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Jean Peduzzi-NelsonView profile

Associate Professor

• Spinal Cord Injury
• Neural Regeneration
• Stem Cell Therapy
• +3 more

Jean Peduzzi-Nelson is an Associate Professor and Director of Medical Neuroscience at Wayne State University's School of Medicine. Her research focuses on developing innovative treatments for chronic spinal cord injuries (SCI) and traumatic brain injuries, emphasizing neural regeneration, stem cell therapies, and rehabilitation protocols. She collaborates with neurosurgeons and bioengineers on preclinical studies involving artificial spinal cord grafts and clinical trials examining exercise-induced cognitive recovery in brain injury patients. Her work spans neuroimmunology, biomaterials, and translational medicine, with publications exploring olfactory mucosa autografts, poliovirus-based gene therapies, and enriched environmental interventions. She has received teaching awards from Wayne State University (WSU) and the School of Medicine (SOM) and has testified before US Senate committees on neuroscience research. Scientific Awards: WSU Teaching Award SOM Teaching Award Peduzzi-Nelson leads multidisciplinary teams, including collaborations with Dr. Harini Sundaraghavan (Bioengineering) and Dr. Asad Mazhari (Neurosurgery), and maintains active international partnerships, such as a pivotal clinical study with Portuguese researchers.

Jian-Ping JinView profile

Professor

• Muscle contractility
• Cell motility
• Gene regulation
• +6 more

Jian-Ping Jin is a Professor and Chairman of the Department of Physiology at Wayne State University School of Medicine. He holds a secondary appointment in Obstetrics and Gynecology and has held leadership roles at multiple institutions, including the University of Calgary, Case Western Reserve University, and Northwestern University. Education: M.Sc. in Immunology (1986), Ph.D. in Biology (1989) Dr. Jin specializes in muscle contractility and cytoskeleton protein regulation, with a focus on gene expression, structural dynamics, and pathophysiological adaptations. His work bridges molecular mechanisms and translational applications for cardiovascular diseases and cancer metastasis. He has secured significant NIH funding (R01, R21, T32 grants) and directed the Detroit Cardiovascular Training Program. Dr. Jin's laboratory investigates actin thin filament regulators like troponin and calponin, connecting basic science to clinical innovations. Scientific Awards: William D. Traitel Professor, Wayne State University Academy of Scholars His mentorship extends to numerous trainees, many of whom have established independent careers. Dr. Jin also serves as Editor-in-Chief for Archives of Biochemistry and Biophysics and holds four US patents related to cardiac and cancer therapies.

Jostein HallénView profile

Professor

• Exercise Physiology
• Sports Physiology
• Cardiovascular Physiology
• +5 more

Jostein Hallén is a Professor at the Norwegian School of Sport Sciences, Institute of Physical Performance, where he leads the Integrated Physiology research group. His work focuses on exercise physiology, cardiovascular adaptation, and endurance training, with a particular interest in youth athletes and hypoxia effects. Hallén has published extensively on topics like blood volume, cardiac remodeling, and metabolic responses to training. PhD in Physiology from the University of Oslo Former Head of the Department of Physical Performance Former middle-distance runner and track coach His recent research explores the impact of aerobic exercise on cancer survivors, high-intensity training in youth, and mechanisms of fatigue during hypoxia. Collaborative projects often involve interdisciplinary teams and advanced physiological measurements. See ResearchGate for complete publications.

