genetic and epigenetic regulation of neuronal activation Analysis of Dr. Gotoh's recent publications reveals a strong focus on neural stem cell biology, epigenetic regulation, and neurodevelopmental disorders. Her work demonstrates how chromatin modifiers like Polycomb group proteins and HMGA proteins regulate neural stem cell fate decisions during brain development. A significant portion of her research explores the embryonic origins of adult neural stem cells and how dysregulation of these processes contributes to conditions like autism spectrum disorders and schizophrenia. Her laboratory also investigates the basic mechanisms of cellular responses to viral infection in the brain and their relevance to neurodevelopmental disorders. Dr. Gotoh has made significant contributions to understanding: The role of Polycomb group proteins in neural development How chromatin modifiers regulate neurogenic potential Cell cycle regulation in neural stem cells The PDK1-Akt pathway in neuronal migration Layer-specific heterogeneity of astrocytes Mechanisms underlying schizophrenia-related abnormalities Dr. Gotoh's laboratory conducts research on multiple fronts related to neural development and stem cell biology. Her team investigates: Mechanisms regulating neural stem-progenitor cell fate during neocortical development Genetic and epigenetic regulation of neuronal activation The embryonic origin of adult neural stem cells Dysregulation of neural stem-progenitor cell and neuronal fate in neurodevelopmental disorders Innate immune responses in the brain

Albert M. BerghuisView profile

Professor

• Antibiotic Resistance
• Structural Biology
• X-ray Crystallography
• +3 more

Albert M. Berghuis is a Professor in the Department of Biochemistry at McGill University's Faculty of Medicine. His research focuses on structural mechanisms of antibiotic resistance and fungal pathogenesis using advanced techniques including X-ray crystallography, electron microscopy, and computational chemistry. His primary research interests include: Structural basis of antibiotic resistance mechanisms, particularly against aminoglycosides Development of novel antimicrobials through structure-based drug design Structural studies of fungal-specific metabolic pathways for antifungal drug discovery Enzyme mechanisms involving protein-small molecule interactions Analysis of his recent publications reveals a consistent focus on structural elucidation of resistance mechanisms, with particular emphasis on aminoglycoside-modifying enzymes and fungal targets. His work bridges structural biology with therapeutic development, showing strong translational potential in combating antimicrobial resistance. Professor Berghuis maintains the Berghuis Lab with facilities in both the McIntyre Medical Sciences Building and the Francesco Bellini Life Sciences Building. His laboratory employs integrated structural biology approaches to tackle pressing problems in infectious disease treatment.

• Plant Developmental Biology
• Epigenetics
• Plant Genetics
• +5 more

Ueli Grossniklaus is an Ordinary Professor at the University of Zurich within the Faculty of Mathematical and Natural Sciences , affiliated with the Department of Plant and Microbiology . His work focuses on plant developmental biology, particularly epigenetic and genetic mechanisms governing reproduction and adaptation. Key Courses: Epigenetics, Plant Biology Workshop, Group Seminars on Current Research Laboratory Techniques: Advanced methods in plant cell mechanics, transcriptomics, and genome editing Research Interests span plant epigenetics, reproductive biology, and the interplay between environmental stress and genetic regulation. He investigates: Mechanistic control of gametogenesis and fertilization Epigenetic contributions to plant adaptation Evolutionary implications of asexual reproduction Biophysical forces in plant cell growth Publication Trends (2025–2018) reveal expertise in: Arabidopsis and fern model systems Epigenetic regulation (DNA methylation, histone dynamics) Apomixis and hybrid seed failure mechanisms Biomechanics of pollen tubes and carnivorous plants Genome editing tools (CRISPR) and long-read sequencing Scientific Collaborations include interdisciplinary projects on: Microfluidic devices for plant cell analysis Gene drive ecology and ethics 3D imaging of plant reproductive structures Advising and Grants focus on mentoring through research internships in developmental biology, genetics, and systems biology. His lab engages in: Epigenetic response to environmental stress Cell wall mechanics in reproduction Computational modeling of plant growth Laboratory Teams integrate plant biologists, bioengineers, and computational scientists to study: Mechanistic gene regulation Evolutionary developmental biology Microrobotics for cellular force measurement

