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Lucy Glover is a Researcher and Group Leader of the Trypanosome Molecular Biology laboratory at the Department of Parasites and Insect Vectors, Institut Pasteur, Paris, France. She joined the institute in March 2016 as a G5 group leader, focusing on the molecular mechanisms of antigenic variation and DNA repair in Trypanosoma brucei , the causative agent of Human African Trypanosomiasis. Her research integrates molecular, biochemical, and high-throughput approaches to study DNA recombination and immune evasion. Institut Pasteur, Paris (2016–Present) PhD, London School of Hygiene and Tropical Medicine Her research interests center on antigenic variation , DNA repair , and homologous recombination in trypanosomes. She investigates how DNA double-strand breaks influence variant surface glycoprotein (VSG) switching, a critical process for parasite survival in the host. Her lab uses advanced techniques such as RIT-seq, phosphoproteomics, and CRISPR-based tools to dissect these mechanisms at the molecular level. The recent publications of Lucy Glover span molecular parasitology, DNA damage response, and diagnostic development. Key themes include the role of the MRN complex in DNA repair, phosphoproteomic profiling of DNA damage responses, and the design of CRISPR-based diagnostics for HAT. Her work reveals how chromosomal context influences repair pathways and antigenic variation, contributing to a deeper understanding of parasite biology. While no formal scientific awards are listed in the provided text, her contributions are evident through high-impact publications and leadership in collaborative research projects. Lucy Glover advises several PhD and postdoctoral researchers, including Emilia MacLaughlin, Nuria Sima Teruel, and Alix Thivolle. Her lab is supported by institutional initiatives such as LabEx IBEID and transversal drug discovery programs. She collaborates with teams working on host-pathogen interactions, genomics, and infectious disease epidemiology. Her laboratory is part of the Department of Parasites and Insect Vectors and participates in departmental retreats and seminars. The team includes post-docs, research engineers, and administrative staff, reflecting a collaborative and interdisciplinary research environment focused on combating neglected tropical diseases.

• Molecular Parasitology
• DNA Repair
• Antigenic Variation
• +7 more

Aleksandra Walczak is a Professor of Biophysics at the École normale supérieure , leading research at the Laboratoire de Physique Théorique (LPENS). Her work bridges statistical physics and biology, focusing on understanding complex living systems through gene regulatory networks, immune system dynamics, and population genetics. Research Interests : Non-equilibrium biological systems, T-cell/B-cell receptor repertoires, stochastic molecular systems, and evolutionary dynamics. Funding & Collaborations : Supported by the Fondation Bettencourt Schueller, she co-organizes interdisciplinary workshops like the Paris Workshop on Immunology and contributes to GDRI Evolution, Regulation and Signaling network. Recent Publications explore gene regulatory principles, immune repertoire modeling, viral-immune coevolution, and collective behavior. She has secured competitive grants and mentors students in theoretical biophysics. Awards : Habilitation à diriger des recherches (2012), Princeton Center for Theoretical Physics Postdoctoral Fellowship (2007-2010). Students & Positions : Actively supervises PhD/Master projects; offers internships in biophysics and quantum engineering.

• Biophysics
• Gene Regulatory Networks
• Immune System Dynamics
• +6 more

Ludovic Tailleux is a Research Professor at the Pasteur Institute , specializing in host-pathogen interactions and tuberculosis immunology . His work focuses on the innate immune response against Mycobacterium tuberculosis, particularly in human dendritic cells and macrophages. He has identified DC-SIGN/CD209 as a critical host cell receptor for M. tuberculosis and collaborates with Laurent Barreiro (University of Montreal) on genetic determinants of immune variation. Education : Not explicitly detailed in the text, but inferred from research depth to include advanced training in immunology/microbiology. Tailleux's research spans innate immunity , antigen presentation , genetic architecture of immune response , and host-directed therapies . His projects include identifying host genetic factors affecting M. tuberculosis interplay and analyzing epigenetic changes in immune cells. The 15 most recent publications highlight trends in zinc toxicity mechanisms , nanocarrier drug delivery , microRNA regulation , and purinergic signaling in TB pathogenesis. He contributes to educational initiatives, including an upcoming MOOC on Tuberculosis (2025) at Pasteur Institute. Collaborative efforts with institutions like University of Montreal and technical teams at Pasteur are central to his work. Tailleux also investigates macrophage polarization , angiogenesis exploitation by TB , and innate immune reprogramming through DNA methylation studies.