• Transfusion Medicine
• Platelet Research
• Blood Safety
• +5 more

Claudia S Cohn is a Professor in the Department of Laboratory Medicine and Pathology with a focus on Transplant and Cellular Therapy at the University of Minnesota. She serves as Principal Investigator for multiple significant research projects including the Chilled Platelet Study (CHIPS) and The BLOODSAFE Data Coordinating Center for safe transfusions in Sub-Saharan Africa. Her expertise spans transfusion medicine, blood safety, and cellular therapy, with particular emphasis on platelet research and convalescent plasma applications. Dr. Cohn's research interests primarily focus on transfusion medicine with specific expertise in: Platelet storage, function, and transfusion protocols Blood safety and hemovigilance systems Convalescent plasma therapy, particularly for pandemic response Transfusion practices in special populations including obstetrics and hematology patients Global blood safety initiatives, particularly in Sub-Saharan Africa Blood product inventory management and optimization Her work has significantly contributed to clinical practice guidelines issued by the Association for the Advancement of Blood and Biotherapies (AABB). Dr. Cohn's publication record demonstrates consistent scholarly output with 108 research outputs documented. Her recent work shows a strong emphasis on evidence-based transfusion medicine practices, with particular focus on platelet transfusion guidelines, blood safety protocols, and addressing challenges in the blood supply chain. She has been instrumental in developing AABB clinical practice guidelines and has contributed significantly to the field's understanding of optimal transfusion practices. Her scientific contributions have been recognized through multiple research grants from prestigious organizations including the NIH National Heart, Lung and Blood Institute, the U.S. Department of Defense, and industry partners. Notable projects include: Chilled Platelet Study (CHIPS) (2022-2026) The BLOODSAFE Data Coordinating Center for safe transfusions in Sub-Saharan Africa (2020-2026) A Comparison of Tube and Gel Technology for anti-D titer testing (2020-2025) Passive Immunity Trial for Our Nation (PassItOn) (2020-2021) Dr. Cohn has served as an expert commentator in the media during critical blood supply challenges, particularly during the COVID-19 pandemic, providing insights on convalescent plasma, blood donation practices, and addressing critical blood shortages. Her work contributes to several United Nations Sustainable Development Goals related to health and well-being.

• Cardiovascular Medicine
• Neuroscience
• Pharmacology
• +7 more

Rasna Sabharwal, PhD is an Assistant Professor at the University of Iowa in the Department of Cardiovascular Medicine and Department of Neuroscience and Pharmacology. Her research focuses on neurohumoral control of circulation in diseases like cardiomyopathy, heart failure, hypertension, Alzheimer’s disease, and amyotrophic lateral sclerosis (ALS), utilizing integrative physiological approaches in genetically modified mice. Education: PhD in Physiology (University of Birmingham, UK); Research Fellow in Internal Medicine (University of Iowa) Affiliations: Biomedical Science (Molecular Medicine), Neuroscience Graduate Program; Cardiovascular Research Center, Fraternal Order of Eagles Diabetes Research Center, Iowa Neuroscience Institute Her laboratory combines in vivo techniques (radiotelemetry, optogenetics, microdialysis) with molecular methods (siRNA, RNAseq) to study the renin-angiotensin system, sympathetic nervous system, and hypothalamic-pituitary-adrenal axis. Recent work includes Alzheimer’s disease models , sex-based differences in autonomic regulation , and microparticle-based therapies for muscular dystrophy. She has received training grants from the National Institutes of Health and collaborates with the Pain Research Program.

• Cancer metabolism
• Signal transduction
• Oncogenes
• +4 more

Thomas Graeber, PhD, is a Professor at the Molecular Biology Institute of the University of California, Los Angeles (UCLA). His research focuses on cancer metabolism, tumor microenvironment dynamics, and metabolic reprogramming across malignancies including glioblastoma, melanoma, and prostate cancer. Recent work demonstrates synthetic lethal interactions in glioblastoma metabolism, neuroendocrine cancer progression mechanisms, and immune-modulatory effects of metabolic interventions. Key research themes: Cancer metabolic vulnerabilities, Signal transduction in oncogenesis, Systems biology of tumor heterogeneity Recent collaborations: Sarcoma metabolic targeting (2024), Cardiac recovery post-infarction (2024), Melanoma redox protection (2024) His 15 most recent publications (2022-2025) reveal trends in mitochondrial dependencies , redox signaling , and oncogenic pathway interactions across solid and hematologic cancers. Emerging themes include synthetic lethality , metabolic crisis induction , and cellular plasticity in therapy resistance .

