Katharina KochView profile
Researcher
Katharina Koch serves as Junior Research Group Leader at the Leibniz Institute for Environmental Medical Research (IUF) in Düsseldorf, Germany, where she heads the Environmental Toxicants and the Brain Research group. Her work focuses on developing and validating alternative methods to animal testing for assessing neurotoxicity, with particular emphasis on developmental and adult neurotoxicity. She collaborates extensively with national and international partners including researchers from Ruhr University Bochum, University of Konstanz, and institutions in the United States and Switzerland. Dr. Koch's research interests center on creating cross-species 3D neurosphere test systems for characterizing developmental neurotoxicity (DNT), which form an integral component of the DNT in vitro battery supported by EFSA and OECD. Her work extends to endocrine-mediated DNT, embryotoxicity, and developmental immunotoxicity. She has established several neurotoxicity Adverse Outcome Pathways (AOPs) and contributes to novel toxicology concepts for cognitive dysfunction with regulatory applications. Her group's work on BrainSphere models is advancing next-generation risk assessment within the EU-PARK project and investigating Cockayne syndrome B disease mechanisms. Her research group operates within a robust funding framework, with projects supported by the German Research Foundation (DFG), European Union Horizon programs, the US National Toxicology Program, and industry partnerships through Leibniz Alternatives. The group has developed AI-based cell identification from high-content imaging analyses and established biostatistical pipelines for comparative data processing. Dr. Koch actively mentors a team of doctoral students, master's students, and postdoctoral researchers, fostering the next generation of toxicology scientists. Her collaborative network spans multiple disciplines, connecting environmental science, neuroscience, and regulatory toxicology to advance human-relevant testing approaches that reduce reliance on animal models.






