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Youngjae You is a Professor of Empire Innovation in the Department of Pharmaceutical Sciences at the University at Buffalo School of Pharmacy. His research focuses on Antibody-Drug Conjugates, Cancer Chemotherapy, Medicinal Chemistry, and Targeted Drug Delivery. He holds adjunct roles at the University of Oklahoma Health Sciences Center and has led numerous grants totaling over $10 million in funding. Key awards include the 2019 Professor of Empire Innovation title and multiple DoD/CDMRP grants. His work emphasizes prodrug design, photodynamic therapy, and combination therapies. Education : PhD in Pharmaceutical Chemistry, Chungnam National University (2001) MS in Pharmaceutical Chemistry, Chungnam National University (2000) BPharm, Chungnam National University (1994) Research Interests : Dr. You specializes in developing light-activatable prodrugs for targeted cancer therapies, including far-red/NIR light-activated delivery systems. His work integrates quantitative pharmacokinetic modeling, singlet oxygen dynamics, and receptor-targeted drug conjugation to enhance therapeutic efficacy while minimizing off-target effects. Key applications include bladder, breast, and ovarian cancers. Funding Highlights : NIH/NIGMS: $1.37M (2023-2027) for light-responsive drug delivery National Cancer Institute: $2.1M (2022-2027) for bladder cancer treatments DoD/CDMRP/PRCRP: $392K (2017-2020) for photodynamic-chemotherapy combinations Awards : PHF Presidential Professorship (2018) American Cancer Society Research Scholar Grant (2013) Multiple DoD/CDMRP Idea Awards Service & Grants : Serves as Principal Investigator on 8 major grants. Active reviewer for Wellcome Trust, NIH, and international funding agencies. Holds patents on BODIPY derivatives and singlet oxygen-labile linkers. Lab & Collaborations : Leads the You Lab at UB, collaborating with bioengineers and clinicians to advance photomedicine and targeted drug delivery systems. Engaged in multidisciplinary teams addressing spatiotemporal control in cancer treatments.

• Antibody-Drug Conjugates
• Cancer Chemotherapy
• Medicinal Chemistry
• +3 more

Bradley D. Olsen is a full professor in the Department of Chemical Engineering at the Massachusetts Institute of Technology (MIT), where he leads research at the intersection of polymer science, soft matter physics, and bioengineering. His work focuses on designing materials for critical applications in biotechnology, hemostasis, and sustainable polymer development while advancing fundamental understanding of polymer network mechanics and self-assembly. Education: Ph.D. in Chemical Engineering, University of California Berkeley (2007) S.B. in Chemical Engineering, Massachusetts Institute of Technology (2003) Olsen's research spans protein-based materials, block copolymer phase behavior, and mechanochemical hydrogels. He has pioneered methods for quantifying polymer network topology, developing hemostatic nanoparticles, and creating bio-inspired materials for selective biomolecular transport and medical applications. His recent publications emphasize data-driven approaches to polymer characterization and educational outreach in materials science. Scientific Awards: American Physical Society (APS) Fellow (2023) Fulbright Amazonia Scholar (2023) Alexander and I. Michael Kasser Chair in Chemical Engineering (2021) ACS Macro Letters Young Investigator Award (2021) MIT Committed to Caring Honor (2019) AIChE Owens Corning Early Career Award (2019) APS Dillon Medal (2018) Kavli Emerging Leader in Chemistry (2017) ACS Polymer Division Fellow (2016) Camille Dreyfus-Teacher Scholar (2015) Alfred P. Sloan Research Fellow (2014) NSF Career Grant (2013) NIH Postdoctoral Fellowship (2008-2009) Hertz Fellow (2003-2007) Barry M. Goldwater Scholarship (2002) Olsen has received significant grant support including NSF Career (2013) and AFOSR (2012) awards. His teaching activities include innovative international outreach like the 2025 soccer-themed science camp in Brazil. The Olsen Group at MIT explores advanced materials with applications ranging from trauma care to sustainable polymers.