Lori IsomView profile

Professor

• Neuroscience
• Pharmacology
• Epilepsy Research
• +5 more

Lori Isom is the Maurice H. Seevers Professor and Chair of the Department of Pharmacology at the University of Michigan Medical School. She also holds professorships in Molecular and Integrative Physiology and Neurology. Dr. Isom has served as Chair of Pharmacology since 2015, following a national search, after serving as Interim Chair from 2014. Prior to this, she was Director of the Program in Biomedical Sciences and Assistant Dean for Graduate Education from 2008-2014. She serves on many institutional committees including as an elected member of the Medical School Executive Committee. Dr. Isom received her PhD in Pharmacology at Vanderbilt University School of Medicine and completed her postdoctoral training in the laboratory of Dr. William A. Catterall at the University of Washington, a renowned expert in ion channel research whose recent passing (2024) she memorialized in publications. Dr. Isom's research program focuses on voltage-gated sodium channel function and the roles of sodium channel gene variants in developmental and epileptic encephalopathy (DEE), including Dravet syndrome. Her lab investigates SCN1A, SCN1B, and SCN8A DEE variants in mouse models and in human induced pluripotent stem cell (iPSC) neurons and cardiac myocytes. She showed, in collaboration with Dr. Jack Parent, that the high risk of SUDEP in Dravet syndrome may result from cardiac arrhythmias in addition to neuronal hyperexcitability. Most recently, she has collaborated with Stoke Therapeutics to develop the first antisense oligonucleotide precision therapeutic agent for Dravet syndrome, which is now in clinical trials. Her recent publications (2023-2025) demonstrate a strong focus on sodium channelopathies, particularly related to Dravet syndrome and other developmental and epileptic encephalopathies. Her work spans molecular mechanisms, animal models, gene therapy approaches, and translational applications. A notable trend is the expansion of her research into cardiac manifestations of sodium channel disorders, reflecting her discovery that Dravet syndrome involves not just neuronal hyperexcitability but also cardiac arrhythmia risks. Her work on SCN1B-related Dravet syndrome has shown that neonatal gene therapy can reduce seizures and prolong lifespan in mouse models. NINDS Javits R37 MERIT award University of Michigan Rackham Distinguished Graduate Mentoring Award Fellow of the American Association for the Advancement of Science Fellow of the American Society for Pharmacology and Experimental Therapeutics Fellow of the American Epilepsy Society Elected to the National Academy of Medicine (2021) American Epilepsy Society Basic Science Award (2022) Dr. Isom serves as PI of the NIH-funded Pharmacological Sciences Training Program T32 grant and is Co-PI of the NINDS-funded EpiMVP Center Without Walls. She has mentored numerous graduate students and postdoctoral fellows, with several of her trainees now holding independent positions. Her mentorship excellence was recognized with the University of Michigan Rackham Distinguished Graduate Mentoring Award. She served as Director of the Program in Biomedical Sciences and Assistant Dean for Graduate Education from 2008-2014, demonstrating her commitment to academic training. Dr. Isom leads a research laboratory focused on sodium channel function and its implications for neurological and cardiac disorders. Her team includes graduate students, postdoctoral fellows, and research staff working on mouse models of sodium channelopathies and human iPSC-derived neurons and cardiac myocytes. She collaborates extensively with clinicians and researchers both within the University of Michigan and internationally, particularly through her leadership roles in epilepsy research organizations including the Dravet Syndrome Foundation Scientific Advisory Board, American Epilepsy Society, and International League Against Epilepsy Translational Task Force.