• Host-Pathogen Interactions
• Tuberculosis Immunology
• Innate Immunity
• +4 more

Milena Hasan is a Researcher at the Institut Pasteur in Paris, France, specializing in UTechS Single Cell Biomarkers unit. Her work focuses on cutting-edge single-cell transcriptomics , immune profiling , and cytometry data analysis across diverse conditions including viral infections, autoimmune diseases, and cancer immunotherapy. Lead investigator for multiple projects (TPAI, TTP, VARIANCE) involving single-cell technology training and advanced immune response analysis Key contributor to the Milieu Intérieur program studying immune system heterogeneity She actively develops tools for multi-omics data integration and leads courses on Single Cell Gene Expression and Beyond (2022, 2025) and Advanced Immunology (2025). Her research spans host-pathogen interactions , T cell dynamics , and inflammatory disease mechanisms through innovative technologies like spectral cytometry and single-cell proteomics.

• Single-cell transcriptomics
• Immunology
• Infectious disease research
• +5 more

Dr. Cécile Gautier is a researcher in the Mycology Department at the Pasteur Institute in Paris, France, specializing in medical mycology and antifungal resistance. Her work focuses on Epidemiology of invasive fungal infections Mechanisms of azole resistance Emerging mould pathogens Clinical microbiology diagnostics Recent publication trends highlight her expertise in: Azole Resistance: Genetic mechanisms (KSR1 loss of heterozygosity), drug tolerance, combination therapies Mucormycosis: National surveillance programs, prognostic factors, public health implications Emerging Pathogens: Uncommon fungal species identification, clinical diagnostic challenges Immunodeficiency-Related Infections: STAT3-deficiency complications, host-pathogen interactions Collaborations with the French Mycoses Study Group and contributions to journals like Lancet Regional Health - Europe and Medical Mycology demonstrate her leadership in clinical mycology research.

• Medical Mycology
• Fungal Infections
• Antifungal Resistance
• +3 more

Sebastian Baumgarten is the Head of the 'Parasite RNA Biology' Group at the Institut Pasteur, France, a position he has held since June 2021. He is affiliated with the Department of Biology of Host-Parasite Interactions. Previously, he was a post-doctoral researcher at the same institute from 2016 to 2021. His educational background includes a Ph.D. (2013–2016) and MSc (2012–2013) from the Red Sea Research Center at King Abdullah University of Science and Technology, Saudi Arabia, and a BSc (2009–2012) from the University of Tübingen, Germany. His research centers on RNA biology in malaria parasites, particularly focusing on RNA modifications such as m6A and tRNA methylation, epigenetic regulation, and post-transcriptional gene control in Plasmodium falciparum . He employs advanced genomic techniques including CRISPR, RNAseq, and ChIPseq to study gene regulation and immune evasion mechanisms in protozoan parasites. His recent publications reveal a strong trend in understanding how RNA modifications influence parasite development, stress response, and antigenic variation. His work bridges molecular parasitology with epitranscriptomics, contributing significantly to the understanding of gene regulation in malaria parasites. Notable scientific contributions include studies published in Nature Microbiology , mBio , EMBO Reports , and Life Science Alliance , focusing on m6A methylation, RUF6 ncRNA interactions, and cohesin-mediated gene repression. He has supervised or collaborated with several researchers including post-doctoral fellows, PhD students, and technicians within his team. His group is actively involved in uncovering the molecular mechanisms of parasite survival and immune evasion, with potential implications for antimalarial drug and vaccine development. The 'Parasite RNA Biology' group operates within the Institut Pasteur's ecosystem, leveraging interdisciplinary platforms for genomics, imaging, and functional analysis to advance understanding of malaria parasite biology.

• RNA modifications
• Parasitology
• Malaria
• +12 more

Mathieu Picardeau is Head of the Biology of Spirochetes Unit at the Institut Pasteur in Paris, France. The unit serves as the French National Reference Center (NRC) for Leptospirosis and a WHO Collaborating Center for Research and Reference on Leptospirosis. He leads research on the genomics, epidemiology, and diagnostics of Leptospira , a significant zoonotic pathogen affecting tropical and underserved populations globally. His research focuses on: Whole-genome sequencing and cgMLST genotyping of Leptospira strains Development of improved diagnostic tools, including ELISA and point-of-care tests Characterization of Leptospira biodiversity and discovery of novel species Epidemiological surveillance in France and overseas territories Application of targeted genome capture to overcome cultivation challenges His recent publications reveal strong trends in molecular epidemiology, diagnostic validation, and global pathogen surveillance. He contributes to international taxonomic efforts and One Health approaches, with studies spanning human, animal, and environmental health across multiple continents. His work is central to improving healthcare outcomes for neglected tropical diseases. Scientific contributions and recognitions include: Leadership of the French NRC and WHO Collaborating Center for Leptospirosis Development of the publicly accessible cgMLST database at https://bigsdb.pasteur.fr/leptospira/ Principal investigator on multiple national and international research projects Active participation in the International Committee on Systematics of Prokaryotes As a principal investigator, Dr. Picardeau mentors junior scientists and collaborates extensively with teams in endemic regions such as Laos, Costa Rica, Algeria, and French Guiana. His research is supported by institutional funding and international collaborations. The Biology of Spirochetes Unit maintains a large, curated collection of Leptospira strains and plays a key role in public health response and outbreak investigation. Future work is expected to focus on real-time genomic surveillance, vaccine development, and expanding diagnostic accessibility in low-resource settings.