Rosana CollepardoView profile

Research Fellow

• Computational Biophysics
• Chromatin Structure
• Epigenetics
• +4 more

Dr. Rosana Collepardo is a Winton Advanced Research Fellow at the Cavendish Laboratory, University of Cambridge, where she leads a research group within the Theory of Condensed Matter (TCM) Group and is also affiliated with the Biological and Soft Systems group. Her research focuses on developing multi-scale computational models to investigate chromatin nanostructure, epigenetic regulation, and biomolecular condensates, with applications in understanding genome organization and sustainable data storage. Her primary research interests include: Computational biophysics of chromatin and epigenetics Mechanisms of biomolecular condensates and phase separation Nanoscale structure of the genome and DNA accessibility Multi-scale modeling from atomistic to mesoscale Design principles for chromatin-inspired data storage Analysis of her recent publications (2023-2025) reveals a dominant focus on chromatin organization, epigenetic mechanisms, and biomolecular condensates. Key trends include the role of nucleosome spacing, linker histones, and epigenetic modifications in chromatin phase separation, alongside investigations into condensate aging, material properties, and the physical principles of phase transitions in RNA-protein systems. Her work consistently integrates computational modeling with experimental validation. Notable scientific awards include: Winton Advanced Research Fellowship ERC Starting Grant Dr. Collepardo actively mentors PhD and MPhil students, including Sivapalan Chelvaniththilan (MPhil in Physics, recipient of Gates and Winton Scholarships), Miguel Garcia Ortegon (MPhil in Scientific Computing), Stephen Farr (PhD in Computational Methods for Materials Science), Akshay Sridhar (MPhil in Scientific Computing), and Adiran Garaizar (PhD with EPSRC scholarship). Her group secures competitive funding through ERC grants and student scholarships. The Collepardo group, established in 2016 at the Maxwell Centre, Cavendish Laboratory, comprises postdoctoral researchers, PhD students, and MPhil candidates. They collaborate with experimental groups to study chromatin dynamics and biomolecular condensates using advanced computational techniques, contributing to fundamental biological understanding and potential biotechnological applications.

Scott RothbartView profile

Professor

• Epigenetics
• Chromatin Regulation
• Cancer Epigenetics
• +4 more

Dr. Scott Rothbart is a Professor in the Department of Epigenetics at Van Andel Institute (VAI), where he leads the Rothbart Laboratory. He earned his B.S. in Food Science and Human Nutrition from the University of Florida and his Ph.D. in Pharmacology and Toxicology from Virginia Commonwealth University. His postdoctoral training was conducted under Dr. Brian Strahl at the University of North Carolina at Chapel Hill. His research focuses on understanding chromatin accessibility, histone post-translational modifications, and DNA methylation's role in disease, particularly cancer. He translates this basic research into epigenetic target identification and drug discovery. Dr. Rothbart has contributed to groundbreaking studies on UHRF1’s role in DNA methylation maintenance and its therapeutic potential in cancer. He co-leads the VAI-SU2C Epigenetics Dream Team and directs the VAI Cancer Epigenetics Training Program. His work has been recognized with awards like the NIH MIRA Award and the American Cancer Society Research Scholar Grant. Research Interests: Chromatin biochemistry, cancer epigenetics, functional proteomics, histone modifications, and epigenetic drug development. His lab develops tools like peptide microarrays and functional proteomics platforms to study histone modifiers and their clinical relevance. Notable Achievements: Published over 122 peer-reviewed papers in 2024, including 63 in high-impact journals. Launched 15 clinical trials through the Epigenetics Dream Team. His lab’s work on viral mimicry therapies and epigenetic drug combinations has advanced cancer treatment strategies. Education: B.S. University of Florida (2004), Ph.D. Virginia Commonwealth University (2009), Postdoctoral Fellowship UNC Chapel Hill (2014).