Avneesh Kumar SinghView profile

Associate Professor

• Xenotransplantation
• Transplant Immunology
• Cardiac Surgery Research
• +5 more

Avneesh Kumar Singh, PhD, serves as Associate Professor in the Department of Surgery at the University of Maryland School of Medicine. His research pioneers cardiac xenotransplantation using genetically engineered pig hearts to address the critical organ shortage for heart failure patients, with landmark contributions including the first FDA-approved pig-to-human heart transplant. Education: B.Sc. (Hons.) in Zoology, Aligarh Muslim University, Aligarh, UP, India M.Sc. in Zoology, Aligarh Muslim University, Aligarh, UP, India Ph.D. in Zoology (Immunogenetics), Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP, India Dr. Singh's research centers on overcoming immunological barriers in xenotransplantation through genetically modified pig donors and novel immunosuppression strategies . His work investigates immune tolerance mechanisms , particularly the role of regulatory T cells and NKT cells in preventing graft rejection. Key focus areas include antibody-mediated rejection , coagulation dysregulation , and innate immune responses in cardiac xenografts, with direct clinical translation potential. His 15 most recent publications (2014-2022) demonstrate consistent progress toward clinical application, evolving from preclinical survival studies to actual human transplantation. The research trajectory shows increasing sophistication in genetic engineering of donor pigs (triple-knockout with multiple human transgenes), targeted immunosuppression (anti-CD40 antibodies), and management of coagulation complications (thrombomodulin expression). Scientific Awards: Young Investigator Travel Grant (2013) for International Xenotransplantation Meeting Sidney P. Colowick Award for Postdoctoral Research (2002) Dr. K.S. Krishnan Research Fellowship (1993) National Merit Scholarship (1985) Dr. Singh has secured significant research funding as Co-Investigator in the NHLBI/NIH Cardiothoracic Surgery Research Program (2007-2017), focusing on pig-to-baboon cardiac xenotransplantation models. His mentorship extends to junior researchers in immunology and transplantation surgery, with collaborative projects spanning Vanderbilt University, Johns Hopkins, and NIH laboratories. His laboratory maintains active collaborations with the University of Maryland Medical Center's transplant program and industry partners developing genetically engineered pigs. Current work focuses on optimizing donor pig genetics and immunosuppression protocols to achieve sustained xenograft survival beyond current benchmarks.

Martin BielView profile

Professor

• Pharmacology
• Ion Channels
• Genetic Mouse Models
• +4 more

Professor Martin Biel serves as Chair of Pharmacology at Ludwig-Maximilians-University Munich's Faculty of Chemistry and Pharmacy, Department of Pharmacy, and Center for Drug Research. His laboratory focuses on ion channel physiology in CNS and cardiovascular systems. Research centers on cyclic-nucleotide modulated channels (CNG/HCN) and endolysosomal ion channels using genetic mouse models , AAV-mediated gene therapy , electrophysiology , imaging , and telemetric monitoring of in vivo function. Key interests include retinal disorders, neuronal circuit dysfunction, and cardiovascular innervation pathologies. Recent publication analysis reveals strong emphasis on Viral entry mechanisms (Ebola) Retinal gene therapy approaches Cardiac electrophysiology Metabolic liver disease models with consistent application of molecular pharmacology and genetic engineering techniques. Current advisees include Manuela Brümmer, with notable graduate Lisa Riedmayr. Laboratory methods encompass OCT/ERG retinal analysis, telemetric EEG/ECG, and organoid systems. Contact: mbiel@cup.uni-muenchen.de | Lab Website

Eunhee ChungView profile

Associate Professor

• Cardiometabolic Health
• Skeletal Muscle Physiology
• Maternal-Fetal Obesity
• +3 more