• Bacteriology
• Leptospirosis
• Genomics
• +7 more

Aleksandra Walczak is a Researcher (CNRS Directrice de Recherche) at the Laboratoire de Physique de l’ENS (LPENS) at École Normale Supérieure in Paris, France. She leads the Statistical Biophysics group, focusing on theoretical and computational approaches to biological systems. Her work bridges physics and biology, addressing challenges in cellular processes, immune systems, and evolutionary dynamics. Research Interests: Walczak’s research explores the interplay between biological function and physical principles. Key areas include gene regulatory networks, collective behavior in biological systems (e.g., immune responses), and population genetics. She develops models to understand how interactions between molecular components influence phenotypes and how immune systems encode complex functions using probabilistic frameworks. Recent projects include studying antigenic escape in viral populations and applying machine learning to immune repertoire analysis. Affiliations & Collaborations: She co-leads the GDRI network on Evolution, Regulation, and Signaling, fostering international collaboration. Her work is supported by the Fondation Bettencourt Schueller and involves interdisciplinary initiatives like the Paris Biological Physics Community Day. Education & Career: Walczak earned her PhD in Physics from UC San Diego (2007) and an HDR (Habilitation) from ENS Paris (2012). She held postdoctoral positions at Princeton University and the Kavli Institute for Theoretical Physics. As a CNRS researcher since 2010, she has contributed to over 100 publications, advancing our understanding of biological systems through physics-based models.

• Biophysics
• Immunology
• Statistical Mechanics
• +4 more

Yasmine Belkaid is the Institute Director at Institut Pasteur , where she leads the Meta-organism research team within the Research Department. She is a leading figure in immunology, focusing on host-microbiota interactions, mucosal immunity, and maternal-child health. Her work bridges fundamental immunology with global health applications. Belkaid’s research explores how the immune system interacts with commensal microbes at barrier sites like the skin and gut. Her team investigates the role of the microbiota in immune development, inflammation, and disease, with particular interest in maternal immunity, skin immunology, and neuroimmune crosstalk. Recent studies have uncovered mechanisms by which immune cells regulate lactogenesis, how hormonal signaling shapes skin immunity, and how neuroimmune pathways modulate adaptive responses. Her recent publications, appearing in Cell , Science , and Nature Communications , reflect a strong trend toward systems-level understanding of immune-microbe-host interactions, integrating immunology, microbiology, metabolism, and neuroscience. Key themes include tissue-resident immunity, immune modulation by microbial metabolites, and sexual dimorphism in immune responses. She has been recognized with prestigious honors, including: Member of the French Academy of Sciences Belkaid mentors postdoctoral researchers and contributes to major educational initiatives, including the annual Pasteur Course on Mother and Child Health. She is also a vocal advocate for scientific freedom and international collaboration, having co-authored a high-profile call to protect researchers from political interference. Her lab is actively involved in several cross-functional projects related to maternal and child health, antimicrobial resistance, and global immunology.

