Marco PaolinoView profile
Associate Professor
Marco Paolino is an Associate Professor in the Department of Biotechnology, Chemistry and Pharmacy at the University of Siena, teaching Drug Analysis for the five-year Pharmacy program (Chimica e Tecnologia Farmaceutiche) across academic years 2023/2024–2025/2026. His office resides in room B_01_86 (Via A. Moro 2, Siena) with laboratory operations at San Miniato biological institutes (Lab 10126). Research centers on Medicinal Chemistry and Drug Design , specializing in TRPV1 agonists, dual AChE/MAO-B inhibitors for neurodegenerative diseases, lysine-targeted covalent ligands, and cytotoxic macrocycles. His group pioneers Morita-Baylis-Hillman reaction chemistry for synthesizing complex therapeutic scaffolds, integrating photochemical control mechanisms and ADME-Tox profiling. 2025 publications reveal a cohesive trend toward multi-target neurological therapeutics and oncology agents, featuring structural innovation in indole carboxamides, photoswitchable inhibitors, and macrocyclic cytotoxins. This work bridges synthetic organic chemistry with biological validation, emphasizing translational potential through rigorous in vitro evaluation. Student advising details are unspecified, though active supervision within Pharmacy programs is implied. Laboratory operations at San Miniato (Lab 10126) support collaborative research in chemical synthesis and biological testing, with infrastructure for advanced ADME-Tox studies and molecular characterization.