• Polymer Science
• Materials Engineering
• Soft Condensed Matter Physics
• +4 more

Matthew L Becker is the Hugo L Blomquist Distinguished Professor of Chemistry at Duke University, with additional appointments in Mechanical Engineering and Material Science, and Biomedical Engineering. His research focuses on polymer chemistry, bioconjugate chemistry, molecular imaging, additive manufacturing, and degradable materials for bone, soft tissue, neural, and vascular tissue engineering. Education: B.S. from Northwest Missouri State University (1998), M.A. (2000) and Ph.D. (2003) from Washington University in St. Louis Research interests include developing tunable degradable polymers for flexible electronics, tissue engineering (bone, neural, vascular), and additive manufacturing. His group is pioneering 3D printing of bioresorbable medical devices and custom inks for biomaterials. Recent work explores stereochemistry-dependent polymer properties, mechanochromism, and machine learning-driven biomaterials design. Key applications: Drug delivery systems Biodegradable adhesives Tissue regeneration scaffolds Scientific honors include: Fellow, National Academy of Inventors (2022) Fellow, American Chemical Society (2020) Carl S. Marvel Award in Creative Polymer Chemistry (2019) Fellow, American Institute for Medical and Biomedical Engineering (2018) Fellow, Royal Society of Chemistry (2017) Biomacromolecules/Macromolecules Young Investigator Award (2015) He teaches advanced courses in mechanical engineering and polymer chemistry, with a focus on 3D printing and biomaterials. His group has developed novel medical devices including resorbable suture anchors, hernia mesh coatings, and neuroprosthetic scaffolds.

• Polymer chemistry
• Bioconjugate chemistry
• Molecular imaging
• +5 more

John E. Moses is a Professor at Cold Spring Harbor Laboratory (CSHL), where he leads the Moses Laboratory and serves as Faculty Head of the Mass Spectrometry Shared Resource for the Cancer Center. He is also a Cancer Center Member focusing on developing chemical tools for biological discovery, particularly in cancer research. Dr. Moses earned his D.Phil. in Synthetic Organic Chemistry from the University of Oxford in 2004. His academic journey includes positions as Professor of Organic Chemistry at La Trobe University (2017-2020), Level 6 Future Fellow at the Australian Research Council (2017-2021), and Reader & Associate Professor in Organic Chemistry at the University of Nottingham (2007-2017). Moses' research focuses on click chemistry, a powerful discovery method that uses robust chemical reactions to synthesize functional molecules. His lab specializes in developing and exploiting bond-forming click reactions for rapid synthesis of small functional molecules, including cancer drugs and chemical probes. They apply these molecular tools in multidisciplinary projects spanning biology and chemistry. His recent work has led to significant advances in click chemistry methodologies, including Diversity Oriented Clicking (DOC) and Phosphorus Fluoride Exchange (PFEx). These approaches have enabled the discovery of new cancer therapeutics and antibiotics effective against multidrug-resistant bacteria like MRSA. Dr. Moses has received numerous honors including the 2021 Organic Division Horizon Prize: Robert Robinson Award in Synthetic Organic Chemistry, Fellow of the Royal Society of Chemistry (2015), Thieme Chemistry Award (2011), and UK & ROI Lilly Award for Excellence in Organic Chemistry (2011). Through his work at CSHL, Moses mentors students and postdoctoral researchers while collaborating with biologists to develop Chemistry For Biology. His lab's innovative approaches have been supported by multiple grants, including those from the National Cancer Institute. The Moses Laboratory is at the forefront of click chemistry research, developing new methodologies while applying them to solve critical problems in cancer biology and antibiotic resistance.

• Click Chemistry
• Cancer Drug Development
• Antibiotic Discovery
• +4 more

Yevgeny Brudno, PhD, is an Associate Professor at the Eshelman School of Pharmacy (UNC-Chapel Hill) with a joint appointment in Biomedical Engineering (UNC and NC State University). He is a member of the UNC Lineberger Comprehensive Cancer Center and leads the Brudno Lab, which specializes in drug delivery and biomaterials for cancer immunotherapy, particularly CAR T cell therapy. Research Focus: Development of implantable biotechnologies for in vivo CAR-T cell production, biomaterials for therapeutic delivery, and click chemistry-based drug targeting. Education: PhD (unspecified institution). The lab’s research bridges chemical and biomaterials science with clinical needs, emphasizing on-demand drug release , solid tumor targeting , and autoimmune disease treatments . Recent work includes bioinstructive scaffolds and tissue-reactive drug depots , leveraging click chemistry and nanomedicine . His scientific contributions are highlighted by 15 publications (2009–2025) in fields like biotechnology, cancer immunotherapy, and epigenetics. Notable awards include the NCI MERIT Award , University Faculty Scholar (NC State), and Outstanding Teacher Award (NC State). Advising: Mentored 13 PhD and Master’s students, including Sharda Pandit (2023), Chris Moody (2021), and Emily Joe (2024). Lab announcements highlight student achievements like NSF and NIH fellowships. The Brudno Lab collaborates with UNC Lineberger and NC State, focusing on streamlining therapy production , enhancing efficacy in solid tumors , and autoimmune disease applications , supported by grants from NCI and CMI.