• Immunology
• Microbiota-Host Interactions
• Mucosal Immunology
• +7 more

Mart Krupovic is a researcher at the Institut Pasteur in Paris, France, where he leads projects in the Department of Cell Biology and Virology of Archaea. He serves as Principal Investigator (PI) for multiple research initiatives, including the ANR-ENVIRA and Emergence(s) MEMREMA projects, focusing on archaeal membrane remodeling and virus egress mechanisms. His research interests include archaeal virology, extracellular vesicles, membrane dynamics, structural biology, and viral evolution . His work leverages advanced techniques such as cryo-electron microscopy (cryo-EM), genomics, and biophysical analysis to study extremophilic archaea and their viruses. Recent publications highlight discoveries in viral capsid malleability, DNA-carrying extracellular vesicles, and the structural evolution of archaeal motility appendages. The trends in his recent publications (2022–2025) reflect a strong emphasis on structural characterization of archaeal systems , particularly viral and surface appendage architectures. His work often bridges evolutionary biology and molecular mechanics, revealing deep homologies between archaeal and bacterial systems, and uncovering novel mechanisms in DNA transfer, membrane remodeling, and virus-host coevolution. Scientific Awards: No awards mentioned in the provided text. Advising and Grants: Dr. Krupovic has supervised or collaborated with several PhD students and postdoctoral researchers, including Emmanuelle Quemin, Sofia Medvedeva, and Miguel Gomez-Raya-Vilanova. He leads externally funded projects such as ANR-ENVIRA, ANR-FunVesi, and the Emergence(s) MEMREMA project, indicating active grant support for his research. Labs and Teams: He is a key member of the 'Evolution & Ecology Moléculaire Microbienne' research group at the Institut Pasteur, specifically within the 'Cell Biology and Virology of Archaea' team. His lab employs interdisciplinary approaches combining virology, structural biology, and microbial genomics to study archaeal systems.

• Virology
• Archaea
• Molecular Evolution
• +7 more

Jean-Pierre Vartanian is a researcher in the Virology department at the Institut Pasteur in Paris, France. He is actively involved in research on viral mutagenesis, host restriction factors, and the role of APOBEC3 enzymes in viral evolution and carcinogenesis, particularly in the context of hepatitis B virus and retroviruses. His research focuses on understanding how host cellular factors such as APOBEC3 enzymes and hypoxia-induced proteins influence viral replication and genome stability. He investigates mechanisms of viral restriction, DNA editing, and the interplay between viral infection and innate immune responses, with implications for cancer development and antiviral strategies. The recent publications highlight a strong trend in molecular virology, especially in host-virus interactions, mutagenesis, and DNA damage responses. His work frequently explores how cellular stress conditions like hypoxia modulate antiviral defenses and how APOBEC3 family proteins contribute to both antiviral activity and genomic instability. Genetic and molecular mechanisms of viral restriction Role of APOBEC3 enzymes in viral evolution and cancer Hepatitis B virus-host interactions Mutagenesis in emerging viruses (e.g., Monkeypox) Innate immunity and DNA damage response He contributes to educational programs at the Institut Pasteur, including the annual Pasteur Course Emerging Viruses , Cours Pasteur Virologie fondamentale , and several MOOCs such as Viral Outbreaks and Pandemics and Viruses and Human Cancers , indicating active mentorship and knowledge dissemination roles. While specific grants or advising relationships are not detailed, his collaborations with prominent scientists like Simon Wain-Hobson and Rémi Suspène suggest strong research network involvement. Jean-Pierre Vartanian is associated with the Institut Pasteur’s research ecosystem, contributing to projects in virology and host-pathogen interactions, particularly within teams focused on viral physiopathology, virus-cell stress, and immunity.

• Virology
• Molecular Virology
• Viral Mutagenesis
• +7 more

Darragh Duffy and Lluis Quintana-Murci are core researchers at Institut Pasteur , leading the LabEx Milieu Intérieur consortium. Duffy specializes in translational immunology and standardized immune phenotyping, while Quintana-Murci focuses on human evolutionary genetics and population-scale immune variation. Their collaborative work integrates genetic, epigenetic, and environmental factors to define the boundaries of healthy immune responses. Key Projects: 1000-donor cohort studies, systems immunology frameworks, microbiome-immunity interplay Methodologies: TruCulture stimulation systems, spectral cytometry protocols, multi-omics integration Their research has produced seminal works on TLR pathway dynamics , IFNγ regulation , and HLA-disease associations , with applications in vaccinology , autoimmune disease and infectious immunity . The Milieu Intérieur project, funded under France's Investissements d'Avenir program, serves as a foundational resource for precision immunology and population health initiatives. Scientific Contributions include: Defining genetic/epigenetic drivers of immune variability Establishing standardized protocols for whole-blood immunophenotyping Revealing microbiome-immunity regulatory networks Characterizing age-, sex-, and genetics-based immune response boundaries Their work underpins 70+ research projects globally, with applications in epidemiology , biomarker discovery , and personalized medicine . The consortium maintains strict data governance through its Data Access Committee , ensuring ethical use of participant data.