• Machine Learning
• Artificial Intelligence
• Data Science
• +5 more

Pan Xu is a tenure-track assistant professor with joint appointments in the Department of Biostatistics & Bioinformatics, Department of Computer Science, and Department of Electrical & Computer Engineering at Duke University's Pratt School of Engineering. Prior to joining Duke, he was a Postdoctoral Scholar Research Associate at the California Institute of Technology, and he earned his Ph.D. in Computer Science from UCLA. His research bridges theoretical foundations with practical applications in machine learning and artificial intelligence. Dr. Xu's research focuses on developing computationally- and data-efficient machine learning algorithms with strong theoretical guarantees, particularly in reinforcement learning, optimization, and high-dimensional statistics. His work addresses two fundamental challenges in sequential decision-making: efficient exploration with minimal interactions and robustness against distributional shifts. His research spans theoretical algorithm design, practical implementation, and real-world applications in bioinformatics and healthcare. His publication record demonstrates consistent high-impact contributions to top-tier conferences including ICML, NeurIPS, ICLR, AAAI, and AISTATS. The research trends show a progression from foundational work in non-convex optimization and multi-armed bandits toward increasingly sophisticated frameworks for robust reinforcement learning, with particular emphasis on distributional robustness, efficient exploration strategies, and practical applications. His work often bridges theoretical guarantees with empirical validation. NSF award on approximate sampling based exploration for sequential decision making Whitehead Scholar award from Duke University School of Medicine PIMCO Postdoctoral Fellowship in Data Science UCLA Outstanding Graduate Student Research Award Rising Stars in Data Science by University of Chicago Best Paper Award for Queer In AI: A Case Study in Community-Led Participatory AI at FAccT 2023 Featured Certification for Wasserstein Distributionally Robust Policy Evaluation and Learning for Contextual Bandits at TMLR Oral Presentation award at AAAI 2024 Dr. Xu actively mentors students and researchers, seeking highly motivated individuals with strong mathematical backgrounds for Ph.D. programs in Biostatistics & Bioinformatics, Computer Science, and Electrical & Computer Engineering at Duke. He has received multiple research grants including an NSF award on approximate sampling based exploration for sequential decision making. His service to the academic community includes roles as area chair for NeurIPS, ICML, ICLR, and AISTATS, as well as action editor for Transactions on Machine Learning Research. His research group develops algorithms that address fundamental challenges in sequential decision-making, with applications spanning healthcare, bioinformatics, and multi-agent systems. Current research directions include distributionally robust reinforcement learning, efficient exploration strategies, and applications of graph neural networks to biological problems.

Zhishan WangView profile

Research Professor

• Environmental Carcinogenesis
• Cancer Biology
• Cancer Therapy
• +4 more

Zhishan Wang, MD, PhD is a Research Professor in the Department of Pathology at Stony Brook University's Renaissance School of Medicine . His work focuses on environmental carcinogenesis , particularly mechanisms of cancer biology and cancer therapy , with a specialization in metal-induced carcinogenicity. Research Interests: Environmental Carcinogenesis Epigenetic and Epitranscriptomic Mechanisms Tumor Microenvironment Remodeling Metal Toxicity Pathobiology Non-Coding RNA Regulatory Networks Scientific Contributions: Analysis of 15 recent publications reveals expertise in: Metal-Induced Oncogenic Pathways (e.g., NF-κB activation, Hedgehog signaling) RNA Modification Dynamics (m6A, lncRNA-splicing interactions) Stem Cell Plasticity in Carcinogenesis Multi-Carcinogen Synergy Mechanisms Epigenetic-Genotoxic Interplay Transcriptomic Reprogramming by Toxicants