Eunhee Chung, Ph.D., is an Associate Professor in the Department of Kinesiology at the University of Texas at San Antonio's College for Health, Community and Policy. She holds a Ph.D. and M.S. in Kinesiology from the University of Wisconsin-Madison, a B.S. in Exercise and Sport Sciences from the University of Georgia, and a B.E. in Environmental Engineering from Kon-Kuk University. Her research program investigates: Sex-specific cardiometabolic outcomes in offspring of obese mothers Skeletal muscle adaptations to obesity/diet interventions Gut microbiome interactions in metabolic diseases Anti-obesity drug mechanisms (CYP8B1 inhibitors) Non-exercise therapies (acupuncture/electrostimulation) for muscle atrophy Her recent publications (2024-2025) demonstrate consistent focus on mitochondrial function regulation in cardiac/skeletal tissues, maternal programming effects on offspring health, and innovative atrophy interventions. Research predominantly utilizes rodent models with advanced molecular and physiological assessments. Awards: American Physiological Society's Established Professional/John F. Perkins, Jr. Research Award (2017) Major Grants: NIH R01: $1,419,790 for 'Sex differences in cardiometabolic health of offspring born to obese mothers' (2019-2024) Pilot grants: $40,998+ for maternal diet/exercise effects on microbiota and mitochondrial function

• membrane cytoskeleton
• microtubules
• spectrin
• +5 more

Jeanine A. Ursitti, PhD, serves as Assistant Professor in the Department of Orthopaedics at the University of Maryland School of Medicine, where her research bridges fundamental cytoskeletal biology with clinical implications for muscular and cardiovascular pathologies. Her work focuses on spectrin-based membrane skeleton organization across diverse cell types including erythrocytes, skeletal myofibers, and cardiomyocytes. Her academic foundation includes: B.S. in Biology from Loyola University Maryland Ph.D. in Membrane Physiology from the University of Maryland Baltimore Postdoctoral Fellowship at The Wistar Institute, Philadelphia, PA Dr. Ursitti's research program centers on the structural and functional roles of spectrin isoforms, with particular emphasis on alternative splicing variants in cardiac and skeletal muscle. Her investigations span from basic erythrocyte membrane architecture to disease mechanisms in muscular dystrophy, cardiomyopathy, and aging-related tissue degeneration. Key contributions include characterizing spectrin's role in costamere formation, connexin 43 localization in cardiomyocytes, and keratin-spectrin interactions in striated muscle. Analysis of her 30-year publication record reveals an evolving trajectory from foundational erythrocyte cytoskeleton studies (1989-1996) toward increasingly clinically relevant cardiac and muscular research (2001-2013). Her recent work demonstrates how αII-spectrin complexes regulate cardiac conduction and protect against dilated cardiomyopathy, highlighting translational potential. The consistent thread throughout her career is the investigation of spectrin's role as a mechanical scaffold and signaling platform across diverse physiological systems. Dr. Ursitti maintains active collaboration with the University of Maryland's muscle biology research group, particularly with Dr. Richard J. Bloch's laboratory, as evidenced by her extensive co-authorship record. While specific grant details aren't provided, her sustained publication output suggests consistent research funding supporting her investigations into cytoskeletal pathologies. Her laboratory likely employs advanced techniques including immunocytochemistry, protein biochemistry, and transgenic mouse models to explore spectrin-related disease mechanisms.

Lamia PınarView profile

Researcher

• Physiology
• Exercise Physiology
• Neuroscience
• +4 more

Lamia Pınar is a faculty member at the Faculty of Medicine , İstanbul Okan University , with extensive research contributions in physiology, neuroscience, and exercise-induced physiological changes . Her work explores the intersection of oxidative stress, neuroplasticity, and ultradian rhythm regulation . Her research focuses include: Exercise physiology (muscle damage, cardiac response, antioxidant mechanisms) Neuroplasticity and ethical implications of neural modulation Circadian/ultradian rhythm effects on cognitive-motor performance Inflammatory markers (IL-6, hepcidin) in trained vs. untrained subjects Analysis of her publications reveals a consistent emphasis on interdisciplinary connections between neuroscience, cardiology, and exercise science , with particular attention to oxidative stress biomarkers , hemispheric brain differences , and long-term exercise adaptations . She has not received explicit awards or grants in the provided data, but her 25+ years of research (1996–2025) demonstrate sustained scholarly activity. Her work appears in journals related to physiological sciences, neurology, and sports medicine .