• Biomaterials
• Nanomedicine
• Cancer Immunotherapy
• +3 more

Raphael Franzini serves as Associate Professor of Medicinal Chemistry at the University of Utah, actively contributing to the Biological Chemistry PhD Program. His research pioneers innovative chemical approaches for therapeutic development, with dual focus on DNA-encoded library technologies and bioorthogonal drug delivery systems. His educational foundation includes an M.S. from the Swiss Federal Institute of Technology (Lausanne) and a Ph.D. from Stanford University. This training underpins his group's multidisciplinary methodology combining organic synthesis, bioconjugation, computational modeling, and advanced imaging techniques. Dr. Franzini's research program centers on two transformative areas: First, advancing DNA-encoded library screening through computational integration to identify leads for challenging targets like Tankyrase and Sirtuin 6, with recent work addressing false negatives in machine learning prediction. Second, developing novel bioorthogonal release chemistry using isonitrile-tetrazine reactions for spatiotemporally controlled drug activation, validated in zebrafish models. His group emphasizes both technological innovation and therapeutic translation, with chemistry designed to minimize off-target effects in solid tumors. Analysis of his 15 most recent publications reveals escalating integration of computational methods with experimental library screening, alongside refinement of bioorthogonal release kinetics. The work spans chemical biology, medicinal chemistry, and pharmaceutical sciences, with growing emphasis on machine learning for library data interpretation and in vivo validation of drug-release systems. Dr. Franzini maintains an active research laboratory that provides comprehensive training in cutting-edge drug discovery methodologies. His group culture prioritizes both scientific innovation and researcher development, with projects spanning from fundamental reaction kinetics to therapeutic applications. The lab's infrastructure supports organic synthesis, molecular imaging, and computational analysis for advancing precision therapeutics.

• Drug Discovery
• Medicinal Chemistry
• Bioorthogonal Chemistry
• +3 more

Christopher J. Chang is the Edward and Virginia Taylor Professor of Bioorganic Chemistry at Princeton University's Department of Chemistry. His research focuses on chemical biology, catalysis, and inorganic chemistry, with an emphasis on transition metal signaling, activity-based sensing, and drug discovery. He leads the Chang Lab, which develops innovative chemical tools to study metal-dependent biological processes, including copper's role in neurobiology and cancer, formaldehyde's role in epigenetic regulation, and redox-driven protein function. His work integrates organic, inorganic, and biological chemistry, enabling discoveries in imaging, proteomics, and precision medicine. Notable achievements include pioneering activity-based sensing platforms for copper and reactive metabolites, revealing metalloplasia in cancer, and developing copper-specific therapies. Christopher Chang has received over 50 prestigious awards, including the Guggenheim Fellowship and the Howard Hughes Medical Institute Investigatorship. His lab's infrastructure includes advanced analytical instruments, synthetic chemistry facilities, and cell culture capabilities, supported by grants from NIH, NSF, and industry partnerships. Awards: ACS Bader Award (2024), Ivano Bertini Award (2022), Blavatnik National Award (2015) Lab Focus Areas: Transition metal signaling, copper-dependent biology, formaldehyde metabolism, redox drug discovery Key Technologies: Activity-based sensors, imaging probes, bioconjugation methods