• Epigenetics
• Epigenomics
• Genetics
• +4 more

Dr. Steven Jacobsen is a Professor in the Molecular, Cell, and Developmental Biology Department at the University of California, Los Angeles (UCLA), where he leads the Jacobsen Lab. His work focuses on epigenetic inheritance and gene regulation in Arabidopsis thaliana and mammalian stem cells, utilizing genetic screens, genomics, epigenomics, and biochemical approaches. The lab also pioneers CRISPR-mediated genome editing techniques. University: University of California, Los Angeles Department: Molecular, Cell, and Developmental Biology Research Interests: Jacobsen's research spans multiple interconnected domains in epigenetics, including DNA methylation patterning, histone modification interplay, and transposable element silencing. His team investigates how chromatin structure influences gene expression and epigenetic inheritance, with applications from plant development to human health. Key areas include: CRISPR-based epigenetic modifications RNA-directed DNA methylation (RdDM) mechanisms Chromatin compaction via MORC proteins Histone variant functions in methylation Transposon control in plant genomes Comparative epigenomics across species Advising Legacy: Over two decades, Dr. Jacobsen has mentored 21 former lab members who now hold academic and industry positions globally, including professors at Chinese Academy of Sciences, University of Georgia, and Southern University of Science & Technology. His lab's publications reveal a consistent focus on DNA methylation dynamics, chromatin remodeling, and small RNA pathways, with recent work emphasizing CRISPR innovations and structural insights into epigenetic regulators.

• Autism Genetics
• Genetic Architecture
• Copy Number Variants
• +5 more

Lauren Weiss, PhD is a Professor of Psychiatry at the University of California, San Francisco (UCSF) School of Medicine and a faculty member at the UCSF Weill Institute for Neurosciences. Her research focuses on understanding the genetic architecture of autism spectrum disorder through genome-wide genetic data analysis and human induced pluripotent stem cell (iPSC) models. Dr. Weiss's laboratory investigates the genetic mechanisms by which DNA variants influence autism risk, examining questions about copy number vs. SNP variation, rare vs. common variation, gene-sex interaction, gene-gene interaction, and gene-environment interaction. Her team uses rich genetic datasets to identify susceptibility loci and the physiological pathways these risk loci implicate. Additionally, they employ iPSC models to study known mutations or copy number variants predisposing to autism, first identifying the effects of genetic risk variants and then determining whether these effects can be modified at the cellular level by environmental or pharmacological agents. Analysis of Dr. Weiss's recent publications reveals a strong focus on sex differences in autism genetics, the role of specific copy number variants (particularly 16p11.2 and 22q11.2), maternal environmental factors during pregnancy, and the integration of multi-omics data to understand neurodevelopmental pathways. Her work bridges basic genetic research with potential clinical applications for improving understanding, prevention, diagnosis, and treatment of autism and related traits. Dr. Weiss has secured significant research funding as Principal Investigator on multiple NIH grants, including R01MH114924 (Decoding the Genetics of Sexual Dimorphism in Autism Spectrum Disorders), R01MH107467 (Utilizing eQTL networks to gain biological insight into multigenic CNVs), and DP2OD007449 (Dissecting Epistasis and Pleiotropy in Autism towards Personalized Medicine). Her laboratory offers research opportunities for students interested in analytical genetics projects related to gene-environment effects, gene-sex effects, gene-gene effects, and the relationship between ASD and brain size. Dr. Weiss actively collaborates with numerous researchers across institutions, particularly on large-scale genomic studies of autism and other neurodevelopmental disorders. Her work has contributed significantly to our understanding of the complex genetic architecture underlying autism spectrum disorder and related conditions.

