Zohar Sachs

Zohar Sachs, MD, PhD is an Assistant Professor at the University of Minnesota, affiliated with the Department of Medicine Division of Hematology, Oncology and Transplantation, the Microbiology, Immunology and Cancer Biology (MICaB) Graduate Program, and the Bioinformatics and Computational Biology Graduate Program (BICB). He serves as a Preceptor for the Medical Scientist Training Program and is a Member of the Masonic Cancer Center.

Education:

• BS in Biochemistry, University of Wisconsin (2016)

Research Focus: The Sachs Lab investigates molecular mechanisms of leukemia stem cell self-renewal in AML using single-cell high-throughput technologies (mass cytometry/CyTOF, single-cell RNA sequencing) and patient-derived xenografts. Key areas include therapeutic targeting of TP53-altered AML, computational methods for scRNA-seq analysis, and modeling MDS progression to AML.

Notable Contributions: Presented research on crizotinib's effects in TP53-altered AML at the 2019 ASH Annual Meeting. Collaborates with the Masonic Cancer Center's Genetic Mechanisms of Cancer Program.

Labs & Teams: Leads the Sachs Lab, managing a team including Research Associate Marie Lue Antony (PhD), Lab Manager Klara Noble-Orcutt (MS), and PhD candidates in the Bioinformatics and Computational Biology Program.