• Chemical Biology
• Catalysis/Synthesis
• Inorganic Chemistry
• +5 more

Sharon Rozovsky is a Professor in the Department of Chemistry and Biochemistry at the University of Delaware's College of Arts & Sciences, where she leads research on oxidative stress response mechanisms and protein quality control pathways. Her work bridges biochemistry, chemical biology, and structural biology with direct implications for understanding neurodegenerative diseases and viral pathogenesis. Her academic foundation includes a B.S. from Tel Aviv University (1994) and a Ph.D. from Columbia University (2000), establishing her expertise in protein dynamics and redox biochemistry. These credentials underpin her innovative approaches to studying cellular stress responses. Rozovsky's research program centers on selenoproteins—proteins containing the rare amino acid selenocysteine—and their critical roles in endoplasmic reticulum (ER) stress resolution. She investigates how membrane-bound selenoproteins like Selenoprotein S and K regulate the ER-associated degradation (ERAD) pathway, with recent work revealing their surprising autoproteolytic activity and involvement in SARS-CoV-2 replication. Her lab pioneers chemical tools including expressed protein ligation and advanced 77Se NMR spectroscopy to characterize these systems at molecular resolution. Analysis of her 2021-2025 publications shows dominant themes in selenoprotein structure-function relationships, ER stress mechanisms, and viral interactions, alongside methodological innovations in cryo-EM grid technology and NMR. This body of work demonstrates consistent focus on redox biochemistry with expanding applications in virology and structural biology. No major scientific awards or fellowships were explicitly documented in the available materials, though her research impact is evident through high-impact publications and methodological contributions. She directs the active Rozovsky Research Group, mentoring graduate students and postdoctoral researchers in biochemical and biophysical techniques. Her laboratory operations are supported by competitive funding including an NSF CAREER award (2011) focused on selenoprotein reactivity, reflecting sustained recognition of her innovative research program.

• Oxidative Stress
• Protein Quality Control
• ERAD Pathway
• +5 more

Matthew R. Jones is an Associate Professor in the Department of Chemistry at Rice University and holds the Gene and Norman Hackerman Junior Chair and Norman Hackerman-Welch Young Investigator titles. He joined Rice in 2017 after postdoctoral research at UC Berkeley under Paul Alivisatos and a PhD at Northwestern University under Chad Mirkin. His research focuses on systems-level nanoparticle assembly, plasmonics, and metamaterials, with applications in energy storage and biomedicine. Jones has pioneered techniques like 4D-STEM for catalytic nanoparticles and developed adaptive materials via strain-controlled synthesis. Education: B.S. in Materials Science and Biomedical Engineering (Carnegie Mellon University), Ph.D. in Chemistry (Northwestern University as an NSF Fellow). Key awards include the Packard Fellowship (2018) and NSF CAREER Award (2022). His lab hosts over 20 graduate students and postdocs, with notable advisees including Bukky, Zhihua Cheng, and Saxton. Research emphasizes interdisciplinary approaches: combining in-situ microscopy, ligand engineering, and computational modeling to control nanoparticle behavior. Recent studies include strain-preserved nanocatalysts (2024) and chiral superlattices (2024). Collaborations span Rice’s Center for Nanoscale Imaging Sciences and the Electrochemical Society. Lab: Jones Research Group Grants: NSF CAREER, Packard Fellowship, Rice Seed Award Publications: Over 50 peer-reviewed articles, including Science Advances (2024) and Nature Communications (2023)

• Nanoparticle Assembly
• Plasmonics
• Metamaterials
• +5 more

Geoffrey Tranmer is a Tenured Associate Professor in the College of Pharmacy at the University of Manitoba. His research integrates medicinal chemistry, drug discovery, and synthetic organic methodologies, with a focus on flow chemistry and targeted cancer therapies. NSERC Post-Doctoral Fellow, University of Cambridge Post-Doctoral Fellow, Princeton University PhD in Organic Chemistry, University of Guelph BSc (Hons) in Chemistry, Brock University His research explores: Development of flow chemistry techniques to enhance synthetic organic methods Lead generation and optimization in drug discovery Bioconjugation strategies for chemical biology applications Targeted cancer therapies leveraging hypoxia-activated prodrugs Recent publications highlight his work in neurodegenerative disease drug design, biomarker discovery, and sustainable synthesis technologies. Scientific Awards CIHR Project Grant (2024-2029) NSERC Discovery Grant (2023-2028) CIHR Bridge Grant (2022) NSERC Alliance Grant (2020) NSERC Engage Grant (2017) Research Manitoba New Investigator Operating Grant (2017) Dr. Tranmer's industrial experience at Merck Frosst and academic leadership at Manitoba position him uniquely to bridge chemistry-biology-industry collaborations. His lab actively trains graduate students in cutting-edge synthesis platforms.

