Kevin DeanView profile
Assistant Professor
Kevin Dean is an Assistant Professor at the UT Southwestern Medical Center , affiliated with the Lyda Hill Department of Bioinformatics and the Cecil H. and Ida Green Center for Systems Biology . His research focuses on developing and applying advanced microscopy techniques to address complex biological challenges, particularly in cancer metastasis and cellular mechanobiology. Co-developer of autonomous 'self-driving' microscopes using computer vision Expert in spectral unmixing and cyclic immunofluorescence for molecular multiplexing Creator of high-throughput histopathology systems with 300 nm resolution Collaborator with leading scientists (Drs. Danuser, Fiolka, Morrison, Amatruda, Sorger) Principal Investigator for NIH/NCI-funded cancer imaging programs Research Themes: The Dean Lab specializes in cutting-edge imaging solutions that bridge technology development and biological discovery. Their work spans: Cancer Biology: Metastatic colonization mechanisms, tumor microenvironment imaging Biomedical Technology: Light-sheet microscopy, optical probes, time-series analysis software Cellular Mechanobiology: Force-driven morphogenesis, matrix deformation quantification Neuroscience: Stress-induced anhedonia, lateral habenula neuronal signaling Grant Leadership: Dean serves as Principal Investigator for the NCI-funded Imaging Mechanisms of Metastatic Tumor Formation and the NIGMS-supported UTSW-UNC Center for Cell Signaling Analysis , where his team develops open-source platforms like Navigate for smart light-sheet microscopy. Collaborative Networks: Active in multiple interdisciplinary programs including: Prune Belly Syndrome research with Filamin A mutations Drosophila germband extension mechanobiology with micro-cantilevers Lateral habenula functional mapping with multi-modal imaging