• Muscle Metabolism
• Aging Research
• mTORC1 Signaling
• +6 more

Dr. Stephanie de Alcantara Fernandes is a Minerva Fast Track Group Leader at the Max Planck Institute for Biology of Ageing in Cologne, Germany, where she leads research on muscle metabolism and aging. Her laboratory investigates how spatial and functional regulation of mTORC1 signaling influences skeletal muscle health, growth, and regeneration throughout the lifespan, with implications for understanding and promoting healthy aging. Dr. Fernandes completed her academic training through a distinguished path: PhD in Biology (Summa cum laude, with distinction), University of Cologne/Max Planck Institute for Biology of Ageing (2017-2023) Master of Science in Genetics, University of São Paulo (2015-2017) Bachelor of Science in Biological Sciences, University of São Paulo (2009-2014) Exchange year at University of Birmingham, UK (2013) Her research focuses on skeletal muscle biology, particularly the balance between anabolic and catabolic processes that maintain muscle health. Dr. Fernandes investigates how mTORC1 (mechanistic Target of Rapamycin Complex 1), a central signaling hub, is spatially organized within cells to selectively regulate specific cellular functions in response to different nutrient sources. Her work reveals that mTORC1 is not simply "on or off" but can be finely tuned to control distinct processes in different cellular compartments, particularly in skeletal muscle cells. A key aspect of her research examines how these regulatory mechanisms change with age, contributing to age-related muscle loss (sarcopenia). By understanding the molecular basis of muscle maintenance and regeneration, her laboratory aims to identify targets for interventions that could promote healthier aging and prevent age-related decline in muscle function. Analysis of Dr. Fernandes' publication record shows a clear trajectory of increasingly independent research focused on mTORC1 signaling, nutrient sensing, and their roles in aging and muscle biology. Her most recent work demonstrates sophisticated understanding of mTORC1's spatial regulation, revealing how different pools of mTORC1 respond to distinct amino acid sources to control specific cellular processes. This research bridges fundamental cell biology with translational applications for aging-related conditions. Dr. Fernandes has received numerous prestigious awards recognizing her scientific excellence: Minerva Fast Track Fellowship (2025) - Group Leader Position for Outstanding Female Scientists from Max Planck Society Graduate School for Biological Sciences (GSfBS) doctoral award for 2023 (2025) World Muscle Society Fellowship (2016) Cologne Graduate School of Ageing Research fellowship (2017-2020) Master's scholarship from São Paulo Research Foundation (2015-2017) Science Without Borders Scholarship from Brazilian Council for Scientific and Technological Development (2013) As a newly appointed Group Leader through the Minerva Fast Track program, Dr. Fernandes is establishing her independent research program with substantial institutional support. Her laboratory combines advanced techniques including high-throughput omics approaches (proteomics, metabolomics), molecular biology, biochemistry, cell biology, and super-resolution microscopy. She utilizes multiple model systems including mouse models, skeletal muscle cell lines, and iPSC-derived skeletal muscle cells to identify evolutionarily conserved mechanisms relevant to human health. Dr. Fernandes leads the Minerva Fast Track Group at the Max Planck Institute for Biology of Ageing, which focuses specifically on "Muscle metabolism and aging." Her team investigates how selective mTORC1 signaling is coordinated between different skeletal muscle cell types and how it changes with age, with the ultimate goal of understanding how muscle health can be maintained throughout life.

Richard KatzView profile

Professor

• Epigenetic Regulation
• Cancer Epigenetics
• Nuclear Lamina
• +7 more

Richard Katz, PhD, is a Professor and Adjunct Professor at the Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, based at Fox Chase Cancer Center. His research focuses on epigenetic regulation in cancer, particularly the role of the nuclear lamina in organizing heterochromatin and gene silencing. PhD in Microbiology, Columbia University (1983) BS in Biology, Summa cum laude, Syracuse University (1975) Dr. Katz's research spans several key areas in epigenetics and cancer biology. He investigates how the nuclear lamina controls epigenetic silencing through proteins like PRR14, which tethers heterochromatin to the nuclear periphery. His lab uses siRNA-based genome-wide screens to identify novel epigenetic silencing networks. Another major focus is melanoma plasticity, where his team discovered ID4 as a key mediator. He also studies epigenetic antiviral responses involving Daxx and retroviral silencing, and functional analysis of breast cancer genes from GWAS and DASE studies using BioID for protein interaction mapping. His recent publications reveal a strong trend in understanding chromatin dynamics, epigenetic silencing mechanisms, and their implications in cancer and viral defense. His work integrates molecular biology, functional genomics, and systems approaches to dissect complex regulatory networks. Notable scientific recognitions include being selected for Cover Art in Epigenetics (2014) and an Article of Significant Interest by the editors of Journal of Virology (2013). Dr. Katz actively mentors students and technicians in his lab, including graduate students and post-baccalaureate researchers. He collaborates widely across Fox Chase, including with J.P. Issa, A. Bellacosa, and A.M. Skalka. His lab participates in the Undergraduate Summer Research Fellowship and research volunteering programs, indicating a strong commitment to training and education. His lab at Fox Chase (R422/W422) includes current members such as Valentina Medvedeva (Graduate Student), Trinity Pellegrin (Scientific Technician), and several student assistants, reflecting an active and collaborative research environment.

