David FeuerbornView profile
Researcher
Dr. David Feuerborn is a Researcher at the Leibniz Research Centre for Working Environment and Human Factors (IFADO) in Dortmund, Germany, within the Toxicology department's Regulatory Networks of Stem Cell Differentiation group. His work focuses on modeling stem cell differentiation into hepatocyte-like cells for toxicology applications, with contact details feuerborn@ifado.de and +49 231 1084-344. His research centers on regulatory mechanisms in stem cell differentiation, particularly hepatocyte development influenced by environmental toxins like bisphenols. He employs genome-wide expression profiling and bioinformatic analysis to study transcription factors (HNF4α, FXR) and cellular responses to toxicants, bridging stem cell biology and toxicology. Analysis of his 2018-2022 publications reveals consistent use of iPSC-derived hepatocyte models to assess compound toxicity, with increasing integration of single-cell genomics and computational methods. Key trends include characterizing hybrid cell states, dissecting endocrine disruptor effects, and developing predictive frameworks for transcription factor activity. As part of IFADO's Regulatory Networks of Stem Cell Differentiation team, he collaborates on projects examining molecular pathways governing cell fate decisions in toxicological contexts, contributing to stem cell-based testing methodologies for drug development and safety assessment.