• Immunology
• Genetics
• Population Genetics
• +3 more

Philippe Bastin is a full Professor and Director of the Trypanosome Cell Biology Unit at Institut Pasteur and INSERM U1201, Paris. He also chairs the Labex IBEID program (Integrative Biology of Emerging Infectious Diseases) and leads multiple international collaborations. University Paris-Descartes (HDR, 2005) Université Catholique de Louvain (PhD, 1993; Degree, 1989) His research focuses on Trypanosoma brucei and Toxoplasma gondii , with specific interests in: Flagellar assembly and intraflagellar transport (IFT) Tubulin post-translational modifications Centrosome and basal body biology Motility mechanisms of vector-borne pathogens Microfluidic tools for parasite imaging Recent work includes Tryp-Chip microfluidic devices for longitudinal parasite imaging, LRRC56 roles in dynein docking, and glutamylation studies in flagellum construction. His 2025 publications explore IFT selectivity and tubulin dynamics. Awards include: Fondation pour la Recherche Médicale Team (2022, 2015) Honorary Christoffel Plantin Award (2021) Pasteur-Vallery-Radot Prize (2013) He has trained 10 PhD students and 13 postdocs, with 1/3 of former trainees in academia, 1/3 in industry (including a startup CEO), and 1/3 in international postdocs.

• Cell Biology
• Molecular Biology
• Parasitology
• +7 more

Jessica Bryant is a Research Fellow in the Biology of Host-Parasite Interactions Unit within the Department of Parasites and Insect Vectors at the Institut Pasteur, Paris. She conducts cutting-edge research on epigenetic and transcriptional regulation in Plasmodium falciparum , the deadliest malaria parasite, focusing on the var multigene family and antigenic variation. Ph.D. in Cell and Molecular Biology, University of Pennsylvania (2008–2014) B.S. in Cellular Biology, University of Georgia (2004–2008) Her research expertise lies in chromatin biology, gene regulation, and CRISPR-based technologies in parasitology. She investigates how epigenetic mechanisms control virulence gene expression and immune evasion in malaria parasites. Her work integrates molecular biology, genomics, and functional assays to dissect transcriptional networks in Plasmodium . The recent publications highlight a strong focus on CRISPR applications, m6A mRNA methylation, noncoding RNA regulation, and chromatin remodeling in Plasmodium . These studies reveal complex regulatory layers controlling antigenic variation and stage-specific gene expression, with implications for malaria pathogenesis and therapeutic development. Scientific Awards and Fellowships: EMBO Long-term Postdoctoral Fellowship (2015–2017) Institut Pasteur Roux-Cantarini Postdoctoral Fellowship (2015–2016) Goldwater Scholar (2008) Biomedical Graduate Studies Travel Grant (2012, 2013) University of Pennsylvania Genetics T32 Training Grant (2010–2012) Jessica Bryant has contributed significantly to mentoring and scientific community building, having served as Departmental Postdoc Representative at the Institut Pasteur. She has taught epigenetics and next-generation sequencing courses at Sorbonne University and the University of Bern. She co-organized the international CRISPR in Parasitology Symposium, fostering collaboration across the field. Her research is supported by prestigious grants and conducted within a leading parasitology research unit, with no indication of retirement or former status.

• Parasitology
• Epigenetics
• Gene Regulation
• +7 more

Gorochov Guy is a Research Professor and Team Leader at Sorbonne Université, leading a multidisciplinary research group focused on immunopathology and tolerance mechanisms. His work bridges basic science and clinical translation, particularly in autoimmunity, antiviral immunity, and microbiota interactions. He collaborates with AP-HP (Assistance Publique - Hôpitaux de Paris), integrating clinical insights into his investigations. Research Interests: Host-microbiota interface in health/disease Therapeutic antibody engineering Regulatory T cell (Treg) therapies Antiviral immunity (SARS-CoV-2, autoantibody pathogenesis) Immune dysregulation in autoimmunity and immunodeficiency Articles Trends: Recent work emphasizes IgA's role in mucosal immunity, microbiota-mediated disease, and CAR-T cell therapies. Key contributions include identifying IgA's early neutralizing role in SARS-CoV-2 and linking gut microbiota alterations to autoimmune conditions like multiple sclerosis. Scientific Awards: No awards explicitly mentioned in current texts. Advising & Grants: Supervises doctoral students (e.g., Sterlin Delphine, Fadlallah Jehane) and postdocs (e.g., Pineton de Chambrun Marc, Imamovic Lejla). Active in clinical trials for Treg-based therapies in transplantation and autoimmunity. Collaborates on large-scale projects like the CoviCompare vaccine platform comparison. Labs/Teams: Leads the Immunopathology team at Sorbonne, focusing on translational research in immunodeficiency, autoimmunity, and antiviral strategies. Collaborates internationally on microbiota-immune axis studies and CAR-T cell optimization.

• Immunology
• Autoimmunity
• Antiviral Immunity
• +3 more