Julie AhringerView profile

Professor

• Chromatin Regulation
• Epigenetics
• Genome Organization
• +3 more

Julie Ahringer is Professor of Genetics and Genomics at the University of Cambridge and Director of the Wellcome Trust/Cancer Research UK Gurdon Institute. She leads a research group investigating chromatin structure and gene regulation using C. elegans as a model system. Her work integrates genomics, super-resolution microscopy, and computational approaches to understand epigenetic controls in development and disease. She holds fellowships from the Royal Society (FRS) and Academy of Medical Sciences (FMedSci). Research Focus: Her laboratory studies chromatin regulation mechanisms including heterochromatin formation, Polycomb domain function, genome architecture, and enhancer/promoter interactions. Key approaches include single-cell multiomics, high-throughput genomics, and super-resolution microscopy to analyze developmental trajectories. Research areas span: H3K27me3 domain formation and Polycomb repression Constitutive heterochromatin organization Regulatory element characterization 3D genome architecture via ARC-C technology Single-cell resolution developmental mapping Awards & Honors: Fellow of the Royal Society (FRS) Fellow of the Academy of Medical Sciences (FMedSci) Wellcome Senior Research Fellowship Academic Leadership: She mentors PhD students and postdoctoral researchers, with funding from Wellcome, MRC, and CRUK. Her lab develops open-source bioinformatics tools (VplotR, periodicDNA) and maintains the genome-wide C. elegans RNAi feeding library. Lab & Collaborations: The Ahringer Lab is based at the Gurdon Institute and collaborates widely on chromatin dynamics, nuclear organization, and developmental genomics projects across model organisms.

• Chemical Biology
• Biochemistry
• Cell Biology
• +5 more

Ciaran Seath is an Assistant Professor of Chemistry at Scripps-UF (The Wertheim Scripps UF Institute) in Jupiter, Florida, where he leads the Seath Research Chemistry Lab. His research focuses on using chemical biology methods to discover new therapeutically relevant protein-biomolecule interactions that contribute to disease. Dr. Seath completed his PhD in chemistry from the University of Strathclyde in 2017 under the supervision of Dr. Allan Watson, studying chemoselective transition-metal catalysis. He then conducted postdoctoral research at Emory University with Professor Nathan Jui, developing novel reductive photoredox methodologies, and at Princeton University with Professors David MacMillan and Tom Muir, exploring photocatalytic methods for proximity labeling in cancer biology. His research interests span several critical areas in chemical biology: New Therapeutic Strategies: Using proximity labeling methods to understand how mutations and post-translational modifications lead to diseased phenotypes Understanding Transcription in Disease: Investigating "undruggable" proteins that control transcriptional activation with the goal of finding new cancer therapies PhotoChemical Biology: Developing new chemical reactions in cells driven by visible light irradiation to modify proteins and biomolecules Dr. Seath's laboratory focuses on using state-of-the-art methods in chemical biology to discover new protein-biomolecule interactions relevant to disease, with particular interest in pediatric brain tumors, biochemistry and cell biology, and clinical and translational science. His recent work demonstrates a strong trend toward developing and applying proximity labeling techniques, particularly photoproximity labeling methods with varying activation wavelengths and spatial resolution, to study protein interactions in complex biological systems. His research bridges chemistry, biology, and medicine, with a clear translational focus on developing new therapeutic approaches for challenging diseases. Dr. Seath has secured multiple research grants as Principal Investigator from prestigious sources including Pfizer Inc, the National Institutes of Health (NIGMS, NCI), and the American Chemical Society Petroleum Research Fund. These grants support his innovative work in chromatin chemical biology, photocatalysis, and epigenetic drug discovery. He is actively involved in translational research at Scripps-UF to understand human disease, with his laboratory (The Laboratory of Subcellular Technologies) focusing on developing new chemical tools to address fundamental biological questions with therapeutic implications.