• Medicinal Chemistry
• Drug Discovery
• Organic Synthesis
• +4 more

Matthew Gaunt is the 1702 Yusuf Hamied Professor of Chemistry at the University of Cambridge , specializing in C–H activation , visible-light photocatalysis , and bioconjugation . He leads a research group in Lab 177 , focusing on alkylamine synthesis and chemical biology applications. Gaunt's group has 23 members, including 14 PhD students and 6 postdocs. His research spans catalytic reactivity for organic synthesis, with a focus on metal-catalyzed C–H activation , photoredox strategies , and high-throughput experimentation for rapid reaction development. Key innovations include stereoselective methods for β-lactam synthesis and methionine-targeted protein modification . Scientific Awards & Fellowships: GlaxoWellcome Postdoctoral Fellowship Ramsay Memorial Fellow His group contributes to the SynTech Centre for Doctoral Training , integrating automation and data science into chemical synthesis education. Current students include Joseph Phelps, Marcus Grocott, James Robinson, and Tobias Kraus under his direct supervision.

• Organic Chemistry
• Catalysis
• Chemical Biology
• +6 more

Adam Caparco is the DiPietro Assistant Professor of Chemical Engineering at Northeastern University, with a 25% joint appointment in the Department of Chemistry and Chemical Biology. He leads the Caparco Research Group, focusing on agricultural and environmental biotechnology, enzyme immobilization, and protein assemblies. His work integrates plant virology, nanotechnology, and molecular engineering to address sustainability challenges in agriculture and environmental remediation. He is a member of the Institute for Plant-Human Interface and holds affiliations with Northeastern’s College of Engineering and School of Arts and Sciences. Education: B.S. in Chemical and Biomolecular Engineering from UCLA (2015), Ph.D. from Georgia Tech (2020) under Julie Champion and Andreas Bommarius, followed by a USDA NIFA Postdoctoral Fellowship at UC San Diego under Nicole Steinmetz. His research spans plant immunoengineering, biomanufacturing in plants, and protein-based nanomaterials for bioremediation. Research Interests Plant excretion pathways for pathogen defense and environmental remediation Design of immobilized enzymes for green chemical synthesis Plant virus nanoparticles for nucleic acid delivery and immunity modulation Multifunctional protein engineering for sustainable agriculture Recent articles highlight advancements in plant virus-based delivery systems, enzyme immobilization strategies, and nano-enabled precision agriculture. Awards include the USDA NIFA Postdoctoral Fellowship. Caparco advises graduate and undergraduate researchers, including Julia Hilgemberg Merlin (PhD ChE), Olha Bereziuk (PhD CCB), and Paul Carter (PhD ChE). He collaborates widely and seeks to expand interdisciplinary research in plant biotechnology. Labs/Teams: Caparco Research Group (EXP 420 lab, EXP 530B office) and the Institute for Plant-Human Interface.

• Agricultural Biotechnology
• Environmental Biotechnology
• Enzyme Immobilization
• +6 more

Jason Micklefield is a Professor of Chemical Biology at the University of Manchester's School of Chemistry and Manchester Institute of Biotechnology. His research focuses on sustainable bio-inspired molecular synthesis, integrating organic chemistry, enzymology, and molecular microbiology. He holds an honorary Visiting Professorship at East China University of Science and Technology. Micklefield earned his PhD in Chemistry from the University of Cambridge in 1993 and completed postdoctoral work at the University of Washington before joining Manchester in 1998. His lab specializes in biosynthesis pathway engineering, biocatalysis, and nucleic acid chemistry. Education: PhD in Chemistry (1993), University of Cambridge NATO Postdoctoral Fellowship, University of Washington, USA (1993–1995) Lecturer in Organic Chemistry, Birkbeck College, University of London (1995–1998) Research Themes: Biosynthesis of novel antibiotics to combat AMR, including pathway engineering for agrochemicals and drug discovery. Biocatalysis and integrated catalysis for sustainable synthesis of pharmaceuticals, focusing on amide ligases and halogenases. Nucleic acid therapeutics and riboswitch engineering for synthetic genetic control. Key Achievements: Discovered CfaL ligases enabling amide synthesis without protecting groups. Engineered vitamin K-dependent carboxylases for novel antibiotic pathways. Developed orthogonal riboswitches for synthetic biology applications. Awards: RSC Bader Award (2019) NPR Lecture Award Lab & Collaborations: The interdisciplinary Micklefield Lab includes chemists, biochemists, and bioinformaticians. Projects include MESNA (modified nucleic acid synthesis) and collaborations on sustainable chemical manufacturing.