Andres F OberhauserView profile

Professor

• Single-Molecule Biophysics
• Protein Folding
• Muscle Biology
• +3 more

Andres F. Oberhauser is a Professor in the Department of Neurobiology at the University of Texas Medical Branch (UTMB) , with a secondary affiliation at the Sealy Center for Structural Biology & Molecular Biophysics . His research focuses on single-molecule biophysics, particularly the molecular mechanisms of chaperones like UNC-45 and Hsp90 in myosin folding and sarcomere assembly. PhD in Physiology & Biophysics, University of Chile Postdoctoral training at University of Pennsylvania and Mayo Clinic His work utilizes advanced techniques such as single-molecule atomic force microscopy , site-specific fluorescence probes , and in vitro myosin motility assays to investigate protein mechanics in muscle development and repair. Key findings include the role of UNC-45 in preventing premature myosin powerstrokes and Hsp90's involvement in relieving this inhibition. Recent publications highlight his expanding research into mechanobiology , muscle aging , and cancer cell adhesion . Collaborative projects span C. elegans genetics , cardiovascular protein interactions , and anti-fibrotic therapies . His lab's work has implications for skeletal myopathies , cardiomyopathies , and tumor invasiveness . Selected Contributions: Elucidated UNC-45's dual role in myosin folding and powerstroke inhibition Developed novel single-molecule approaches for chaperone studies Identified nucleolin as a key mediator in cancer cell-L-selectin interactions Explored temperature-dependent structural changes in molecular chaperones

Elizabeth A. CragoView profile

Associate Professor

• Neurocritical Care
• Emergency Nursing
• Critical Care Nursing
• +4 more

Dr. Elizabeth A. Crago is an Associate Professor at the University of Pittsburgh School of Nursing and Dean of the paramedic program at Mutual Aid Ambulance Service . Her clinical and research expertise focuses on acute neurological injury recovery , particularly in aneurysmal subarachnoid hemorrhage (aSAH) patients, examining biomarkers like sex steroids , insulin-like growth factors , and DNA methylation . Research Interests : Neurocritical care biomarkers, genomic pathways in aSAH, neurocardiac injury, and epigenetic mechanisms. Clinical Roles : Emergency and critical care nursing for neurological injuries; faculty practice at Independence Health Emergency Department . Teaching : Primary instructor for NUR1121 (Advanced Clinical Decision Making) and NUR3287 (Research Designs and Methods) . Dr. Crago contributes to clinical practice guidelines and serves on editorial/review boards for journals like Journal of NeuroCritical Care and Journal of Emergency Nursing . She mentors DNP, PhD, and honors students. Her work is funded by NIH and foundation grants .

• Muscle Biology
• Calcium Signaling
• Muscular Disorders
• +4 more

Christopher W. Ward is a Professor in the Department of Orthopaedics, with secondary appointments in Biochemistry & Molecular Biology. His research focuses on muscle biology, calcium signaling, and age-related pathologies. Primary: Orthopaedics Secondary: Biochemistry & Molecular Biology Research Interests Ward's work investigates the role of microtubule dynamics, calcium signaling, and protein modifications in muscular dystrophy and aging. Key areas include: Calcium dysregulation in heart failure and muscular disorders Microtubule modifications and cytoskeletal stiffness Mechanotransduction in bone and skeletal muscle Sex-specific differences in muscle aging and pathology Therapeutic strategies for Duchenne muscular dystrophy Cardiac arrhythmogenesis and mitochondrial oxidative stress Recent Publications Recent work spans muscle aging, calcium signaling, and translational therapies. Trends include: Microtubule detyrosination in dystrophic muscle Nitric oxide effects on sclerostin degradation Targeting lysosomal calcium in arrhythmias Obscurin and titin interactions in cardiac pathology Exercise and mechanical load impacts on muscle and bone Advancing CAR T-cell therapy for cancer