• Biosynthesis
• Biocatalysis
• Antimicrobial Resistance (AMR)
• +3 more

Dr. Martin Anthony Fascione is a Reader in Chemistry at the University of York, where he leads the Fascione Lab within the Department of Chemistry. His research focuses on the interface between chemistry and biology, particularly in the field of chemical glycobiology. He has established himself as a leading researcher in carbohydrate chemistry with expertise in synthetic methods and biological applications. Dr. Fascione received his Ph.D. from the University of Leeds in 2009 under the supervision of W. Bruce Turnbull, followed by a Marie Curie International Outgoing Fellowship at the University of British Columbia with Prof. Steve Withers and the University of York with Prof. Gideon Davies. Since August 2014, he has been at the York Structural Biology Laboratory, progressing from Lecturer to his current position as Reader. His research centers on complex sugars (glycans) and their roles in biological processes and disease, with particular emphasis on sialic acid-like molecules critical for bacterial pathogens. The Fascione group develops chemical tools to study and perturb glycan activity in vivo using synthetic and enzymatic carbohydrate chemistry, organocatalysis, enzymology, and molecular biology. Key research areas include pseudaminic acid biosynthesis, protein bioconjugation, and glycoconjugate development for therapeutic applications. Analysis of Dr. Fascione's recent publications reveals a strong focus on bacterial glycans, particularly pseudaminic acid, and their role in pathogenesis. His work combines synthetic chemistry with biological applications, developing novel methods for protein modification, carbohydrate synthesis, and glycan-based therapeutics. Major themes include bioorthogonal chemistry, enzymatic synthesis of complex carbohydrates, and the development of glycoconjugates for therapeutic and diagnostic applications. Dr. Fascione has received significant recognition for his work, including: Marie Curie International Outgoing Fellowship (2012-2014) ERC Consolidator Grant (2022) As an active researcher, Dr. Fascione supervises PhD students and collaborates extensively with researchers in the UK and internationally. His laboratory is involved in multiple research projects focused on chemical glycobiology for infectious disease research and therapeutic development. The Fascione Lab has established itself as a leading center for research at the chemistry-biology interface, with particular expertise in carbohydrate-active enzymes and glycan-based tools for biological investigation.

• Carbohydrate Chemistry
• Chemical Glycobiology
• Glycomedicine
• +11 more

Anne-Sophie Chauvin is a Senior Lecturer and Researcher at École Polytechnique Fédérale de Lausanne (EPFL), School of Basic Sciences, within the Institute of Chemical Sciences and Engineering and the Supramolecular Chemistry Laboratory. She actively engages in supramolecular and inorganic chemistry, focusing on f-element (lanthanides and actinides) coordination polymers and luminescent bioprobes for biological and technological applications, including invisible inks and dye-sensitized solar cells. PhD in Bioinorganic Chemistry from University Paris V-René Descartes (thesis on Nitrile Hydratase mimetics) Postdoctoral work at University of Geneva on chiral alcohol configuration analysis Habilitation à Diriger des Recherches (HDR) from University René Descartes (2006) Her research spans Lanthanide and Actinide Chemistry , Luminescence , Coordination Polymers , Metallacages , and Photovoltaic Materials . Recent publications emphasize catalytic spiro stereocenter formation, actinide coordination polymers, and photoredox-enabled biomolecule functionalization. She has supervised PhD students including Andrei Andreichenko , Julien Andrès , Steve Comby , and Aurélien Willauer . Recognitions include Fellowship of the Royal Society of Chemistry (FRSC) and membership in the Swiss Chemical Society (SCS). Current roles include teaching General and Analytical Chemistry to first-year Pharmacy and Biology students at the University of Lausanne (UNIL), overseeing practical sessions, and serving on the EPFL School of Basic Sciences Faculty Council.

• Supramolecular Chemistry
• Inorganic Chemistry
• Lanthanide Chemistry
• +7 more